+C	Two-component system	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Two-Component System - Salmonella enterica subsp. enterica serovar Agona SL483</h2>
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A<b>OmpR family</b>
B  PhoR-PhoB (phosphate starvation response)
C    SeAg_B0436 phoR; phosphate regulon sensor protein PhoR	K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] 
C    SeAg_B0435 phoB; phosphate regulon transcriptional regulatory protein PhoB	K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB 
B  SenX3-RegX3 (phosphate starvation response)
B  PhoQ-PhoP (magnesium transport)
C    SeAg_B1954 sensor protein PhoQ	K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3] 
C    SeAg_B1953 transcriptional regulatory protein PhoP	K07660 phoP; two-component system, OmpR family, response regulator PhoP 
B  EnvZ-OmpR (osmotic stress response)
C    SeAg_B3702 envZ; osmolarity sensor protein EnvZ	K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] 
C    SeAg_B3703 ompR; transcriptional regulatory protein OmpR	K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR 
B  RstB-RstA
C    SeAg_B1703 sensor protein RstB	K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3] 
C    SeAg_B1699 transcriptional regulatory protein RstA	K07661 rstA; two-component system, OmpR family, response regulator RstA 
B  CpxA-CpxR (envelope stress response)
C    SeAg_B4304 sensor protein CpxA	K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3] 
C    SeAg_B4305 cpxR; transcriptional regulatory protein CpxR	K07662 cpxR; two-component system, OmpR family, response regulator CpxR 
B  CssS-CssR (secretion stress response)
B  CreC-CreB (phosphate regulation)
C    SeAg_B4913 sensor protein CreC	K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3] 
C    SeAg_B4912 transcriptional regulatory protein CreB	K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB 
B  BaeS-BaeR (envelope stress response)
C    SeAg_B2260 signal transduction histidine-protein kinase BaeS	K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3] 
C    SeAg_B2261 baeR; DNA-binding response regulator BaeR	K07664 baeR; two-component system, OmpR family, response regulator BaeR 
B  BasS-BasR (antimicrobial peptide resistance)
C    SeAg_B4553 sensor protein BasS/pmrB	K07643 basS; two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3] 
C    SeAg_B4554 transcriptional regulatory protein BasR/pmrA	K07771 basR; two-component system, OmpR family, response regulator BasR 
B  CusS-CusR (copper tolerance)
B  QseC-QseB (quorum sensing)
C    SeAg_B3359 sensor protein QseC	K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3] 
C    SeAg_B3358 transcriptional regulatory protein QseB	K07666 qseB; two-component system, OmpR family, response regulator QseB 
B  KdpD-KdpE (potassium transport)
C    SeAg_B0751 sensor protein KdpD	K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] 
C    SeAg_B0750 KDP operon transcriptional regulatory protein KdpE	K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE 
B  TorS-TorR (TMAO respiration)
C    SeAg_B4054 torS; TMAO reductase sytem sensor TorS	K07647 torS; two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3] 
C    SeAg_B4052 TorCAD operon transcriptional regulatory protein TorR	K07772 torR; two-component system, OmpR family, torCAD operon response regulator TorR 
B  ArcB-ArcA (anoxic redox control)
C    SeAg_B3519 aerobic respiration control sensor protein ArcB	K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3] 
C    SeAg_B4922 arcA; aerobic respiration control protein ArcA	K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA 
B  TctE-TctD (tricarboxylic acid transport)
C    SeAg_B2896 tricarboxylic transport: regulatory protein	K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3] 
C    SeAg_B2897 DNA-binding response regulator TctD	K07774 tctD; two-component system, OmpR family, response regulator TctD 
B  ResE-ResD (aerobic and anaerobic respiration)
B  VicK-VicR (cell wall metabolism)
B  MprB-MprA (maintenance of persistent infection)
B  MtrB-MtrA (osmotic stress response)
B  PrrB-PrrA (intracellular multiplication)
B  TrcS-TrcR
B  NrsS-NrsR (nickel tolerance)
B  ManS-ManR (manganese homeostasis)
B  NblS-NblR (photosynthesis)
B  SasA-RpaAB (circadian timing mediating)
B  SaeS-SaeR (staphylococcal virulence regulation)
B  BceS-BceR (bacitracin transport)
B  BraS-BraR (bacitracin transport)
B  GraS-GraR (cationic antimicrobial peptide transport)
B  YxdK-YxdJ (antimicrobial peptide response)
B  ChvG-ChvI (acidity sensing)
B  CiaH-CiaR
B  ParS-ParR (polymyxin-adaptive resistance)
B  AdeS-AdeR
B  VanS-VanR (VanB type vancomycin resistance)
B  VanS-VanR (VanE type vancomycin resistance)
B  VanS-VanR (actinomycete type vancomycin resistance)
B  ArlS-ArlR (virulence regulation)
B  Ihk-Irr (virulence regulation)
B  PfeS-PfeR (enterobactin-dependent iron acquisition)
B  NisK-NisR (lantibiotic biosynthesis)
B  Unclassified
C    SeAg_B1054 heavy metal sensor kinase subfamily	K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] 
C    SeAg_B1055 transcriptional activator protein IrlR	K02483 K02483; two-component system, OmpR family, response regulator 
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A<b>NarL family</b>
B  NarX-NarL (nitrate respiration)
C    SeAg_B1374 nitrate/nitrite sensor protein NarX	K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3] 
C    SeAg_B1373 narL; nitrate/nitrite response regulator protein NarL	K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL 
B  NarQ-NarP (nitrate respiration)
C    SeAg_B2624 nitrate/nitrite sensor protein NarQ	K07674 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3] 
C    SeAg_B2381 nitrate/nitrite response regulator protein NarP	K07685 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP 
B  UhpB-UhpA (hexose phosphates uptake)
C    SeAg_B4015 uhpB; sensor histidine kinase UhpB	K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3] 
C    SeAg_B4016 uhpA; transcriptional regulatory protein UhpA	K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA 
B  FusK-FusR (virulence regulation)
B  RcsC-RcsD-RcsB (capsule synthesis)
C    SeAg_B2407 sensor kinase protein RcsC	K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3] 
C    SeAg_B2405 Hpt domain protein	K07676 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3] 
C    SeAg_B2406 rcsB; capsular synthesis regulator component B	K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB 
B  BarA-UvrY (central carbon metabolism)
C    SeAg_B3099 signal transduction histidine-protein kinase BarA	K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3] 
C    SeAg_B1173 uvrY; response regulator UvrY	K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY 
B  ComP-ComA (competence)
B  EvgS-EvgA (acid and drug tolerance)
C    SeAg_B0595 fimbriae Z protein	K07688 fimZ; two-component system, NarL family, response regulator, fimbrial Z protein, FimZ 
B  DegS-DegU (multicellular behavior control)
B  DesK-DesR (membrane lipid fluidity regulation)
B  VraS-VraR (cell-wall peptidoglycan synthesis)
B  LiaS-LiaR (cell wall stress response)
B  DevS-DevR (redox response)
B  NreB-NreC (dissimilatory nitrate/nitrite reduction)
B  YdfH-YdfI
B  SalK-SalR
B  PprA–PprB (biofilm formation)
B  Unclassified
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A<b>Spo family</b>
B  KinABCDE-Spo0FA (sporulation control)
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A<b>CitB family</b>
B  CitA-CitB (citrate fermentation)
C    SeAg_B0060 sensor kinase DpiB	K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3] 
C    SeAg_B0666 sensor kinase DpiB	K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3] 
C    SeAg_B0667 transcriptional regulatory protein DpiA	K07702 dpiA; two-component system, CitB family, response regulator CitB 
C    SeAg_B0059 transcriptional regulatory protein CitB	K07702 dpiA; two-component system, CitB family, response regulator CitB 
B  CitS-CitT (magnesium-citrate transport)
B  DcuS-DcuR (C4-dicarboxylate metabolism)
C    SeAg_B4567 sensor protein DcuS	K07701 dcuS; two-component system, CitB family, sensor histidine kinase DcuS [EC:2.7.13.3] 
C    SeAg_B4566 response regulator	K07703 dcuR; two-component system, CitB family, response regulator DcuR 
B  DctS-DctR (C4-dicarboxylate transport)
B  MalK-MalR (malate transport)
B  Unclassified
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A<b>LytTR family</b>
B  LysS-LysR
B  AlgZ-AlgR (alginate production)
B  NatK-NatR (sodium extrusion)
B  AgrC-AgrA (exoprotein synthesis)
B  AgrC2-AgrA2 (virulence regulation)
B  ComD-ComE (competence)
B  Unclassified
C    SeAg_B2305 sensor histidine kinase	K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] 
C    SeAg_B2304 DNA-binding response regulator	K02477 K02477; two-component system, LytTR family, response regulator 
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A<b>NtrC family</b>
B  GlnL-GlnG (nitrogen regulation)
C    SeAg_B4238 glnL; nitrogen regulation protein NR	K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3] 
C    SeAg_B4237 ntrC; nitrogen regulation protein NR	K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG 
B  NtrY-NtrX (nitrogen regulation)
B  HydH-HydG (metal tolerance)
C    SeAg_B4417 sensor protein ZraS	K07709 zraS; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3] 
C    SeAg_B4418 transcriptional regulatory protein ZraR	K07713 zraR; two-component system, NtrC family, response regulator HydG 
B  AtoS-AtoC (cPHB biosynthesis)
B  PilS-PilR (type 4 fimbriae synthesis)
B  GlrK-GlrR (amino sugar metabolism)
C    SeAg_B2721 sigma-54 dependent transcriptional regulator/response regulator	K07715 glrR; two-component system, NtrC family, response regulator GlrR 
B  PgtB-PgtA (phosphoglycerate transport)
C    SeAg_B2537 phosphoglycerate transport system sensor protein PgtB	K08475 pgtB; two-component system, NtrC family, phosphoglycerate transport system sensor histidine kinase PgtB [EC:2.7.13.3] 
C    SeAg_B2536 phosphoglycerate transport system transcriptional regulatory protein pgtA	K08476 pgtA; two-component system, NtrC family, phosphoglycerate transport system response regulator PgtA 
B  DctB-DctD (C4-dicarboxylate transport)
B  KinB-AlgB (alginate production)
B  HupT-HupR (hydrogenase synthesis regulation)
B  Unclassified
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A<b>CheA family</b>
B  CheA-CheYBV (chemotaxis)
C    SeAg_B1200 chemotaxis protein CheA	K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] 
C    SeAg_B1206 cheY; chemotaxis response regulator CheY	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    SeAg_B1205 cheB; chemotaxis response regulator protein-glutamate methylesterase CheB	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    SeAg_B2450 CheW protein	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
B  ChpA-ChpB/PilGH (chemosensory)
B  PixL-PixGH (positive phototaxis)
B  WspE-WspRF (chemosensory)
B  Cph1-Rcp1 (light response)
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A<b>Cell cycle family</b>
B  PleC-PleD (cell fate control)
B  CckA-CtrA/CpdR (cell cycle control)
B  Hk1-Rrp1 (glycerol uptake and utilization)
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A<b>Lux family</b>
B  LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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A<b>LuxR family</b>
B  DctS-DctR (C4-dicarboxylate transport)
B  TtrS-TtrR (tetrathionate respiration)
C    SeAg_B1785 sensor-kinase	K13040 ttrS; two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3] 
C    SeAg_B1784 response regulator	K13041 ttrR; two-component system, LuxR family, response regulator TtrR 
B  FixL-FixJ (nitrogen fixation)
B  SsrA-SsrB
C    SeAg_B1779 secretion system regulator:Sensor component	K14978 ssrA; two-component system, LuxR family, secretion system sensor histidine kinase SsrA 
C    SeAg_B1780 EsrB	K14979 ssrB; two-component system, LuxR family, secretion system response regulator SsrB 
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A<b>Other families</b>
B  FlrB-FlrC (polar flagellar synthesis)
B  AauS-AauR (acidic amino acids utilization)
B  SLN1-YPD1-SSK1/SKN7 (osmosensing)
B  RpfC-RpfG (cell-to-cell signaling)
B  GlnK-GlnL (glutamine utilization)
B  HspS-HspR (hexose phosphates uptake)
B  YesM-YesN
B  CikA
B  RegB-RegA (redox response)
B  FitF-FitH (insecticidal toxin regulation)
B  PhcS-PhcRQ
B  SagS-HptB-HsbR (swarming activity and biofilm formation)
B  PdtaS-PdtaR
B  NasS-NasT
B  Unclassified
C    SeAg_B1392 response regulator receiver domain	K02485 rssB; two-component system, response regulator 
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#Last updated: December 14, 2023