+F Repair protein KO
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DNA Repair and Recombination Proteins - Apis mellifera (honey bee)
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 552814 activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 551610 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 408649 trithorax group protein osa isoform X2 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 725801 G/T mismatch-specific thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 724157 uncharacterized protein LOC724157 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 413439 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 107964412 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 551204 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 551153 uncharacterized protein LOC551153 isoform X1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 551398 DNA polymerase delta catalytic subunit isoform X2 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 727251 DNA polymerase delta small subunit isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
F 725330 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
F 100578479 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 409673 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 724891 DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 726923 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 725835 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 727275 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 412308 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 408752 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 724170 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 100577027 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 413086 DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 408668 probable tyrosyl-DNA phosphodiesterase isoform X2 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 408601 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 100578746 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 552254 uncharacterized protein F21D5.5 isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 725551 high mobility group protein DSP1 K10802 HMGB1; high mobility group protein B1
E 552095 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 552498 DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 409340 UV excision repair protein RAD23 homolog B isoform X1 K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 408691 RING-box protein 1A isoform X1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 409279 cullin-4A K10609 CUL4; cullin 4
F 412593 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 550829 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 552156 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 552458 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 413110 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 410494 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 552599 DNA-directed RNA polymerase II subunit RPB7 isoform X2 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 102655904 DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 412547 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 724625 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 551607 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 727025 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 408691 RING-box protein 1A isoform X1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 409279 cullin-4A K10609 CUL4; cullin 4
F 412593 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 724695 DNA excision repair protein ERCC-6 isoform X2 K10841 ERCC6; DNA excision repair protein ERCC-6
F 102654012 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 551734 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 412700 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 550895 general transcription factor IIH subunit 1 isoform X2 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 411526 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 411231 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 412010 general transcription factor IIH subunit 4 isoform X2 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 408269 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 412339 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 410459 cyclin-H K06634 CCNH; cyclin H
E 412613 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 725934 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 725418 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 113219256 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 726757 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 412240 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 551316 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 725405 DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 410097 DNA repair protein complementing XP-G cells K10846 ERCC5; DNA excision repair protein ERCC-5
E 408752 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 552848 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 552700 cullin-3 K03869 CUL3; cullin 3
E 551563 cullin-5 isoform X2 K10612 CUL5; cullin 5
E 409140 elongin-C isoform X2 K03872 ELOC; elongin-C
E 551511 elongin-B K03873 ELOB; elongin-B
E 413407 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 413433 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 725348 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 408815 probable DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 100577449 PMS1 protein homolog 1 K10864 PMS1; DNA mismatch repair protein PMS1
E 724296 DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 100576649 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 551398 DNA polymerase delta catalytic subunit isoform X2 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 727251 DNA polymerase delta small subunit isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
E 725330 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
E 100578479 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 725934 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 725418 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 113219256 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 726757 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 413807 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 551540 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 726018 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
E 410266 replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
E 551990 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 727275 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 550962 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 725551 high mobility group protein DSP1 K10802 HMGB1; high mobility group protein B1
E 408752 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 413400 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 726642 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 102653753 nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 100576640 uncharacterized protein LOC100576640 isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 724551 BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 100576640 uncharacterized protein LOC100576640 isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 724855 BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 412589 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 552601 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 100576640 uncharacterized protein LOC100576640 isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 411185 Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 410940 DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 100576640 uncharacterized protein LOC100576640 isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 413400 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 726642 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 102653753 nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 100576640 uncharacterized protein LOC100576640 isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 725687 breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 552450 DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 552450 DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
E 100576677 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 102656733 DNA repair protein XRCC2 homolog K10879 XRCC2; DNA-repair protein XRCC2
E 726326 DNA repair protein XRCC3-like isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 409447 DNA repair and recombination protein RAD54-like isoform X1 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 413753 uncharacterized protein LOC413753 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 552169 DNA repair and recombination protein RAD54B isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 413362 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 412756 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 410301 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 412756 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 552787 DNA topoisomerase 3-beta-1 isoform X2 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 410571 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D RPA (replication factor A)
E 725934 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 725418 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 113219256 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 726757 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 552290 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 726544 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 727222 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 410056 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 410045 serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
D SMC5-SMC6 complex
E 724244 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 727192 structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 727247 non-structural maintenance of chromosomes element 1 homolog isoform X1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 100578530 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 550978 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 551740 non-structural maintenance of chromosome element 4 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 552851 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 725586 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 725951 LOW QUALITY PROTEIN: crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 552741 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 102656197 swi5-dependent recombination DNA repair protein 1 homolog isoform X1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 102656132 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 724240 flap endonuclease GEN K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 726567 SPG11; spatacsin K19026 SPG11; spatacsin
E 725704 uncharacterized protein LOC725704 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 413181 mortality factor 4-like protein 1 isoform X2 K11339 MORF4L1; mortality factor 4-like protein 1
E 552806 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 726906 uncharacterized protein LOC726906 K23112 BRAT1; BRCA1-associated ATM activator 1
E 411663 protein tilB homolog isoform X2 K23456 CFAP410; cilla- and flagella-associated protein
E 551150 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 100577896 heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 100576374 protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 724663 tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 411802 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 726261 WRNexo; Werner Syndrome-like exonuclease K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 552680 X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 552750 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 552548 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 413400 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 726642 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 726551 DNA ligase 4 isoform X1 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 102654398 uncharacterized protein LOC102654398 K10886 XRCC4; DNA-repair protein XRCC4
E 113219086 uncharacterized protein LOC113219086 isoform X1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 724170 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 408601 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 100578746 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 726638 protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 727490 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
D FA core complex binding factors
E 726740 ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 412756 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 552787 DNA topoisomerase 3-beta-1 isoform X2 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 410571 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D FANCD2-I complex
E 726651 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 100576640 uncharacterized protein LOC100576640 isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 725687 breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 411185 Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 100577784 fanconi-associated nuclease 1 isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 552450 DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
E 409389 ubiquitin specific protease-like K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 411121 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 410924 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 551486 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 552812 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 100576412 E3 ubiquitin-protein ligase RNF8 isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 410198 kinesin-related protein 4 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 411536 E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 411839 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 100578910 zinc finger CW-type PWWP domain protein 1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 410205 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 726583 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 551219 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 726862 DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 100578071 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 551852 ubiquitin-conjugating enzyme E2-17 kDa isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 725208 E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 409920 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 409386 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 727275 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 724424 sprT-like domain-containing protein Spartan isoform X1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 102653961 acidic repeat-containing protein isoform X1 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 100576872 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 100577296 checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 551008 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 724559 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 551540 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 726018 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 410266 replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 551990 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 551008 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 550811 protein timeless homolog isoform X1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 725981 protein TIPIN homolog K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 725935 claspin-like K25773 CLSPN; claspin
C Triple T complex
D 724472 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 100577931 TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 408889 large proline-rich protein BAG6 isoform X4 K23390 BAG6; large proline-rich protein BAG6
D 551718 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 411795 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 100576402 serine/threonine-protein kinase atr-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 725613 serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 413964 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 551949 ovarian-specific serine/threonine-protein kinase Lok K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 726510 M-phase inducer phosphatase 1 isoform X2 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 102655329 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 408951 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 408725 protein sickie K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 551677 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 406112 Per; period circadian protein K02633 PER2; period circadian protein 2
D 100577253 GRIP and coiled-coil domain-containing protein PFC0235w isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 408694 plastin-2 isoform X1 K17336 PLS3; plastin-3
D 410194 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 408697 KN motif and ankyrin repeat domain-containing protein 3 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 409756 vacuolar protein sorting-associated protein 4B isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 552088 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 113218808 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 724423 DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 725618 myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 726041 DNA-directed primase/polymerase protein isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 100577651 three prime repair exonuclease 2 isoform X2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 412510 uncharacterized protein LOC412510 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 724475 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 408750 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 552527 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 408527 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 552198 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 410765 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 413933 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 725673 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 414008 ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 551610 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 413439 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 724157 uncharacterized protein LOC724157 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 551204 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 727210 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 727210 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024