+E Replication protein KO
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DNA Replication Proteins - Arabidopsis thaliana (thale cress)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D AT4G12620 ORC1B; origin of replication complex 1B K02603 ORC1; origin recognition complex subunit 1
D AT4G14700 ORC1A; origin recognition complex 1 K02603 ORC1; origin recognition complex subunit 1
D AT2G37560 ORC2; origin recognition complex second largest subunit 2 K02604 ORC2; origin recognition complex subunit 2
D AT5G16690 ORC3; origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D AT2G01120 ORC4; origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D AT4G29910 ORC5; origin recognition complex protein 5 K02607 ORC5; origin recognition complex subunit 5
D AT1G26840 ORC6; origin recognition complex protein 6 K02608 ORC6; origin recognition complex subunit 6
D AT3G54710 CDT1B; CDT1-like protein B K10727 CDT1; chromatin licensing and DNA replication factor 1
D AT2G31270 CDT1A; CDT1-like protein A K10727 CDT1; chromatin licensing and DNA replication factor 1
D AT1G07270 Cell division control, Cdc6 K02213 CDC6; cell division control protein 6
D AT2G29680 CDC6; cell division control 6 K02213 CDC6; cell division control protein 6
D AT1G44900 MCM2; minichromosome maintenance (MCM2/3/5) family protein K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D AT5G46280 MCM3; Minichromosome maintenance (MCM2/3/5) family protein K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D AT2G16440 MCM4; Minichromosome maintenance (MCM2/3/5) family protein K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D AT2G07690 MCM5; Minichromosome maintenance (MCM2/3/5) family protein K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D AT5G44635 MCM6; minichromosome maintenance (MCM2/3/5) family protein K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D AT4G02060 PRL; Minichromosome maintenance (MCM2/3/5) family protein K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D AT5G43080 CYCA3;1; Cyclin A3;1 K06627 CCNA; cyclin-A
D AT1G44110 CYCA1;1; Cyclin A1;1 K06627 CCNA; cyclin-A
D AT1G77390 CYCA1;2; CYCLIN A1;2 K06627 CCNA; cyclin-A
D AT1G80370 CYCA2;4; Cyclin A2;4 K06627 CCNA; cyclin-A
D AT1G47210 CYCA3;2; cyclin-dependent protein kinase 3;2 K06627 CCNA; cyclin-A
D AT1G15570 CYCA2;3; CYCLIN A2;3 K06627 CCNA; cyclin-A
D AT5G11300 CYC3B; mitotic-like cyclin 3B from Arabidopsi K06627 CCNA; cyclin-A
D AT5G25380 CYCA2;1; cyclin a2;1 K06627 CCNA; cyclin-A
D AT1G47230 CYCA3;4; CYCLIN A3;4 K06627 CCNA; cyclin-A
D AT1G47220 CYCA3;3; Cyclin A3;3 K06627 CCNA; cyclin-A
D AT3G48750 CDC2; cell division control 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D AT4G16970 Protein kinase superfamily protein K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D AT1G80190 PSF1; partner of SLD five 1 K10732 GINS1; GINS complex subunit 1
D AT3G12530 PSF2; PSF2 K10733 GINS2; GINS complex subunit 2
D AT3G55490 GINS complex protein K10734 GINS3; GINS complex subunit 3
D AT1G19080 TTN10; GINS complex protein K10734 GINS3; GINS complex subunit 3
D AT5G49010 SLD5; DNA replication protein-like protein K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D AT1G77320 MEI1; transcription coactivator K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D AT4G02110 transcription coactivator K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D AT1G27880 DEAD/DEAH box RNA helicase family protein K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D AT3G25100 CDC45; cell division cycle 45 K06628 CDC45; cell division control protein 45
D AT3G09660 MCM8; minichromosome maintenance 8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D AT2G14050 MCM9; minichromosome maintenance 9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D AT2G20980 MCM10; minichromosome maintenance 10 K10736 MCM10; minichromosome maintenance protein 10
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D AT5G67100 ICU2; DNA-directed DNA polymerase K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D AT1G67630 POLA2; DNA polymerase alpha 2 K02321 POLA2; DNA polymerase alpha subunit B
D AT5G41880 POLA3; DNA primase POLA3 K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D AT1G67320 EMB2813; DNA primase, large subunit family K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D AT1G08260 TIL1; DNA polymerase epsilon catalytic subunit K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D AT2G27120 TIL2; DNA polymerase epsilon catalytic subunit K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D AT5G22110 DPB2; DNA polymerase epsilon subunit B2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D AT2G27470 NF-YB11; nuclear factor Y, subunit B11 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
C DNA polymerase delta complex
D AT5G63960 DNA polymerase delta subunit 1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D AT2G42120 POLD2; DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
D AT1G78650 POLD3; DNA-directed DNA polymerase K03504 POLD3; DNA polymerase delta subunit 3
D AT1G09815 POLD4; polymerase delta 4 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
C RPA (replication protein A)
D AT5G45400 RPA70C; Replication factor-A protein 1-like protein K07466 RFA1; replication factor A1
D AT4G19130 Replication factor-A protein 1-like protein K07466 RFA1; replication factor A1
D AT2G06510 RPA1A; replication protein A 1A K07466 RFA1; replication factor A1
D AT5G61000 RPA70D; Replication factor-A protein 1-like protein K07466 RFA1; replication factor A1
D AT5G08020 RPA70B; RPA70-kDa subunit B K07466 RFA1; replication factor A1
D AT2G24490 RPA2; replicon protein A2 K10739 RFA2; replication factor A2
D AT3G02920 RPA32B; Replication protein A, subunit RPA32 K10739 RFA2; replication factor A2
D AT3G52630 Nucleic acid-binding, OB-fold-like protein K10740 RPA3; replication factor A3
D AT4G18590 Nucleic acid-binding, OB-fold-like protein K10740 RPA3; replication factor A3
C RFC (replication factor C)
D AT5G22010 RFC1; replication factor C1 K10754 RFC1; replication factor C subunit 1
D AT1G21690 EMB1968; ATPase family associated with various cellular activities (AAA) K10755 RFC2_4; replication factor C subunit 2/4
D AT1G63160 RFC2; replication factor C 2 K10755 RFC2_4; replication factor C subunit 2/4
D AT1G77470 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D AT5G27740 EMB2775; ATPase family associated with various cellular activities (AAA) K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D AT2G25100 Polynucleotidyl transferase, ribonuclease H-like superfamily protein K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D AT4G20325 ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D AT2G39440 ribonuclease H2 subunit C-like protein K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D AT2G29570 PCNA2; proliferating cell nuclear antigen 2 K04802 PCNA; proliferating cell nuclear antigen
D AT1G07370 PCNA1; proliferating cellular nuclear antigen 1 K04802 PCNA; proliferating cell nuclear antigen
D AT1G08840 emb2411; DNA replication helicase K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D AT5G26680 5'-3' exonuclease family protein K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D AT1G29630 5'-3' exonuclease family protein K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D AT1G18090 5'-3' exonuclease family protein K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D AT5G07810 SNF2 domain-containing protein / helicase domain-containing protein / HNH endonuclease domain-containing protein K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D AT1G08130 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D AT1G77620 P-loop containing nucleoside triphosphate hydrolases superfamily protein K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D AT4G13610 MEE57; DNA (cytosine-5-)-methyltransferase family protein K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D AT4G14140 DMT2; DNA methyltransferase 2 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D AT5G49160 MET1; methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D AT1G69770 CMT3; chromomethylase 3 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D AT1G80740 CMT1; chromomethylase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D AT4G19020 CMT2; chromomethylase 2 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D AT4G08990 DNA (cytosine-5-)-methyltransferase family protein K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D AT5G27650 Tudor/PWWP/MBT superfamily protein K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
C Prevention of re-replication factors
D AT1G14750 SDS; Cyclin family protein K21777 CCNB; G2/mitotic-specific cyclin-B, other
D AT2G26760 CYCB1;4; Cyclin B1;4 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D AT1G20610 CYCB2;3; Cyclin B2;3 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D AT1G76310 CYCB2;4; CYCLIN B2;4 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D AT1G16330 CYCB3;1; cyclin b3;1 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D AT3G11520 CYCB1;3; CYCLIN B1;3 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D AT4G37490 CYCB1;1; CYCLIN B1;1 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D AT5G06150 CYC1BAT; Cyclin family protein K21777 CCNB; G2/mitotic-specific cyclin-B, other
D AT1G34460 CYCB1;5; CYCLIN B1;5 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D AT1G20590 cyclin K21777 CCNB; G2/mitotic-specific cyclin-B, other
D AT2G17620 CYCB2;1; Cyclin B2;1 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D AT4G35620 CYCB2;2; Cyclin B2;2 K21777 CCNB; G2/mitotic-specific cyclin-B, other
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
E AT1G07130 STN1; Nucleic acid-binding, OB-fold-like protein K23312 STN1; CST complex subunit STN1
E AT1G56260 MDO1; telomere-capping, CST complex subunit K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D AT5G16850 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E AT3G03920 H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 protein K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E AT5G18180 H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 protein K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E AT5G08180 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E AT2G20490 NOP10; nucleolar RNA-binding Nop10p family protein K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E AT3G57150 NAP57; homologue of NAP57 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D AT5G16850 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E AT4G20440 smB; small nuclear ribonucleoprotein associated protein B K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E AT5G44500 Small nuclear ribonucleoprotein family protein K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E AT3G07590 Small nuclear ribonucleoprotein family protein K11087 SNRPD1; small nuclear ribonucleoprotein D1
E AT4G02840 Small nuclear ribonucleoprotein family protein K11087 SNRPD1; small nuclear ribonucleoprotein D1
E AT2G47640 Small nuclear ribonucleoprotein family protein K11096 SNRPD2; small nuclear ribonucleoprotein D2
E AT3G62840 Small nuclear ribonucleoprotein family protein K11096 SNRPD2; small nuclear ribonucleoprotein D2
E AT1G76300 SmD3; snRNP core protein SMD3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E AT1G20580 Small nuclear ribonucleoprotein family protein K11088 SNRPD3; small nuclear ribonucleoprotein D3
E AT4G30330 Small nuclear ribonucleoprotein family protein K11097 SNRPE; small nuclear ribonucleoprotein E
E AT2G18740 Small nuclear ribonucleoprotein family protein K11097 SNRPE; small nuclear ribonucleoprotein E
E AT4G30220 RUXF; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E AT2G14285 Small nuclear ribonucleoprotein family protein K11098 SNRPF; small nuclear ribonucleoprotein F
E AT3G11500 Small nuclear ribonucleoprotein family protein K11099 SNRPG; small nuclear ribonucleoprotein G
E AT2G23930 SNRNP-G; Putative small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D AT1G21690 EMB1968; ATPase family associated with various cellular activities (AAA) K10755 RFC2_4; replication factor C subunit 2/4
D AT1G63160 RFC2; replication factor C 2 K10755 RFC2_4; replication factor C subunit 2/4
D AT1G77470 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D AT5G27740 EMB2775; ATPase family associated with various cellular activities (AAA) K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D AT5G54260 MRE11; DNA repair and meiosis protein (Mre11) K10865 MRE11; double-strand break repair protein MRE11
D AT2G31970 RAD50; DNA repair-recombination protein (RAD50) K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D AT3G02680 NBS1; nijmegen breakage syndrome 1 K10867 NBN; nibrin
C Other termination factors
D AT3G48190 ATM; Serine/Threonine-kinase ATM-like protein K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D AT5G27680 RECQSIM; RECQ helicase SIM K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D AT1G10930 RECQ4A; DNA helicase (RECQl4A) K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D AT1G60930 RECQ4B; RECQ helicase L4B K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D AT4G35740 RecQl3; DEAD/DEAH box RNA helicase family protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D AT5G41150 UVH1; Restriction endonuclease, type II-like superfamily protein K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D AT2G31320 PARP1; poly(ADP-ribose) polymerase 2 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D AT4G02390 PARP2; poly(ADP-ribose) polymerase K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D AT5G22470 poly ADP-ribose polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D AT1G63980 D111/G-patch domain-containing protein K11135 PINX1; Pin2-interacting protein X1
D AT1G79950 RAD3-like DNA-binding helicase protein K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D AT3G48470 EMB2423; embryo defective 2423 K11137 TELO2; telomere length regulation protein
D AT3G51690 PIF1 helicase K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D AT2G32080 PUR_ALPHA-1; purin-rich alpha 1 K21772 PURA; transcriptional activator protein Pur-alpha
D AT4G21520 Transducin/WD40 repeat-like superfamily protein K23314 WRAP53; telomerase Cajal body protein 1
D AT4G01000 Ubiquitin-like superfamily protein K25059 SDE2; replication stress response regulator SDE2
D AT5G58020 RTF2 RING-finger protein K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C AT5G55300 TOP1ALPHA; DNA topoisomerase I alpha K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C AT5G55310 TOP1BETA; DNA topoisomerase 1 beta K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C AT3G23890 TOPII; topoisomerase II K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C AT5G63920 TOP3A; topoisomerase 3alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C AT2G32000 DNA topoisomerase, type IA, core K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D AT3G18580 Nucleic acid-binding, OB-fold-like protein K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
D Other elongation factors
E AT1G50840 POLGAMMA2; polymerase gamma 2 K02335 polA; DNA polymerase I [EC:2.7.7.7]
E AT3G20540 POLGAMMA1; polymerase gamma 1 K02335 polA; DNA polymerase I [EC:2.7.7.7]
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
D RFC (replication factor C)
D Other elongation factors
E AT1G08840 emb2411; DNA replication helicase K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E AT5G26680 5'-3' exonuclease family protein K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E AT1G08130 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
C AT3G10690 GYRA; DNA GYRASE A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
C AT3G10270 GYRB1; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
C AT5G04130 GYRB2; DNA GYRASE B2 K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
C AT5G04110 GYRB3; DNA GYRASE B3 K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
C AT3G20780 TOP6B; topoisomerase 6 subunit B K03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022