+F	Repair protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Repair and Recombination Proteins - Canis lupus familiaris (dog)</h2>
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A<b>Eukaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      442978 MGMT; methylated-DNA--protein-cysteine methyltransferase	K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 
D      477524 ALKBH2; DNA oxidative demethylase ALKBH2	K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33] 
D      475938 ALKBH3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X2	K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54] 
D      475008 ASCC3; activating signal cointegrator 1 complex subunit 3 isoform X1	K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4] 
C    BER (base exicision repair)
D      DNA glycosylases
E        486315 UNG; uracil-DNA glycosylase	K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] 
E        487208 CCNO; cyclin-O	K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-] 
E        475448 TDG; G/T mismatch-specific thymine DNA glycosylase isoform X1	K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29] 
E        611597 MPG; DNA-3-methyladenine glycosylase isoform X1	K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] 
E        486497 SMUG1; single-strand selective monofunctional uracil DNA glycosylase isoform X1	K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-] 
E        100856592 MUTYH; adenine DNA glycosylase isoform X7	K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] 
E        100684130 MBD4; methyl-CpG-binding domain protein 4 isoform X3	K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-] 
E        484666 OGG1; N-glycosylase/DNA lyase isoform X2	K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18] 
E        611615 NEIL1; endonuclease 8-like 1 isoform X1	K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18] 
E        486078 NEIL2; endonuclease 8-like 2	K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18] 
E        475639 NEIL3; endonuclease 8-like 3 isoform X7	K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18] 
E        610981 NTHL1; endonuclease III-like protein 1 isoform X3	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
E        482558 APEX1; DNA-(apurinic or apyrimidinic site) endonuclease	K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2] 
E        100855516 APEX2; DNA-(apurinic or apyrimidinic site) endonuclease 2	K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2] 
D      Long Patch-BER factors
E        DNA polymerase delta complex
F          610047 POLD1; DNA polymerase delta catalytic subunit isoform X1	K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7] 
F          482686 POLD2; DNA polymerase delta subunit 2 isoform X3	K02328 POLD2; DNA polymerase delta subunit 2 
F          476806 POLD3; DNA polymerase delta subunit 3 isoform X3	K03504 POLD3; DNA polymerase delta subunit 3 
F          611847 DNA polymerase delta subunit 4 isoform X4	K03505 POLD4; DNA polymerase delta subunit 4 
E        DNA polymerase epsilon complex
F          486223 POLE; DNA polymerase epsilon catalytic subunit A isoform X2	K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7] 
F          608973 POLE2; DNA polymerase epsilon subunit 2 isoform X8	K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7] 
F          612550 POLE3; DNA polymerase epsilon subunit 3	K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7] 
F          483096 POLE4; DNA polymerase epsilon subunit 4 isoform X3	K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7] 
E        477166 PCNA; proliferating cell nuclear antigen	K04802 PCNA; proliferating cell nuclear antigen 
E        476063 FEN1; flap endonuclease 1	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
E        100686967 LIG1; DNA ligase 1 isoform X1	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
D      Short Patch-BER factors
E        494001 POLB; DNA polymerase beta isoform X2	K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-] 
E        476447 XRCC1; DNA repair protein XRCC1	K10803 XRCC1; DNA-repair protein XRCC1 
E        491145 LIG3; DNA ligase 3 isoform X1	K10776 LIG3; DNA ligase 3 [EC:6.5.1.1] 
D      Other BER factors
E        490828 TDP1; tyrosyl-DNA phosphodiesterase 1 isoform X1	K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-] 
E        442943 APTX; aprataxin	K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72] 
E        481405 APLF; aprataxin and PNK-like factor isoform X3	K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-] 
E        484373 PNKP; bifunctional polynucleotide phosphatase/kinase isoform X1	K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78] 
E        403170 HMGB1; high mobility group protein B1	K10802 HMGB1; high mobility group protein B1 
E        100682891 LOW QUALITY PROTEIN: high mobility group protein B1-like	K10802 HMGB1; high mobility group protein B1 
E        608341 POLL; DNA polymerase lambda isoform X2	K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-] 
E        490385 PARP1; poly [ADP-ribose] polymerase 1	K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] 
E        475392 PARP2; poly [ADP-ribose] polymerase 2	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
E        484745 PARP3; protein mono-ADP-ribosyltransferase PARP3	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
E        477348 PARP4; protein mono-ADP-ribosyltransferase PARP4	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
E        XPC-HR23B-CETN2 complex
F          476521 XPC; DNA repair protein complementing XP-C cells isoform X1	K10838 XPC; xeroderma pigmentosum group C-complementing protein 
F          481656 RAD23B; UV excision repair protein RAD23 homolog B isoform X2	K10839 RAD23; UV excision repair protein RAD23 
F          484922 RAD23A; UV excision repair protein RAD23 homolog A isoform X1	K10839 RAD23; UV excision repair protein RAD23 
F          481078 CETN2; centrin-2	K10840 CETN2; centrin-2 
F          482008 LOW QUALITY PROTEIN: centrin-2-like isoform X1	K10840 CETN2; centrin-2 
E        Cul4-DDB2 complex
F          474494 RBX1; E3 ubiquitin-protein ligase RBX1 isoform X2	K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32] 
F          492102 CUL4B; cullin-4B isoform X3	K10609 CUL4; cullin 4 
F          607683 CUL4A; cullin-4A isoform X5	K10609 CUL4; cullin 4 
F          476067 DDB1; DNA damage-binding protein 1	K10610 DDB1; DNA damage-binding protein 1 
F          483626 DDB2; DNA damage-binding protein 2 isoform X1	K10140 DDB2; DNA damage-binding protein 2 
E        NER4 complex
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase II complex
F          479483 POLR2A; DNA-directed RNA polymerase II subunit RPB1	K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6] 
F          475152 POLR2B; DNA-directed RNA polymerase II subunit RPB2	K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6] 
F          478109 POLR2C; DNA-directed RNA polymerase II subunit RPB3	K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3 
F          483863 POLR2D; DNA-directed RNA polymerase II subunit RPB4	K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4 
F          611859 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1	K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1 
F          474512 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1	K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2 
F          476052 POLR2G; DNA-directed RNA polymerase II subunit RPB7 isoform X2	K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7 
F          478656 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3	K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3 
F          476476 POLR2I; DNA-directed RNA polymerase II subunit RPB9	K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9 
F          111090847 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5	K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5 
F          100686835 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a isoform X1	K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11 
F          100688583 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4	K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4 
F          119870926 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like	K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4 
E        Cul4-CSA complex
F          474494 RBX1; E3 ubiquitin-protein ligase RBX1 isoform X2	K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32] 
F          492102 CUL4B; cullin-4B isoform X3	K10609 CUL4; cullin 4 
F          607683 CUL4A; cullin-4A isoform X5	K10609 CUL4; cullin 4 
F          476067 DDB1; DNA damage-binding protein 1	K10610 DDB1; DNA damage-binding protein 1 
F          487225 ERCC8; DNA excision repair protein ERCC-8 isoform X3	K10570 ERCC8; DNA excision repair protein ERCC-8 
E        Other TCR factor
F          477747 ERCC6; DNA excision repair protein ERCC-6	K10841 ERCC6; DNA excision repair protein ERCC-6 
F          488812 UVSSA; UV-stimulated scaffold protein A isoform X1	K23720 UVSSA; UV-stimulated scaffold protein A 
F          100687887 ELOF1; transcription elongation factor 1 homolog isoform X1	K25829 ELOF1; transcription elongation factor 1 
D      TFIIH complex
E        476105 ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB	K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4] 
E        493995 ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD isoform X1	K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3] 
E        476881 GTF2H1; general transcription factor IIH subunit 1	K03141 TFIIH1; transcription initiation factor TFIIH subunit 1 
E        478089 general transcription factor IIH subunit 2	K03142 TFIIH2; transcription initiation factor TFIIH subunit 2 
E        477446 GTF2H3; general transcription factor IIH subunit 3 isoform X2	K03143 TFIIH3; transcription initiation factor TFIIH subunit 3 
E        100685309 LOW QUALITY PROTEIN: general transcription factor IIH subunit 3-like	K03143 TFIIH3; transcription initiation factor TFIIH subunit 3 
E        612182 GTF2H5; general transcription factor IIH subunit 5	K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit 
E        608441 CDK7; cyclin-dependent kinase 7 isoform X1	K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23] 
E        479156 CCNH; cyclin-H isoform X1	K06634 CCNH; cyclin H 
E        480346 MNAT1; CDK-activating kinase assembly factor MAT1 isoform X3	K10842 MNAT1; CDK-activating kinase assembly factor MAT1 
D      RPA (replication factor A)
E        100855690 RPA1; replication protein A 70 kDa DNA-binding subunit	K07466 RFA1; replication factor A1 
E        100856421 RPA2; replication protein A 32 kDa subunit	K10739 RFA2; replication factor A2 
E        481449 RPA3; replication protein A 14 kDa subunit	K10740 RPA3; replication factor A3 
D      Other NER factors
E        481623 XPA; DNA repair protein complementing XP-A cells	K10847 XPA; DNA-repair protein complementing XP-A cells 
E        612282 ERCC1; DNA excision repair protein ERCC-1 isoform X1	K10849 ERCC1; DNA excision repair protein ERCC-1 
E        479842 ERCC4; DNA repair endonuclease XPF isoform X1	K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-] 
E        100855935 ERCC5; DNA repair protein complementing XP-G cells isoform X1	K10846 ERCC5; DNA excision repair protein ERCC-5 
E        100686967 LIG1; DNA ligase 1 isoform X1	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
E        477788 MMS19; MMS19 nucleotide excision repair protein homolog isoform X1	K15075 MET18; DNA repair/transcription protein MET18/MMS19 
E        477392 CUL3; cullin-3 isoform X5	K03869 CUL3; cullin 3 
E        489422 CUL5; LOW QUALITY PROTEIN: cullin-5	K10612 CUL5; cullin 5 
E        477914 ELOC; elongin-C	K03872 ELOC; elongin-C 
E        119866339 elongin-C-like	K03872 ELOC; elongin-C 
E        119870849 elongin-C-like	K03872 ELOC; elongin-C 
E        479873 ELOB; elongin-B isoform X1	K03873 ELOB; elongin-B 
E        478188 ELOA; elongin-A	K15076 ELOA; elongin-A 
E        481583 UBAP2; ubiquitin-associated protein 2 isoform X2	K26545 UBAP2; ubiquitin-associated protein 2 
E        480135 UBAP2L; ubiquitin-associated protein 2-like isoform X62	K26545 UBAP2; ubiquitin-associated protein 2 
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
E        494002 MSH2; DNA mismatch repair protein Msh2	K08735 MSH2; DNA mismatch repair protein MSH2 
E        479164 MSH3; DNA mismatch repair protein Msh3 isoform X1	K08736 MSH3; DNA mismatch repair protein MSH3 
E        474585 MSH6; DNA mismatch repair protein Msh6	K08737 MSH6; DNA mismatch repair protein MSH6 
D      MutL homologs
E        478840 PMS1; PMS1 protein homolog 1 isoform X1	K10864 PMS1; DNA mismatch repair protein PMS1 
E        477019 MLH1; DNA mismatch repair protein Mlh1 isoform X2	K08734 MLH1; DNA mismatch repair protein MLH1 
E        479751 PMS2; mismatch repair endonuclease PMS2 isoform X1	K10858 PMS2; DNA mismatch repair protein PMS2 
E        480389 MLH3; DNA mismatch repair protein Mlh3 isoform X3	K08739 MLH3; DNA mismatch repair protein MLH3 
D      DNA polymerase delta complex
E        610047 POLD1; DNA polymerase delta catalytic subunit isoform X1	K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7] 
E        482686 POLD2; DNA polymerase delta subunit 2 isoform X3	K02328 POLD2; DNA polymerase delta subunit 2 
E        476806 POLD3; DNA polymerase delta subunit 3 isoform X3	K03504 POLD3; DNA polymerase delta subunit 3 
E        611847 DNA polymerase delta subunit 4 isoform X4	K03505 POLD4; DNA polymerase delta subunit 4 
D      RPA (replication factor A)
E        100855690 RPA1; replication protein A 70 kDa DNA-binding subunit	K07466 RFA1; replication factor A1 
E        100856421 RPA2; replication protein A 32 kDa subunit	K10739 RFA2; replication factor A2 
E        481449 RPA3; replication protein A 14 kDa subunit	K10740 RPA3; replication factor A3 
D      RFC (replication factor C)
E        479112 RFC1; replication factor C subunit 1 isoform X3	K10754 RFC1; replication factor C subunit 1 
E        478667 RFC4; replication factor C subunit 4 isoform X1	K10755 RFC2_4; replication factor C subunit 2/4 
E        489798 RFC2; replication factor C subunit 2 isoform X1	K10755 RFC2_4; replication factor C subunit 2/4 
E        477499 RFC5; replication factor C subunit 5 isoform X2	K10756 RFC3_5; replication factor C subunit 3/5 
E        477308 RFC3; replication factor C subunit 3 isoform X2	K10756 RFC3_5; replication factor C subunit 3/5 
D      Other MMR factors
E        477166 PCNA; proliferating cell nuclear antigen	K04802 PCNA; proliferating cell nuclear antigen 
E        100855525 EXO1; exonuclease 1 isoform X1	K10746 EXO1; exonuclease 1 [EC:3.1.-.-] 
E        403170 HMGB1; high mobility group protein B1	K10802 HMGB1; high mobility group protein B1 
E        100682891 LOW QUALITY PROTEIN: high mobility group protein B1-like	K10802 HMGB1; high mobility group protein B1 
E        100686967 LIG1; DNA ligase 1 isoform X1	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
E        487529 WDR76; WD repeat-containing protein 76 isoform X3	K24755 WDR76; WD repeat-containing protein 76 
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      MRN(MRX) complex
E        494006 MRE11; double-strand break repair protein MRE11 isoform X1	K10865 MRE11; double-strand break repair protein MRE11 
E        474674 RAD50; DNA repair protein RAD50 isoform X2	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
E        611315 NBN; nibrin isoform X2	K10867 NBN; nibrin 
D      BRCA1-core complex
E        403437 BRCA1; breast cancer type 1 susceptibility protein homolog	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        610190 BARD1; BRCA1-associated RING domain protein 1 isoform X1	K10683 BARD1; BRCA1-associated RING domain protein 1 
E        102156002 LOW QUALITY PROTEIN: BRCA1-associated RING domain protein 1-like isoform X3	K10683 BARD1; BRCA1-associated RING domain protein 1 
D      BRCA1-A complex
E        403437 BRCA1; breast cancer type 1 susceptibility protein homolog	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        478459 ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X1	K20774 FAM175A; BRCA1-A complex subunit Abraxas 
E        611298 UIMC1; BRCA1-A complex subunit RAP80 isoform X2	K20775 UIMC1; BRCA1-A complex subunit RAP80 
E        476676 BABAM1; BRISC and BRCA1-A complex member 1	K20776 BABAM; BRISC and BRCA1-A complex member 1 
E        475711 BABAM2; BRISC and BRCA1-A complex member 2 isoform X2	K12173 BRE; BRCA1-A complex subunit BRE 
E        612642 BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X4	K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-] 
E        610150 LOW QUALITY PROTEIN: lys-63-specific deubiquitinase BRCC36-like	K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-] 
D      BRCA1-B complex
E        403437 BRCA1; breast cancer type 1 susceptibility protein homolog	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        491122 BRIP1; Fanconi anemia group J protein	K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3] 
E        477070 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X2	K10728 TOPBP1; topoisomerase (DNA) II binding protein 1 
D      BRCA1-C complex
E        403437 BRCA1; breast cancer type 1 susceptibility protein homolog	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        480175 RBBP8; DNA endonuclease RBBP8	K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-] 
E        111094686 DNA endonuclease RBBP8-like	K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-] 
E        494006 MRE11; double-strand break repair protein MRE11 isoform X1	K10865 MRE11; double-strand break repair protein MRE11 
E        474674 RAD50; DNA repair protein RAD50 isoform X2	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
E        611315 NBN; nibrin isoform X2	K10867 NBN; nibrin 
D      BRCA complex
E        403437 BRCA1; breast cancer type 1 susceptibility protein homolog	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        474180 BRCA2; breast cancer type 2 susceptibility protein	K08775 BRCA2; breast cancer 2 susceptibility protein 
E        608527 PALB2; partner and localizer of BRCA2	K10897 PALB2; partner and localizer of BRCA2 
E        403568 RAD51; DNA repair protein RAD51 homolog 1	K04482 RAD51; DNA repair protein RAD51 
D      RecA family proteins
E        403568 RAD51; DNA repair protein RAD51 homolog 1	K04482 RAD51; DNA repair protein RAD51 
E        490746 RAD51B; DNA repair protein RAD51 homolog 2 isoform X2	K10869 RAD51L1; RAD51-like protein 1 
E        480573 RAD51C; DNA repair protein RAD51 homolog 3 isoform X1	K10870 RAD51L2; RAD51-like protein 2 
E        491143 RAD51D; DNA repair protein RAD51 homolog 4 isoform X2	K10871 RAD51L3; RAD51-like protein 3 
E        475548 XRCC2; DNA repair protein XRCC2	K10879 XRCC2; DNA-repair protein XRCC2 
E        100687200 XRCC3; DNA repair protein XRCC3	K10880 XRCC3; DNA-repair protein XRCC3 
D      Rad52 family proteins
E        477729 RAD52; DNA repair protein RAD52 homolog isoform X1	K10873 RAD52; DNA repair and recombination protein RAD52 
E        100683711 LOW QUALITY PROTEIN: uncharacterized protein LOC100683711	K10874 RDM1; RAD52 motif-containing protein 1 
D      Rad54 family proteins
E        475368 RAD54L; DNA repair and recombination protein RAD54-like isoform X3	K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-] 
E        476608 RAD54L2; helicase ARIP4 isoform X1	K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-] 
E        487053 RAD54B; DNA repair and recombination protein RAD54B isoform X3	K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-] 
D      RecQ family DNA helicases
E        486641 RECQL; ATP-dependent DNA helicase Q1	K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4] 
E        493997 WRN; Werner syndrome ATP-dependent helicase isoform X5	K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4] 
E        100685609 BLM; Bloom syndrome protein isoform X2	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        482101 RECQL4; ATP-dependent DNA helicase Q4 isoform X1	K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4] 
E        483317 RECQL5; ATP-dependent DNA helicase Q5 isoform X1	K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4] 
D      Bloom's syndrome complex (BTR)
E        100685609 BLM; Bloom syndrome protein isoform X2	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        477576 TOP3B; DNA topoisomerase 3-beta-1 isoform X1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        489537 TOP3A; DNA topoisomerase 3-alpha	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        100684392 RMI1; recQ-mediated genome instability protein 1 isoform X1	K10990 RMI1; RecQ-mediated genome instability protein 1 
E        609907 RMI2; recQ-mediated genome instability protein 2	K15365 RMI2; RecQ-mediated genome instability protein 2 
D      RPA (replication factor A)
E        100855690 RPA1; replication protein A 70 kDa DNA-binding subunit	K07466 RFA1; replication factor A1 
E        100856421 RPA2; replication protein A 32 kDa subunit	K10739 RFA2; replication factor A2 
E        481449 RPA3; replication protein A 14 kDa subunit	K10740 RPA3; replication factor A3 
D      Protein phosphatase 4
E        489947 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit isoform X2	K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16] 
E        477273 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X3	K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 
E        480207 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X3	K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 
E        476556 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X1	K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 
E        474603 PPP4R3B; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X2	K17491 SMEK; protein phosphatase 4 regulatory subunit 3 
E        612974 PPP4R3A; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1	K17491 SMEK; protein phosphatase 4 regulatory subunit 3 
E        491791 serine/threonine-protein phosphatase 4 regulatory subunit 3B-like	K17491 SMEK; protein phosphatase 4 regulatory subunit 3 
E        490837 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X5	K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 
D      AP-5 complex
E        476023 AP5B1; AP-5 complex subunit beta-1	K19022 AP5B1; AP-5 complex subunit beta-1 
E        100685159 LOW QUALITY PROTEIN: AP-5 complex subunit mu-1 isoform X2	K19023 AP5M1; AP-5 complex subunit mu-1 
E        609098 AP5S1; AP-5 complex subunit sigma-1	K19024 AP5S1; AP-5 complex subunit sigma-1 
E        609375 AP5Z1; AP-5 complex subunit zeta-1 isoform X1	K19025 AP5Z1; AP-5 complex subunit zeta-1 
D      SMC5-SMC6 complex
E        476327 SMC5; structural maintenance of chromosomes protein 5 isoform X2	K22803 SMC5; structural maintenance of chromosomes protein 5 
E        475675 SMC6; structural maintenance of chromosomes protein 6	K22804 SMC6; structural maintenance of chromosomes protein 6 
E        610235 LRATD1; protein LRATD1	K22805 FAM84A; protein FAM84A 
E        479800 NSMCE1; non-structural maintenance of chromosomes element 1 homolog	K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27] 
E        475096 NSMCE2; E3 SUMO-protein ligase NSE2 isoform X1	K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-] 
E        102153224 LOW QUALITY PROTEIN: non-structural maintenance of chromosomes element 4 homolog A-like	K22825 NSMCE4; non-structural maintenance of chromosomes element 4 
E        100687031 EID3; EP300-interacting inhibitor of differentiation 3	K22826 EID3; EP300-interacting inhibitor of differentiation 3 
E        488907 SLF1; SMC5-SMC6 complex localization factor protein 1 isoform X2	K26126 SLF1; SMC5-SMC6 complex localization factor protein 1 
E        612816 SLF2; SMC5-SMC6 complex localization factor protein 2 isoform X2	K26127 SLF2; SMC5-SMC6 complex localization factor protein 2 
D      Other HR factors
E        491079 EME1; crossover junction endonuclease EME1 isoform X1	K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-] 
E        490072 EME2; LOW QUALITY PROTEIN: probable crossover junction endonuclease EME2 isoform X4	K10883 EME2; crossover junction endonuclease EME2 
E        490750 EXD2; exonuclease 3'-5' domain-containing protein 2 isoform X2	K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1] 
E        476021 MUS81; crossover junction endonuclease MUS81 isoform X4	K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-] 
E        608719 SEM1; 26S proteasome complex subunit SEM1	K10881 SHFM1; 26 proteasome complex subunit DSS1 
E        102152833 SWI5; DNA repair protein SWI5 homolog	K10991 SWI5; DNA repair protein Swi5/Sae3 
E        609700 SFR1; swi5-dependent recombination DNA repair protein 1 homolog isoform X2	K10992 SFR1; Swi5-dependent recombination DNA repair protein 1 
E        607780 SLX1A; structure-specific endonuclease subunit SLX1 isoform X2	K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-] 
E        479867 SLX4; structure-specific endonuclease subunit SLX4	K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) 
E        482980 GEN1; flap endonuclease GEN homolog 1 isoform X2	K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-] 
E        100856719 SPG11; spatacsin isoform X1	K19026 SPG11; spatacsin 
E        490745 ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X2	K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26 
E        611768 RAD51AP1; RAD51-associated protein 1 isoform X1	K20778 RAD51AP1; RAD51-associated protein 1 
E        610223 MORF4L1; mortality factor 4-like protein 1 isoform X1	K11339 MORF4L1; mortality factor 4-like protein 1 
E        485862 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X2	K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-] 
E        483232 FIGNL1; fidgetin-like protein 1	K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-] 
E        478694 SPIDR; DNA repair-scaffolding protein isoform X9	K22806 SPIDR; DNA repair-scaffolding protein 
E        102157178 LRATD2; protein LRATD2	K22810 FAM84B; protein FAM84B 
E        611424 CFAP410; cilia- and flagella-associated protein 410 isoform X1	K23456 CFAP410; cilla- and flagella-associated protein 
E        485036 HDGFL2; hepatoma-derived growth factor-related protein 2 isoform X1	K25065 HDGFL2; hepatoma-derived growth factor-related protein 2 
E        611130 SWSAP1; ATPase SWSAP1	K25771 SWSAP1; ATPase SWSAP1 
E        476800 EMSY; BRCA2-interacting transcriptional repressor EMSY isoform X41	K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY 
E        611230 HSF2BP; heat shock factor 2-binding protein isoform X5	K25791 HSF2BP; heat shock factor 2-binding protein 
E        481930 MMS22L; protein MMS22-like isoform X1	K26125 MMS22L; protein MMS22-like 
E        475127 TONSL; tonsoku-like protein isoform X2	K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2 
E        479089 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 isoform X3	K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 
E        612196 PARPBP; PCNA-interacting partner isoform X2	K27412 PARPBP; PCNA-interacting partner 
C    NHEJ (non-homologous end-joining)
D      DNA-PK complex
E        474485 XRCC6; X-ray repair cross-complementing protein 6	K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1 
E        478902 XRCC5; X-ray repair cross-complementing protein 5	K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2 
E        474176 PRKDC; DNA-dependent protein kinase catalytic subunit	K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1] 
D      MRX complex
E        494006 MRE11; double-strand break repair protein MRE11 isoform X1	K10865 MRE11; double-strand break repair protein MRE11 
E        474674 RAD50; DNA repair protein RAD50 isoform X2	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
D      DNA Ligase 4 complex
E        485544 LIG4; DNA ligase 4 isoform X2	K10777 LIG4; DNA ligase 4 [EC:6.5.1.1] 
E        488923 XRCC4; DNA repair protein XRCC4 isoform X1	K10886 XRCC4; DNA-repair protein XRCC4 
E        610570 NHEJ1; non-homologous end-joining factor 1	K10980 NHEJ1; non-homologous end-joining factor 1 
D      X-family DNA polymerases
E        608341 POLL; DNA polymerase lambda isoform X2	K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-] 
E        100685589 POLM; DNA-directed DNA/RNA polymerase mu isoform X1	K03513 POLM; DNA polymerase mu [EC:2.7.7.7] 
E        486815 DNTT; DNA nucleotidylexotransferase isoform X1	K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31] 
E        494001 POLB; DNA polymerase beta isoform X2	K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-] 
D      Other NHEJ factors
E        442943 APTX; aprataxin	K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72] 
E        481405 APLF; aprataxin and PNK-like factor isoform X3	K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-] 
E        487123 DCLRE1C; protein artemis isoform X1	K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-] 
E        478737 TDP2; tyrosyl-DNA phosphodiesterase 2	K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-] 
E        490535 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1	K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 
E        610246 PWWP3B; PWWP domain-containing DNA repair factor 3B	K23386 PWWP3; PWWP domain-containing DNA repair factor 3 
E        612320 PWWP3A; PWWP domain-containing DNA repair factor 3A isoform X1	K23386 PWWP3; PWWP domain-containing DNA repair factor 3 
E        102152370 PWWP domain-containing DNA repair factor 3B-like	K23386 PWWP3; PWWP domain-containing DNA repair factor 3 
E        480670 PAXX; protein PAXX	K25772 PAXX; protein PAXX 
E        610293 CYREN; cell cycle regulator of non-homologous end joining isoform X1	K26155 CYREN; cell cycle regulator of non-homologous end joining 
E        490091 JMJD8; jmjC domain-containing protein 8 isoform X1	K25792 JMJD8; jumonji domain-containing protein 8 
E        100855997 SHLD1; shieldin complex subunit 1 isoform X1	K26128 SHLD1; shieldin complex subunit 1 
E        100683609 SHLD2; LOW QUALITY PROTEIN: shieldin complex subunit 2 isoform X3	K26129 SHLD2; shieldin complex subunit 2 
E        119870270 SHLD3; shieldin complex subunit 3	K26130 SHLD3; shieldin complex subunit 3 
C    FA (Fanconi anemia) pathway
D      FA core complex
E        608713 FANCA; Fanconi anemia group A protein isoform X7	K10888 FANCA; fanconi anemia group A protein 
E        100687493 FANCB; Fanconi anemia group B protein	K10889 FANCB; fanconi anemia group B protein 
E        607277 FANCC; Fanconi anemia group C protein isoform X3	K10890 FANCC; fanconi anemia group C protein 
E        100856274 FANCE; Fanconi anemia group E protein isoform X1	K10892 FANCE; fanconi anemia group E protein 
E        102152851 FANCF; Fanconi anemia group F protein isoform X3	K10893 FANCF; fanconi anemia group F protein 
E        611887 FANCG; Fanconi anemia group G protein	K10894 FANCG; fanconi anemia group G protein 
E        612161 FANCL; E3 ubiquitin-protein ligase FANCL isoform X5	K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27] 
E        480307 FANCM; Fanconi anemia group M protein	K10896 FANCM; fanconi anemia group M protein 
E        476496 FAAP24; Fanconi anemia core complex-associated protein 24 isoform X3	K10898 FAAP24; fanconi anemia-associated protein 
E        608134 FAAP100; Fanconi anemia core complex-associated protein 100 isoform X1	K10993 FAAP100; fanconi anemia core complex 100 kDa subunit 
D      FA core complex binding factors
E        119865321 HES1; transcription factor HES-1	K06054 HES1; hairy and enhancer of split 1 
E        487450 CENPS; centromere protein S	K11511 APITD1; centromere protein S 
E        119873204 CENPX; centromere protein X isoform X1	K15360 STRA13; centromere protein X 
E        607154 UBE2T; ubiquitin-conjugating enzyme E2 T	K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23] 
D      Bloom's syndrome complex (BTR)
E        100685609 BLM; Bloom syndrome protein isoform X2	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        477576 TOP3B; DNA topoisomerase 3-beta-1 isoform X1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        489537 TOP3A; DNA topoisomerase 3-alpha	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        100684392 RMI1; recQ-mediated genome instability protein 1 isoform X1	K10990 RMI1; RecQ-mediated genome instability protein 1 
E        609907 RMI2; recQ-mediated genome instability protein 2	K15365 RMI2; RecQ-mediated genome instability protein 2 
D      FANCD2-I complex
E        484659 FANCD2; Fanconi anemia group D2 protein isoform X1	K10891 FANCD2; fanconi anemia group D2 protein 
E        100856370 FANCI; Fanconi anemia group I protein isoform X1	K10895 FANCI; fanconi anemia group I protein 
D      Downstream FA components
E        403437 BRCA1; breast cancer type 1 susceptibility protein homolog	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        474180 BRCA2; breast cancer type 2 susceptibility protein	K08775 BRCA2; breast cancer 2 susceptibility protein 
E        491122 BRIP1; Fanconi anemia group J protein	K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3] 
E        608527 PALB2; partner and localizer of BRCA2	K10897 PALB2; partner and localizer of BRCA2 
D      Other FA pathway factors
E        479017 FAN1; fanconi-associated nuclease 1 isoform X1	K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1] 
E        403568 RAD51; DNA repair protein RAD51 homolog 1	K04482 RAD51; DNA repair protein RAD51 
E        480573 RAD51C; DNA repair protein RAD51 homolog 3 isoform X1	K10870 RAD51L2; RAD51-like protein 2 
E        490076 TELO2; telomere length regulation protein TEL2 homolog isoform X1	K11137 TELO2; telomere length regulation protein 
E        479549 USP1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1	K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12] 
E        477027 WDR48; WD repeat-containing protein 48	K15361 WDR48; WD repeat-containing protein 48 
C    Other DSBR factors
D      Protein phosphatase 6
E        608922 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit	K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16] 
E        484298 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X8	K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1 
E        481191 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X2	K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 
E        483688 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1	K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 
E        477058 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X5	K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A 
E        478852 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X4	K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B 
E        481109 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C isoform X1	K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C 
D      Ubiquitin ligases
E        481775 RNF8; E3 ubiquitin-protein ligase RNF8	K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27] 
E        488029 RNF168; E3 ubiquitin-protein ligase RNF168	K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31] 
E        609300 RNF169; E3 ubiquitin-protein ligase RNF169	K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31] 
E        479005 HERC2; E3 ubiquitin-protein ligase HERC2 isoform X2	K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26] 
D      Others
E        607892 WRAP53; LOW QUALITY PROTEIN: telomerase Cajal body protein 1	K23314 WRAP53; telomerase Cajal body protein 1 
E        119873341 TPRN; taperin	K24164 TPRN; taperin 
E        489840 ZCWPW1; zinc finger CW-type PWWP domain protein 1 isoform X8	K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1 
E        489225 WDR70; WD repeat-containing protein 70 isoform X3	K24752 WDR70; WD repeat-containing protein 70 
E        487529 WDR76; WD repeat-containing protein 76 isoform X3	K24755 WDR76; WD repeat-containing protein 76 
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
D      474915 POLH; DNA polymerase eta isoform X3	K03509 POLH; DNA polymerase eta [EC:2.7.7.7] 
D      100683243 POLI; DNA polymerase iota isoform X3	K03510 POLI; DNA polymerase iota [EC:2.7.7.7] 
D      479180 POLK; DNA polymerase kappa isoform X1	K03511 POLK; DNA polymerase kappa [EC:2.7.7.7] 
D      481337 REV1; DNA repair protein REV1 isoform X4	K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-] 
C    B-family DNA polymerases
D      481963 REV3L; DNA polymerase zeta catalytic subunit isoform X1	K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7] 
C    A-family DNA polymerase
D      488804 POLN; DNA polymerase nu isoform X1	K16618 POLN; DNA polymerase nu [EC:2.7.7.7] 
C    Rad6 epistasis group
D      492095 UBE2A; ubiquitin-conjugating enzyme E2 A	K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23] 
D      119870395 ubiquitin-conjugating enzyme E2 A-like	K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23] 
D      474683 UBE2B; ubiquitin-conjugating enzyme E2 B	K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23] 
D      100856010 ubiquitin-conjugating enzyme E2 B-like isoform X2	K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23] 
D      476544 RAD18; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RAD18 isoform X1	K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27] 
D      477106 HLTF; helicase-like transcription factor isoform X4	K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27] 
D      608470 UBE2V2; ubiquitin-conjugating enzyme E2 variant 2	K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant 
D      100538347 UBE2V1; ubiquitin-conjugating enzyme E2 variant 1	K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant 
D      119868036 ubiquitin-conjugating enzyme E2 variant 2	K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant 
D      607817 ubiquitin-conjugating enzyme E2 N-like	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      611865 UBE2N; ubiquitin-conjugating enzyme E2 N	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      610206 ubiquitin-conjugating enzyme E2 N	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      608680 ubiquitin-conjugating enzyme E2 N-like isoform X2	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      607889 ubiquitin-conjugating enzyme E2 N-like	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      609637 ubiquitin-conjugating enzyme E2 N-like	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      100684029 ubiquitin-conjugating enzyme E2 N-like isoform X4	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      476784 ubiquitin-conjugating enzyme E2 N-like	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      611801 ubiquitin-conjugating enzyme E2 N-like	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      609108 ubiquitin-conjugating enzyme E2 N-like	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      479932 ubiquitin-conjugating enzyme E2 N-like isoform X2	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      106558148 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 N-like	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      111094434 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 N-like	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      119863875 ubiquitin-conjugating enzyme E2 N-like	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
C    Other TLS factors
D      477166 PCNA; proliferating cell nuclear antigen	K04802 PCNA; proliferating cell nuclear antigen 
D      612196 PARPBP; PCNA-interacting partner isoform X2	K27412 PARPBP; PCNA-interacting partner 
D      488972 SPRTN; DNA-dependent metalloprotease SPRTN isoform X2	K24051 SPRTN; SprT-like domain-contaning protein Spartan 
D      102154564 GCNA; acidic repeat-containing protein isoform X1	K26957 GCNA; germ cell nuclear acidic protein 
B  Check point factors
C    Rad9-Hus1-Rad1 complex
D      483696 RAD9A; cell cycle checkpoint control protein RAD9A isoform X1	K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2] 
D      100855506 RAD9B; cell cycle checkpoint control protein RAD9B isoform X1	K10995 RAD9B; cell cycle checkpoint control protein RAD9B 
D      606789 HUS1; checkpoint protein HUS1 isoform X10	K10903 HUS1; HUS1 checkpoint protein 
D      479366 RAD1; cell cycle checkpoint protein RAD1 isoform X4	K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] 
C    HRAD17(Rad24)-RFC complex
D      478088 RAD17; cell cycle checkpoint protein RAD17	K06662 HRAD17; cell cycle checkpoint protein 
D      478667 RFC4; replication factor C subunit 4 isoform X1	K10755 RFC2_4; replication factor C subunit 2/4 
D      489798 RFC2; replication factor C subunit 2 isoform X1	K10755 RFC2_4; replication factor C subunit 2/4 
D      477499 RFC5; replication factor C subunit 5 isoform X2	K10756 RFC3_5; replication factor C subunit 3/5 
D      477308 RFC3; replication factor C subunit 3 isoform X2	K10756 RFC3_5; replication factor C subunit 3/5 
C    Rad17-Mec3-Ddc1 complex
D      479366 RAD1; cell cycle checkpoint protein RAD1 isoform X4	K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] 
C    FPC (fork protection complex)
D      481112 TIMELESS; protein timeless homolog isoform X1	K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1 
D      100683743 TIPIN; TIMELESS-interacting protein	K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3 
D      482481 CLSPN; claspin	K25773 CLSPN; claspin 
C    Triple T complex
D      490076 TELO2; telomere length regulation protein TEL2 homolog isoform X1	K11137 TELO2; telomere length regulation protein 
D      477225 TTI1; TELO2-interacting protein 1 homolog isoform X2	K20403 TTI1; TELO2-interacting protein 1 
D      608405 TTI2; LOW QUALITY PROTEIN: TELO2-interacting protein 2 isoform X1	K23115 TTI2; TELO2-interacting protein 2 
C    BAG6-UBL4A-GET4 complex
D      474842 BAG6; large proline-rich protein BAG6 isoform X17	K23390 BAG6; large proline-rich protein BAG6 
D      100856125 UBL4B; ubiquitin-like protein 4B	K23388 UBL4; ubiquitin-like protein 4 
D      491599 GET4; Golgi to ER traffic protein 4 homolog isoform X3	K23387 GET4; golgi to ER traffic protein 4 
C    Other check point factors
D      100856315 ATR; serine/threonine-protein kinase ATR isoform X1	K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1] 
D      608504 ATRIP; ATR-interacting protein isoform X1	K10905 ATRIP; ATR interacting protein 
D      479450 ATM; serine-protein kinase ATM	K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1] 
D      403869 TP53; cellular tumor antigen p53	K04451 TP53; tumor protein p53 
D      609767 CHEK1; serine/threonine-protein kinase Chk1 isoform X8	K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1] 
D      486338 CHEK2; serine/threonine-protein kinase Chk2 isoform X3	K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1] 
D      484780 CDC25A; M-phase inducer phosphatase 1	K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48] 
D      485790 CDC25B; M-phase inducer phosphatase 2 isoform X1	K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48] 
D      610456 CDC25C; M-phase inducer phosphatase 3 isoform X3	K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48] 
D      475864 YWHAZ; 14-3-3 protein zeta/delta	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      477237 YWHAB; 14-3-3 protein beta/alpha	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      607060 YWHAQ; 14-3-3 protein theta	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      479459 LOW QUALITY PROTEIN: 14-3-3 protein theta-like	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      100855903 14-3-3 protein zeta/delta-like isoform X3	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      609669 LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      100687866 YWHAH; 14-3-3 protein eta	K16198 YWHAG_H; 14-3-3 protein gamma/eta 
D      489818 YWHAG; 14-3-3 protein gamma	K16198 YWHAG_H; 14-3-3 protein gamma/eta 
D      480645 YWHAE; 14-3-3 protein epsilon isoform X2	K06630 YWHAE; 14-3-3 protein epsilon 
D      608573 LOW QUALITY PROTEIN: 14-3-3 protein epsilon-like	K06630 YWHAE; 14-3-3 protein epsilon 
D      485411 NAV2; neuron navigator 2 isoform X6	K19483 NAV2; neuron navigator 2 [EC:5.6.2.4] 
D      476847 WEE1; wee1-like protein kinase isoform X1	K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1] 
D      475525 WEE2; wee1-like protein kinase 2	K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1] 
D      489488 PER1; period circadian protein homolog 1	K21944 PER1; period circadian protein 1 
D      486180 PER2; period circadian protein homolog 2	K02633 PER2; period circadian protein 2 
D      608256 PER3; period circadian protein homolog 3 isoform X1	K21945 PER3; period circadian protein 3 
D      100855462 MDC1; mediator of DNA damage checkpoint protein 1 isoform X2	K20780 MDC1; mediator of DNA damage checkpoint protein 1 
D      481025 PLS3; plastin-3	K17336 PLS3; plastin-3 
D      488728 AEN; apoptosis-enhancing nuclease isoform X1	K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-] 
D      475380 PLK3; serine/threonine-protein kinase PLK3	K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21] 
D      485081 PLK5; LOW QUALITY PROTEIN: inactive serine/threonine-protein kinase PLK5 isoform X5	K19596 PLK5; inactive serine/threonine-protein kinase PLK5 
D      486058 NEK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek1 isoform X1	K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] 
D      100683905 NEK5; LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek5 isoform X5	K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] 
D      476591 NEK4; serine/threonine-protein kinase Nek4 isoform X4	K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] 
D      485638 NEK10; serine/threonine-protein kinase Nek10 isoform X1	K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1] 
D      485660 NEK11; serine/threonine-protein kinase Nek11 isoform X1	K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1] 
D      100856622 DONSON; protein downstream neighbor of Son isoform X1	K22422 DONSON; protein downstream neighbor of Son 
D      100682578 KANK2; KN motif and ankyrin repeat domain-containing protein 2	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      100684819 KANK4; KN motif and ankyrin repeat domain-containing protein 4	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      100687276 KANK1; KN motif and ankyrin repeat domain-containing protein 1 isoform X1	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      476723 KANK3; KN motif and ankyrin repeat domain-containing protein 3 isoform X5	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      477926 CHMP4C; charged multivesicular body protein 4c	K24782 CHMP4C; charged multivesicular body protein 4C 
D      607306 VPS4B; vacuolar protein sorting-associated protein 4B	K12196 VPS4; vacuolar protein-sorting-associated protein 4 
D      479674 VPS4A; vacuolar protein sorting-associated protein 4A isoform X2	K12196 VPS4; vacuolar protein-sorting-associated protein 4 
D      100855483 ZFYVE19; abscission/NoCut checkpoint regulator	K24778 ZFYVE19; abscission/NoCut checkpoint regulator 
D      480111 SDE2; replication stress response regulator SDE2 isoform X2	K25059 SDE2; replication stress response regulator SDE2 
B  Other factors with a suspected DNA repair function
C    DNA polymerases
D      488003 POLQ; DNA polymerase theta isoform X2	K02349 POLQ; DNA polymerase theta [EC:2.7.7.7] 
D      489442 MYBBP1A; myb-binding protein 1A isoform X1	K02331 POL5; DNA polymerase phi [EC:2.7.7.7] 
D      475632 PRIMPOL; DNA-directed primase/polymerase protein isoform X1	K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7] 
C    Nucleases
D      102155466 TREX1; three-prime repair exonuclease 1 isoform X1	K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2] 
D      492236 TREX2; three prime repair exonuclease 2	K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2] 
D      477824 DCLRE1A; DNA cross-link repair 1A protein	K15340 DCLRE1A; DNA cross-link repair 1A protein 
D      606778 DCLRE1B; 5' exonuclease Apollo isoform X2	K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-] 
D      475314 EXO5; exonuclease V isoform X3	K17815 EXO5; exonuclease V [EC:3.1.-.-] 
D      608430 ENDOV; endonuclease V isoform X1	K21813 ENDOV; endonuclease V [EC:3.1.26.-] 
D      476128 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X1	K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-] 
D      610155 ANKLE1; ankyrin repeat and LEM domain-containing protein 1	K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1 
C    Helicases
D      487837 HELQ; helicase POLQ-like isoform X2	K19178 HELQ; POLQ-like helicase [EC:5.6.2.4] 
D      476297 ERCC6L2; DNA excision repair protein ERCC-6-like 2 isoform X1	K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-] 
C    PSO4 complex
D      611552 PRPF19; pre-mRNA-processing factor 19 isoform X1	K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27] 
D      474921 CDC5L; cell division cycle 5-like protein	K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1 
D      475805 BCAS2; pre-mRNA-splicing factor SPF27 isoform X2	K12861 BCAS2; pre-mRNA-splicing factor SPF27 
D      612490 PLRG1; pleiotropic regulator 1 isoform X1	K12862 PLRG1; pleiotropic regulator 1 
C    Modulation of nucleotide pools
D      100685818 NUDT15; nucleotide triphosphate diphosphatase NUDT15	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      489894 NUDT1; 7,8-dihydro-8-oxoguanine triphosphatase	K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56] 
D      609139 NUDT18; 8-oxo-dGDP phosphatase NUDT18 isoform X2	K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58] 
D      609526 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
D      476823 RRM1; ribonucleoside-diphosphate reductase large subunit isoform X2	K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] 
D      481988 RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X4	K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] 
D      482963 RRM2; ribonucleoside-diphosphate reductase subunit M2	K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] 
#
A<b>Prokaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      442978 MGMT; methylated-DNA--protein-cysteine methyltransferase	K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 
C    BER (base exicision repair)
D      DNA glycosylases
E        486315 UNG; uracil-DNA glycosylase	K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] 
E        486497 SMUG1; single-strand selective monofunctional uracil DNA glycosylase isoform X1	K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-] 
E        611597 MPG; DNA-3-methyladenine glycosylase isoform X1	K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] 
E        100856592 MUTYH; adenine DNA glycosylase isoform X7	K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] 
E        610981 NTHL1; endonuclease III-like protein 1 isoform X3	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
D      RecJ
D      DNA ligase
D      DNA polymerase I
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase complex (RNAP)
E        TRCF (transcription-repair coupling factor)
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
D      Molecular matchmaker
D      Strand discrimination factor
D      DNA exonucleases
D      DNA polymerase III holoenzyme
D      DNA ligase
D      Other MMR factors
E        475524 SSBP1; single-stranded DNA-binding protein, mitochondrial	K03111 ssb; single-strand DNA-binding protein 
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      RecBC pathway proteins
D      RecFOR pathway proteins
D      AddAB pathway proteins
D      Other HR factor
D      Archaeal homologous recombinant proteins
C    NHEJ (non-homologous end-joining)
D      Two-component NHEJ DNA repair complex
D      SHIIR (short-homology-independent illegitimate recombination)
E        Facilitator
E        Supressor
D      SHDIR (short-homology-dependent illegitimate recombination)
E        RecET pathway
E        Facilitator
E        Supressor
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
C    Other SOS response factors
D      475524 SSBP1; single-stranded DNA-binding protein, mitochondrial	K03111 ssb; single-strand DNA-binding protein 
B  Other factors with a suspected DNA repair function
C    DNA polymerase
C    DNA helicases
C    Modulation of nucleotide pools
D      100685818 NUDT15; nucleotide triphosphate diphosphatase NUDT15	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      609526 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
C    Others
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#Last updated: March 29, 2024