+E Messenger RNA Biogenesis KO
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Messenger RNA Biogenesis - Cryptosporidium hominis
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AEukaryotic type
B mRNA processing factors
C 5' end processing
D Capping factors
E Chro.70328 hypothetical protein K00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]
E Chro.70041 cell division control protein 28 K04563 CDC28; cyclin-dependent kinase [EC:2.7.11.22]
E Chro.50127 cdc2-like protein kinase K04563 CDC28; cyclin-dependent kinase [EC:2.7.11.22]
E Chro.70056 cyclin-dependent kinase-related kinase K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E Chro.60277 mRNA capping enzyme alpha subunit K00987 CEG1; mRNA guanylyltransferase [EC:2.7.7.50]
E Chro.70293 hypothetical protein K14590 CMTR2; cap2 methyltransferase [EC:2.1.1.296]
D Cap binding complex
E Chro.60207 nuclear cap-binding protein K12883 NCBP2; nuclear cap-binding protein subunit 2
C 3' end processing
D Pre-mRNA cleavage factor Im (CFIm)
E Chro.60436 hypothetical protein K14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5
D Pre-mRNA cleavage factor IIm (CFIIm)
E Chro.50085 pre-mRNA cleavage complex ii protein clp1-related K14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]
D Cleavage and polyadenylation specificity factor (CPSF) complex
E Chro.80059 cleavage and polyadenylation specifity factor protein K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E Chro.60210 zf-CCCH zinc finger protein K14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4
E Chro.50279 hypothetical protein K14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4
E Chro.60056 CCAAT-box DNA binding protein subunit B K14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1
E Chro.80429 development protein DG1124 K15541 MPE1; protein MPE1
E Chro.70459 CG1109-PA K15542 PFS2; polyadenylation factor subunit 2
E Chro.70303 hypothetical protein K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
D Cleavage stimulation factor (CSTF) complex
E Chro.40101 Cstf1-prov protein K14406 CSTF1; cleavage stimulation factor subunit 1
E Chro.10152 cleavage stimulation factor K14407 CSTF2; cleavage stimulation factor subunit 2
D U7-dependent histone pre-mRNA processing factors
E Chro.10324 small nuclear ribonucleoprotein K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E Chro.10256 aspartyl protease-like K11088 SNRPD3; small nuclear ribonucleoprotein D3
E Chro.10304 hypothetical protein K11098 SNRPF; small nuclear ribonucleoprotein F
E Chro.80059 cleavage and polyadenylation specifity factor protein K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E Chro.10152 cleavage stimulation factor K14407 CSTF2; cleavage stimulation factor subunit 2
E Chro.70362 CG15040 gene product K18710 SLBP; histone RNA hairpin-binding protein
E Chro.60191 replication-associated histone mRNA stem loop-bindingprotein K18710 SLBP; histone RNA hairpin-binding protein
D DRB sensitivity inducing factor (DSIF) complex
E Chro.60534 spt5-like transcription initiation protein K15172 SUPT5H; transcription elongation factor SPT5
D N6-methyltransferase complex
D Poly(A) addition factors
E Chro.40112 hypothetical protein K14376 PAP; poly(A) polymerase [EC:2.7.7.19]
D Negative regulators of mRNA 3' end processing
C Other processing factors
D Chro.70318 hypothetical protein K13102 KIN; DNA/RNA-binding protein KIN17
D Chro.30155 coronin binding protein K23038 ZC3H14; zinc finger CCCH domain-containing protein 14
B mRNA surveillance and transport factors
C Transport factors
D EJC complex
E Chro.80448 helicase K12812 DDX39B; ATP-dependent RNA helicase UAP56/SUB2 [EC:5.6.2.7]
E Chro.70440 eukaryotic initiation factor 4A-3 (eIF4A-3) (eIF-4A-3) K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]
D TREX complex
D TREX-2 complex
E Chro.50390 centrin K16466 CETN3; centrin-3
D Nuclear pore complex
E Chro.60529 mRNA export protein K14298 RAE1; mRNA export factor
E Chro.80472 hypothetical protein K14004 SEC13; protein transport protein SEC13
E Chro.20379 hypothetical protein K14306 NUP62; nuclear pore complex protein Nup62
E Chro.80185 hypothetical protein K14297 NUP98; nuclear pore complex protein Nup98-Nup96
E Chro.50390 centrin K16466 CETN3; centrin-3
E Chro.70044 hypothetical protein K18723 GLE1; nucleoporin GLE1
D Ran-mediated transport factors
E Chro.70035 GTP-binding nuclear protein ran/tc4 K07936 RAN; GTP-binding nuclear protein Ran
E Chro.10112 hypothetical protein K18647 ANP32B; acidic leucine-rich nuclear phosphoprotein 32 family member B
E Chro.30163 hypothetical protein K18726 FAF2; FAS-associated factor 2
E Chro.10043 cell division cycle protein 48 K13525 VCP; transitional endoplasmic reticulum ATPase
E Chro.30346 exportin 1 (chromosome region maintenance protein 1) (caffeine resistance protein 2) K14290 XPO1; exportin-1
E Chro.70197 hypothetical protein K18460 XPO7; exportin-7
D eIF4F and regulatory proteins
E Chro.60132 initiation factor e4 K03259 EIF4E; translation initiation factor 4E
E Chro.10108 eukaryotic initiation factor 4A (eIF4A) (eIF-4A) K03257 EIF4A; translation initiation factor 4A
E Chro.40341 DEAD box polypeptide, Y chromosome-related K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E Chro.60347 poly(a)-binding protein fabm K13126 PABPC; polyadenylate-binding protein
E Chro.30448 hypothetical protein K07575 MCTS; malignant T-cell-amplified sequence
E Chro.80336 hypothetical protein K24272 DENR; density-regulated protein
D APOBEC1-ACF complex
D Other transport factors
E Chro.50321 ribonucleoprotein K14411 MSI; RNA-binding protein Musashi
E Chro.50046 RNA recognition motif (RRM)-containing protein K14411 MSI; RNA-binding protein Musashi
E Chro.80212 pelota (PEL1) K06965 PELO; protein pelota
E Chro.60057 poly(A) binding protein II K14396 PABPN1; polyadenylate-binding protein 2
E Chro.80546 DEAD-box RNA helicase K18655 DDX19; ATP-dependent RNA helicase DDX19/DBP5 [EC:5.6.2.7]
E Chro.30173 hypothetical protein K18732 SARNP; SAP domain-containing ribonucleoprotein
E Chro.40154 regulator of chromosome condensation K11493 RCC1; regulator of chromosome condensation
E Chro.60538 SAC3/GANP domain protein K23802 LENG8; SAC3 family protein LENG8/THP3
C Surveillance factors
D Surveillance complex
E Chro.60391 eukaryotic peptide chain release factor K03265 ETF1; peptide chain release factor subunit 1
E Chro.20224 translation elongation factor EF-1, subunit alpha K03267 ERF3; peptide chain release factor subunit 3
D Protein phosphatase 2A
E Chro.70100 hypothetical protein K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
E Chro.50440 hypothetical protein K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
E Chro.70554 CG4733-PA K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
D Other surveillance factors
C Factors involved in mRNA localization
D Cargo complex
E Chro.50114 hypothetical protein K14844 PUF6; pumilio homology domain family member 6
E Chro.70483 myosin B K10357 MYO5; myosin V
E Chro.60497 myosin-related protein K10357 MYO5; myosin V
D Factors that have mRNA localization signals
D Trans-acting binding proteins
E Chro.60459 elongation factor 1-alpha (EF-1-ALPHA) K03231 EEF1A; elongation factor 1-alpha
E Chro.70492 elongation factor 1-gamma K03233 EEF1G; elongation factor 1-gamma
D Other mRNA localization factors
C mRNA cycle factors
D Common to processing body (P body) and stress granule
E Chro.60132 initiation factor e4 K03259 EIF4E; translation initiation factor 4E
E Chro.40341 DEAD box polypeptide, Y chromosome-related K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E Chro.80211 ATP-dependent RNA helicase K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
E Chro.20338 alphaSNBP(A) K18749 LSM14; protein LSM14
E Chro.80396 karyopherin (importin) beta 2 K18752 TNPO1; transportin-1
E Chro.30344 protein kinase, cAMP-dependent, catalytic chain K04345 PKA; protein kinase A [EC:2.7.11.11]
D P-body specific factors
E Chro.70307 hypothetical protein K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E Chro.50482 hypothetical protein K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E Chro.40305 ENSANGP00000016613 K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E Chro.70505 U6 snRNA associated SM-like protein LSM5 K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E Chro.70235 Sm protein F K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E Chro.70595 u6 snRNA-associated sm-like protein K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
E Chro.70483 myosin B K10357 MYO5; myosin V
E Chro.60497 myosin-related protein K10357 MYO5; myosin V
E Chro.40322 alpha-tubulin K07374 TUBA; tubulin alpha
E Chro.60241 transcription regulatory protein K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E Chro.60287 f24b9.20 K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E Chro.70553 protein potential transcriptional repressor Not4hp K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
E Chro.40217 hypothetical protein K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E Chro.30052 hypothetical protein K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E Chro.80587 exoribonuclease, VacB/Rnb family K18758 DIS3L2; DIS3-like exonuclease 2 [EC:3.1.13.-]
E Chro.80562 1200014O24Rik protein K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]
E Chro.20350 PABP1-dependent poly A-specific ribonuclease subunit PAN3; PABP-dependent poly(A) nuclease 3 K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3
D Stress granule specific factors
E Chro.60347 poly(a)-binding protein fabm K13126 PABPC; polyadenylate-binding protein
E Chro.70110 hypothetical protein K15026 EIF2A; translation initiation factor 2A
E Chro.20043 hypothetical protein K03253 EIF3B; translation initiation factor 3 subunit B
E Chro.10108 eukaryotic initiation factor 4A (eIF4A) (eIF-4A) K03257 EIF4A; translation initiation factor 4A
E Chro.70440 eukaryotic initiation factor 4A-3 (eIF4A-3) (eIF-4A-3) K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]
E Chro.20203 guanine nucleotide-binding protein K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein
B mRNA degradation factors
C 5'-3' decay
D Decapping complex
E Chro.70307 hypothetical protein K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E Chro.80211 ATP-dependent RNA helicase K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
D Lsm complex
E Chro.50482 hypothetical protein K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E Chro.40305 ENSANGP00000016613 K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E Chro.70505 U6 snRNA associated SM-like protein LSM5 K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E Chro.70235 Sm protein F K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E Chro.70595 u6 snRNA-associated sm-like protein K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
D 5' exonucleases
E Chro.80265 pacman protein K12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
E Chro.80264 CG10354-PA K12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
D Other 5'-3' decay factors
C 3'-5' decay
D Core exosome factors
E Chro.80033 hypothetical protein K07573 CSL4; exosome complex component CSL4
E Chro.80348 hypothetical protein K03679 RRP4; exosome complex component RRP4
E Chro.30107 hypothetical protein K03681 RRP40; exosome complex component RRP40
E Chro.40450 exosome complex exonuclease RRP41 K11600 RRP41; exosome complex component RRP41
E Chro.40220 hypothetical protein K12590 RRP46; exosome complex component RRP46
E Chro.70036 exosome complex exonuclease RRP43 (Ribosomal RNA processing protein 43) K12586 RRP43; exosome complex component RRP43
E Chro.70272 polymyositis/scleroderma autoantigen 1 K03678 RRP45; exosome complex component RRP45
D Exosome cofactors
E Chro.20227 mitotic control protein dis3 K12585 DIS3; exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-]
E Chro.50386 hypothetical protein K12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-]
E Chro.50172 DEAD/DEAH box helicase K20103 DDX60; ATP-dependent RNA helicase DDX60 [EC:5.6.2.7]
D TRAMP complex
E Chro.70404 hypothetical protein K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
E Chro.80294 ATP-dependent RNA helicase; ATP-dependent RNA helicase K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
D Ski complex
D Ccr4-NOT complex
E Chro.40217 hypothetical protein K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E Chro.60241 transcription regulatory protein K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E Chro.60287 f24b9.20 K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E Chro.70553 protein potential transcriptional repressor Not4hp K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
E Chro.30052 hypothetical protein K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E Chro.80511 cell differentiation protein rcd1 K12606 RCD1; CCR4-NOT transcription complex subunit 9
D Pan complex
E Chro.80562 1200014O24Rik protein K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]
E Chro.20350 PABP1-dependent poly A-specific ribonuclease subunit PAN3; PABP-dependent poly(A) nuclease 3 K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3
D Other 3'-5' decay factors
E Chro.40208 C0850c K19612 PDE12; 2',5'-phosphodiesterase [EC:3.1.13.4 3.1.4.-]
C Other degradation factors
D RNases
#
AProkaryotic type
B Bacterial mRNA degradation factors
C RNA degradosome components
D Ribonucreases
D Helicases
D Other RNA degradosome components
E Chro.50184 enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
C Other RNA degradation factors
D Chaperones
E Chro.30389 dnaK-type molecular chaperone hsp70, organellar K04043 dnaK; molecular chaperone DnaK
E Chro.60573 Hsp60 K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D Others
D Bacterial Small RNA Regulators
B Archeal mRNA degradation factors
C Exosome components
D Core exosome
E Chro.80348 hypothetical protein K03679 RRP4; exosome complex component RRP4
E Chro.80033 hypothetical protein K07573 CSL4; exosome complex component CSL4
D Cofactors
E Chro.40450 exosome complex exonuclease RRP41 K11600 RRP41; exosome complex component RRP41
D Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 25, 2024