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Transfer RNA Biogenesis - Escherichia coli K-12 MG1655
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AEukaryotic type
B 5'processing factors
C Ribonucrease P
B 3'processing and CCA adding factors
C 3'processing factors
D b2268 rbn; ribonuclease BN K00784 rnz; ribonuclease Z [EC:3.1.26.11]
C CCA adding factors
D b3056 cca; fused CCA tRNA nucleotidyltransferase/phosphohydrolase K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
B tRNA spricing factors
C tRNA splicing endonuclease complex
C tRNA splicing ligase complex
D b3421 rtcB; RNA-splicing ligase K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
C Other tRNA splicing factors
B tRNA transport factors
C tRNA export factors
C tRNA import factors
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D b2400 gltX; glutamate--tRNA ligase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D b0194 proS; proline--tRNA ligase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D b0026 ileS; isoleucine--tRNA ligase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D b0642 leuS; leucine--tRNA ligase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D b2114 metG; methionine--tRNA ligase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D b0680 glnS; glutamine--tRNA ligase K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D b1876 argS; arginine--tRNA ligase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D b2890 lysS; lysine--tRNA ligase, constitutive K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D b4129 lysU; lysine--tRNA ligase/Ap4A synthetase/Ap3A synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D b1866 aspS; aspartate--tRNA ligase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
C Other AARSs
D b2697 alaS; alanine--tRNA ligase/DNA-binding transcriptional repressor K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D b0930 asnS; asparagine--tRNA ligase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D b1719 thrS; threonine--tRNA ligase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D b0893 serS; serine--tRNA ligase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D b0526 cysS; cysteine--tRNA ligase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D b4258 valS; valine--tRNA ligase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D b2514 hisS; histidine--tRNA ligase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D b1714 pheS; phenylalanine--tRNA ligase subunit alpha K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D b1713 pheT; phenylalanine--tRNA ligase subunit beta K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D b1637 tyrS; tyrosine--tRNA ligase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D b3384 trpS; tryptophan--tRNA ligase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
C Trans-editing factors
D b3887 dtd; D-aminoacyl-tRNA deacylase K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
C AARS associated factors
D b1103 hinT; purine nucleoside phosphoramidase K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
B tRNA modification factors
C Deaminases
C Dihydorouridine synthases
C Methylthiotransferase
C Methyltransferases
D b2960 trmB; tRNA m(7)G46 methyltransferase K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D b0195 trmO; tRNA m(6)t(6)A37 methyltransferase K22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
C Psudouridine synthases
D b2318 truA; tRNA pseudouridine(38-40) synthase K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D b3166 truB; tRNA pseudouridine(55) synthase K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D b2745 truD; tRNA pseudouridine(13) synthase K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
C Thiolation factors
D b2530 iscS; cysteine desulfurase IscS K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C KEOPS/EKC complex
C Elongator complex
C Elongator related proteins
C Other tRNA modification factors
D b3282 tsaC; threonylcarbamoyl-AMP synthase K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D b4171 miaA; tRNA dimethylallyltransferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D b3706 mnmE; 5-carboxymethylaminomethyluridine-tRNA synthase GTPase subunit K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
D b3741 mnmG; 5-carboxymethylaminomethyluridine-tRNA synthase subunit MnmG K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D b1764 selD; selenide, water dikinase K01008 selD; selenide, water dikinase [EC:2.7.9.3]
B tRNA degradation factors
C TRAMP complex
C Rapid tRNA decay (RTD) pathway factors
D b4214 cysQ; 3'(2'),5'-bisphosphate nucleotidase K01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]
C Other tRNA degradation factors
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AProkaryotic type
B 5'processing factors
C Ribonucrease P
D b3704 rnpA; RNase P protein component K03536 rnpA; ribonuclease P protein component [EC:3.1.26.5]
D b3123 rnpB; RNase P catalytic RNA component K01978 rnpB; M1 RNA
B 3'processing and CCA adding factors
C 3'processing factors
D b2268 rbn; ribonuclease BN K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D b1652 rnt; RNase T K03683 rnt; ribonuclease T [EC:3.1.13.-]
D b3643 rph; truncated RNase PH K00989 rph; ribonuclease PH [EC:2.7.7.56]
D b0611 rna; RNase I K01169 rna; ribonuclease I (enterobacter ribonuclease) [EC:4.6.1.21]
D b1286 rnb; RNase II K01147 rnb; exoribonuclease II [EC:3.1.13.1]
D b1804 rnd; RNase D K03684 rnd; ribonuclease D [EC:3.1.13.5]
C CCA adding factors
D b3056 cca; fused CCA tRNA nucleotidyltransferase/phosphohydrolase K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
B tRNA spricing factors
C tRNA splicing endonucleases
C tRNA splicing ligases
D b3421 rtcB; RNA-splicing ligase K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
C Other tRNA splicing factors
D b0147 thpR; RNA 2',3'-cyclic phosphodiesterase K01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]
D b4331 kptA; RNA 2'-phosphotransferase K07559 kptA; putative RNA 2'-phosphotransferase [EC:2.7.1.-]
B tRNA transport factors
C tRNA export factors
D b4391 ettA; energy-dependent translational throttle protein EttA K06020 ettA; energy-dependent translational throttle protein EttA
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D b0642 leuS; leucine--tRNA ligase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D b0194 proS; proline--tRNA ligase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
C Other AARSs
D b1637 tyrS; tyrosine--tRNA ligase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D b3384 trpS; tryptophan--tRNA ligase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D b1719 thrS; threonine--tRNA ligase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D b0026 ileS; isoleucine--tRNA ligase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D b2890 lysS; lysine--tRNA ligase, constitutive K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D b4129 lysU; lysine--tRNA ligase/Ap4A synthetase/Ap3A synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D b2697 alaS; alanine--tRNA ligase/DNA-binding transcriptional repressor K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D b4258 valS; valine--tRNA ligase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D b2114 metG; methionine--tRNA ligase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D b0893 serS; serine--tRNA ligase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D b1866 aspS; aspartate--tRNA ligase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D b3560 glyQ; glycine--tRNA ligase subunit alpha K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D b3559 glyS; glycine--tRNA ligase subunit beta K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D b0526 cysS; cysteine--tRNA ligase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D b2400 gltX; glutamate--tRNA ligase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D b0680 glnS; glutamine--tRNA ligase K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D b1876 argS; arginine--tRNA ligase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D b1714 pheS; phenylalanine--tRNA ligase subunit alpha K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D b1713 pheT; phenylalanine--tRNA ligase subunit beta K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D b2514 hisS; histidine--tRNA ligase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D b0930 asnS; asparagine--tRNA ligase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D b0144 gluQ; glutamyl-Q tRNA(Asp) synthetase K01894 gluQ; glutamyl-Q tRNA(Asp) synthetase [EC:6.1.1.-]
C Trans-editing factors
D b3887 dtd; D-aminoacyl-tRNA deacylase K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D b0481 ybaK; Cys-tRNA(Pro) and Cys-tRNA(Cys) deacylase K03976 ybaK; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]
D b1787 yeaK; mischarged aminoacyl-tRNA deacylase K19055 prdX; Ala-tRNA(Pro) deacylase [EC:3.1.1.-]
B tRNA modification factors
C Deaminases
D b2559 tadA; tRNA adenosine(34) deaminase K11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]
C Dihydorouridine synthases
D b4049 dusA; tRNA-dihydrouridine synthase A K05539 dusA; tRNA-dihydrouridine synthase A [EC:1.-.-.-]
D b3260 dusB; tRNA-dihydrouridine synthase B K05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-]
D b2140 dusC; tRNA-dihydrouridine(16) synthase K05541 dusC; tRNA-dihydrouridine synthase C [EC:1.-.-.-]
C Methylthiotransferases
D b0661 miaB; isopentenyl-adenosine A37 tRNA methylthiolase K06168 miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]
C Methyltransferases
D b1870 cmoA; carboxy-S-adenosyl-L-methionine synthase K15256 cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-]
D b1871 cmoB; tRNA U34 carboxymethyltransferase K15257 cmoB; tRNA (mo5U34)-methyltransferase [EC:2.1.1.-]
D b0921 cmoM; tRNA cmo(5)U34 methyltransferase K06219 smtA; tRNA 5-carboxymethoxyuridine methyltransferase [EC:2.1.1.-]
D b4403 yjtD; putative rRNA methyltransferase K02533 lasT; tRNA/rRNA methyltransferase [EC:2.1.1.-]
D b3965 trmA; tRNA m(5)U54 methyltransferase K00557 trmA; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35]
D b2960 trmB; tRNA m(7)G46 methyltransferase K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D b2607 trmD; tRNA m(1)G37 methyltransferase K00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D b3706 mnmE; 5-carboxymethylaminomethyluridine-tRNA synthase GTPase subunit K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
D b2581 yfiF; putative methyltransferase YfiF K03214 yfiF; RNA methyltransferase, TrmH family [EC:2.1.1.-]
D b3651 trmH; tRNA (Gm18) 2'-O-methyltransferase K00556 trmH; tRNA (guanosine-2'-O-)-methyltransferase [EC:2.1.1.34]
D b2532 trmJ; tRNA Cm32/Um32 methyltransferase K15396 trmJ; tRNA (cytidine32/uridine32-2'-O)-methyltransferase [EC:2.1.1.200]
D b3606 trmL; tRNA (cytidine/uridine-2'-O)-ribose methyltransferase K03216 trmL; tRNA (cytidine/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]
D b0195 trmO; tRNA m(6)t(6)A37 methyltransferase K22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
D b2575 yfiC; tRNA m(6)A37 methyltransferase K15460 yfiC; tRNA1Val (adenine37-N6)-methyltransferase [EC:2.1.1.223]
C Psudouridine synthases
D b2318 truA; tRNA pseudouridine(38-40) synthase K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D b3166 truB; tRNA pseudouridine(55) synthase K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D b2791 truC; tRNA pseudouridine(65) synthase K06175 truC; tRNA pseudouridine65 synthase [EC:5.4.99.26]
D b2745 truD; tRNA pseudouridine(13) synthase K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D b0058 rluA; 23S rRNA pseudouridine(746) and tRNA pseudouridine(32) synthase K06177 rluA; tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]
C Thiolation factors
D b1133 mnmA; tRNA-specific 2-thiouridylase K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]
D b1344 ttcA; tRNA cytosine(32) 2-sulfurtransferase TtcA K14058 ttcA; tRNA 2-thiocytidine biosynthesis protein TtcA
D b3470 tusA; sulfur transfer protein TusA K04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]
D b3343 tusB; sulfurtransferase complex subunit TusB K07237 tusB; tRNA 2-thiouridine synthesizing protein B
D b3344 tusC; sulfurtransferase complex subunit TusC K07236 tusC; tRNA 2-thiouridine synthesizing protein C
D b3345 tusD; sulfurtransferase complex subunit TusD K07235 tusD; tRNA 2-thiouridine synthesizing protein D [EC:2.8.1.-]
D b0969 tusE; sulfur transfer protein TusE K11179 tusE; tRNA 2-thiouridine synthesizing protein E [EC:2.8.1.-]
D b2528 iscA; iron-sulfur cluster insertion protein IscA K13628 iscA; iron-sulfur cluster assembly protein
D b2530 iscS; cysteine desulfurase IscS K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D b2898 ygfZ; folate-binding protein K06980 ygfZ; tRNA-modifying protein YgfZ
C KEOPS/EKC complex
C Other tRNA modification factors
D b3741 mnmG; 5-carboxymethylaminomethyluridine-tRNA synthase subunit MnmG K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D b4171 miaA; tRNA dimethylallyltransferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D b2324 mnmC; fused 5-methylaminomethyl-2-thiouridine-forming methyltransferase and FAD-dependent demodification enzyme K15461 mnmC; tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein [EC:2.1.1.61 1.5.-.-]
D b0405 queA; tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase K07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]
D b0444 queC; 7-cyano-7-deazaguanine synthase K06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]
D b2765 queD; 6-carboxy-5,6,7,8-tetrahydropterin synthase K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
D b2777 queE; putative 7-carboxy-7-deazaguanine synthase QueE K10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]
D b2794 queF; 7-cyano-7-deazaguanine reductase K06879 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
D b4166 queG; epoxyqueuosine reductase K18979 queG; epoxyqueuosine reductase [EC:1.17.99.6]
D b1764 selD; selenide, water dikinase K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D b0503 selU; tRNA 2-selenouridine synthase K06917 selU; tRNA 2-selenouridine synthase [EC:2.9.1.3]
D b0406 tgt; tRNA-guanine transglycosylase K00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]
D b0423 thiI; tRNA uridine 4-sulfurtransferase K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]
D b0188 tilS; tRNA(Ile)-lysidine synthetase K04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]
D b2474 tmcA; tRNA(Met) cytidine acetyltransferase K06957 tmcA; tRNA(Met) cytidine acetyltransferase [EC:2.3.1.193]
D b1807 tsaB; N(6)-L-threonylcarbamoyladenine synthase, TsaB subunit K14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB
D b3282 tsaC; threonylcarbamoyl-AMP synthase K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D b3064 tsaD; N(6)-L-threonylcarbamoyladenine synthase, TsaD subunit K25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234]
D b4168 tsaE; N(6)-L-threonylcarbamoyladenine synthase, TsaE subunit K06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
D b2812 tcdA; tRNA threonylcarbamoyladenosine dehydratase K22132 tcdA; tRNA threonylcarbamoyladenosine dehydratase
B tRNA degradation factors
C b4179 rnr; RNase R K12573 rnr; ribonuclease R [EC:3.1.13.1]
C b3164 pnp; polynucleotide phosphorylase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: February 29, 2024