+F Repair protein KO
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DNA Repair and Recombination Proteins - Gallus gallus (chicken)
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 423965 MGMT; methylated-DNA--protein-cysteine methyltransferase isoform X1 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 416897 ALKBH2; DNA oxidative demethylase ALKBH2 isoform 2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 423169 ALKBH3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 421790 ASCC3; activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 424919 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 374010 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 100857393 CCNO; cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 395510 TDG; G/T mismatch-specific thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 416648 MPG; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 431025 SMUG1; single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 424594 MUTYH; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 395428 MBD4; methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 771001 OGG1; N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 770068 NEIL1; endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 422037 NEIL2; endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 428750 NEIL3; endonuclease 8-like 3 isoform X2 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 416551 NTHL1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 112531093 LOW QUALITY PROTEIN: DNA-(apurinic or apyrimidinic site) lyase-like K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 107057377 DNA polymerase delta subunit 2 isoform X2 K02328 POLD2; DNA polymerase delta subunit 2
F 419053 POLD3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 416997 POLE; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 423567 POLE2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 417275 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 107055326 POLE4; DNA polymerase epsilon subunit 4 isoform X3 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 373984 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 769677 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 430516 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 426794 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 100857925 TRPC2L; short transient receptor potential channel 2-like K10803 XRCC1; DNA-repair protein XRCC1
E 417530 LIG3; DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 423403 TDP1; tyrosyl-DNA phosphodiesterase 1 isoform X2 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 395173 APTX; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 421264 APLF; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 395724 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 423853 POLL; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 396199 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 418958 PARP4; poly [ADP-ribose] polymerase 4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 771158 PARP3; poly [ADP-ribose] polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 416039 XPC; DNA repair protein complementing XP-C cells isoform X2 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 431623 RAD23B; UV excision repair protein RAD23 homolog B isoform X4 K10839 RAD23; UV excision repair protein RAD23
F 100859241 RAD23A; UV excision repair protein RAD23 homolog A isoform X2 K10839 RAD23; UV excision repair protein RAD23
F 422303 CETN2; centrin-2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 418001 RBX1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 422364 CUL4B; cullin-4B K10609 CUL4; cullin 4
F 418744 CUL4A; cullin-4A isoform X1 K10609 CUL4; cullin 4
F 374050 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 423185 DDB2; DNA damage-binding protein 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 422621 POLR2B; DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 415635 POLR2C; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 424754 POLR2D; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 420103 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 395486 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 424954 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 426289 POLR2I; DNA-directed RNA polymerase II subunit RPB9 isoform X1 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 770704 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 107049063 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 112529926 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 418001 RBX1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 422364 CUL4B; cullin-4B K10609 CUL4; cullin 4
F 418744 CUL4A; cullin-4A isoform X1 K10609 CUL4; cullin 4
F 374050 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 427153 ERCC8; DNA excision repair protein ERCC-8 isoform X2 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 423785 ERCC6; DNA excision repair protein ERCC-6 isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 422903 UVSSA; UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 107057620 ELOF1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 424226 ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 423081 GTF2H1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 100858972 GTF2H2; general transcription factor IIH subunit 2 isoform X1 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 771837 GTF2H3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 769754 GTF2H5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 771294 CDK7; cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 427328 CCNH; cyclin-H K06634 CCNH; cyclin H
E 423521 MNAT1; CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 417563 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 419566 RPA4; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 420578 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 395659 XPA; DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 416420 ERCC4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 428019 ERCC5; DNA repair protein complementing XP-G cells K10846 ERCC5; DNA excision repair protein ERCC-5
E 430516 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 423842 MMS19; MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 424804 CUL3; cullin-3 K03869 CUL3; cullin 3
E 418969 CUL5; cullin-5 isoform X1 K10612 CUL5; cullin 5
E 420187 ELOC; elongin-C K03872 ELOC; elongin-C
E 419683 TCEB3; elongin-A K15076 ELOA; elongin-A
E 421892 elongin-A K15076 ELOA; elongin-A
E 426147 UBAP2L; ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 407092 ubiquitin-associated protein 2 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 378799 MSH2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 427318 MSH3; DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 421291 MSH6; DNA mismatch repair protein Msh6 isoform X1 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 423980 PMS1; PMS1 protein homolog 1 K10864 PMS1; DNA mismatch repair protein PMS1
E 420729 MLH1; DNA mismatch repair protein Mlh1 isoform X3 K08734 MLH1; DNA mismatch repair protein MLH1
E 101752182 PMS2; mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 100859200 MLH3; DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 107057377 DNA polymerase delta subunit 2 isoform X2 K02328 POLD2; DNA polymerase delta subunit 2
E 419053 POLD3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 417563 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 419566 RPA4; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 420578 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 422788 RFC1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 424958 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 396542 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 418907 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 100859719 RFC5; replication factor C subunit 5 isoform X2 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 373984 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 421505 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 395724 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 430516 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 426208 WDR76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 395555 MRE11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 416329 RAD50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 374246 NBN; nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 373983 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 424010 BARD1; BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 373983 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 422608 FAM175A; BRCA1-A complex subunit Abraxas K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 416145 UIMC1; BRCA1-A complex subunit RAP80 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 776677 BABAM1; BRISC and BRCA1-A complex member 1 isoform X1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 421417 BABAM2; BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 422201 BRCC3; lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 373983 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 417642 BRIP1; Fanconi anemia group J protein homolog K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 420694 TOPBP1; DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 373983 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 421071 RBBP8; DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 395555 MRE11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 416329 RAD50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 374246 NBN; nibrin K10867 NBN; nibrin
D BRCA complex
E 373983 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 374139 BRCA2; breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 416572 PALB2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
E 396086 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 396086 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 769071 RAD51B; DNA repair protein RAD51 homolog 2 K10869 RAD51L1; RAD51-like protein 1
E 417626 RAD51C; DNA repair protein RAD51 homolog 3 isoform X2 K10870 RAD51L2; RAD51-like protein 2
E 417528 RAD51D; DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 420438 XRCC2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 423485 XRCC3; DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 418152 RAD52; DNA repair protein RAD52 homolog isoform 2 K10873 RAD52; DNA repair and recombination protein RAD52
E 395228 RDM1; RAD52 motif-containing protein 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 424611 RAD54L; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 415933 RAD54L2; helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 395449 RAD54B; DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 378910 RECQL; ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 422505 WRN; Werner syndrome ATP-dependent helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 415577 BLM; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 373891 RECQL5; ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 415577 BLM; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 416517 TOP3A; DNA topoisomerase 3-alpha isoform 1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 416771 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 431669 RMI1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 416628 RMI2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 417563 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 419566 RPA4; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 420578 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 101748916 serine/threonine-protein phosphatase 4 catalytic subunit B K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 425903 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X5 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 416098 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 423411 PPP4R3A; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X2 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 426680 PPP4R3B; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X2 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 423430 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 423548 AP5M1; AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 101749247 AP5S1; AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 416478 AP5Z1; AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 431608 SMC5; structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 421950 SMC6; structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 421946 FAM84A; protein FAM84A K22805 FAM84A; protein FAM84A
E 416584 NSMCE1; non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 420333 NSMCE2; E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 100125831 NSMCE3; melanoma-associated antigen G1 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 423937 NSMCE4A; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 427111 SLF1; SMC5-SMC6 complex localization factor protein 1 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 423858 SLF2; SMC5-SMC6 complex localization factor protein 2 isoform X3 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 422104 EME1; crossover junction endonuclease EME1 isoform X3 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 416400 EME2; probable crossover junction endonuclease EME2 K10883 EME2; crossover junction endonuclease EME2
E 423264 EXD2; exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 101748102 MUS81; crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 772237 SEM1; 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 770846 SFR1; swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 424727 structure-specific endonuclease subunit SLX1-like isoform X1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 416665 SLX4; structure-specific endonuclease subunit SLX4 isoform X1 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 421951 GEN1; flap endonuclease GEN homolog 1 isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 415572 SPG11; spatacsin isoform X1 K19026 SPG11; spatacsin
E 423276 ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 419042 RAD51AP1; RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 554283 MORF4L1; mortality factor 4-like protein 1 isoform 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 419125 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 420946 FIGNL1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 421106 DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 770776 FAM84B; protein FAM84B K22810 FAM84B; protein FAM84B
E 769893 BRAT1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 424866 C9H21orf2; uncharacterized protein LOC424866 K23456 CFAP410; cilla- and flagella-associated protein
E 772302 HDGFL2; hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 417596 ZSWIM7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 107050152 ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 419090 EMSY; LOW QUALITY PROTEIN: BRCA2-interacting transcriptional repressor EMSY K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 418548 HSF2BP; heat shock factor 2-binding protein isoform X1 K25791 HSF2BP; heat shock factor 2-binding protein
E 421799 MMS22L; protein MMS22-like isoform X2 K26125 MMS22L; protein MMS22-like
E 422838 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 418092 PARPBP; PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 395767 XRCC6; X-ray repair cross-complementing protein 5 precursor K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 424222 XRCC5; X-ray repair cross-complementing protein 5 isoform X2 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 395376 PRKDC; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 395555 MRE11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 416329 RAD50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 418764 LIG4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 427325 XRCC4; DNA repair protein XRCC4 isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 424205 NHEJ1; non-homologous end-joining factor 1 isoform X1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 423853 POLL; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 396351 DNTT; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 426794 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 395173 APTX; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 421264 APLF; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 430764 DCLRE1C; protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 421007 TDP2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 421057 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 425514 MUM1; PWWP domain-containing protein MUM1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 107052183 PAXX; protein PAXX isoform X2 K25772 PAXX; protein PAXX
E 100857684 C7orf49; cell cycle regulator of non-homologous end joining K26155 CYREN; cell cycle regulator of non-homologous end joining
E 426917 JMJD8; jmjC domain-containing protein 8 precursor K25792 JMJD8; jumonji domain-containing protein 8
E 423613 FAM35A; protein FAM35A K26129 SHLD2; shieldin complex subunit 2
C FA (Fanconi anemia) pathway
D FA core complex
E 415854 FANCA; Fanconi anemia group A protein K10888 FANCA; fanconi anemia group A protein
E 418628 FANCB; Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 427468 FANCC; Fanconi anemia group C protein K10890 FANCC; fanconi anemia group C protein
E 419891 FANCE; Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 101750641 FANCF; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 378893 FANCG; Fanconi anemia group G protein K10894 FANCG; fanconi anemia group G protein
E 421202 FANCL; E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 100857997 FANCM; Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
E 415770 FAAP24; Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 100049617 FAAP100; Fanconi anemia core complex-associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 395128 HES4; transcription factor HES-4 isoform 1 K06054 HES1; hairy and enhancer of split 1
E 769039 HES1; transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 771417 CENPS; centromere protein S K11511 APITD1; centromere protein S
E 101751277 CENPX; centromere protein X K15360 STRA13; centromere protein X
E 421149 UBE2T; ubiquitin-conjugating enzyme E2 T isoform X2 K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 415577 BLM; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 416517 TOP3A; DNA topoisomerase 3-alpha isoform 1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 416771 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 431669 RMI1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 416628 RMI2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 415935 FANCD2; Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 415491 FANCI; Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 373983 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 374139 BRCA2; breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 417642 BRIP1; Fanconi anemia group J protein homolog K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 416572 PALB2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 415383 FAN1; fanconi-associated nuclease 1 isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 396086 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 417626 RAD51C; DNA repair protein RAD51 homolog 3 isoform X2 K10870 RAD51L2; RAD51-like protein 2
E 416757 TELO2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 424685 USP1; ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 420427 WDR48; WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 772354 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 430580 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 423116 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 420640 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 424055 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 426469 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 421435 RNF8; E3 ubiquitin-protein ligase RNF8 isoform X3 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 770166 RNF168; E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 419055 RNF169; E3 ubiquitin-protein ligase RNF169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 418682 HERC2; E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 417259 TPRN; taperin K24164 TPRN; taperin
E 427444 WDR70; WD repeat-containing protein 70 isoform 2 K24752 WDR70; WD repeat-containing protein 70
E 426208 WDR76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 395102 POLH; DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 374003 POLK; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 418703 REV1; DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 428622 REV3L; DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 422892 POLN; DNA polymerase nu isoform X2 K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 395672 UBE2A; ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 100857678 UBE2B; ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 416114 RAD18; E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 421109 UBE2V2; ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 100538349 UBE2V1; ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 417898 UBE2N; ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 373984 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 418092 PARPBP; PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
D 421530 SPRTN; sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 422202 GCNA; acidic repeat-containing protein isoform X1 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 404777 RAD9A; cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 416868 RAD9B; cell cycle checkpoint control protein RAD9B isoform X1 K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 428471 HUS1; checkpoint protein HUS1 isoform X4 K10903 HUS1; HUS1 checkpoint protein
D 427432 RAD1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 404778 RAD17; cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 424958 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 396542 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 418907 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 100859719 RFC5; replication factor C subunit 5 isoform X2 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 427432 RAD1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 101751192 TIMELESS; protein timeless homolog isoform X1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 415548 TIPIN; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 428223 CLSPN; claspin K25773 CLSPN; claspin
C Triple T complex
D 416757 TELO2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 419296 TTI1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 426923 TTI2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 416450 GET4; Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 424777 ATR; serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 415949 ATRIP; ATR-interacting protein K10905 ATRIP; ATR interacting protein
D 395401 ATM; serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 374260 CHEK1; serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 768913 CHEK2; serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 420375 CDC25A; M-phase inducer phosphatase 1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 107049885 LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 425619 YWHAZ; 14-3-3 protein zeta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 419190 YWHAB; 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 421932 YWHAQ; 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 416955 YWHAH; 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 427820 YWHAG; 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 417554 YWHAE; 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 422977 NAV2; neuron navigator 2 isoform X6 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 423045 WEE1; wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 427918 WEE2; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 374116 PER2; period circadian protein homolog 2 K02633 PER2; period circadian protein 2
D 419366 PER3; period circadian protein homolog 3 K21945 PER3; period circadian protein 3
D 101751335 MDC1; mediator of DNA damage checkpoint protein 1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 422222 PLS3; plastin-3 K17336 PLS3; plastin-3
D 415496 AEN; apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 424586 PLK3; serine/threonine-protein kinase PLK3 isoform X2 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 418881 NEK5; serine/threonine-protein kinase Nek5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 422433 NEK1; serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 415900 NEK4; serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 776071 NEK10; serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 100857506 NEK11; serine/threonine-protein kinase Nek11 isoform X1 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 418504 DONSON; protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 395475 KANK1; KN motif and ankyrin repeat domain-containing protein 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 424684 KANK4; KN motif and ankyrin repeat domain-containing protein 4 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 428321 KANK3; KN motif and ankyrin repeat domain-containing protein 3 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 420201 CHMP4C; charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 425637 VPS4A; vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 420901 VPS4B; vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 423204 ZFYVE19; abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 421318 SDE2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 418326 POLQ; LOW QUALITY PROTEIN: DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 417491 MYBBP1A; myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 422549 PRIMPOL; DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 423902 DCLRE1A; DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 428269 DCLRE1B; 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 422079 ENDOV; endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 424291 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 100857739 ANKLE1; LOW QUALITY PROTEIN: ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 422606 HELQ; helicase POLQ-like isoform X2 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 427469 ERCC6L2; DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 430767 PRPF19; pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 422052 CDC5L; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 419884 BCAS2; pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 422401 PLRG1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 418858 NUDT15; nucleotide triphosphate diphosphatase NUDT15 isoform X1 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 416467 NUDT1; 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 769338 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 419081 RRM1; ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 420253 RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 421936 RRM2; ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 423965 MGMT; methylated-DNA--protein-cysteine methyltransferase isoform X1 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 424919 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 374010 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 431025 SMUG1; single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 416648 MPG; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 424594 MUTYH; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 416551 NTHL1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 418122 SSBP1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 418122 SSBP1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 418858 NUDT15; nucleotide triphosphate diphosphatase NUDT15 isoform X1 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 769338 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024