+E Replication protein KO
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DNA Replication Proteins - Homo sapiens (human)
%
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 4998 ORC1; origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 4999 ORC2; origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 23595 ORC3; origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 5000 ORC4; origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 5001 ORC5; origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 23594 ORC6; origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 81620 CDT1; chromatin licensing and DNA replication factor 1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 990 CDC6; cell division cycle 6 K02213 CDC6; cell division control protein 6
D 4171 MCM2; minichromosome maintenance complex component 2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 4172 MCM3; minichromosome maintenance complex component 3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 4173 MCM4; minichromosome maintenance complex component 4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 4174 MCM5; minichromosome maintenance complex component 5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 4175 MCM6; minichromosome maintenance complex component 6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 4176 MCM7; minichromosome maintenance complex component 7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 890 CCNA2; cyclin A2 K06627 CCNA; cyclin-A
D 8900 CCNA1; cyclin A1 K06627 CCNA; cyclin-A
D 898 CCNE1; cyclin E1 K06626 CCNE; G1/S-specific cyclin-E1
D 9134 CCNE2; cyclin E2 K06626 CCNE; G1/S-specific cyclin-E1
D 1017 CDK2; cyclin dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 8317 CDC7; cell division cycle 7 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 10926 DBF4; DBF4-CDC7 kinase regulatory subunit K06629 DBF4; protein DBF4
D 80174 DBF4B; DBF4B-CDC7 kinase regulatory subunit K06629 DBF4; protein DBF4
C GINS complex
D 9837 GINS1; GINS complex subunit 1 K10732 GINS1; GINS complex subunit 1
D 51659 GINS2; GINS complex subunit 2 K10733 GINS2; GINS complex subunit 2
D 64785 GINS3; GINS complex subunit 3 K10734 GINS3; GINS complex subunit 3
D 84296 GINS4; GINS complex subunit 4 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 11073 TOPBP1; DNA topoisomerase II binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 9401 RECQL4; RecQ like helicase 4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 8318 CDC45; cell division cycle 45 K06628 CDC45; cell division control protein 45
D 84515 MCM8; minichromosome maintenance 8 homologous recombination repair factor K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 254394 MCM9; minichromosome maintenance 9 homologous recombination repair factor K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 55388 MCM10; minichromosome maintenance 10 replication initiation factor K10736 MCM10; minichromosome maintenance protein 10
D 92797 HELB; DNA helicase B K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 63901 FAM111A; FAM111 trypsin like peptidase A K24274 FAM111A; protein FAM111A
D 51550 CINP; cyclin dependent kinase 2 interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 27085 MTBP; MDM2 binding protein K26116 MTBP; Mdm2-binding protein
D 90381 TICRR; TOPBP1 interacting checkpoint and replication regulator K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 5422 POLA1; DNA polymerase alpha 1, catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 23649 POLA2; DNA polymerase alpha 2, accessory subunit K02321 POLA2; DNA polymerase alpha subunit B
D 5557 PRIM1; DNA primase subunit 1 K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 5558 PRIM2; DNA primase subunit 2 K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 5426 POLE; DNA polymerase epsilon, catalytic subunit K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 5427 POLE2; DNA polymerase epsilon 2, accessory subunit K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 54107 POLE3; DNA polymerase epsilon 3, accessory subunit K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 56655 POLE4; DNA polymerase epsilon 4, accessory subunit K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 5424 POLD1; DNA polymerase delta 1, catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 5425 POLD2; DNA polymerase delta 2, accessory subunit K02328 POLD2; DNA polymerase delta subunit 2
D 10714 POLD3; DNA polymerase delta 3, accessory subunit K03504 POLD3; DNA polymerase delta subunit 3
D 57804 POLD4; DNA polymerase delta 4, accessory subunit K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 5428 POLG; DNA polymerase gamma, catalytic subunit K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 11232 POLG2; DNA polymerase gamma 2, accessory subunit K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 6117 RPA1; replication protein A1 K07466 RFA1; replication factor A1
D 6118 RPA2; replication protein A2 K10739 RFA2; replication factor A2
D 6119 RPA3; replication protein A3 K10740 RPA3; replication factor A3
D 29935 RPA4; replication protein A4 K10741 RPA4; replication factor A4
C RFC (replication factor C)
D 5981 RFC1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 5984 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 5982 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 5985 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 5983 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 246243 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 10535 RNASEH2A; ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 79621 RNASEH2B; ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 84153 RNASEH2C; ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 5111 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 1763 DNA2; DNA replication helicase/nuclease 2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 2237 FEN1; flap structure-specific endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 9156 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 84083 ZRANB3; zinc finger RANBP2-type containing 3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 3978 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 79915 ATAD5; ATPase family AAA domain containing 5 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 1786 DNMT1; DNA methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 1788 DNMT3A; DNA methyltransferase 3 alpha K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 1789 DNMT3B; DNA methyltransferase 3 beta K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 51053 GMNN; geminin DNA replication inhibitor K10749 GMNN; geminin
D 345643 MCIDAS; multiciliate differentiation and DNA synthesis associated cell cycle protein K26119 MCIDAS; multicilin
D 891 CCNB1; cyclin B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 9133 CCNB2; cyclin B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 85417 CCNB3; cyclin B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 983 CDK1; cyclin dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 25913 POT1; protection of telomeres 1 K11109 POT1; protection of telomeres protein 1
E 7013 TERF1; telomeric repeat binding factor 1 K11110 TERF1; telomeric repeat-binding factor 1
E 7014 TERF2; telomeric repeat binding factor 2 K11111 TERF2; telomeric repeat-binding factor 2
E 26277 TINF2; TERF1 interacting nuclear factor 2 K11112 TINF2; TERF1-interacting nuclear factor 2
E 54386 TERF2IP; TERF2 interacting protein K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 65057 ACD; ACD shelterin complex subunit and telomerase recruitment factor K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 283847 TERB1; telomere repeat binding bouquet formation protein 1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 145645 TERB2; telomere repeat binding bouquet formation protein 2 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 283129 MAJIN; membrane anchored junction protein K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 80169 CTC1; CST telomere replication complex component 1 K23311 CTC1; CST complex subunit CTC1
E 79991 STN1; STN1 subunit of CST complex K23312 STN1; CST complex subunit STN1
E 100134934 TEN1; TEN1 subunit of CST complex K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 23293 SMG6; SMG6 nonsense mediated mRNA decay factor K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 23381 SMG5; SMG5 nonsense mediated mRNA decay factor K11125 SMG5; protein SMG5
D 7015 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 7011 TEP1; telomerase associated protein 1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 54433 GAR1; GAR1 ribonucleoprotein K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 55651 NHP2; NHP2 ribonucleoprotein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 55505 NOP10; NOP10 ribonucleoprotein K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 1736 DKC1; dyskerin pseudouridine synthase 1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 7015 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 6628 SNRPB; small nuclear ribonucleoprotein polypeptides B and B1 K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 6632 SNRPD1; small nuclear ribonucleoprotein D1 polypeptide K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 6633 SNRPD2; small nuclear ribonucleoprotein D2 polypeptide K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 6634 SNRPD3; small nuclear ribonucleoprotein D3 polypeptide K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 6635 SNRPE; small nuclear ribonucleoprotein polypeptide E K11097 SNRPE; small nuclear ribonucleoprotein E
E 6636 SNRPF; small nuclear ribonucleoprotein polypeptide F K11098 SNRPF; small nuclear ribonucleoprotein F
E 6637 SNRPG; small nuclear ribonucleoprotein polypeptide G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 5984 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 5982 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 5985 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 5983 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 4361 MRE11; MRE11 homolog, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
D 10111 RAD50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 4683 NBN; nibrin K10867 NBN; nibrin
C Other termination factors
D 472 ATM; ATM serine/threonine kinase K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 7486 WRN; WRN RecQ like helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 641 BLM; BLM RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 5591 PRKDC; protein kinase, DNA-activated, catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 2072 ERCC4; ERCC excision repair 4, endonuclease catalytic subunit K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 142 PARP1; poly(ADP-ribose) polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 10038 PARP2; poly(ADP-ribose) polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 10039 PARP3; poly(ADP-ribose) polymerase family member 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 143 PARP4; poly(ADP-ribose) polymerase family member 4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 8658 TNKS; tankyrase K10799 TNKS; tankyrase [EC:2.4.2.30]
D 80351 TNKS2; tankyrase 2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 54984 PINX1; PIN2 (TERF1) interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 51750 RTEL1; regulator of telomere elongation helicase 1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 9894 TELO2; telomere maintenance 2 K11137 TELO2; telomere length regulation protein
D 79002 TRIR; telomerase RNA component interacting RNase K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 55183 RIF1; replication timing regulatory factor 1 K11138 RIF1; telomere-associated protein RIF1
D 80119 PIF1; PIF1 5'-to-3' DNA helicase K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 5813 PURA; purine rich element binding protein A K21772 PURA; transcriptional activator protein Pur-alpha
D 29942 PURG; purine rich element binding protein G K21800 PURG; purine-rich element-binding protein gamma
D 55135 WRAP53; WD repeat containing antisense to TP53 K23314 WRAP53; telomerase Cajal body protein 1
D 163859 SDE2; SDE2 telomere maintenance homolog K25059 SDE2; replication stress response regulator SDE2
D 51507 RTF2; replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 7150 TOP1; DNA topoisomerase I K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 116447 TOP1MT; DNA topoisomerase I mitochondrial K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 7155 TOP2B; DNA topoisomerase II beta K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 7153 TOP2A; DNA topoisomerase II alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 7156 TOP3A; DNA topoisomerase III alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 8940 TOP3B; DNA topoisomerase III beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 6742 SSBP1; single stranded DNA binding protein 1 K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 246243 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 246243 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 1763 DNA2; DNA replication helicase/nuclease 2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 2237 FEN1; flap structure-specific endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 3978 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022