+F Repair protein KO
#
DNA Repair and Recombination Proteins - Homo sapiens (human)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 4255 MGMT; O-6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 121642 ALKBH2; alkB homolog 2, alpha-ketoglutarate dependent dioxygenase K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 221120 ALKBH3; alkB homolog 3, alpha-ketoglutarate dependent dioxygenase K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 10973 ASCC3; activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 7374 UNG; uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 10309 CCNO; cyclin O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 6996 TDG; thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 4350 MPG; N-methylpurine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 23583 SMUG1; single-strand-selective monofunctional uracil-DNA glycosylase 1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 4595 MUTYH; mutY DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 8930 MBD4; methyl-CpG binding domain 4, DNA glycosylase K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 4968 OGG1; 8-oxoguanine DNA glycosylase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 79661 NEIL1; nei like DNA glycosylase 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 252969 NEIL2; nei like DNA glycosylase 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 55247 NEIL3; nei like DNA glycosylase 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 4913 NTHL1; nth like DNA glycosylase 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 328 APEX1; apurinic/apyrimidinic endodeoxyribonuclease 1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 27301 APEX2; apurinic/apyrimidinic endodeoxyribonuclease 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 5424 POLD1; DNA polymerase delta 1, catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 5425 POLD2; DNA polymerase delta 2, accessory subunit K02328 POLD2; DNA polymerase delta subunit 2
F 10714 POLD3; DNA polymerase delta 3, accessory subunit K03504 POLD3; DNA polymerase delta subunit 3
F 57804 POLD4; DNA polymerase delta 4, accessory subunit K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 5426 POLE; DNA polymerase epsilon, catalytic subunit K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 5427 POLE2; DNA polymerase epsilon 2, accessory subunit K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 54107 POLE3; DNA polymerase epsilon 3, accessory subunit K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 56655 POLE4; DNA polymerase epsilon 4, accessory subunit K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 5111 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 2237 FEN1; flap structure-specific endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 3978 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 5423 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 7515 XRCC1; X-ray repair cross complementing 1 K10803 XRCC1; DNA-repair protein XRCC1
E 3980 LIG3; DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 55775 TDP1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 54840 APTX; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 200558 APLF; aprataxin and PNKP like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 11284 PNKP; polynucleotide kinase 3'-phosphatase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 3146 HMGB1; high mobility group box 1 K10802 HMGB1; high mobility group protein B1
E 27343 POLL; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 142 PARP1; poly(ADP-ribose) polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 10038 PARP2; poly(ADP-ribose) polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 10039 PARP3; poly(ADP-ribose) polymerase family member 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 143 PARP4; poly(ADP-ribose) polymerase family member 4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 7508 XPC; XPC complex subunit, DNA damage recognition and repair factor K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 5887 RAD23B; RAD23 homolog B, nucleotide excision repair protein K10839 RAD23; UV excision repair protein RAD23
F 5886 RAD23A; RAD23 homolog A, nucleotide excision repair protein K10839 RAD23; UV excision repair protein RAD23
F 1069 CETN2; centrin 2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 9978 RBX1; ring-box 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 8450 CUL4B; cullin 4B K10609 CUL4; cullin 4
F 8451 CUL4A; cullin 4A K10609 CUL4; cullin 4
F 1642 DDB1; damage specific DNA binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 1643 DDB2; damage specific DNA binding protein 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 5430 POLR2A; RNA polymerase II subunit A K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 5431 POLR2B; RNA polymerase II subunit B K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 5432 POLR2C; RNA polymerase II subunit C K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 5433 POLR2D; RNA polymerase II subunit D K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 5434 POLR2E; RNA polymerase II, I and III subunit E K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 5435 POLR2F; RNA polymerase II, I and III subunit F K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 5436 POLR2G; RNA polymerase II subunit G K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 5437 POLR2H; RNA polymerase II, I and III subunit H K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 5438 POLR2I; RNA polymerase II subunit I K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 5441 POLR2L; RNA polymerase II, I and III subunit L K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 5439 POLR2J; RNA polymerase II subunit J K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 548644 POLR2J3; RNA polymerase II subunit J3 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 246721 POLR2J2; RNA polymerase II subunit J2 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 5440 POLR2K; RNA polymerase II, I and III subunit K K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 9978 RBX1; ring-box 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 8450 CUL4B; cullin 4B K10609 CUL4; cullin 4
F 8451 CUL4A; cullin 4A K10609 CUL4; cullin 4
F 1642 DDB1; damage specific DNA binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 1161 ERCC8; ERCC excision repair 8, CSA ubiquitin ligase complex subunit K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 2074 ERCC6; ERCC excision repair 6, chromatin remodeling factor K10841 ERCC6; DNA excision repair protein ERCC-6
F 57654 UVSSA; UV stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 84337 ELOF1; elongation factor 1 K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 2071 ERCC3; ERCC excision repair 3, TFIIH core complex helicase subunit K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 2068 ERCC2; ERCC excision repair 2, TFIIH core complex helicase subunit K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 2965 GTF2H1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 2966 GTF2H2; general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 730394 GTF2H2C_2; GTF2H2 family member C, copy 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 728340 GTF2H2C; GTF2H2 family member C K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 2967 GTF2H3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 2968 GTF2H4; general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 404672 GTF2H5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 1022 CDK7; cyclin dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 902 CCNH; cyclin H K06634 CCNH; cyclin H
E 4331 MNAT1; MNAT1 component of CDK activating kinase K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 6117 RPA1; replication protein A1 K07466 RFA1; replication factor A1
E 6118 RPA2; replication protein A2 K10739 RFA2; replication factor A2
E 6119 RPA3; replication protein A3 K10740 RPA3; replication factor A3
E 29935 RPA4; replication protein A4 K10741 RPA4; replication factor A4
D Other NER factors
E 7507 XPA; XPA, DNA damage recognition and repair factor K10847 XPA; DNA-repair protein complementing XP-A cells
E 2067 ERCC1; ERCC excision repair 1, endonuclease non-catalytic subunit K10849 ERCC1; DNA excision repair protein ERCC-1
E 2072 ERCC4; ERCC excision repair 4, endonuclease catalytic subunit K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 2073 ERCC5; ERCC excision repair 5, endonuclease K10846 ERCC5; DNA excision repair protein ERCC-5
E 100533467 BIVM-ERCC5; BIVM-ERCC5 readthrough K10846 ERCC5; DNA excision repair protein ERCC-5
E 3978 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 64210 MMS19; MMS19 homolog, cytosolic iron-sulfur assembly component K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 8452 CUL3; cullin 3 K03869 CUL3; cullin 3
E 8065 CUL5; cullin 5 K10612 CUL5; cullin 5
E 6921 ELOC; elongin C K03872 ELOC; elongin-C
E 6923 ELOB; elongin B K03873 ELOB; elongin-B
E 51224 ELOA2; elongin A2 K15076 ELOA; elongin-A
E 6924 ELOA; elongin A K15076 ELOA; elongin-A
E 55833 UBAP2; ubiquitin associated protein 2 K26545 UBAP2; ubiquitin-associated protein 2
E 9898 UBAP2L; ubiquitin associated protein 2 like K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 4436 MSH2; mutS homolog 2 K08735 MSH2; DNA mismatch repair protein MSH2
E 4437 MSH3; mutS homolog 3 K08736 MSH3; DNA mismatch repair protein MSH3
E 2956 MSH6; mutS homolog 6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 5378 PMS1; PMS1 homolog 1, mismatch repair system component K10864 PMS1; DNA mismatch repair protein PMS1
E 4292 MLH1; mutL homolog 1 K08734 MLH1; DNA mismatch repair protein MLH1
E 5395 PMS2; PMS1 homolog 2, mismatch repair system component K10858 PMS2; DNA mismatch repair protein PMS2
E 27030 MLH3; mutL homolog 3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 5424 POLD1; DNA polymerase delta 1, catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 5425 POLD2; DNA polymerase delta 2, accessory subunit K02328 POLD2; DNA polymerase delta subunit 2
E 10714 POLD3; DNA polymerase delta 3, accessory subunit K03504 POLD3; DNA polymerase delta subunit 3
E 57804 POLD4; DNA polymerase delta 4, accessory subunit K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 6117 RPA1; replication protein A1 K07466 RFA1; replication factor A1
E 6118 RPA2; replication protein A2 K10739 RFA2; replication factor A2
E 6119 RPA3; replication protein A3 K10740 RPA3; replication factor A3
E 29935 RPA4; replication protein A4 K10741 RPA4; replication factor A4
D RFC (replication factor C)
E 5981 RFC1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 5984 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 5982 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 5985 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 5983 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 5111 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 9156 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 3146 HMGB1; high mobility group box 1 K10802 HMGB1; high mobility group protein B1
E 3978 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 79968 WDR76; WD repeat domain 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 4361 MRE11; MRE11 homolog, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 10111 RAD50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 4683 NBN; nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 672 BRCA1; BRCA1 DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 580 BARD1; BRCA1 associated RING domain 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 672 BRCA1; BRCA1 DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 84142 ABRAXAS1; abraxas 1, BRCA1 A complex subunit K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 51720 UIMC1; ubiquitin interaction motif containing 1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 29086 BABAM1; BRISC and BRCA1 A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 9577 BABAM2; BRISC and BRCA1 A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 79184 BRCC3; BRCA1/BRCA2-containing complex subunit 3 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 672 BRCA1; BRCA1 DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 83990 BRIP1; BRCA1 interacting helicase 1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 11073 TOPBP1; DNA topoisomerase II binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 672 BRCA1; BRCA1 DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 5932 RBBP8; RB binding protein 8, endonuclease K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 4361 MRE11; MRE11 homolog, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 10111 RAD50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 4683 NBN; nibrin K10867 NBN; nibrin
D BRCA complex
E 672 BRCA1; BRCA1 DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 675 BRCA2; BRCA2 DNA repair associated K08775 BRCA2; breast cancer 2 susceptibility protein
E 79728 PALB2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 5888 RAD51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 5888 RAD51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
E 5890 RAD51B; RAD51 paralog B K10869 RAD51L1; RAD51-like protein 1
E 5889 RAD51C; RAD51 paralog C K10870 RAD51L2; RAD51-like protein 2
E 5892 RAD51D; RAD51 paralog D K10871 RAD51L3; RAD51-like protein 3
E 7516 XRCC2; X-ray repair cross complementing 2 K10879 XRCC2; DNA-repair protein XRCC2
E 7517 XRCC3; X-ray repair cross complementing 3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 5893 RAD52; RAD52 homolog, DNA repair protein K10873 RAD52; DNA repair and recombination protein RAD52
E 201299 RDM1; RAD52 motif containing 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 8438 RAD54L; RAD54 like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 23132 RAD54L2; RAD54 like 2 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 25788 RAD54B; RAD54 homolog B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 5965 RECQL; RecQ like helicase K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 7486 WRN; WRN RecQ like helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 641 BLM; BLM RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 9401 RECQL4; RecQ like helicase 4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 9400 RECQL5; RecQ like helicase 5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 641 BLM; BLM RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 7156 TOP3A; DNA topoisomerase III alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 8940 TOP3B; DNA topoisomerase III beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 80010 RMI1; RecQ mediated genome instability 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 116028 RMI2; RecQ mediated genome instability 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 6117 RPA1; replication protein A1 K07466 RFA1; replication factor A1
E 6118 RPA2; replication protein A2 K10739 RFA2; replication factor A2
E 6119 RPA3; replication protein A3 K10740 RPA3; replication factor A3
E 29935 RPA4; replication protein A4 K10741 RPA4; replication factor A4
D Protein phosphatase 4
E 5531 PPP4C; protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 9989 PPP4R1; protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 151987 PPP4R2; protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 55671 PPP4R3A; protein phosphatase 4 regulatory subunit 3A K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 57223 PPP4R3B; protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 139420 PPP4R3C; protein phosphatase 4 regulatory subunit 3C K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 57718 PPP4R4; protein phosphatase 4 regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 91056 AP5B1; adaptor related protein complex 5 subunit beta 1 K19022 AP5B1; AP-5 complex subunit beta-1
E 55745 AP5M1; adaptor related protein complex 5 subunit mu 1 K19023 AP5M1; AP-5 complex subunit mu-1
E 55317 AP5S1; adaptor related protein complex 5 subunit sigma 1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 9907 AP5Z1; adaptor related protein complex 5 subunit zeta 1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 23137 SMC5; structural maintenance of chromosomes 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 79677 SMC6; structural maintenance of chromosomes 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 151354 LRATD1; LRAT domain containing 1 K22805 FAM84A; protein FAM84A
E 197370 NSMCE1; NSE1 homolog, SMC5-SMC6 complex component K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 286053 NSMCE2; NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 56160 NSMCE3; NSE3 homolog, SMC5-SMC6 complex component K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 54780 NSMCE4A; NSE4 homolog A, SMC5-SMC6 complex component K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 493861 EID3; EP300 interacting inhibitor of differentiation 3 K22826 EID3; EP300-interacting inhibitor of differentiation 3
E 84250 SLF1; SMC5-SMC6 complex localization factor 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 55719 SLF2; SMC5-SMC6 complex localization factor 2 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 146956 EME1; essential meiotic structure-specific endonuclease 1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 197342 EME2; essential meiotic structure-specific endonuclease subunit 2 K10883 EME2; crossover junction endonuclease EME2
E 55218 EXD2; exonuclease 3'-5' domain containing 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 80198 MUS81; MUS81 structure-specific endonuclease subunit K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 7979 SEM1; SEM1 26S proteasome subunit K10881 SHFM1; 26 proteasome complex subunit DSS1
E 375757 SWI5; SWI5 homologous recombination repair protein K10991 SWI5; DNA repair protein Swi5/Sae3
E 119392 SFR1; SWI5 dependent homologous recombination repair protein 1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 548593 SLX1A; SLX1 homolog A, structure-specific endonuclease subunit K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 79008 SLX1B; SLX1 homolog B, structure-specific endonuclease subunit K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 84464 SLX4; SLX4 structure-specific endonuclease subunit K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 348654 GEN1; GEN1 Holliday junction 5' flap endonuclease K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 80208 SPG11; SPG11 vesicle trafficking associated, spatacsin K19026 SPG11; spatacsin
E 23503 ZFYVE26; zinc finger FYVE-type containing 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 10635 RAD51AP1; RAD51 associated protein 1 K20778 RAD51AP1; RAD51-associated protein 1
E 10933 MORF4L1; mortality factor 4 like 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 25939 SAMHD1; SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 63979 FIGNL1; fidgetin like 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 23514 SPIDR; scaffold protein involved in DNA repair K22806 SPIDR; DNA repair-scaffolding protein
E 157638 LRATD2; LRAT domain containing 2 K22810 FAM84B; protein FAM84B
E 221927 BRAT1; BRCA1 associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 755 CFAP410; cilia and flagella associated protein 410 K23456 CFAP410; cilla- and flagella-associated protein
E 84717 HDGFL2; HDGF like 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 125150 ZSWIM7; zinc finger SWIM-type containing 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 126074 SWSAP1; SWIM-type zinc finger 7 associated protein 1 K25771 SWSAP1; ATPase SWSAP1
E 56946 EMSY; EMSY transcriptional repressor, BRCA2 interacting K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 11077 HSF2BP; heat shock transcription factor 2 binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 253714 MMS22L; MMS22 like, DNA repair protein K26125 MMS22L; protein MMS22-like
E 4796 TONSL; tonsoku like, DNA repair protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 259282 BOD1L1; biorientation of chromosomes in cell division 1 like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 55010 PARPBP; PARP1 binding protein K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 2547 XRCC6; X-ray repair cross complementing 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 7520 XRCC5; X-ray repair cross complementing 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 5591 PRKDC; protein kinase, DNA-activated, catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 4361 MRE11; MRE11 homolog, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 10111 RAD50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 3981 LIG4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 7518 XRCC4; X-ray repair cross complementing 4 K10886 XRCC4; DNA-repair protein XRCC4
E 79840 NHEJ1; non-homologous end joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 27343 POLL; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 27434 POLM; DNA polymerase mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 1791 DNTT; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 5423 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 54840 APTX; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 200558 APLF; aprataxin and PNKP like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 64421 DCLRE1C; DNA cross-link repair 1C K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 51567 TDP2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 23347 SMCHD1; structural maintenance of chromosomes flexible hinge domain containing 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 139221 PWWP3B; PWWP domain containing 3B K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 84939 PWWP3A; PWWP domain containing 3A, DNA repair factor K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 286257 PAXX; PAXX non-homologous end joining factor K25772 PAXX; protein PAXX
E 78996 CYREN; cell cycle regulator of NHEJ K26155 CYREN; cell cycle regulator of non-homologous end joining
E 339123 JMJD8; jumonji domain containing 8 K25792 JMJD8; jumonji domain-containing protein 8
E 149840 SHLD1; shieldin complex subunit 1 K26128 SHLD1; shieldin complex subunit 1
E 54537 SHLD2; shieldin complex subunit 2 K26129 SHLD2; shieldin complex subunit 2
E 112441434 SHLD3; shieldin complex subunit 3 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 2175 FANCA; FA complementation group A K10888 FANCA; fanconi anemia group A protein
E 2187 FANCB; FA complementation group B K10889 FANCB; fanconi anemia group B protein
E 2176 FANCC; FA complementation group C K10890 FANCC; fanconi anemia group C protein
E 2178 FANCE; FA complementation group E K10892 FANCE; fanconi anemia group E protein
E 2188 FANCF; FA complementation group F K10893 FANCF; fanconi anemia group F protein
E 2189 FANCG; FA complementation group G K10894 FANCG; fanconi anemia group G protein
E 55120 FANCL; FA complementation group L K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 57697 FANCM; FA complementation group M K10896 FANCM; fanconi anemia group M protein
E 91442 FAAP24; FA core complex associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 80233 FAAP100; FA core complex associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 3280 HES1; hes family bHLH transcription factor 1 K06054 HES1; hairy and enhancer of split 1
E 378708 CENPS; centromere protein S K11511 APITD1; centromere protein S
E 100526739 CENPS-CORT; CENPS-CORT readthrough K11511 APITD1; centromere protein S
E 201254 CENPX; centromere protein X K15360 STRA13; centromere protein X
E 29089 UBE2T; ubiquitin conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 641 BLM; BLM RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 7156 TOP3A; DNA topoisomerase III alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 8940 TOP3B; DNA topoisomerase III beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 80010 RMI1; RecQ mediated genome instability 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 116028 RMI2; RecQ mediated genome instability 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 2177 FANCD2; FA complementation group D2 K10891 FANCD2; fanconi anemia group D2 protein
E 55215 FANCI; FA complementation group I K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 672 BRCA1; BRCA1 DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 675 BRCA2; BRCA2 DNA repair associated K08775 BRCA2; breast cancer 2 susceptibility protein
E 83990 BRIP1; BRCA1 interacting helicase 1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 79728 PALB2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 22909 FAN1; FANCD2 and FANCI associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 5888 RAD51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
E 5889 RAD51C; RAD51 paralog C K10870 RAD51L2; RAD51-like protein 2
E 9894 TELO2; telomere maintenance 2 K11137 TELO2; telomere length regulation protein
E 7398 USP1; ubiquitin specific peptidase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 57599 WDR48; WD repeat domain 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 5537 PPP6C; protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 22870 PPP6R1; protein phosphatase 6 regulatory subunit 1 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 9701 PPP6R2; protein phosphatase 6 regulatory subunit 2 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 55291 PPP6R3; protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 23243 ANKRD28; ankyrin repeat domain 28 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 91526 ANKRD44; ankyrin repeat domain 44 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 283373 ANKRD52; ankyrin repeat domain 52 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 9025 RNF8; ring finger protein 8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 165918 RNF168; ring finger protein 168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 254225 RNF169; ring finger protein 169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 8924 HERC2; HECT and RLD domain containing E3 ubiquitin protein ligase 2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 55135 WRAP53; WD repeat containing antisense to TP53 K23314 WRAP53; telomerase Cajal body protein 1
E 286262 TPRN; taperin K24164 TPRN; taperin
E 55063 ZCWPW1; zinc finger CW-type and PWWP domain containing 1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 55100 WDR70; WD repeat domain 70 K24752 WDR70; WD repeat-containing protein 70
E 79968 WDR76; WD repeat domain 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 5429 POLH; DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 11201 POLI; DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 51426 POLK; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 51455 REV1; REV1 DNA directed polymerase K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 5980 REV3L; REV3 like, DNA directed polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 353497 POLN; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 7319 UBE2A; ubiquitin conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 7320 UBE2B; ubiquitin conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 56852 RAD18; RAD18 E3 ubiquitin protein ligase K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 6596 HLTF; helicase like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 7335 UBE2V1; ubiquitin conjugating enzyme E2 V1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 7336 UBE2V2; ubiquitin conjugating enzyme E2 V2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 389898 UBE2NL; ubiquitin conjugating enzyme E2 N like (gene/pseudogene) K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 7334 UBE2N; ubiquitin conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 5111 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 55010 PARPBP; PARP1 binding protein K27412 PARPBP; PCNA-interacting partner
D 83932 SPRTN; SprT-like N-terminal domain K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 93953 GCNA; germ cell nuclear acidic peptidase K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 5883 RAD9A; RAD9 checkpoint clamp component A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 144715 RAD9B; RAD9 checkpoint clamp component B K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 3364 HUS1; HUS1 checkpoint clamp component K10903 HUS1; HUS1 checkpoint protein
D 135458 HUS1B; HUS1 checkpoint clamp component B K10996 HUS1B; checkpoint protein HUS1B
D 5810 RAD1; RAD1 checkpoint DNA exonuclease K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 5884 RAD17; RAD17 checkpoint clamp loader component K06662 HRAD17; cell cycle checkpoint protein
D 5984 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 5982 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 5985 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 5983 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 5810 RAD1; RAD1 checkpoint DNA exonuclease K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 8914 TIMELESS; timeless circadian regulator K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 54962 TIPIN; TIMELESS interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 63967 CLSPN; claspin K25773 CLSPN; claspin
C Triple T complex
D 9894 TELO2; telomere maintenance 2 K11137 TELO2; telomere length regulation protein
D 9675 TTI1; TELO2 interacting protein 1 K20403 TTI1; TELO2-interacting protein 1
D 80185 TTI2; TELO2 interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 7917 BAG6; BAG cochaperone 6 K23390 BAG6; large proline-rich protein BAG6
D 8266 UBL4A; ubiquitin like 4A K23388 UBL4; ubiquitin-like protein 4
D 164153 UBL4B; ubiquitin like 4B K23388 UBL4; ubiquitin-like protein 4
D 51608 GET4; guided entry of tail-anchored proteins factor 4 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 545 ATR; ATR serine/threonine kinase K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 84126 ATRIP; ATR interacting protein K10905 ATRIP; ATR interacting protein
D 472 ATM; ATM serine/threonine kinase K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 7157 TP53; tumor protein p53 K04451 TP53; tumor protein p53
D 1111 CHEK1; checkpoint kinase 1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 11200 CHEK2; checkpoint kinase 2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 993 CDC25A; cell division cycle 25A K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 994 CDC25B; cell division cycle 25B K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 995 CDC25C; cell division cycle 25C K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 7534 YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 7529 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 7533 YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 7532 YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 7531 YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 89797 NAV2; neuron navigator 2 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 7465 WEE1; WEE1 G2 checkpoint kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 494551 WEE2; WEE2 oocyte meiosis inhibiting kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 5187 PER1; period circadian regulator 1 K21944 PER1; period circadian protein 1
D 8864 PER2; period circadian regulator 2 K02633 PER2; period circadian protein 2
D 8863 PER3; period circadian regulator 3 K21945 PER3; period circadian protein 3
D 9656 MDC1; mediator of DNA damage checkpoint 1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 5358 PLS3; plastin 3 K17336 PLS3; plastin-3
D 64782 AEN; apoptosis enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 1263 PLK3; polo like kinase 3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 126520 PLK5; polo like kinase 5 (inactive) K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 341676 NEK5; NIMA related kinase 5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 4750 NEK1; NIMA related kinase 1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 6787 NEK4; NIMA related kinase 4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 152110 NEK10; NIMA related kinase 10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 79858 NEK11; NIMA related kinase 11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 29980 DONSON; DNA replication fork stabilization factor DONSON K22422 DONSON; protein downstream neighbor of Son
D 163782 KANK4; KN motif and ankyrin repeat domains 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 23189 KANK1; KN motif and ankyrin repeat domains 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 256949 KANK3; KN motif and ankyrin repeat domains 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 25959 KANK2; KN motif and ankyrin repeat domains 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100144748 KLLN; killin, p53 regulated DNA replication inhibitor K23389 KLLN; killin
D 91607 SLFN11; schlafen family member 11 K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]
D 92421 CHMP4C; charged multivesicular body protein 4C K24782 CHMP4C; charged multivesicular body protein 4C
D 9525 VPS4B; vacuolar protein sorting 4 homolog B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 27183 VPS4A; vacuolar protein sorting 4 homolog A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 84936 ZFYVE19; zinc finger FYVE-type containing 19 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 163859 SDE2; SDE2 telomere maintenance homolog K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 10721 POLQ; DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 10514 MYBBP1A; MYB binding protein 1a K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 201973 PRIMPOL; primase and DNA directed polymerase K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 11277 TREX1; three prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 11219 TREX2; three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 9937 DCLRE1A; DNA cross-link repair 1A K15340 DCLRE1A; DNA cross-link repair 1A protein
D 64858 DCLRE1B; DNA cross-link repair 1B K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 64789 EXO5; exonuclease 5 K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 284131 ENDOV; endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 84083 ZRANB3; zinc finger RANBP2-type containing 3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 126549 ANKLE1; ankyrin repeat and LEM domain containing 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 113510 HELQ; helicase, POLQ like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 375748 ERCC6L2; ERCC excision repair 6 like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 27339 PRPF19; pre-mRNA processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 988 CDC5L; cell division cycle 5 like K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 10286 BCAS2; BCAS2 pre-mRNA processing factor K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 5356 PLRG1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 55270 NUDT15; nudix hydrolase 15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 4521 NUDT1; nudix hydrolase 1 K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 79873 NUDT18; nudix hydrolase 18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 1854 DUT; deoxyuridine triphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 6240 RRM1; ribonucleotide reductase catalytic subunit M1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 50484 RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 6241 RRM2; ribonucleotide reductase regulatory subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 4255 MGMT; O-6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 7374 UNG; uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 23583 SMUG1; single-strand-selective monofunctional uracil-DNA glycosylase 1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 4350 MPG; N-methylpurine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 4595 MUTYH; mutY DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 4913 NTHL1; nth like DNA glycosylase 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 6742 SSBP1; single stranded DNA binding protein 1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 6742 SSBP1; single stranded DNA binding protein 1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 55270 NUDT15; nudix hydrolase 15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 1854 DUT; deoxyuridine triphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024