+C Two-component system KO
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Two-Component System - Pseudomonas aeruginosa PAO1
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C PA5361 phoR; two-component sensor PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C PA5360 phoB; two-component response regulator PhoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C PA1180 phoQ; two-component sensor PhoQ K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C PA1179 phoP; two-component response regulator PhoP K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C PA5199 amgS; protein AmgS K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C PA5200 amgR; osmolarity response regulator K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C PA1158 two-component sensor K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C PA1157 two-component response regulator K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
C PA3204 two-component response regulator K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C PA0464 creC; sensory histidine kinase CreC K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C PA0463 creB; DNA-binding response regulator CreB K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
C PA1438 two-component sensor K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PA2810 copS; two-component sensor CopS K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PA4886 two-component sensor K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PA2524 two-component sensor K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PA1437 two-component response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C PA2523 two-component response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C PA4885 irlR; two-component response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C PA2809 copR; two-component response regulator CopR K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C PA4777 pmrB; two-component regulator system signal sensor kinase PmrB K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C PA2480 two-component sensor K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C PA4776 pmrA; two-component regulator system response regulator PmrA K07666 qseB; two-component system, OmpR family, response regulator QseB
C PA2479 two-component response regulator K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C PA1636 kdpD; two-component sensor KdpD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C PA1637 kdpE; two-component response regulator KdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
C PA0757 two-component sensor K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C PA0756 two-component response regulator K07774 tctD; two-component system, OmpR family, response regulator TctD
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
C PA1798 parS; two-component sensor ParS K18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]
C PA1799 parR; two-component response regulator ParR K18073 parR; two-component system, OmpR family, response regulator ParR
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
C PA2687 pfeS; two-component sensor histidine kinase PfeS K19609 pfeS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3]
C PA0930 two-component sensor K19609 pfeS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3]
C PA0929 two-component response regulator K19610 pfeR; two-component system, OmpR family, response regulator PfeR
C PA2686 pfeR; two-component response regulator PfeR K19610 pfeR; two-component system, OmpR family, response regulator PfeR
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C PA3206 two-component sensor K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C PA4101 bfmR; protein BfmR K02483 K02483; two-component system, OmpR family, response regulator
C PA2657 two-component response regulator K02483 K02483; two-component system, OmpR family, response regulator
C PA3192 gltR; two-component response regulator GltR K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C PA3878 narX; two-component sensor NarX K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C PA3879 narL; transcriptional regulator NarL K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
C PA2376 transcriptional regulator K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
C PA1980 eraR; response regulator EraR K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C PA4080 response regulator K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C PA3714 two-component response regulator K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C PA2899 transcriptional regulator K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C PA0928 gacS; sensor/response regulator hybrid protein K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C PA2586 gacA; response regulator GacA K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C PA3946 rocS1; two-component sensor K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C PA2583 sensor/response regulator hybrid protein K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C PA3948 rocA1; two-component response regulator RocA1 K07690 evgA; two-component system, NarL family, response regulator EvgA
C PA3045 two-component response regulator K07690 evgA; two-component system, NarL family, response regulator EvgA
C PA0034 two-component response regulator K07690 evgA; two-component system, NarL family, response regulator EvgA
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
C PA4293 pprA; two-component sensor PprA K27076 pprA; two-component system, NarL family, sensor histidine kinase PprA [EC:2.7.13.3]
C PA4296 pprB; two-component response regulator PprB K27077 pprB; two-component system, NarL family, response regulator PprB
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
C PA5262 algZ; alginate biosynthesis protein AlgZ/FimS K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]
C PA5261 algR; alginate biosynthesis regulatory protein AlgR K08083 algR; two-component system, LytTR family, response regulator AlgR
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C PA5124 ntrB; two-component sensor NtrB K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C PA5125 ntrC; two-component response regulator NtrC K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
C PA4726 cbrB; two-component response regulator CbrB K07713 zraR; two-component system, NtrC family, response regulator HydG
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
C PA4546 pilS; two-component sensor PilS K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]
C PA4547 pilR; two-component response regulator PilR K02667 pilR; two-component system, NtrC family, response regulator PilR
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
C PA5165 two-component sensor K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C PA5512 mifS; sensor histidine kinase MifS K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C PA5166 two-component response regulator K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
C PA5511 mifR; DNA-binding response regulator MifR K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
B KinB-AlgB (alginate production)
C PA5484 two-component sensor K11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3]
C PA5483 algB; two-component response regulator AlgB K11384 algB; two-component system, NtrC family, response regulator AlgB
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
C PA2571 two-component sensor K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
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ACheA family
B CheA-CheYBV (chemotaxis)
C PA0178 two-component sensor K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C PA1458 two-component sensor K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C PA0179 two-component response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C PA1456 cheY; chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C PA0173 chemotaxis response regulator protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C PA1459 chemotaxis-specific methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C PA3349 chemotaxis protein K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
C PA0413 chpA; chemotactic signal transduction system protein K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
C PA0408 pilG; pilus biosynthesis/twitching motility protein PilG K02657 pilG; twitching motility two-component system response regulator PilG
C PA0409 pilH; twitching motility protein PilH K02658 pilH; twitching motility two-component system response regulator PilH
C PA0414 chpB; methylesterase K06597 chpB; chemosensory pili system protein ChpB (putative protein-glutamate methylesterase)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
C PA3704 wspE; chemotaxis sensor/effector fusion protein K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE
C PA3702 wspR; two-component response regulator K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65]
C PA3703 wspF; chemotaxis-specific methylesterase K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61]
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
C PA1098 fleS; two-component sensor K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3]
C PA1099 fleR; two-component response regulator K10943 flrC; two-component system, response regulator FlrC
B AauS-AauR (acidic amino acids utilization)
C PA1336 two-component sensor K17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3]
C PA1335 two-component response regulator K17061 aauR; two-component system, response regulator AauR
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
C PA4494 roxS; sensor histidine kinase RoxS K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
C PA4493 roxR; DNA-binding response regulator RoxR K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
C PA2824 sensor/response regulator hybrid protein K20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3]
C PA1611 sensor/response regulator hybrid protein K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C PA1976 ercS'; sensor histidine kinase K20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3]
C PA3345 hypothetical protein K20976 hptB; histidine phosphotransfer protein HptB
C PA3346 two-component response regulator K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator
B PdtaS-PdtaR
B NasS-NasT
C PA1786 hypothetical protein K22067 nasS; two-component system, oxyanion-binding sensor
C PA1785 hypothetical protein K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
C PA3363 amiR; aliphatic amidase regulator K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
B Unclassified
C PA3974 ladS; lost adherence sensor LadS K20971 ladS; two-component system, sensor histidine kinase LadS
C PA4856 retS; sensor histidine kinase MifS K20972 retS; two-component system, sensor histidine kinase RetS
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023