+C Lipid biosynthesis protein KO
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Lipid Biosynthesis Proteins - Rattus norvegicus (rat)
%
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AFatty acid synthase
B Animal type
C 50671 Fasn; fatty acid synthase K00665 FASN; fatty acid synthase, animal type [EC:2.3.1.85]
B Yeast type
B Bacteria type
B Component type
C 315173 Mcat; malonyl-CoA-acyl carrier protein transacylase, mitochondrial K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
C 289934 Oxsm; 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
C 84013 Hsd17b12; very-long-chain 3-oxoacyl-CoA reductase K10251 HSD17B12; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase [EC:1.1.1.62 1.1.1.330]
C 680115 Hacd1; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 K10703 HACD; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [EC:4.2.1.134]
C 362540 Hacd4; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 K10703 HACD; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [EC:4.2.1.134]
C 300783 Hacd3; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 K10703 HACD; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [EC:4.2.1.134]
C 113956 Pecr; peroxisomal trans-2-enoyl-CoA reductase K07753 PECR; peroxisomal trans-2-enoyl-CoA reductase [EC:1.3.1.38]
C 191576 Tecr; very-long-chain enoyl-CoA reductase isoform 1 K10258 TER; very-long-chain enoyl-CoA reductase [EC:1.3.1.93]
C 499018 Tecrl2; very-long-chain enoyl-CoA reductase-like K10258 TER; very-long-chain enoyl-CoA reductase [EC:1.3.1.93]
C 64669 Olah; S-acyl fatty acid synthase thioesterase, medium chain K01071 MCH; medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21]
C 29411 Ppt1; palmitoyl-protein thioesterase 1 precursor K01074 PPT; palmitoyl-protein thioesterase [EC:3.1.2.22]
C 54398 Ppt2; lysosomal thioesterase PPT2 precursor K01074 PPT; palmitoyl-protein thioesterase [EC:3.1.2.22]
C 50559 Acot1; acyl-coenzyme A thioesterase 1 K01068 ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]
C 192272 Acot2; acyl-coenzyme A thioesterase 2, mitochondrial K01068 ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]
C 314304 Acot3; acyl-CoA thioesterase 3 K01068 ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]
C 503049 Acot5; acyl-coenzyme A thioesterase 5 K01068 ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]
C 681337 Acot4; acyl-coenzyme A thioesterase 4 K01068 ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]
C 299193 Acot6; acyl-coenzyme A thioesterase 6 K11993 ACOT6; acyl-CoA thioesterase 6 [EC:3.1.2.-]
C 26759 Acot7; cytosolic acyl coenzyme A thioester hydrolase isoform 1 K17360 ACOT7; acyl-coenzyme A thioesterase 7 [EC:3.1.2.2]
C 302640 Acot9; acyl-coenzyme A thioesterase 9, mitochondrial K17361 ACOT9; acyl-coenzyme A thioesterase 9 [EC:3.1.2.-]
C 100363074 Acot11; acyl-coenzyme A thioesterase 11 K12417 ACOT11; acyl-CoA thioesteraes 11 [EC:3.1.2.-]
C 291135 Acot13; acyl-coenzyme A thioesterase 13 K17362 ACOT13; acyl-coenzyme A thioesterase 13 [EC:3.1.2.-]
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ADesaturase
B First
C 83792 Scd2; stearoyl-CoA desaturase 2 K00507 SCD; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]
C 246074 Scd; acyl-CoA desaturase 1 K00507 SCD; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]
C 499358 Scd4; stearoyl-CoA desaturase 4 K00507 SCD; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]
C 681458 Scd3; acyl-CoA desaturase 3 K00507 SCD; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]
B Omega
C 286922 Fads3; fatty acid desaturase 3 K10225 FADS3; fatty acid desaturase 3 (Delta-13 desaturase) [EC:1.14.19.-]
B Front-end
C 84575 Fads1; acyl-CoA (8-3)-desaturase K10224 FADS1; acyl-CoA (8-3)-desaturase (Delta-5 desaturase) [EC:1.14.19.44]
C 83512 Fads2; acyl-CoA 6-desaturase K10226 FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase) [EC:1.14.19.3]
B Sphingolipid
C 58970 Degs1; sphingolipid delta(4)-desaturase DES1 K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]
C 314438 Degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]
C 289322 Degs1l2; sphingolipid delta(4)-desaturase DES1 K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]
C 498300 Degs1l1; sphingolipid delta(4)-desaturase DES1 isoform X2 K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]
B Other
C 303671 Fads6; fatty acid desaturase 6 K12419 FADS6; fatty acid desaturase 6 [EC:1.14.19.-]
#
AElongase
B LCFA
B PUFA
C 679532 Elovl1; elongation of very long chain fatty acids protein 1 K10247 ELOVL1; elongation of very long chain fatty acids protein 1 [EC:2.3.1.199]
C 498728 Elovl2; very long chain fatty acid elongase 2 isoform 1 K10205 ELOVL2; elongation of very long chain fatty acids protein 2 [EC:2.3.1.199]
C 315851 Elovl4; elongation of very long chain fatty acids protein 4 K10249 ELOVL4; elongation of very long chain fatty acids protein 4 [EC:2.3.1.199]
C 171400 Elovl5; very long chain fatty acid elongase 5 K10244 ELOVL5; elongation of very long chain fatty acids protein 5 [EC:2.3.1.199]
C 171402 Elovl6; very long chain fatty acid elongase 6 K10203 ELOVL6; elongation of very long chain fatty acids protein 6 [EC:2.3.1.199]
C 361895 Elovl7; very long chain fatty acid elongase 7 K10250 ELOVL7; elongation of very long chain fatty acids protein 7 [EC:2.3.1.199]
B Unclassified
C 309449 Elovl3; elongation of very long chain fatty acids protein 3 K10248 ELOVL3; elongation of very long chain fatty acids protein 3 [EC:2.3.1.199]
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APolyketide synthase
B Modular PKS
B Component type
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AAcyl-CoA synthetase
B Short/medium chain acyl-CoA synthetase
C 296259 Acss1; acetyl-coenzyme A synthetase 2-like, mitochondrial K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]
C 311569 Acss2; acetyl-coenzyme A synthetase, cytoplasmic K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]
C 314800 Acss3; acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 2 K01908 ACSS3; propionyl-CoA synthetase [EC:6.2.1.17]
C 65984 Aacs; acetoacetyl-CoA synthetase K01907 AACS; acetoacetyl-CoA synthetase [EC:6.2.1.16]
C 361638 Acsm1; acyl-coenzyme A synthetase ACSM1, mitochondrial K23756 ACSM1; medium-chain acyl-CoA ligase / lipoate-activating enzyme [EC:6.2.1.2]
C 246263 Acsm2; acyl-coenzyme A synthetase ACSM2, mitochondrial K01896 ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2]
C 353317 Acsm4; acyl-coenzyme A synthetase ACSM4, mitochondrial precursor K01896 ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2]
C 361637 Acsm5; acyl-coenzyme A synthetase ACSM5, mitochondrial precursor K01896 ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2]
C 24763 Acsm3; acyl-coenzyme A synthetase ACSM3, mitochondrial K01896 ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2]
C 619561 Acsf2; medium-chain acyl-CoA ligase ACSF2, mitochondrial precursor K23617 ACSF2; medium-chain acyl-CoA ligase, mitochondrial [EC:6.2.1.2]
B Long/very long chain acyl-CoA synthetase
C 94340 Acsl5; long-chain-fatty-acid--CoA ligase 5 K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
C 113976 Acsl4; long-chain-fatty-acid--CoA ligase 4 K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
C 114024 Acsl3; fatty acid CoA ligase Acsl3 K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
C 117243 Acsl6; long-chain-fatty-acid--CoA ligase 6 K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
C 25288 Acsl1; long-chain-fatty-acid--CoA ligase 1 K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
C 171410 Acsbg1; long-chain-fatty-acid--CoA ligase ACSBG1 K15013 ACSBG; long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
C 301120 Acsbg2; long-chain-fatty-acid--CoA ligase ACSBG2 K15013 ACSBG; long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
C 316124 Acsbg3; uncharacterized protein LOC316124 K15013 ACSBG; long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
C 94172 Slc27a1; long-chain fatty acid transport protein 1 K08745 SLC27A1_4; solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-]
C 311839 Slc27a4; long-chain fatty acid transport protein 4 K08745 SLC27A1_4; solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-]
C 65192 Slc27a2; long-chain fatty acid transport protein 2 K08746 SLC27A2; solute carrier family 27 (fatty acid transporter), member 2 [EC:6.2.1.- 6.2.1.3]
C 295219 Slc27a3; long-chain fatty acid transport protein 3 precursor K08772 SLC27A3; solute carrier family 27 (fatty acid transporter), member 3 [EC:6.2.1.-]
B Unknown
#
APhospholipid acyltransferase
B GPAT
C 29653 Gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial K00629 GPAT1_2; glycerol-3-phosphate O-acyltransferase 1/2 [EC:2.3.1.15]
C 296130 Gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial K00629 GPAT1_2; glycerol-3-phosphate O-acyltransferase 1/2 [EC:2.3.1.15]
C 290843 Gpat4; glycerol-3-phosphate acyltransferase 6 K13506 GPAT3_4; glycerol-3-phosphate O-acyltransferase 3/4 [EC:2.3.1.15]
C 305166 Gpat3; glycerol-3-phosphate acyltransferase 3 K13506 GPAT3_4; glycerol-3-phosphate O-acyltransferase 3/4 [EC:2.3.1.15]
B LPAAT/LPLAT
C 406165 Agpat1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha K13509 AGPAT1_2; lysophosphatidate acyltransferase [EC:2.3.1.51]
C 311821 Agpat2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta precursor K13509 AGPAT1_2; lysophosphatidate acyltransferase [EC:2.3.1.51]
C 316122 Abhd5; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 K13699 ABHD5; abhydrolase domain-containing protein 5 [EC:2.3.1.51]
C 362702 Lclat1; lysocardiolipin acyltransferase 1 isoform X1 K13513 LCLAT1; lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.51]
C 363521 tafazzin K13511 TAZ; monolysocardiolipin acyltransferase [EC:2.3.1.-]
C 498741 Mboat1; lysophospholipid acyltransferase 1 K13517 MBOAT1_2; lysophospholipid acyltransferase 1/2 [EC:2.3.1.51 2.3.1.-]
C 313997 Mboat2; lysophospholipid acyltransferase 2 K13517 MBOAT1_2; lysophospholipid acyltransferase 1/2 [EC:2.3.1.51 2.3.1.-]
C 294324 Agpat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma K13523 AGPAT3_4; lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase [EC:2.3.1.51 2.3.1.-]
C 170919 Agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta K13523 AGPAT3_4; lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase [EC:2.3.1.51 2.3.1.-]
C 100359680 Lpcat2; lysophosphatidylcholine acyltransferase 2 K13510 LPCAT1_2; lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67]
C 361467 Lpcat1; lysophosphatidylcholine acyltransferase 1 K13510 LPCAT1_2; lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67]
C 289439 Lpcat2b; lysophosphatidylcholine acyltransferase 2B K13510 LPCAT1_2; lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67]
C 296048 Lpcat4; lysophospholipid acyltransferase LPCAT4 K13512 LPCAT4; lysophospholipid acyltransferase [EC:2.3.1.23 2.3.1.-]
C 679692 Lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 K13514 LPGAT1; lysophosphatidylglycerol acyltransferase 1 [EC:2.3.1.-]
C 362434 Lpcat3; lysophospholipid acyltransferase 5 K13515 LPCAT3; lysophospholipid acyltransferase 5 [EC:2.3.1.23 2.3.1.-]
C 308309 Mboat7; lysophospholipid acyltransferase 7 K13516 MBOAT7; lysophospholipid acyltransferase 7 [EC:2.3.1.-]
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AOthers
B Multifunctional type
B Component type
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: November 27, 2023
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Desaturase/elongase family classification based on Hashimoto et al. (2008)