+E Polyketide biosynthesis proteins KO #

  Polyketide Biosynthesis Proteins - Streptomyces coelicolor

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APolyketide synthase (PKS) B Modular type I PKS C cis-AT PKS D Erythronolide PKS D Oleandomycin synthase D Pikromycin PKS D Avermectin PKS D Tylactone synthase D Protomycinolide IV synthase D Niddamycin PKS D Rapamycin PKS D Immunomycin PKS D Ansamitocin PKS D Rifamycin PKS D Polyene macrolide PKS D Pimaricinolide synthase D Candicidin PKS D Soraphen PKS D Stigmatellin PKS D Mycolactone PKS D Coelimycin PKS E SCO6275 SC1G7.01c; type I polyketide synthase K23365 cpkA; 5-hydroxydodecatetraenal polyketide synthase CpkA [EC:2.3.1.281] E SCO6274 SC2C4.04c; type I polyketide synthase K23366 cpkB; 5-hydroxydodecatetraenal polyketide synthase CpkB [EC:2.3.1.281] E SCO6273 SC2C4.03c; type I polyketide synthase K23367 cpkC; 5-hydroxydodecatetraenal polyketide synthase CpkC [EC:2.3.1.281] D Aureothin PKS D Spectinabilin PKS D Phthiocerol / Phenolphthiocerol PKS C trans-AT PKS D Bacillanene hybrid PKS-NRPS D Chivosazol hybrid PKS-NRPS E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133] D Macrolactin PKS D Difficidin PKS D Rhizoxin hybrid PKS-NRPS D Myxovirescin hybrid PKS-NRPS E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932] D Albicidin synthase, hybrid PKS-NRPS E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516] E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523] D Etnangien PKS E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193] B Iterative type I PKS C Fungal nonreducing PKS (NR-PKS) C Fungal partially reducing PKS (PR-PKS) C Fungal highly reducing PKS (HR-PKS) C Fungal hybrid type D Zearalenone synthase D Asperfuranone NR/HR-PKS E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2] E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2] C Bacterial type B Type II PKS C C9-C14 cyclized polyketide type D Spore pigment PKS E SCO5318 SC6G9.15; polyketide beta-ketoacyl synthase alpha K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-] E SCO5317 SC6G9.16; polyketide beta-ketoacyl synthase beta K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-] E SCO5316 SC6G9.17; acyl carrier protein K14669 whiEV; minimal PKS acyl carrier protein E SCO5315 SC6G9.18; polyketide cyclase K14670 whiEVI; aromatase E SCO5314 SC6G9.19; whiE protein VII K14671 whiEVII; cyclase C C7-C14 cyclized polyketide type D Octaketide PKS E SCO5087 actIORF1; actinorhodin polyketide beta-ketoacyl synthase subunit alpha K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SCO5088 actIORF2; actinorhodin polyketide beta-ketoacyl synthase subunit beta K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SCO5089 actIORF3; actinorhodin polyketide synthase K05553 actI3; minimal PKS acyl carrier protein E SCO1272 2SCG18.19c; acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E SCO5086 actIII; ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E SCO5090 actVII; actinorhodin polyketide synthase bifunctional cyclase/dehydratase K05554 actVII; aromatase [EC:4.2.1.-] E SCO5091 actIV; cyclase K05555 actIV; cyclase [EC:4.-.-.-] D Nonaketide PKS E SCO5087 actIORF1; actinorhodin polyketide beta-ketoacyl synthase subunit alpha K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SCO5088 actIORF2; actinorhodin polyketide beta-ketoacyl synthase subunit beta K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SCO5089 actIORF3; actinorhodin polyketide synthase K05553 actI3; minimal PKS acyl carrier protein E SCO1272 2SCG18.19c; acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E SCO5086 actIII; ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] D Decaketide PKS E SCO5087 actIORF1; actinorhodin polyketide beta-ketoacyl synthase subunit alpha K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SCO5088 actIORF2; actinorhodin polyketide beta-ketoacyl synthase subunit beta K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SCO5089 actIORF3; actinorhodin polyketide synthase K05553 actI3; minimal PKS acyl carrier protein E SCO1272 2SCG18.19c; acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E SCO5086 actIII; ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] B Type III PKS C Plant type C Fungal type C Bacterial type D SCO1206 2SCG58.06; 1,3,6,8-tetrahydroxynaphthalene synthase K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233] D SCO7221 SC2H12.20c; polyketide synthase K16232 gcs; germicidin synthase D SCO7671 SC4C2.06c; transferase K16167 bpsA; alkylresorcinol/alkylpyrone synthase D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550] D ------ arsC; alkylpyrone synthase [AVN:Avin_29530] B PKS-NRPS hybrid C Bacterial type (modular) D Myxalamid hybrid PKS-NRPS D Myxothiazol hybrid PKS-NRPS E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019] D Coronatine hybrid PKS-NRPS D Microcystin synthetase D Epothilone synthetase D Bleomycin synthetase D Colibactin synthetase C Fungal type (trans-ER, iterative) D Aspyridone synthetase C Fungal type (iterative) # ANonribosomal peptide synthetase (NRPS) B Linear NRPS C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2] C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500] C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000] C ACV synthetase C Bacitracin synthetase C Viomycin synthetase C Pristinamycin I synthetase C Tyrocidine synthetase C Surfactin family lipopeptide synthetase C Iturin family lipopeptide synthetase C Fengycin family lipopeptide synthetase C Arthrofactin type cyclic lipopeptide synthetase C Vancomycin synthetase C Nocardicin synthetase D SCO3218 SCE8.11c; hypothetical protein K05375 mbtH; MbtH protein D SCO0489 SCF34.08c; hypothetical protein K05375 mbtH; MbtH protein C Bialaphos synthetase C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase B Iterative NRPS C Enterobactin synthetase D SCO7681 SC4C2.16c; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Bacillibactin synthetase D SCO7681 SC4C2.16c; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Gramicidin synthetase B Nonlinear NRPS C Yersiniabactin synthetase C Pyochelin synthetase D SCO7683 SC4C2.18; non-ribosomal peptide synthase K12240 pchF; L-cysteine---[L-cysteinyl-carrier protein] ligase PchF [EC:6.2.1.69] C Mycobactin synthetase C Vibriobactin synthetase D SCO7681 SC4C2.16c; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Myxochelin synthetase D SCO7681 SC4C2.16c; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Petrobacin synthetase C Syringomycin synthetase C Vanchrobactin synthetase D SCO7681 SC4C2.16c; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] # APolyketide tailoring proteins B Hydrolase B Ketoreductase C SCO5072 SCBAC20F6.15; hydroxylacyl-CoA dehydrogenase K05556 actVI1; ketoreductase RED1 [EC:1.1.1.-] B Oxygenase C SCO5080 actVA5; hydrolase K14630 actVA5; two-component flavin-dependent monooxygenase [EC:1.14.14.-] C SCO5081 actVA6; hypothetical protein K14632 actVA6; C-6 monooxygenase C SCO7417 SC6D11.13c; cytochrome P450-family protein K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C SCO2884 SCE6.21; cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C SCO5319 SC6G9.14; whiE protein II K14673 whiEII; putative monooxygenase C SCO5321 SC6G9.12c; polyketide hydroxylase K14672 whiEVIII; putative polyketide hydroxylase B Methylase C SCO7452 SC5C11.09c; O-methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-] C SCO7670 SC4C2.05c; hypothetical protein K16168 bpsB; methyltransferase B Glycosyltransferase B Halogenase C SCO1275 2SCG18.22; halogenase K14257 ctcP; tetracycline 7-halogenase / FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-] B beta-Branched incorporating proteins B Others C SCO5071 SCBAC20F6.14c; hydroxylacyl-CoA dehydrogenase K14626 actVIA; actinorhodin biosynthesis protein ActVIA C SCO5074 SCBAC20F6.17; dehydratase K14627 actVI3; dehydratase [EC:4.2.1.-] C SCO5023 SCK15.25; hypothetical protein K14628 actVI2; enoyl reductase C SCO5075 ORF4; oxidoreductase K14629 actVI4; enoyl reductase C SCO5092 actVB; actinorhodin polyketide dimerase K14631 actVB; flavin reductase ActVB [EC:1.5.1.-] # ANonribosomal peptide tailoring proteins B Reductase C SCO7685 SC4C2.20; hypothetical protein K12241 pchG; pyochelin biosynthesis protein PchG B Thioesterase C SCO7687 SC4C2.22; thioesterase K12242 pchC; pyochelin biosynthesis protein PchC B Oxygenase B Glycosyltransferase B Aminotransferase C SCO3227 SCE63.06; aminotransferase K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103] B Others C SCO3229 SCE63.04; 4-hydroxyphenylpyruvate dioxygenase K16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46] C SCO3228 SCE63.05; glycolate oxidase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46] ! #
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: February 19, 2024