+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Streptomyces avermitilis
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
E SAVERM_938 aveA1; type I polyketide synthase AVES 1 K14371 aveA1; avermectin polyketide synthase AveA1
E SAVERM_939 aveA2; type I polyketide synthase AVES 2 K24567 aveA2; avermectin polyketide synthase AveA2
E SAVERM_942 aveA3; type I polyketide synthase AVES 3 K24568 aveA3; avermectin polyketide synthase AveA3
E SAVERM_943 aveA4; type I polyketide synthase AVES 4 K24569 aveA4; avermectin polyketide synthase AveA4
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
D Chivosazol hybrid PKS-NRPS
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
D Difficidin PKS
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2]
C Bacterial type
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
E SAVERM_2838 sppA; putative 3-oxoacyl-ACP synthase I K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-]
E SAVERM_2839 sppB; putative chain length factor (3-oxoacyl-ACP synthase II) K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-]
E SAVERM_2840 sppC; putative acyl carrier protein K14669 whiEV; minimal PKS acyl carrier protein
E SAVERM_2841 sppD; putative cyclase I K14670 whiEVI; aromatase
E SAVERM_2842 sppE; putative cyclase II K14671 whiEVII; cyclase
C C7-C14 cyclized polyketide type
D Octaketide PKS
E SAVERM_2376 pks9-4; putative 3-oxoacyl-ACP synthase I K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E SAVERM_2375 pks9-3; putative 3-oxoacyl-ACP synthase II (probably chain length factor) K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E SAVERM_2373 pks9-1; putative acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E SAVERM_6616 putative polyketide cyclase K05555 actIV; cyclase [EC:4.-.-.-]
D Nonaketide PKS
E SAVERM_2376 pks9-4; putative 3-oxoacyl-ACP synthase I K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E SAVERM_2375 pks9-3; putative 3-oxoacyl-ACP synthase II (probably chain length factor) K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E SAVERM_2373 pks9-1; putative acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
D Decaketide PKS
E SAVERM_2376 pks9-4; putative 3-oxoacyl-ACP synthase I K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E SAVERM_2375 pks9-3; putative 3-oxoacyl-ACP synthase II (probably chain length factor) K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E SAVERM_2373 pks9-1; putative acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D SAVERM_7131 rppA; type III polyketide synthase K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233]
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D SAVERM_851 putative MbtH-like protein K05375 mbtH; MbtH protein
D SAVERM_3644 putative MbtH-like protein K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
C Bacillibactin synthetase
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
C Mycobactin synthetase
C Vibriobactin synthetase
C Myxochelin synthetase
D SAVERM_603 nrps6; putative non-ribosomal peptide synthetase K15653 mxcG; nonribosomal peptide synthetase MxcG
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
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APolyketide tailoring proteins
B Hydrolase
B Ketoreductase
C SAVERM_936 aveF; C-5 ketoreductase K14373 aveF; C-5 ketoreductase
C SAVERM_1348 fadC7; putative 3-hydroxyacyl-CoA dehydrogenase K05556 actVI1; ketoreductase RED1 [EC:1.1.1.-]
B Oxygenase
C SAVERM_941 aveE; cytochrome P450 hydroxylase K14372 aveE; cytochrome P450 hydroxylase [EC:1.14.-.-]
C SAVERM_109 cyp1; cytochrome P450 hydroxylase K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C SAVERM_1308 cyp6; cytochrome P450 hydroxylase K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C SAVERM_3882 cyp19; cytochrome P450 hydroxylase K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C SAVERM_3704 cyp17; cytochrome P450 hydroxylase K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C SAVERM_2837 sppH; putative WhiE II homolog K14673 whiEII; putative monooxygenase
C SAVERM_2835 sppF; putative polyketide hydroxylase K14672 whiEVIII; putative polyketide hydroxylase
B Methylase
C SAVERM_937 aveD; C5-O-methyltransferase K14374 aveD; avermectin B 5-O-methyltransferase [EC:2.1.1.-]
C SAVERM_2382 putative O-methyltransferase K20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]
C SAVERM_2843 putative O-methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-]
B Glycosyltransferase
C SAVERM_945 aveBI; dTDP-L-oleandrose transferase (glycosyltransferase) K14375 aveBI; dTDP-L-oleandrosyltransferase [EC:2.4.1.-]
B Halogenase
B beta-Branched incorporating proteins
B Others
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ANonribosomal peptide tailoring proteins
B Reductase
B Thioesterase
B Oxygenase
B Glycosyltransferase
B Aminotransferase
B Others
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: February 19, 2024