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#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Mitochondrial Biogenesis - Streptococcus pyogenes Manfredo (serotype M5)</h2>
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A<b>Mitochondrial DNA transcription, translation, and replication factors</b>
B  Mitochondrial DNA-encoded proteins
C    Mitochondrial respiratory chain complex I
C    Mitochondrial respiratory chain complex III
C    Cytochrome c oxidase
C    F-type ATPase
B  Mitochondrial transcription and translation factors
C    Mitochondrial RNA polymerase
C    Mitochondrial transcription factors
C    Mitochondrial translation factors
D      SpyM50382 infB; translation initiation factor IF-2	K02519 infB; translation initiation factor IF-2 
D      SpyM51188 infC; translation initiation factor IF-3	K02520 infC; translation initiation factor IF-3 
D      SpyM51740 tsf; elongation factor Ts	K02357 tsf; elongation factor Ts 
D      SpyM51355 tufA; elongation factor Tu (EF-Tu)	K02358 tuf; elongation factor Tu 
D      SpyM50211 fus; elongation factor G (EF-G)	K02355 fusA; elongation factor G 
C    RNase MRP
C    Mitochondrial ribonuclease P
C    Other mitochondrial DNA transcription and translation factors
D      SpyM51478 era; GTP-binding protein Era homolog	K03595 era; GTPase 
D      SpyM50079 tyrS; putative tyrosyl-tRNA synthetase	K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] 
D      SpyM50141 leuS; leucyl-tRNA synthetase	K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] 
D      SpyM51788 aspS; aspartyl-tRNA synthetase	K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] 
D      SpyM51783 argS; arginyl-tRNA synthetase	K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] 
D      SpyM50338 gatA; glutamyl-tRNA amidotransferase subunit A	K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7] 
D      SpyM50339 gatB; glutamyl-tRNA amidotransferase subunit B	K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7] 
D      SpyM50337 gatC; glutamyl-tRNA amidotransferase subunit C	K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7] 
B  Mitochondrial DNA replication factors
C    Mitochondrial DNA polymerase
C    Mitochondrial DNA maintenance factors
C    Other Mitochondrial DNA replication factors
D      SpyM50296 ssb; single strand binding protein (SSB)	K03111 ssb; single-strand DNA-binding protein 
D      SpyM50099 putative single stranded DNA-binding protein	K03111 ssb; single-strand DNA-binding protein 
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A<b>Mitochondrial protein import machinery</b>
B  Endoplasmic reticulum membrane and cytosol
C    ER-mitochondria encounter structure (ERMES) complex
C    Other ER-memrane and cytosol factors
B  Outer membrane
C    Transporter outer membrane (TOM) complex
C    TOB/SAM complex
C    Porin
C    ERMES complex
C    Other outer membrane factor
B  Inter membrane space
C    Transporter inner membrane (TIM) 9/10 complex
C    TIM8/13 complex
C    Mitochondrial intermembrane space assembly (MIA) complex
B  Inner mambrane
C    MICOS complex
C    MICOS complex (yeast)
C    TIM22 complex
C    TIM23 complex
C    Mitochondrial calcium uniporter complex
C    Other inner membrane factors
B  Matrix
C    MMC/PAM proteins
D      SpyM50347 dnaK; chaperone protein DnaK (heat shock protein 70)	K04043 dnaK; molecular chaperone DnaK 
D      SpyM50346 grpE; GrpE protein (HSP-70 cofactor)	K03687 GRPE; molecular chaperone GrpE 
C    Other matrix factors
D      SpyM51721 groEL; 60 kDa chaperonin	K04077 groEL; chaperonin GroEL [EC:5.6.1.7] 
D      SpyM51722 groES; 10 kDa chaperonin	K04078 groES; chaperonin GroES 
D      SpyM50348 dnaJ; chaperone protein DnaJ	K03686 dnaJ; molecular chaperone DnaJ 
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A<b>Mitochondrial quality control factors</b>
B  Regulator of mitochondrial biogenesis
C    Ubiquitas transcription factors
D      SpyM50211 fus; elongation factor G (EF-G)	K02355 fusA; elongation factor G 
C    Nuclear respiratory factors
C    Coactivators
C    Proteins involved in Fe-S cluster biogenesis
D      SpyM51177 putative cysteine desulfhydrase	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
D      SpyM50944 putative cysteine desulfurase	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
D      SpyM50347 dnaK; chaperone protein DnaK (heat shock protein 70)	K04043 dnaK; molecular chaperone DnaK 
C    Other regulator of mitochondrial biogenesis
B  Mitochondrial respiratory chain complex assembly factors
C    Complex-I assembly factors
C    Complex-II assembly factors
C    Complex-III assembly factors
C    Complex-IV assembly factors
D      SpyM51561 membrane protein OxaA 2 precursor	K03217 yidC; YidC/Oxa1 family membrane protein insertase 
D      SpyM50188 membrane protein OxaA 1 precursor	K03217 yidC; YidC/Oxa1 family membrane protein insertase 
C    Complex-V assembly factors
B  Mitochondrial dynamics
C    Fission and Fusion factors
C    Actin cytoskeleton organization
C    Mitochondrial movement
C    Retention of mitochondria
C    Morphogenesis factors
B  Mitophagy factors
C    Autophagy-related proteins
C    Parkin-dependent mechanism factors
C    Parkin-independent mechanism factors
C    Other mitophagy factors
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#Last updated: March 14, 2024