+C Two-component system KO #

  Two-Component System - Streptococcus pyogenes MGAS9429 (serotype M12)

% ! AOmpR family B PhoR-PhoB (phosphate starvation response) B SenX3-RegX3 (phosphate starvation response) B PhoQ-PhoP (magnesium transport) B EnvZ-OmpR (osmotic stress response) B RstB-RstA B CpxA-CpxR (envelope stress response) B CssS-CssR (secretion stress response) B CreC-CreB (phosphate regulation) B BaeS-BaeR (envelope stress response) B BasS-BasR (antimicrobial peptide resistance) B CusS-CusR (copper tolerance) B QseC-QseB (quorum sensing) B KdpD-KdpE (potassium transport) B TorS-TorR (TMAO respiration) B ArcB-ArcA (anoxic redox control) B TctE-TctD (tricarboxylic acid transport) B ResE-ResD (aerobic and anaerobic respiration) B VicK-VicR (cell wall metabolism) C MGAS9429_Spy0435 vicK; two-component sensor histidine kinase K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] C MGAS9429_Spy0434 vicR; two-component response regulator K07668 vicR; two-component system, OmpR family, response regulator VicR B MprB-MprA (maintenance of persistent infection) B MtrB-MtrA (osmotic stress response) B PrrB-PrrA (intracellular multiplication) B TrcS-TrcR B NrsS-NrsR (nickel tolerance) B ManS-ManR (manganese homeostasis) B NblS-NblR (photosynthesis) B SasA-RpaAB (circadian timing mediating) B SaeS-SaeR (staphylococcal virulence regulation) B BceS-BceR (bacitracin transport) B BraS-BraR (bacitracin transport) B GraS-GraR (cationic antimicrobial peptide transport) B YxdK-YxdJ (antimicrobial peptide response) B ChvG-ChvI (acidity sensing) B CiaH-CiaR C MGAS9429_Spy1050 ciaH; sensor protein K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] C MGAS9429_Spy1051 ciaR; transcriptional regulatory protein K14983 ciaR; two-component system, OmpR family, response regulator CiaR B ParS-ParR (polymyxin-adaptive resistance) B AdeS-AdeR B VanS-VanR (VanB type vancomycin resistance) B VanS-VanR (VanE type vancomycin resistance) B VanS-VanR (actinomycete type vancomycin resistance) B ArlS-ArlR (virulence regulation) C MGAS9429_Spy0283 covS; transmembrane histidine kinase K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3] C MGAS9429_Spy0282 covR; response regulator K18941 arlR; two-component system, OmpR family, response regulator ArlR B Ihk-Irr (virulence regulation) C MGAS9429_Spy1729 ihk; two-component system histidine kinase K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3] C MGAS9429_Spy1730 irr; two-component response regulator K18987 irr; two-component system, OmpR family, response regulator Irr B PfeS-PfeR (enterobactin-dependent iron acquisition) B NisK-NisR (lantibiotic biosynthesis) C MGAS9429_Spy0921 srtK; lantibiotic biosynthesis sensor protein K20487 nisK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3] C MGAS9429_Spy0920 srtR; lantibiotic biosynthesis two-component response regulator K20488 nisR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR/SpaR B Unclassified # ANarL family B NarX-NarL (nitrate respiration) B NarQ-NarP (nitrate respiration) B UhpB-UhpA (hexose phosphates uptake) B FusK-FusR (virulence regulation) B RcsC-RcsD-RcsB (capsule synthesis) B BarA-UvrY (central carbon metabolism) B ComP-ComA (competence) B EvgS-EvgA (acid and drug tolerance) B DegS-DegU (multicellular behavior control) B DesK-DesR (membrane lipid fluidity regulation) B VraS-VraR (cell-wall peptidoglycan synthesis) B LiaS-LiaR (cell wall stress response) C MGAS9429_Spy1328 yvqE; two-component sensor protein K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3] C MGAS9429_Spy1327 yvqC; two-component response regulator K11618 liaR; two-component system, NarL family, response regulator LiaR B DevS-DevR (redox response) B NreB-NreC (dissimilatory nitrate/nitrite reduction) B YdfH-YdfI B SalK-SalR C MGAS9429_Spy1629 sensory transduction protein kinase K14988 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK C MGAS9429_Spy1628 salR; transcriptional regulatory protein K14989 salR; two-component system, NarL family, secretion system response regulator SalR B PprA–PprB (biofilm formation) B Unclassified # ASpo family B KinABCDE-Spo0FA (sporulation control) # ACitB family B CitA-CitB (citrate fermentation) B CitS-CitT (magnesium-citrate transport) B DcuS-DcuR (C4-dicarboxylate metabolism) B DctS-DctR (C4-dicarboxylate transport) B MalK-MalR (malate transport) B Unclassified C MGAS9429_Spy0950 dpiB; sensor kinase K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3] C MGAS9429_Spy0949 dpiA; transcriptional regulatory protein K02475 K02475; two-component system, CitB family, response regulator # ALytTR family B LysS-LysR B AlgZ-AlgR (alginate production) B NatK-NatR (sodium extrusion) B AgrC-AgrA (exoprotein synthesis) C MGAS9429_Spy1312 rocA; sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] C MGAS9429_Spy0205 fasB; sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] C MGAS9429_Spy0206 fasC; sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] C MGAS9429_Spy0207 fasA; response regulator K07707 agrA; two-component system, LytTR family, response regulator AgrA B AgrC2-AgrA2 (virulence regulation) B ComD-ComE (competence) B Unclassified # ANtrC family B GlnL-GlnG (nitrogen regulation) B NtrY-NtrX (nitrogen regulation) B HydH-HydG (metal tolerance) B AtoS-AtoC (cPHB biosynthesis) B PilS-PilR (type 4 fimbriae synthesis) B GlrK-GlrR (amino sugar metabolism) B PgtB-PgtA (phosphoglycerate transport) B DctB-DctD (C4-dicarboxylate transport) B KinB-AlgB (alginate production) B HupT-HupR (hydrogenase synthesis regulation) B Unclassified # ACheA family B CheA-CheYBV (chemotaxis) B ChpA-ChpB/PilGH (chemosensory) B PixL-PixGH (positive phototaxis) B WspE-WspRF (chemosensory) B Cph1-Rcp1 (light response) # ACell cycle family B PleC-PleD (cell fate control) B CckA-CtrA/CpdR (cell cycle control) B Hk1-Rrp1 (glycerol uptake and utilization) # ALux family B LuxQN/CqsS-LuxU-LuxO (quorum sensing) # ALuxR family B DctS-DctR (C4-dicarboxylate transport) B TtrS-TtrR (tetrathionate respiration) B FixL-FixJ (nitrogen fixation) B SsrA-SsrB # AOther families B FlrB-FlrC (polar flagellar synthesis) B AauS-AauR (acidic amino acids utilization) B SLN1-YPD1-SSK1/SKN7 (osmosensing) B RpfC-RpfG (cell-to-cell signaling) B GlnK-GlnL (glutamine utilization) B HspS-HspR (hexose phosphates uptake) B YesM-YesN C MGAS9429_Spy1300 two-component sensor kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] C MGAS9429_Spy1274 two-component sensor kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] C MGAS9429_Spy1299 two-component response regulator K07720 yesN; two-component system, response regulator YesN C MGAS9429_Spy0902 two-component response regulator K07720 yesN; two-component system, response regulator YesN B CikA B RegB-RegA (redox response) B FitF-FitH (insecticidal toxin regulation) B PhcS-PhcRQ B SagS-HptB-HsbR (swarming activity and biofilm formation) B PdtaS-PdtaR B NasS-NasT B Unclassified ! #
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#Last updated: December 14, 2023