+D GENES KO #

  KEGG Orthology (KO) - Streptococcus pyogenes MGAS8232 (serotype M18)

% ! A09100 Metabolism B B 09101 Carbohydrate metabolism C 00010 Glycolysis / Gluconeogenesis [PATH:spm00010] D spyM18_1546 glucose kinase K25026 glk; glucokinase [EC:2.7.1.2] D spyM18_0204 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D spyM18_1231 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D spyM18_1954 putative fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D spyM18_0680 tpiA; putative triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] D spyM18_0261 gapA; glyceraldehyde-3-phosphate dehydrogenase, plasmin receptor K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D spyM18_1946 pgk; putative phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3] D spyM18_1439 putative phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] D spyM18_0798 eno; putative enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D spyM18_1230 pyk; putative pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] D spyM18_1009 acoA; putative acetoin dehydrogenase (TPP-dependent) alpha chain K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D spyM18_1010 acoB; putative acetoin dehydrogenase (TPP-dependent) beta chain K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D spyM18_1011 acoC; putative dihydrolipoamide S-acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] D spyM18_1013 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D spyM18_1111 ldh; putative L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D spyM18_0043 adhE; putative Adh2 K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] D spyM18_0045 adhP; putative alcohol dehydrogenase I K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] D spyM18_1176 putative phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D spyM18_1383 gapN; putative NADP-dependent glyceraldehyde-3-phosphate dehydrogenase K00131 gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9] D spyM18_0642 putative beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86] D spyM18_1338 bglA; putative beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86] C 00020 Citrate cycle (TCA cycle) [PATH:spm00020] D spyM18_1013 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D spyM18_1009 acoA; putative acetoin dehydrogenase (TPP-dependent) alpha chain K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D spyM18_1010 acoB; putative acetoin dehydrogenase (TPP-dependent) beta chain K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D spyM18_1011 acoC; putative dihydrolipoamide S-acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] C 00030 Pentose phosphate pathway [PATH:spm00030] D spyM18_0204 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D spyM18_0248 putative ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1] D spyM18_1687 putative transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] D spyM18_1689 putative transaldolase K00616 TALDO1; transaldolase [EC:2.2.1.2] D spyM18_2015 putative transaldolase K00616 TALDO1; transaldolase [EC:2.2.1.2] D spyM18_0950 rpiA; putative ribose 5-phosphate isomerase K01807 rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6] D spyM18_1931 deoC; putative deoxyribose-phosphate aldolase K01619 deoC; deoxyribose-phosphate aldolase [EC:4.1.2.4] D spyM18_0951 deoB; putative phosphopentomutase K01839 deoB; phosphopentomutase [EC:5.4.2.7] D spyM18_1176 putative phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D spyM18_0021 prsA; putative ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] D spyM18_1084 prsA; putative phosphoribosyl pyrophosphate synthetase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] D spyM18_0702 alkH; putative 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] D spyM18_1383 gapN; putative NADP-dependent glyceraldehyde-3-phosphate dehydrogenase K00131 gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9] D spyM18_0701 kdgK; putative 2-keto-3-deoxygluconate kinase K00874 kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45] D spyM18_1954 putative fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D spyM18_1231 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] C 00040 Pentose and glucuronate interconversions [PATH:spm00040] D spyM18_2237 hasB; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D spyM18_0608 putative nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D spyM18_2240 hasC; UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D spyM18_0210 hasC2; putative UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D spyM18_0176 putative hexulose-6-phosphate synthase K03078 ulaD; 3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85] D spyM18_0177 putative hexulose-6-phosphate isomerase K03079 ulaE; L-ribulose-5-phosphate 3-epimerase [EC:5.1.3.22] D spyM18_0178 putative L-ribulose 5-phosphate K03077 araD; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4] D spyM18_0248 putative ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1] C 00051 Fructose and mannose metabolism [PATH:spm00051] D spyM18_1877 putative fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4] D spyM18_1876 manA; putative mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8] D spyM18_1521 putative phosphomannomutase K01840 manB; phosphomannomutase [EC:5.4.2.8] D spyM18_1231 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D spyM18_0913 fruK; putative fructose-1-phosphate kinase K00882 fruK; 1-phosphofructokinase [EC:2.7.1.56] D spyM18_1954 putative fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D spyM18_0680 tpiA; putative triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] D spyM18_0914 fruA; putative fructose-specific enzyme II, PTS system BC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202] D spyM18_1034 hypothetical protein K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191] D spyM18_1810 mannose-specific phosphotransferase system component IIAB K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191] D spyM18_1036 putative phosphotransferase system (PTS), enzyme II, component C K02795 manY; mannose PTS system EIIC component D spyM18_1811 putative mannose-specific phosphotransferase system component II K02795 manY; mannose PTS system EIIC component D spyM18_1812 putative mannose-specific phosphotransferase system component IID K02796 manZ; mannose PTS system EIID component D spyM18_1037 putative phospotransferase system (PTS), enzyme II component D K02796 manZ; mannose PTS system EIID component C 00052 Galactose metabolism [PATH:spm00052] D spyM18_2240 hasC; UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D spyM18_0210 hasC2; putative UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D spyM18_1176 putative phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D spyM18_1546 glucose kinase K25026 glk; glucokinase [EC:2.7.1.2] D spyM18_1594 putative beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D spyM18_1989 putative tagatose 6-phosphate kinase K00917 lacC; tagatose 6-phosphate kinase [EC:2.7.1.144] D spyM18_1231 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D spyM18_1714 putative tagatose 1,6-diphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40] D spyM18_1987 putative tagatose 1,6-diphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40] D spyM18_1716 putative galactose-6-phosphate isomerase K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26] D spyM18_1717 putative galactose-6-phosphate isomerase K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26] D spyM18_1990 putative galactose-6-phosphate isomerase (B subunit) K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26] D spyM18_1991 galactosidase acetyltransferase K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26] D spyM18_1984 putative phospho-beta-D-galactosidase K01220 E3.2.1.85; 6-phospho-beta-galactosidase [EC:3.2.1.85] D spyM18_1986 putative PTS system, lactose-specific component IIA K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207] D spyM18_1985 putative PTS system, lactose-specific component IIBC K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207] D spyM18_1882 putative sucrose-6-phosphate hydrolase K01193 INV; beta-fructofuranosidase [EC:3.2.1.26] D spyM18_0698 putative PTS dependent N-acetyl-galactosamine- and galactosamine IIA component K02744 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-] D spyM18_0696 putative PTS dependent N-acetyl-galactosamine-IIB component K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-] D spyM18_0695 putative PTS dependent N-acetyl-galactosamine-IIC component K02746 agaW; N-acetylgalactosamine PTS system EIIC component D spyM18_0694 putative PTS dependent galactosamine IID component K02747 agaE; N-acetylgalactosamine PTS system EIID component D spyM18_0784 agaS; putative tagatose-6-phosphate aldose/ketose isomerase K02082 agaS; D-galactosamine 6-phosphate deaminase/isomerase [EC:3.5.99.-] C 00053 Ascorbate and aldarate metabolism [PATH:spm00053] D spyM18_2237 hasB; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D spyM18_0608 putative nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D spyM18_0175 conserved hypothetical protein K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D spyM18_2018 conserved hypothetical protein K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D spyM18_0174 conserved hypothetical protein K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D spyM18_2017 conserved hypothetical protein K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D spyM18_0173 conserved hypothetical protein K03475 ulaA; ascorbate PTS system EIIC component D spyM18_2016 conserved hypothetical protein K03475 ulaA; ascorbate PTS system EIIC component D spyM18_0180 conserved hypothetical protein K03476 ulaG; L-ascorbate 6-phosphate lactonase [EC:3.1.1.-] D spyM18_0176 putative hexulose-6-phosphate synthase K03078 ulaD; 3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85] D spyM18_0177 putative hexulose-6-phosphate isomerase K03079 ulaE; L-ribulose-5-phosphate 3-epimerase [EC:5.1.3.22] D spyM18_0178 putative L-ribulose 5-phosphate K03077 araD; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4] C 00500 Starch and sucrose metabolism [PATH:spm00500] D spyM18_1881 putative sucrose-specific PTS permease, enzyme II K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211] D spyM18_1882 putative sucrose-6-phosphate hydrolase K01193 INV; beta-fructofuranosidase [EC:3.2.1.26] D spyM18_2240 hasC; UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D spyM18_0210 hasC2; putative UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D spyM18_1605 putative beta-glucosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] D spyM18_1333 ptcA; putative PTS enzyme III K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D spyM18_2114 putative PTS system, enzyme III K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D spyM18_1334 ptcB; putative PTS system enzyme II K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D spyM18_2113 putative PTS system, enzyme IIB K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D spyM18_1331 putative PTS system IIC component K02761 celB; cellobiose PTS system EIIC component D spyM18_2111 putative PTS system, enzyme IIC component K02761 celB; cellobiose PTS system EIIC component D spyM18_0642 putative beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86] D spyM18_1338 bglA; putative beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86] D spyM18_1311 glgP; putative glycogen phosphorylase K00688 PYG; glycogen phosphorylase [EC:2.4.1.1] D spyM18_1312 malQ; putative 4-alpha-glucanotransferase K00705 malQ; 4-alpha-glucanotransferase [EC:2.4.1.25] D spyM18_2050 ptsG; putative PTS system, enzyme II, A component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208] D spyM18_2049 hypothetical protein K06896 mapP; maltose 6'-phosphate phosphatase [EC:3.1.3.90] D spyM18_2155 putative PTS system enzyme II K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201] D spyM18_2154 putative dextran glucosidase K01226 treC; trehalose-6-phosphate hydrolase [EC:3.2.1.93] D spyM18_1176 putative phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D spyM18_1546 glucose kinase K25026 glk; glucokinase [EC:2.7.1.2] D spyM18_0204 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D spyM18_1877 putative fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4] C 00520 Amino sugar and nucleotide sugar metabolism [PATH:spm00520] D spyM18_1705 nagA; putative N-acetylglucosamine-6-phosphate deacetylase K01443 nagA; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25] D spyM18_1407 nagB; putative N-acetylglucosamine-6-phosphate isomerase K02564 nagB; glucosamine-6-phosphate deaminase [EC:3.5.99.6] D spyM18_1877 putative fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4] D spyM18_1228 glmS; putative L-glutamine-D-fructose-6-phosphate amidotransferase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] D spyM18_1020 putative phospho-sugar mutase K03431 glmM; phosphoglucosamine mutase [EC:5.4.2.10] D spyM18_0486 glmU; putative UDP-N-acetylglucosamine pyrophosphorylase K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157] D spyM18_1371 murA; putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D spyM18_0821 murA; putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D spyM18_1063 murB; putative UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] D spyM18_0233 putative N-acetylmannosamine-6-P K01788 nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9] D spyM18_0240 putative acylneuraminate lyase K01639 E4.1.3.3; N-acetylneuraminate lyase [EC:4.1.3.3] D spyM18_1546 glucose kinase K25026 glk; glucokinase [EC:2.7.1.2] D spyM18_1176 putative phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D spyM18_2240 hasC; UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D spyM18_0210 hasC2; putative UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D spyM18_2237 hasB; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D spyM18_0608 putative nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D spyM18_1034 hypothetical protein K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191] D spyM18_1810 mannose-specific phosphotransferase system component IIAB K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191] D spyM18_1036 putative phosphotransferase system (PTS), enzyme II, component C K02795 manY; mannose PTS system EIIC component D spyM18_1811 putative mannose-specific phosphotransferase system component II K02795 manY; mannose PTS system EIIC component D spyM18_1812 putative mannose-specific phosphotransferase system component IID K02796 manZ; mannose PTS system EIID component D spyM18_1037 putative phospotransferase system (PTS), enzyme II component D K02796 manZ; mannose PTS system EIID component D spyM18_0204 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D spyM18_1876 manA; putative mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8] D spyM18_1521 putative phosphomannomutase K01840 manB; phosphomannomutase [EC:5.4.2.8] C 00620 Pyruvate metabolism [PATH:spm00620] D spyM18_1009 acoA; putative acetoin dehydrogenase (TPP-dependent) alpha chain K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D spyM18_1010 acoB; putative acetoin dehydrogenase (TPP-dependent) beta chain K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D spyM18_1011 acoC; putative dihydrolipoamide S-acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] D spyM18_1013 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D spyM18_1912 pfl; putative pyruvate formate-lyase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54] D spyM18_0043 adhE; putative Adh2 K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] D spyM18_0045 adhP; putative alcohol dehydrogenase I K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] D spyM18_0111 acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1] D spyM18_1089 pta; putative phosphotransacetylase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8] D spyM18_1230 pyk; putative pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] D spyM18_1815 accA; putative acetyl-CoA carboxylase alpha subunit K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] D spyM18_1819 accB; putative biotoin carboxyl carrier protein K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein D spyM18_1817 accC; putative acetyl-CoA carboxylase biotin carboxylase subunit K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14] D spyM18_1816 accD; putative acetyl-CoA carboxylase beta subunit K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15] D spyM18_0405 putative acylphosphatase K01512 acyP; acylphosphatase [EC:3.6.1.7] D spyM18_1111 ldh; putative L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D spyM18_0569 putative lactoylglutathione lyase K01759 GLO1; lactoylglutathione lyase [EC:4.4.1.5] D spyM18_0708 conserved hypothetical protein K01069 gloB; hydroxyacylglutathione hydrolase [EC:3.1.2.6] D spyM18_1072 putative malic enzyme ((S)-malate:NAD+ oxidoreductase (decarboxylating)) K00027 ME2; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38] D spyM18_1126 putative transcarboxylase subunit K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2] D spyM18_1142 oadA; putative oxaloacetate decarboxylase alpha chain K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2] D spyM18_1129 putative methylmalonyl-CoA decarboxylase, beta-subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D spyM18_1135 putative decarboxylase, beta subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D spyM18_1127 hypothetical protein K01573 oadG; oxaloacetate decarboxylase (Na+ extruding) subunit gamma D spyM18_0675 pepC; putative phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31] D spyM18_0136 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1645 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0590 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] C 00630 Glyoxylate and dicarboxylate metabolism [PATH:spm00630] D spyM18_0136 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1645 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0590 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1942 glnA; putative glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D spyM18_1105 glyA; putative serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D spyM18_1013 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D spyM18_1973 conserved hypothetical protein K00865 glxK; glycerate 2-kinase [EC:2.7.1.165] D spyM18_0702 alkH; putative 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] C 00640 Propanoate metabolism [PATH:spm00640] D spyM18_0111 acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1] D spyM18_1089 pta; putative phosphotransacetylase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8] D spyM18_1013 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D spyM18_1912 pfl; putative pyruvate formate-lyase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54] D spyM18_1815 accA; putative acetyl-CoA carboxylase alpha subunit K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] D spyM18_1819 accB; putative biotoin carboxyl carrier protein K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein D spyM18_1817 accC; putative acetyl-CoA carboxylase biotin carboxylase subunit K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14] D spyM18_1816 accD; putative acetyl-CoA carboxylase beta subunit K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15] D spyM18_1111 ldh; putative L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D spyM18_2108 gldA; putative glycerol dehydrogenase K00005 gldA; glycerol dehydrogenase [EC:1.1.1.6] C 00650 Butanoate metabolism [PATH:spm00650] D spyM18_0136 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1645 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0590 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1646 atoD; putative Acetyl-CoA:acetoacetyl-CoA transferase A subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D spyM18_0137 putative acetyl-CoA:acetoacetyl-CoA transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D spyM18_0138 butyrate-acetoacetate CoA-transferase, beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D spyM18_1647 atoA; putative Acetyl-CoA:acetoacetyl-CoA transferase b subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D spyM18_0043 adhE; putative Adh2 K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] D spyM18_1129 putative methylmalonyl-CoA decarboxylase, beta-subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D spyM18_1135 putative decarboxylase, beta subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D spyM18_1128 putative methylmalonyl-CoA decarboxylase, gamma-subunit K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D spyM18_1134 putative decarboxylase, gamma chain K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D spyM18_1041 putative succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] D spyM18_1912 pfl; putative pyruvate formate-lyase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54] D spyM18_0942 mvaS2; HMG-CoA synthase K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] D spyM18_1649 putative oxidoreductase K00019 BDH1; 3-hydroxybutyrate dehydrogenase [EC:1.1.1.30] D spyM18_1073 putative zinc-containing alcohol dehydrogenase K18369 adh2; alcohol dehydrogenase [EC:1.1.1.-] D spyM18_0709 putative acetoin reductase K03366 butA; meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.- 1.1.1.76 1.1.1.304] C 00660 C5-Branched dibasic acid metabolism C 00562 Inositol phosphate metabolism [PATH:spm00562] D spyM18_1196 putative myo-inositol-1(or 4)-monophosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25] D spyM18_0484 conserved hypothetical protein K22230 iolU; scyllo-inositol 2-dehydrogenase (NADP+) [EC:1.1.1.-] D spyM18_0680 tpiA; putative triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] B B 09102 Energy metabolism C 00190 Oxidative phosphorylation [PATH:spm00190] D spyM18_0816 atpA; putative proton-translocating ATPase, alpha subunit K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1] D spyM18_0818 atpD; putative proton-translocating ATPase, beta subunit K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1] D spyM18_0817 atpG; putative proton-translocating ATPase, gamma subunit K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma D spyM18_0815 atpH; putative proton-translocating ATPase, delta subunit K02113 ATPF1D; F-type H+-transporting ATPase subunit delta D spyM18_0819 atpE; putative proton-translocating ATPase, epsiron subunit K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon D spyM18_0813 atpB; putative proton-translocating ATPase a subunit K02108 ATPF0A; F-type H+-transporting ATPase subunit a D spyM18_0814 atpF; putative proton-translocating ATPase, subunit b K02109 ATPF0B; F-type H+-transporting ATPase subunit b D spyM18_0812 atpL7; H+-transporting ATP synthase chain C K02110 ATPF0C; F-type H+-transporting ATPase subunit c D spyM18_0150 putative V-type Na+ -ATPase alpha subunit K02117 ATPVA; V/A-type H+/Na+-transporting ATPase subunit A [EC:7.1.2.2 7.2.2.1] D spyM18_0151 putative V-type Na+ -ATPase subunit B K02118 ATPVB; V/A-type H+/Na+-transporting ATPase subunit B D spyM18_0147 putative V-type Na+ -ATPase subunit C K02119 ATPVC; V/A-type H+/Na+-transporting ATPase subunit C D spyM18_0153 putative V-type Na+ -ATPase subunit D K02120 ATPVD; V/A-type H+/Na+-transporting ATPase subunit D D spyM18_0146 putative V-type Na+ -ATPase subunit E K02121 ATPVE; V/A-type H+/Na+-transporting ATPase subunit E D spyM18_0148 putative V-type Na+ ATP synthase subunit G K02122 ATPVF; V/A-type H+/Na+-transporting ATPase subunit F D spyM18_0143 hypothetical protein K02107 ATPVG; V/A-type H+/Na+-transporting ATPase subunit G/H D spyM18_0144 V-type Na+ -ATPase subunit I K02123 ATPVI; V/A-type H+/Na+-transporting ATPase subunit I D spyM18_0145 V-type Na+ -ATPase subunit K K02124 ATPVK; V/A-type H+/Na+-transporting ATPase subunit K D spyM18_0434 putative manganese-dependent inorganic pyrophosphatase K15986 ppaC; manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1] C 00195 Photosynthesis C 00196 Photosynthesis - antenna proteins C 00710 Carbon fixation in photosynthetic organisms C 00720 Carbon fixation pathways in prokaryotes C 00680 Methane metabolism [PATH:spm00680] D spyM18_1105 glyA; putative serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D spyM18_0798 eno; putative enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D spyM18_0675 pepC; putative phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31] D spyM18_1954 putative fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D spyM18_1231 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D spyM18_0111 acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1] D spyM18_1089 pta; putative phosphotransacetylase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8] D spyM18_1439 putative phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] D spyM18_0602 conserved hypothetical protein K12234 cofE; coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase [EC:6.3.2.31 6.3.2.34] C 00910 Nitrogen metabolism [PATH:spm00910] D spyM18_1942 glnA; putative glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D spyM18_1558 putative carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2] D spyM18_0221 conserved hypothetical protein K01673 cynT; carbonic anhydrase [EC:4.2.1.1] C 00920 Sulfur metabolism [PATH:spm00920] D spyM18_0787 conserved hypothetical protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3] D spyM18_2012 putative serine acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] D spyM18_1627 cysK; putative O-acetylserine lyase K01738 cysK; cysteine synthase [EC:2.5.1.47] B B 09103 Lipid metabolism C 00061 Fatty acid biosynthesis [PATH:spm00061] D spyM18_1815 accA; putative acetyl-CoA carboxylase alpha subunit K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] D spyM18_1819 accB; putative biotoin carboxyl carrier protein K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein D spyM18_1817 accC; putative acetyl-CoA carboxylase biotin carboxylase subunit K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14] D spyM18_1816 accD; putative acetyl-CoA carboxylase beta subunit K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15] D spyM18_1825 putative acyl carrier protein K02078 acpP; acyl carrier protein D spyM18_0024 acp; putative acyl carrier protein K02078 acpP; acyl carrier protein D spyM18_1822 putative malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] D spyM18_1826 putative beta-ketoacyl-[ACP] synthase III K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] D spyM18_1820 putative beta-ketoacyl-ACP synthase II K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D spyM18_1821 putative beta-ketoacyl-ACP reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D spyM18_0483 putative dehydrogenease / oxidoreductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D spyM18_1818 putative beta-hydroxyacyl-ACP dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] D spyM18_1823 putative trans-2-enoyl-ACP reductase II K02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9] D spyM18_1829 putative enoyl CoA hydratase K18474 fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14] D spyM18_0592 hypothetical protein K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] C 00062 Fatty acid elongation C 00071 Fatty acid degradation [PATH:spm00071] D spyM18_0136 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1645 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0590 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0592 hypothetical protein K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D spyM18_0043 adhE; putative Adh2 K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] D spyM18_0045 adhP; putative alcohol dehydrogenase I K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] C 00073 Cutin, suberine and wax biosynthesis C 00100 Steroid biosynthesis C 00120 Primary bile acid biosynthesis C 00121 Secondary bile acid biosynthesis C 00140 Steroid hormone biosynthesis C 00561 Glycerolipid metabolism [PATH:spm00561] D spyM18_1973 conserved hypothetical protein K00865 glxK; glycerate 2-kinase [EC:2.7.1.165] D spyM18_0585 putative dihydroxyacetone kinase K05878 dhaK; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaK [EC:2.7.1.121] D spyM18_0586 putative dihydroxyacetone kinase K05879 dhaL; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaL [EC:2.7.1.121] D spyM18_0587 conserved hypothetical protein K05881 dhaM; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaM [EC:2.7.1.121] D spyM18_2108 gldA; putative glycerol dehydrogenase K00005 gldA; glycerol dehydrogenase [EC:1.1.1.6] D spyM18_1696 glpK; putative glycerol kinase K00864 glpK; glycerol kinase [EC:2.7.1.30] D spyM18_0023 putative fatty acid/phospholipid synthesis protein K03621 plsX; phosphate acyltransferase [EC:2.3.1.274] D spyM18_0966 conserved hypothetical protein K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] D spyM18_1418 putative 1-acylglycerol-3-phosphate O-acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] D spyM18_0811 conserved hypothetical protein K07029 dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107] D spyM18_0575 putative glucosyl transferase K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337] D spyM18_0574 putative sugar transferase K13677 dgs; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-glucosyltransferase [EC:2.4.1.208] D spyM18_0869 conserved hypothetical protein K19005 ltaS; lipoteichoic acid synthase [EC:2.7.8.20] C 00564 Glycerophospholipid metabolism [PATH:spm00564] D spyM18_0212 gpdA; putative NAD(P)H-dependent glycerol-3-phosphate dehydrogenase K00057 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94] D spyM18_1695 glpA; putative alpha-glycerophosphate oxidase K00105 E1.1.3.21; alpha-glycerophosphate oxidase [EC:1.1.3.21] D spyM18_0966 conserved hypothetical protein K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] D spyM18_1418 putative 1-acylglycerol-3-phosphate O-acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] D spyM18_0811 conserved hypothetical protein K07029 dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107] D spyM18_0899 putative glycerophosphodiester phosphodiesterase K01126 E3.1.4.46; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46] D spyM18_2032 cdsA; putative phosphatidate cytidylyltransferase K00981 E2.7.7.41; phosphatidate cytidylyltransferase [EC:2.7.7.41] D spyM18_2231 phosphatidylglycerophosphate synthase K00995 pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5] D spyM18_1902 conserved hypothetical protein K01096 pgpB; phosphatidylglycerophosphatase B [EC:3.1.3.27 3.6.1.75 3.1.3.4 3.6.1.27] D spyM18_1164 cls; putative cardiolipin synthetase K06131 clsA_B; cardiolipin synthase A/B [EC:2.7.8.-] C 00565 Ether lipid metabolism C 00600 Sphingolipid metabolism D spyM18_1594 putative beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] C 00590 Arachidonic acid metabolism C 00591 Linoleic acid metabolism C 00592 alpha-Linolenic acid metabolism C 01040 Biosynthesis of unsaturated fatty acids B B 09104 Nucleotide metabolism C 00230 Purine metabolism [PATH:spm00230] D spyM18_0487 conserved hypothetical protein K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-] D spyM18_0951 deoB; putative phosphopentomutase K01839 deoB; phosphopentomutase [EC:5.4.2.7] D spyM18_1176 putative phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D spyM18_0021 prsA; putative ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] D spyM18_1084 prsA; putative phosphoribosyl pyrophosphate synthetase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] D spyM18_0027 purF; putative phosphoribosylpyrophosphate amidotransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14] D spyM18_0032 purD; phosphoribosylamine-glycine ligase K01945 purD; phosphoribosylamine---glycine ligase [EC:6.3.4.13] D spyM18_0029 purN; Phosphoribosylglycinamide formyltransferase K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] D spyM18_0026 purL; putative phosphoribosylformylglycinamidine synthase II K01952 PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3] D spyM18_0028 purM; putative phosphoribosylformylglycinamide cyclo-ligase K01933 purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1] D spyM18_0034 purK; phosphoribosylaminoimidazole carboxylase II K01589 purK; 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18] D spyM18_0033 purE; putative phosphoribosylaminoimidazole carboxylase I K01588 purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18] D spyM18_0025 purC; putative phosphoribosylaminoimidazole - succinocarboxamide synthase K01923 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6] D spyM18_0037 purB; adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2] D spyM18_0030 purH; putative phosphoribosyl carboxyamide aminoimidazole transformylase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] D spyM18_0984 apt; putative adenine phosphoribosyltransferase K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7] D spyM18_0933 putative secreted 5'-nucleotidase K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5] D spyM18_0953 pnp; putative purine nucleoside phosphorylase K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1] D spyM18_0955 deoD; putative purine nucleoside phosphorylase K03784 deoD; purine-nucleoside phosphorylase [EC:2.4.2.1] D spyM18_0013 hpt; putative hypoxanthine-guanine phosphoribosyltransferase K00760 hprT; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8] D spyM18_2244 impd; inosine monophosphate dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205] D spyM18_0924 hypothetical protein K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6] D spyM18_0412 hypothetical protein K01519 rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66] D spyM18_1096 xpt; putative xanthine phosphoribosyltransferase K03816 xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22] D spyM18_1155 guaA; putative GMP synthase K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] D spyM18_1095 putative GMP reductase K00364 guaC; GMP reductase [EC:1.7.1.7] D spyM18_1642 gmk; putative guanylate kinase K00942 gmk; guanylate kinase [EC:2.7.4.8] D spyM18_1387 nrdE; putative ribonucleotide reductase alpha-chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D spyM18_0472 ribonucleoside-diphosphate reductase, large chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D spyM18_1389 nrdF; ribonucleotide diphosphate reductase small subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D spyM18_0470 nrdF; putative ribonucleotide reductase 2 K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D spyM18_2168 nrdD; putative anaerobic ribonucleoside-triphosphate reductase K21636 nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6] D spyM18_2045 (p)ppGpp synthetase K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2] D spyM18_1086 putative GTP pyrophosphokinase K07816 E2.7.6.5; GTP pyrophosphokinase [EC:2.7.6.5] D spyM18_0934 conserved hypothetical protein K07816 E2.7.6.5; GTP pyrophosphokinase [EC:2.7.6.5] D spyM18_0156 putative adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4] D spyM18_0074 adk; adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3] D spyM18_1558 putative carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2] C 00240 Pyrimidine metabolism [PATH:spm00240] D spyM18_0895 carB; putative carbamoylphosphate synthetase K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] D spyM18_0893 carA; putative carbamoyl phosphate synthetase small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] D spyM18_0892 pyrB; putative aspartate transcarbamoylase K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] D spyM18_0965 pyrC; putative dihydroorotase K01465 URA4; dihydroorotase [EC:3.5.2.3] D spyM18_1441 putative dihydroorotate dehydrogenase K00226 pyrD; dihydroorotate dehydrogenase (fumarate) [EC:1.3.98.1] D spyM18_0960 pyrE; putative orotate phosphoribosyltransferase K00762 pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10] D spyM18_0959 pyrF; putative orotidine-5'-decarboxylase K01591 pyrF; orotidine-5'-phosphate decarboxylase [EC:4.1.1.23] D spyM18_0505 pyrH; putative uridylate kinase K09903 pyrH; uridylate kinase [EC:2.7.4.22] D spyM18_0924 hypothetical protein K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6] D spyM18_1959 pyrG; putative CTP synthetase K01937 pyrG; CTP synthase [EC:6.3.4.2] D spyM18_0865 cmk; putative cytidylate kinase K00945 cmk; CMP/dCMP kinase [EC:2.7.4.25] D spyM18_1380 udk; putative uridine kinase K00876 udk; uridine kinase [EC:2.7.1.48] D spyM18_0933 putative secreted 5'-nucleotidase K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5] D spyM18_1933 udp; putative uridine phosphorylase K00757 udp; uridine phosphorylase [EC:2.4.2.3] D spyM18_0443 upp; putative uracil phosphoribosyltransferase K00761 upp; uracil phosphoribosyltransferase [EC:2.4.2.9] D spyM18_0890 pyrR; putative pyrimidine regulatory protein K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9] D spyM18_1181 cdd; putative cytidine deaminase K01489 cdd; cytidine deaminase [EC:3.5.4.5] D spyM18_2168 nrdD; putative anaerobic ribonucleoside-triphosphate reductase K21636 nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6] D spyM18_1387 nrdE; putative ribonucleotide reductase alpha-chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D spyM18_0472 ribonucleoside-diphosphate reductase, large chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D spyM18_1389 nrdF; ribonucleotide diphosphate reductase small subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D spyM18_0470 nrdF; putative ribonucleotide reductase 2 K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D spyM18_1888 putative late competence protein K01493 comEB; dCMP deaminase [EC:3.5.4.12] D spyM18_0449 tdk; putative thymidylate kinase K00943 tmk; dTMP kinase [EC:2.7.4.9] D spyM18_0219 dut; putative dUTPase, phage associated K01520 dut; dUTP diphosphatase [EC:3.6.1.23] D spyM18_1100 tdk; putative thymidine kinase K00857 tdk; thymidine kinase [EC:2.7.1.21] D spyM18_0943 thyA; putative thymidylate synthase K00560 thyA; thymidylate synthase [EC:2.1.1.45] D spyM18_1090 putative short chain dehydrogenase/reductase K16066 ydfG; 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-] B B 09105 Amino acid metabolism C 00250 Alanine, aspartate and glutamate metabolism [PATH:spm00250] D spyM18_1853 putative L-asparaginase K01424 E3.5.1.1; L-asparaginase [EC:3.5.1.1] D spyM18_1556 putative asparagine synthetase A K01914 asnA; aspartate--ammonia ligase [EC:6.3.1.1] D spyM18_0711 aspC; putative aspartate aminotransferase K22457 E2.6.1.14; asparagine---oxo-acid transaminase [EC:2.6.1.14] D spyM18_1849 putative aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] D spyM18_0156 putative adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4] D spyM18_0037 purB; adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2] D spyM18_0892 pyrB; putative aspartate transcarbamoylase K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] D spyM18_1041 putative succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] D spyM18_1942 glnA; putative glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D spyM18_0895 carB; putative carbamoylphosphate synthetase K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] D spyM18_0893 carA; putative carbamoyl phosphate synthetase small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] D spyM18_1228 glmS; putative L-glutamine-D-fructose-6-phosphate amidotransferase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] D spyM18_0027 purF; putative phosphoribosylpyrophosphate amidotransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14] C 00260 Glycine, serine and threonine metabolism [PATH:spm00260] D spyM18_1105 glyA; putative serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D spyM18_1973 conserved hypothetical protein K00865 glxK; glycerate 2-kinase [EC:2.7.1.165] D spyM18_1439 putative phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] D spyM18_1090 putative short chain dehydrogenase/reductase K16066 ydfG; 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-] D spyM18_1013 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D spyM18_2224 putative L-serine dehydratase beta subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17] D spyM18_2225 putative L-serine dehydratase alpha subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17] C 00270 Cysteine and methionine metabolism [PATH:spm00270] D spyM18_2012 putative serine acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] D spyM18_1627 cysK; putative O-acetylserine lyase K01738 cysK; cysteine synthase [EC:2.5.1.47] D spyM18_0170 putative cystathionine beta-lyase K01760 metC; cysteine-S-conjugate beta-lyase [EC:4.4.1.13] D spyM18_1372 metK; S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D spyM18_0604 putative S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D spyM18_0490 pfs; putative MTA/SAH nucleosidase K01243 mtnN; adenosylhomocysteine nucleosidase [EC:3.2.2.9] D spyM18_1377 conserved hypothetical protein K08968 msrC; L-methionine (R)-S-oxide reductase [EC:1.8.4.14] D spyM18_1653 luxS; LuxS K07173 luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21] D spyM18_0969 ilvE; putative branched-chain-amino-acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D spyM18_1111 ldh; putative L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D spyM18_2224 putative L-serine dehydratase beta subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17] D spyM18_2225 putative L-serine dehydratase alpha subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17] C 00280 Valine, leucine and isoleucine degradation [PATH:spm00280] D spyM18_0969 ilvE; putative branched-chain-amino-acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D spyM18_1013 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D spyM18_0136 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1645 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0590 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0942 mvaS2; HMG-CoA synthase K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] C 00290 Valine, leucine and isoleucine biosynthesis [PATH:spm00290] D spyM18_0969 ilvE; putative branched-chain-amino-acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D spyM18_1849 putative aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] C 00300 Lysine biosynthesis D spyM18_1429 putative D-Ala-D-Ala adding enzyme K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10] C 00310 Lysine degradation [PATH:spm00310] D spyM18_1013 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D spyM18_0136 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1645 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0590 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1041 putative succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] D spyM18_1646 atoD; putative Acetyl-CoA:acetoacetyl-CoA transferase A subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D spyM18_0137 putative acetyl-CoA:acetoacetyl-CoA transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D spyM18_0138 butyrate-acetoacetate CoA-transferase, beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D spyM18_1647 atoA; putative Acetyl-CoA:acetoacetyl-CoA transferase b subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] C 00220 Arginine biosynthesis [PATH:spm00220] D spyM18_1562 arcB; putative ornithine carbamoyltransferase K00611 OTC; ornithine carbamoyltransferase [EC:2.1.3.3] D spyM18_1564 arcA; arginine deiminase K01478 arcA; arginine deiminase [EC:3.5.3.6] D spyM18_1942 glnA; putative glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D spyM18_1558 putative carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2] D spyM18_1849 putative aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] C 00330 Arginine and proline metabolism [PATH:spm00330] D spyM18_0961 amiC; putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] D spyM18_2055 putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] D spyM18_0113 putative pyrroline carboxylate reductase K00286 proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2] D spyM18_1681 proB; putative gamma-glutamyl kinase K00931 proB; glutamate 5-kinase [EC:2.7.2.11] D spyM18_1679 proA; putative gamma-glutamyl phosphate reductase K00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] C 00340 Histidine metabolism [PATH:spm00340] D spyM18_2147 putative histidine ammonia-lyase K01745 hutH; histidine ammonia-lyase [EC:4.3.1.3] D spyM18_2141 hutU; putative urocanate hydratase K01712 hutU; urocanate hydratase [EC:4.2.1.49] D spyM18_2139 hutI; putative imidazolonepropionase K01468 hutI; imidazolonepropionase [EC:3.5.2.7] D spyM18_2148 putative formiminoglutamate hydrolase K01479 hutG; formiminoglutamase [EC:3.5.3.8] D spyM18_2142 putative formiminotransferase cyclodeaminase K00603 fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2] C 00350 Tyrosine metabolism [PATH:spm00350] D spyM18_0043 adhE; putative Adh2 K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] D spyM18_0045 adhP; putative alcohol dehydrogenase I K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] D spyM18_1041 putative succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] C 00360 Phenylalanine metabolism D spyM18_0961 amiC; putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] D spyM18_2055 putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] C 00380 Tryptophan metabolism [PATH:spm00380] D spyM18_1013 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D spyM18_0136 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1645 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0590 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0961 amiC; putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] D spyM18_2055 putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] C 00400 Phenylalanine, tyrosine and tryptophan biosynthesis [PATH:spm00400] D spyM18_1585 aroA; putative chorismate mutase K03856 AROA2; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54] D spyM18_1586 aroB; putative 3-dehydroquinate synthase K01735 aroB; 3-dehydroquinate synthase [EC:4.2.3.4] D spyM18_0871 aroD; putative 3-dehydroquinate dehydratase K03785 aroD; 3-dehydroquinate dehydratase I [EC:4.2.1.10] D spyM18_0600 aroD; putative shikimate 5-dehydrogenase K00014 aroE; shikimate dehydrogenase [EC:1.1.1.25] D spyM18_1363 aroK; putative shikimate kinase K00891 aroK; shikimate kinase [EC:2.7.1.71] D spyM18_1364 aroA; putative 3-phosphoshikimate 1-carboxyvinyltransferase K00800 aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19] D spyM18_0872 aroC; putative chorismate synthase K01736 aroC; chorismate synthase [EC:4.2.3.5] D spyM18_2057 anthranilate synthase component II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27] D spyM18_0789 cm; conserved hypothetical protein K04516 AROA1; chorismate mutase [EC:5.4.99.5] B B 09106 Metabolism of other amino acids C 00410 beta-Alanine metabolism C 00430 Taurine and hypotaurine metabolism [PATH:spm00430] D spyM18_1089 pta; putative phosphotransacetylase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8] D spyM18_0111 acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1] C 00440 Phosphonate and phosphinate metabolism C 00450 Selenocompound metabolism [PATH:spm00450] D spyM18_0170 putative cystathionine beta-lyase K01760 metC; cysteine-S-conjugate beta-lyase [EC:4.4.1.13] D spyM18_0276 putative aminotransferase K11717 sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16] D spyM18_1666 trxB; thioredoxin reductase K00384 trxB; thioredoxin reductase (NADPH) [EC:1.8.1.9] D spyM18_0468 metS; putative methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] C 00460 Cyanoamino acid metabolism [PATH:spm00460] D spyM18_1605 putative beta-glucosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] D spyM18_1853 putative L-asparaginase K01424 E3.5.1.1; L-asparaginase [EC:3.5.1.1] D spyM18_1556 putative asparagine synthetase A K01914 asnA; aspartate--ammonia ligase [EC:6.3.1.1] D spyM18_1105 glyA; putative serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] C 00470 D-Amino acid metabolism [PATH:spm00470] D spyM18_1871 putative alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1] D spyM18_1431 putative D-ala,D-ala ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D spyM18_1324 dltA; putative D-alanine-D-alanyl carrier protein ligase K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D spyM18_1322 putative D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D spyM18_0411 putative glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3] D spyM18_1542 murD; putative UDP-N-acetylmuramoylalanine-D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] C 00480 Glutathione metabolism [PATH:spm00480] D spyM18_1188 pepN; putative lysyl-aminopeptidase K01256 pepN; aminopeptidase N [EC:3.4.11.2] D spyM18_0974 hypothetical protein K00799 GST; glutathione S-transferase [EC:2.5.1.18] D spyM18_0875 gshR; putative glutathione reductase K00383 GSR; glutathione reductase (NADPH) [EC:1.8.1.7] D spyM18_0672 bsaA; putative glutathione peroxidase K00432 gpx; glutathione peroxidase [EC:1.11.1.9] B B 09107 Glycan biosynthesis and metabolism C 00510 N-Glycan biosynthesis C 00513 Various types of N-glycan biosynthesis C 00512 Mucin type O-glycan biosynthesis C 00515 Mannose type O-glycan biosynthesis C 00514 Other types of O-glycan biosynthesis C 00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate C 00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin C 00533 Glycosaminoglycan biosynthesis - keratan sulfate C 00531 Glycosaminoglycan degradation C 00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis C 00601 Glycosphingolipid biosynthesis - lacto and neolacto series C 00603 Glycosphingolipid biosynthesis - globo and isoglobo series C 00604 Glycosphingolipid biosynthesis - ganglio series C 00511 Other glycan degradation [PATH:spm00511] D spyM18_1594 putative beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D spyM18_1611 conserved hypothetical protein K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24] C 00540 Lipopolysaccharide biosynthesis C 00542 O-Antigen repeat unit biosynthesis [PATH:spm00542] D spyM18_0270 rgpG; putative regulator of genetic competence K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] C 00541 O-Antigen nucleotide sugar biosynthesis [PATH:spm00541] D spyM18_2240 hasC; UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D spyM18_0210 hasC2; putative UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D spyM18_2237 hasB; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D spyM18_0608 putative nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D spyM18_0990 cpsFO; glucose-1-phosphate thymidyl transferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D spyM18_0993 cpsFQ; putative dTDP-glucose-4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D spyM18_0992 cpsFP; putative dTDP-4-keto-6-deoxyglucose-3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] D spyM18_0843 putative dTDP-4-keto-L-rhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] D spyM18_1876 manA; putative mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8] D spyM18_1521 putative phosphomannomutase K01840 manB; phosphomannomutase [EC:5.4.2.8] D spyM18_0486 glmU; putative UDP-N-acetylglucosamine pyrophosphorylase K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157] C 00550 Peptidoglycan biosynthesis [PATH:spm00550] D spyM18_1371 murA; putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D spyM18_0821 murA; putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D spyM18_1063 murB; putative UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] D spyM18_0398 putative UDP-N-acetyl muramate-alanine ligase K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8] D spyM18_1542 murD; putative UDP-N-acetylmuramoylalanine-D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] D spyM18_1431 putative D-ala,D-ala ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D spyM18_1429 putative D-Ala-D-Ala adding enzyme K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10] D spyM18_0516 putative diacylglycerol kinase K00887 dgkA; undecaprenol kinase [EC:2.7.1.66] D spyM18_2033 uppS; putative undecaprenyl pyrophosphate synthetase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] D spyM18_0268 putative undecaprenol kinase K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] D spyM18_0428 conserved hypothetical protein K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] D spyM18_1673 putative undecaprenyl-phosphate-UDP-MurNAc-pentapeptide phospho-MurNAc-pentapeptide transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] D spyM18_1541 murG; putative undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] D spyM18_1661 putative penicillin-binding protein 1a K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D spyM18_2120 penicillin-binding protein 2a K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4] D spyM18_1051 putative D,D-carboxypeptidase, penicillin-binding protein K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D spyM18_0280 dacA; putative penicillin-binding protein K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D spyM18_1835 putative D,D-carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D spyM18_0440 murE; putative UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate ligase K05362 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7] D spyM18_1017 putative UDP-N-acetylmuramyl tripeptide synthetase K23393 murT; lipid II isoglutaminyl synthase (glutamine-hydrolysing) [EC:6.3.5.13] D spyM18_1016 hypothetical protein K07009 gatD; lipid II isoglutaminyl synthase (glutamine-hydrolysing) [EC:6.3.5.13] D spyM18_1156 putative antimicrobial resistance factor K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10] D spyM18_0683 femB; putative peptidoglycan branched peptide synthesis protein, serine/alanine adding enzyme K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10] D spyM18_0682 femA; putative peptidoglycan branched peptide synthesis protein alanine adding enzyme K12554 murN; alanine adding enzyme [EC:2.3.2.-] D spyM18_0098 pbp; putative penicillin-binding protein 1b K03693 pbp1b; penicillin-binding protein 1B D spyM18_1674 putative penicillin binding protein K12556 pbp2X; penicillin-binding protein 2X C 00552 Teichoic acid biosynthesis [PATH:spm00552] D spyM18_0268 putative undecaprenol kinase K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] D spyM18_0428 conserved hypothetical protein K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] D spyM18_0270 rgpG; putative regulator of genetic competence K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D spyM18_1324 dltA; putative D-alanine-D-alanyl carrier protein ligase K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D spyM18_1322 putative D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D spyM18_1323 putative integral membrane protein K03739 dltB; membrane protein involved in D-alanine export D spyM18_1321 putative extramembranal protein K03740 dltD; D-alanine transfer protein D spyM18_1741 putative transcription regulator K01005 tagT_U_V; polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase [EC:2.7.8.-] D spyM18_1362 putative PBP 5 synthesis repressor K01005 tagT_U_V; polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase [EC:2.7.8.-] D spyM18_0869 conserved hypothetical protein K19005 ltaS; lipoteichoic acid synthase [EC:2.7.8.20] D spyM18_0575 putative glucosyl transferase K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337] C 00571 Lipoarabinomannan (LAM) biosynthesis C 00572 Arabinogalactan biosynthesis - Mycobacterium C 00543 Exopolysaccharide biosynthesis [PATH:spm00543] D spyM18_0270 rgpG; putative regulator of genetic competence K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D spyM18_2012 putative serine acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] B B 09108 Metabolism of cofactors and vitamins C 00730 Thiamine metabolism [PATH:spm00730] D spyM18_0878 nifS; putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D spyM18_1083 nifS; putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D spyM18_0879 thiI; putative thiamine biosynthesis protein K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4] D spyM18_0247 conserved hypothetical protein K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] D spyM18_0249 conserved hypothetical protein K00949 thiN; thiamine pyrophosphokinase [EC:2.7.6.2] D spyM18_0074 adk; adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3] C 00740 Riboflavin metabolism [PATH:spm00740] D spyM18_1809 conserved hypothetical protein K21064 ycsE; 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104] D spyM18_1199 putative macrolide-efflux protein K11753 ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2] D spyM18_1074 putative acid phosphatase (class B) K03788 aphA; acid phosphatase (class B) [EC:3.1.3.2] D spyM18_0487 conserved hypothetical protein K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-] C 00750 Vitamin B6 metabolism [PATH:spm00750] D spyM18_1160 pdxK; putative pyridoxal kinase K00868 pdxK; pyridoxine kinase [EC:2.7.1.35] D spyM18_1965 thiD; putative phosphomethylpyrimidine kinase K00868 pdxK; pyridoxine kinase [EC:2.7.1.35] C 00760 Nicotinate and nicotinamide metabolism [PATH:spm00760] D spyM18_1346 putative nicotinate-nucleotide pyrophosphorylase K00767 nadC; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19] D spyM18_1664 putative nicotinate phosphoribosyltransferase K00763 pncB; nicotinate phosphoribosyltransferase [EC:6.3.4.21] D spyM18_0953 pnp; putative purine nucleoside phosphorylase K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1] D spyM18_0955 deoD; putative purine nucleoside phosphorylase K03784 deoD; purine-nucleoside phosphorylase [EC:2.4.2.1] D spyM18_0933 putative secreted 5'-nucleotidase K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5] D spyM18_0304 conserved hypothetical protein K00969 nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18] D spyM18_1663 nadE; putative NAD+ synthase K01916 nadE; NAD+ synthase [EC:6.3.1.5] D spyM18_0163 nga; nicotine adenine dinucleotide glycohydrolase precursor K18153 nga; NAD+ glycohydrolase [EC:3.2.2.5] D spyM18_1087 conserved hypothetical protein K00858 ppnK; NAD+ kinase [EC:2.7.1.23] D spyM18_1041 putative succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] C 00770 Pantothenate and CoA biosynthesis [PATH:spm00770] D spyM18_0911 apbA; putative 2-dehydropantoate 2-reductase K00077 panE; 2-dehydropantoate 2-reductase [EC:1.1.1.169] D spyM18_1183 coaA; putative pantothenate kinase K00867 coaA; type I pantothenate kinase [EC:2.7.1.33] D spyM18_1173 dfpB; putative flavoprotein K21977 coaB; phosphopantothenate---cysteine ligase (CTP) [EC:6.3.2.5] D spyM18_1174 dfp; putative DNA/pantothenate metabolism flavoprotein K01598 PPCDC; phosphopantothenoylcysteine decarboxylase [EC:4.1.1.36] D spyM18_1554 phosphopantetheine andenylyltransferase K00954 E2.7.7.3A; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3] D spyM18_0556 putative dephosphocoenzyme A kinase K00859 coaE; dephospho-CoA kinase [EC:2.7.1.24] D spyM18_1872 acpS; putative holo-(acyl carrier protein) synthase K00997 acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7] D spyM18_0969 ilvE; putative branched-chain-amino-acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] C 00780 Biotin metabolism [PATH:spm00780] D spyM18_1820 putative beta-ketoacyl-ACP synthase II K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D spyM18_1821 putative beta-ketoacyl-ACP reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D spyM18_0483 putative dehydrogenease / oxidoreductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D spyM18_1818 putative beta-hydroxyacyl-ACP dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] D spyM18_1374 birA; putative biotin operon repressor K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] C 00785 Lipoic acid metabolism [PATH:spm00785] D spyM18_1172 conserved hypothetical protein K16869 lipL; octanoyl-[GcvH]:protein N-octanoyltransferase [EC:2.3.1.204] D spyM18_1015 putative lipoate-protein ligase K03800 lplA; lipoate---protein ligase [EC:6.3.1.20] D spyM18_1166 lplA; putative lipoate-protein ligase K03800 lplA; lipoate---protein ligase [EC:6.3.1.20] D spyM18_1013 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D spyM18_1009 acoA; putative acetoin dehydrogenase (TPP-dependent) alpha chain K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D spyM18_1010 acoB; putative acetoin dehydrogenase (TPP-dependent) beta chain K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D spyM18_1011 acoC; putative dihydrolipoamide S-acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] C 00790 Folate biosynthesis [PATH:spm00790] D spyM18_1059 folE; GTP cyclohydrolase K01495 GCH1; GTP cyclohydrolase IA [EC:3.5.4.16] D spyM18_1061 folQ; dihydroneopterin aldolase K01633 folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81] D spyM18_1062 folK; pyrophosphokinase K00950 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3] D spyM18_1060 folP; dihyropteroate synthase K00796 folP; dihydropteroate synthase [EC:2.5.1.15] D spyM18_0944 dfr; putative dihydrofolate reductase K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3] D spyM18_1058 folC; putative folyl-polyglutamate synthetase K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] D spyM18_0876 folC; putative folyl-polyglutamate synthetase K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] D spyM18_2056 putative para-aminobenzoate synthetase K03342 pabBC; para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38] C 00670 One carbon pool by folate [PATH:spm00670] D spyM18_0944 dfr; putative dihydrofolate reductase K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3] D spyM18_1165 fhs; putative formate-tetrahydrofolate ligase K01938 fhs; formate--tetrahydrofolate ligase [EC:6.3.4.3] D spyM18_2144 putative formate-tetrahydrofolate ligase K01938 fhs; formate--tetrahydrofolate ligase [EC:6.3.4.3] D spyM18_1520 folD; putative bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase K01491 folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] D spyM18_2143 putative serine cycle enzyme K01500 fchA; methenyltetrahydrofolate cyclohydrolase [EC:3.5.4.9] D spyM18_1105 glyA; putative serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D spyM18_0029 purN; Phosphoribosylglycinamide formyltransferase K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] D spyM18_0030 purH; putative phosphoribosyl carboxyamide aminoimidazole transformylase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] D spyM18_2142 putative formiminotransferase cyclodeaminase K00603 fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2] D spyM18_1638 fmt; putative methionyl tRNA formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9] D spyM18_0943 thyA; putative thymidylate synthase K00560 thyA; thymidylate synthase [EC:2.1.1.45] C 00830 Retinol metabolism C 00860 Porphyrin metabolism C 00130 Ubiquinone and other terpenoid-quinone biosynthesis B B 09109 Metabolism of terpenoids and polyketides C 00900 Terpenoid backbone biosynthesis [PATH:spm00900] D spyM18_0136 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1645 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0590 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0942 mvaS2; HMG-CoA synthase K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] D spyM18_0941 mvaS1; HMG-CoA reductase K00054 mvaA; hydroxymethylglutaryl-CoA reductase [EC:1.1.1.88] D spyM18_0937 mvaK1; mevalonate kinase K00869 MVK; mevalonate kinase [EC:2.7.1.36] D spyM18_0939 phosphomevalonate kinase K00938 E2.7.4.2; phosphomevalonate kinase [EC:2.7.4.2] D spyM18_0938 mvd; mevalonate pyrophosphate decarboxylase K01597 MVD; diphosphomevalonate decarboxylase [EC:4.1.1.33] D spyM18_0940 conserved hypothetical protein K01823 idi; isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2] D spyM18_1516 ispA; putative geranyltranstransferase K13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29] D spyM18_2033 uppS; putative undecaprenyl pyrophosphate synthetase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] C 00902 Monoterpenoid biosynthesis C 00909 Sesquiterpenoid and triterpenoid biosynthesis C 00904 Diterpenoid biosynthesis C 00906 Carotenoid biosynthesis C 00905 Brassinosteroid biosynthesis C 00981 Insect hormone biosynthesis C 00908 Zeatin biosynthesis C 00903 Limonene degradation [PATH:spm00903] D spyM18_1320 putative esterase K14731 mlhB; epsilon-lactone hydrolase [EC:3.1.1.83] C 00907 Pinene, camphor and geraniol degradation C 01052 Type I polyketide structures C 00522 Biosynthesis of 12-, 14- and 16-membered macrolides C 01051 Biosynthesis of ansamycins D spyM18_1687 putative transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] C 01059 Biosynthesis of enediyne antibiotics C 01056 Biosynthesis of type II polyketide backbone C 01057 Biosynthesis of type II polyketide products C 00253 Tetracycline biosynthesis C 00523 Polyketide sugar unit biosynthesis [PATH:spm00523] D spyM18_0990 cpsFO; glucose-1-phosphate thymidyl transferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D spyM18_0993 cpsFQ; putative dTDP-glucose-4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D spyM18_0992 cpsFP; putative dTDP-4-keto-6-deoxyglucose-3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] D spyM18_0843 putative dTDP-4-keto-L-rhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] C 01054 Nonribosomal peptide structures C 01053 Biosynthesis of siderophore group nonribosomal peptides C 01055 Biosynthesis of vancomycin group antibiotics D spyM18_0993 cpsFQ; putative dTDP-glucose-4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] B B 09110 Biosynthesis of other secondary metabolites C 00940 Phenylpropanoid biosynthesis C 00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis C 00941 Flavonoid biosynthesis C 00944 Flavone and flavonol biosynthesis C 00942 Anthocyanin biosynthesis C 00943 Isoflavonoid biosynthesis C 00946 Degradation of flavonoids [PATH:spm00946] D spyM18_1605 putative beta-glucosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] C 00901 Indole alkaloid biosynthesis C 00403 Indole diterpene alkaloid biosynthesis C 00950 Isoquinoline alkaloid biosynthesis C 00960 Tropane, piperidine and pyridine alkaloid biosynthesis C 00996 Biosynthesis of various alkaloids C 00232 Caffeine metabolism C 00965 Betalain biosynthesis C 00966 Glucosinolate biosynthesis C 00402 Benzoxazinoid biosynthesis C 00311 Penicillin and cephalosporin biosynthesis C 00332 Carbapenem biosynthesis [PATH:spm00332] D spyM18_1681 proB; putative gamma-glutamyl kinase K00931 proB; glutamate 5-kinase [EC:2.7.2.11] D spyM18_1679 proA; putative gamma-glutamyl phosphate reductase K00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] C 00261 Monobactam biosynthesis C 00331 Clavulanic acid biosynthesis C 00521 Streptomycin biosynthesis [PATH:spm00521] D spyM18_1546 glucose kinase K25026 glk; glucokinase [EC:2.7.1.2] D spyM18_1176 putative phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D spyM18_1196 putative myo-inositol-1(or 4)-monophosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25] D spyM18_0990 cpsFO; glucose-1-phosphate thymidyl transferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D spyM18_0993 cpsFQ; putative dTDP-glucose-4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D spyM18_0992 cpsFP; putative dTDP-4-keto-6-deoxyglucose-3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] D spyM18_0843 putative dTDP-4-keto-L-rhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] C 00524 Neomycin, kanamycin and gentamicin biosynthesis D spyM18_1546 glucose kinase K25026 glk; glucokinase [EC:2.7.1.2] C 00525 Acarbose and validamycin biosynthesis [PATH:spm00525] D spyM18_0990 cpsFO; glucose-1-phosphate thymidyl transferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D spyM18_0993 cpsFQ; putative dTDP-glucose-4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] C 00401 Novobiocin biosynthesis C 00404 Staurosporine biosynthesis C 00405 Phenazine biosynthesis D spyM18_2057 anthranilate synthase component II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27] C 00333 Prodigiosin biosynthesis D spyM18_1822 putative malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] D spyM18_1821 putative beta-ketoacyl-ACP reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D spyM18_0483 putative dehydrogenease / oxidoreductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] C 00254 Aflatoxin biosynthesis C 00998 Biosynthesis of various antibiotics D spyM18_1825 putative acyl carrier protein K02078 acpP; acyl carrier protein D spyM18_0024 acp; putative acyl carrier protein K02078 acpP; acyl carrier protein C 00999 Biosynthesis of various plant secondary metabolites [PATH:spm00999] D spyM18_1372 metK; S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D spyM18_0604 putative S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D spyM18_0600 aroD; putative shikimate 5-dehydrogenase K00014 aroE; shikimate dehydrogenase [EC:1.1.1.25] D spyM18_1605 putative beta-glucosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] C 00997 Biosynthesis of various other secondary metabolites B B 09111 Xenobiotics biodegradation and metabolism C 00362 Benzoate degradation [PATH:spm00362] D spyM18_1099 putative 4-oxalocrotonate tautomerase K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6] D spyM18_1129 putative methylmalonyl-CoA decarboxylase, beta-subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D spyM18_1135 putative decarboxylase, beta subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D spyM18_1128 putative methylmalonyl-CoA decarboxylase, gamma-subunit K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D spyM18_1134 putative decarboxylase, gamma chain K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D spyM18_0136 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1645 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0590 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] C 00627 Aminobenzoate degradation [PATH:spm00627] D spyM18_0961 amiC; putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] D spyM18_2055 putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] D spyM18_0405 putative acylphosphatase K01512 acyP; acylphosphatase [EC:3.6.1.7] D spyM18_1646 atoD; putative Acetyl-CoA:acetoacetyl-CoA transferase A subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D spyM18_0137 putative acetyl-CoA:acetoacetyl-CoA transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D spyM18_0138 butyrate-acetoacetate CoA-transferase, beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D spyM18_1647 atoA; putative Acetyl-CoA:acetoacetyl-CoA transferase b subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] C 00364 Fluorobenzoate degradation C 00625 Chloroalkane and chloroalkene degradation [PATH:spm00625] D spyM18_0045 adhP; putative alcohol dehydrogenase I K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] D spyM18_0043 adhE; putative Adh2 K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] C 00361 Chlorocyclohexane and chlorobenzene degradation C 00623 Toluene degradation C 00622 Xylene degradation D spyM18_1099 putative 4-oxalocrotonate tautomerase K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6] C 00633 Nitrotoluene degradation C 00642 Ethylbenzene degradation C 00643 Styrene degradation [PATH:spm00643] D spyM18_0961 amiC; putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] D spyM18_2055 putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] C 00791 Atrazine degradation C 00930 Caprolactam degradation D spyM18_1320 putative esterase K14731 mlhB; epsilon-lactone hydrolase [EC:3.1.1.83] C 00363 Bisphenol degradation C 00621 Dioxin degradation D spyM18_1099 putative 4-oxalocrotonate tautomerase K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6] C 00626 Naphthalene degradation [PATH:spm00626] D spyM18_0045 adhP; putative alcohol dehydrogenase I K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] D spyM18_0043 adhE; putative Adh2 K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] C 00624 Polycyclic aromatic hydrocarbon degradation C 00365 Furfural degradation C 00984 Steroid degradation C 00980 Metabolism of xenobiotics by cytochrome P450 C 00982 Drug metabolism - cytochrome P450 C 00983 Drug metabolism - other enzymes B B 09112 Not included in regular maps C 09113 Global maps only # A09120 Genetic Information Processing B B 09121 Transcription C 03020 RNA polymerase [PATH:spm03020] D spyM18_0099 ropB; putative DNA-dependent RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] D spyM18_0100 ropC; RNA polymerase beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] D spyM18_0079 rpoA; DNA-directed RNA polymerase alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] D spyM18_1640 putative DNA-directed RNA polymerase omega chain K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6] D spyM18_1960 rpoE; probable DNA-directed RNA polymerase delta subunit K03048 rpoE; DNA-directed RNA polymerase subunit delta C 03022 Basal transcription factors C 03040 Spliceosome B B 09122 Translation C 03010 Ribosome [PATH:spm03010] D spyM18_0971 putative ribosomal protein S1-like DNA-binding protein K02945 RP-S1; small subunit ribosomal protein S1 D spyM18_2151 rpsB; 30S ribosomal protein S2 K02967 RP-S2; small subunit ribosomal protein S2 D spyM18_0057 rpsC; 30S ribosomal protein S3 K02982 RP-S3; small subunit ribosomal protein S3 D spyM18_2215 rpsD; 30S ribosomal protein S4 K02986 RP-S4; small subunit ribosomal protein S4 D spyM18_0069 rpsE; 30S ribosomal protein S5 K02988 RP-S5; small subunit ribosomal protein S5 D spyM18_1897 rpS6; 30S ribosomal protein S6 K02990 RP-S6; small subunit ribosomal protein S6 D spyM18_0259 rpsG; 30S ribosomal protein S7 K02992 RP-S7; small subunit ribosomal protein S7 D spyM18_0066 rpsH; 30S ribosomal protein S8 K02994 RP-S8; small subunit ribosomal protein S8 D spyM18_1999 rpS9; ribosomal protein S9 K02996 RP-S9; small subunit ribosomal protein S9 D spyM18_0049 rpsJ; 30S ribosomal protein S10 K02946 RP-S10; small subunit ribosomal protein S10 D spyM18_0078 rpsK; 30S ribosomal protein S11 K02948 RP-S11; small subunit ribosomal protein S11 D spyM18_0258 rpsL; 30S ribosomal protein S12 K02950 RP-S12; small subunit ribosomal protein S12 D spyM18_0077 rpsM; 30S ribosomal protein S13 K02952 RP-S13; small subunit ribosomal protein S13 D spyM18_1936 rs14; 30S ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14 D spyM18_0065 rpsN; 30S ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14 D spyM18_2021 rpS15; 30S ribosomal protein S15 K02956 RP-S15; small subunit ribosomal protein S15 D spyM18_0900 rpsP; 30S ribosomal protein S1 K02959 RP-S16; small subunit ribosomal protein S16 D spyM18_0061 rpsQ; 30S ribosomal protein S17 K02961 RP-S17; small subunit ribosomal protein S17 D spyM18_1895 rpsR; 30S ribosomal protein S18 K02963 RP-S18; small subunit ribosomal protein S18 D spyM18_0054 rpsS; 30S ribosomal protein S19 K02965 RP-S19; small subunit ribosomal protein S19 D spyM18_1184 rpS20; 30S ribosomal protein S20 K02968 RP-S20; small subunit ribosomal protein S20 D spyM18_0838 rpsU; 30S ribosomal protein S21 K02970 RP-S21; small subunit ribosomal protein S21 D spyM18_0504 rl1; 50S ribosomal protein L1 K02863 RP-L1; large subunit ribosomal protein L1 D spyM18_0053 rplB; 50S ribosomal protein L2 K02886 RP-L2; large subunit ribosomal protein L2 D spyM18_0050 rplC; 50S ribosomal protein L3 K02906 RP-L3; large subunit ribosomal protein L3 D spyM18_0051 rplD; 50S ribosomal protein L4 K02926 RP-L4; large subunit ribosomal protein L4 D spyM18_0064 rplE; 50S ribosomal protein L5 K02931 RP-L5; large subunit ribosomal protein L5 D spyM18_0067 rplF; 50S ribosomal protein L6 K02933 RP-L6; large subunit ribosomal protein L6 D spyM18_2218 rpL9; 50S ribosomal protein L9 K02939 RP-L9; large subunit ribosomal protein L9 D spyM18_1048 rpl10; 50S ribosomal protein L10 K02864 RP-L10; large subunit ribosomal protein L10 D spyM18_0503 rl11; 50S ribosomal protein L11 K02867 RP-L11; large subunit ribosomal protein L11 D spyM18_2000 rpL13; 50S ribosomal protein L13 K02871 RP-L13; large subunit ribosomal protein L13 D spyM18_0062 rplN; 50S ribosomal protein L14 K02874 RP-L14; large subunit ribosomal protein L14 D spyM18_0072 rplO; 50S ribosomal protein L15 K02876 RP-L15; large subunit ribosomal protein L15 D spyM18_0058 rplP; 50S ribosomal protein L16 K02878 RP-L16; large subunit ribosomal protein L16 D spyM18_0080 rplQ; 50S ribosomal protein L17 K02879 RP-L17; large subunit ribosomal protein L17 D spyM18_0068 rplR; 50S ribosomal protein L18 K02881 RP-L18; large subunit ribosomal protein L18 D spyM18_0791 rpl19; 50S ribosomal protein L19 K02884 RP-L19; large subunit ribosomal protein L19 D spyM18_0868 rl20; 50S ribosomal protein L20 K02887 RP-L20; large subunit ribosomal protein L20 D spyM18_0883 rpL21; 50S ribosomal protein L21 K02888 RP-L21; large subunit ribosomal protein L21 D spyM18_0056 rplV; 50S ribosomal protein L22 K02890 RP-L22; large subunit ribosomal protein L22 D spyM18_0052 rplW; 50S ribosomal protein L23 K02892 RP-L23; large subunit ribosomal protein L23 D spyM18_0063 rplX; 50S ribosomal protein L24 K02895 RP-L24; large subunit ribosomal protein L24 D spyM18_0885 rpl27; 50S ribosomal protein L27 K02899 RP-L27; large subunit ribosomal protein L27 D spyM18_1953 rl28; 50S ribosomal protein L28 K02902 RP-L28; large subunit ribosomal protein L28 D spyM18_0060 rpmC; 50S ribosomal protein L29 K02904 RP-L29; large subunit ribosomal protein L29 D spyM18_0071 rpmD; 50S ribosomal protein L30 K02907 RP-L30; large subunit ribosomal protein L30 D spyM18_0785 rl31; 50S ribosomal protein L31 K02909 RP-L31; large subunit ribosomal protein L31 D spyM18_2196 rpmF; 50S ribosomal protein L32 K02911 RP-L32; large subunit ribosomal protein L32 D spyM18_2197 rpmG; 50S ribosomal protein L33 K02913 RP-L33; large subunit ribosomal protein L33 D spyM18_0232 rpmH; 50S ribosomal protein L34 K02914 RP-L34; large subunit ribosomal protein L34 D spyM18_0867 rpl35; 50S ribosomal protein L35 K02916 RP-L35; large subunit ribosomal protein L35 D spyM18_0076 rpmJ; 50S ribosomal protein B K02919 RP-L36; large subunit ribosomal protein L36 D spyM18_r05 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r03 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r12 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r01 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r10 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r07 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r02 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r09 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r11 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r04 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r08 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r06 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA C 00970 Aminoacyl-tRNA biosynthesis [PATH:spm00970] D spyM18_0223 gluS; putative glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24] D spyM18_1840 gatA; putative Glutamyl-tRNA Gln amidotransferase subunit A K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7] D spyM18_1839 gatB; putative Glu-tRNAGln amidotransferase subunit B K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7] D spyM18_1841 gatC; putative Glu-tRNA Gln amidotransferase subunit C K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7] D spyM18_1399 alaS; putative alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7] D spyM18_2188 aspS; putative aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D spyM18_0712 asnS; putative asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D spyM18_0624 hypothetical protein K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D spyM18_1701 glyQ; putative glycyl-tRNA synthetase (alpha subunit) K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14] D spyM18_1700 glyS; putative glycyl-tRNA synthetase (beta subunit) K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14] D spyM18_0576 putative threonyl-tRNA synthetase 1 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3] D spyM18_1814 serS; putative seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11] D spyM18_2008 putative cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16] D spyM18_0468 metS; putative methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] D spyM18_1638 fmt; putative methionyl tRNA formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9] D spyM18_1579 valS; putative valine-tRNA ligase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9] D spyM18_0171 leuS; putative leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D spyM18_1531 ileS; putative isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5] D spyM18_0663 lysS; putative lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] D spyM18_2183 argS; putative arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D spyM18_2030 proS; putative prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15] D spyM18_2189 hisS; putative histidine-tRNA ligase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21] D spyM18_0827 pheS; putative phenylalanyl-tRNA synthetase (alpha subunit) K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] D spyM18_0828 pheT; phenylalanyl-tRNA synthetase (beta subunit) K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] D spyM18_0096 tyrS; putative tyrosine-tRNA ligase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D spyM18_2245 trpS; putative tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] C 03013 Nucleocytoplasmic transport C 03015 mRNA surveillance pathway C 03008 Ribosome biogenesis in eukaryotes B B 09123 Folding, sorting and degradation C 03060 Protein export [PATH:spm03060] D spyM18_0073 secY; putative preprotein translocase K03076 secY; preprotein translocase subunit SecY D spyM18_2119 secE; hypothetical protein K03073 secE; preprotein translocase subunit SecE D spyM18_0561 hypothetical protein K03075 secG; preprotein translocase subunit SecG D spyM18_2035 hypothetical protein K03210 yajC; preprotein translocase subunit YajC D spyM18_0229 conserved hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D spyM18_0404 hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D spyM18_1873 secA; putative preprotein translocase binding subunit K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D spyM18_1151 ffh; putative signal recognition particle -inhibited division protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] D spyM18_0638 putative signal recognition particle (docking protein) K03110 ftsY; fused signal recognition particle receptor D spyM18_1229 putative signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D spyM18_1907 lepB; putative signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D spyM18_0127 lepA; LepA K03100 lepB; signal peptidase I [EC:3.4.21.89] D spyM18_0888 lspA; putative prolipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36] C 04141 Protein processing in endoplasmic reticulum C 04130 SNARE interactions in vesicular transport C 04120 Ubiquitin mediated proteolysis C 04122 Sulfur relay system [PATH:spm04122] D spyM18_0878 nifS; putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D spyM18_1083 nifS; putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D spyM18_2222 trmU; tRNA-methyltransferase K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13] D spyM18_0879 thiI; putative thiamine biosynthesis protein K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4] C 03050 Proteasome C 03018 RNA degradation [PATH:spm03018] D spyM18_0798 eno; putative enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D spyM18_2014 pnp; putative polynucleotide phosphorylase, alpha chain K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] D spyM18_0562 vacB; putative exoribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1] D spyM18_1424 deaD; putative ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7] D spyM18_1643 conserved hypothetical protein K18682 rny; ribonucrease Y [EC:3.1.-.-] D spyM18_1941 conserved hypothetical protein K12574 rnj; ribonuclease J [EC:3.1.-.-] D spyM18_1003 conserved hypothetical protein K12574 rnj; ribonuclease J [EC:3.1.-.-] D spyM18_1231 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D spyM18_1831 dnaK; heat shock protein 70 K04043 dnaK; molecular chaperone DnaK D spyM18_2129 groL; heat shock protein (chaperonin) K04077 groEL; chaperonin GroEL [EC:5.6.1.7] B B 09124 Replication and repair C 03030 DNA replication [PATH:spm03030] D spyM18_1928 putative DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D spyM18_1232 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D spyM18_2028 dnaE; DNA polymerase III alpha chain K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D spyM18_1376 dnaX; DNA polymerase III gamma/tau subunits K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D spyM18_0450 putative DNA polymerase III delta subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D spyM18_1415 DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D spyM18_0002 dnaN; beta subunit of DNA polymerase III K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D spyM18_2217 dnaC; DNA polymerase III delta prime subunit K02314 dnaB; replicative DNA helicase [EC:5.6.2.3] D spyM18_0348 putative DNA polymerase III delta prime subunit K02314 dnaB; replicative DNA helicase [EC:5.6.2.3] D spyM18_0840 dnaE; putative DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101] D spyM18_1795 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_0359 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_1896 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_0120 ssb; putative single-strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_1122 rnhB; putative ribonuclease HII K03470 rnhB; ribonuclease HII [EC:3.1.26.4] D spyM18_1906 putative ribonuclease HIII K03471 rnhC; ribonuclease HIII [EC:3.1.26.4] D spyM18_0184 DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D spyM18_0810 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03410 Base excision repair [PATH:spm03410] D spyM18_0986 putative endonuclease III (DNA repair) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] D spyM18_0964 ung; putative uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] D spyM18_1899 mutY; putative A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] D spyM18_0555 putative formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18] D spyM18_2176 tag; putative 3-methyl-adenine DNA glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] D spyM18_0461 putative 3'-exo-deoxyribonuclease K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2] D spyM18_0184 DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D spyM18_0983 recJ; putative single-strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D spyM18_0810 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03420 Nucleotide excision repair [PATH:spm03420] D spyM18_0007 trcF; putative transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4] D spyM18_1890 uvrA; putative excinuclease ABC (subunit A) K03701 uvrA; excinuclease ABC subunit A D spyM18_1326 uvrB; putative excinuclease ABC (subunit B) K03702 uvrB; excinuclease ABC subunit B D spyM18_1042 excinuclease ABC (subunit C) K03703 uvrC; excinuclease ABC subunit C D spyM18_1217 pcrA; putative ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D spyM18_0184 DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D spyM18_0810 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03430 Mismatch repair [PATH:spm03430] D spyM18_2180 putative DNA mismatch repair protein K03555 mutS; DNA mismatch repair protein MutS D spyM18_1903 putative DNA mismatch repair protein K07456 mutS2; DNA mismatch repair protein MutS2 D spyM18_2179 putative DNA mismatch repair protein K03572 mutL; DNA mismatch repair protein MutL D spyM18_1217 pcrA; putative ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D spyM18_1518 putative exodeoxyribonuclease VII (large subunit) K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6] D spyM18_1517 exodeoxyribonuclease VII (small subunit) K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6] D spyM18_0983 recJ; putative single-strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D spyM18_1795 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_0359 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_1896 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_0120 ssb; putative single-strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_1232 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D spyM18_2028 dnaE; DNA polymerase III alpha chain K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D spyM18_0002 dnaN; beta subunit of DNA polymerase III K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D spyM18_1376 dnaX; DNA polymerase III gamma/tau subunits K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D spyM18_1415 DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D spyM18_0450 putative DNA polymerase III delta subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D spyM18_1928 putative DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D spyM18_0810 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03440 Homologous recombination [PATH:spm03440] D spyM18_0983 recJ; putative single-strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D spyM18_1795 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_0359 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_1896 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_0120 ssb; putative single-strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_2242 recF; recF protein K03629 recF; DNA replication and repair protein RecF D spyM18_0022 conserved hypothetical protein K03584 recO; DNA repair protein RecO (recombination protein O) D spyM18_1432 recR; putative recombination protein K06187 recR; recombination protein RecR D spyM18_2174 recA; recombination protein K03553 recA; recombination protein RecA D spyM18_0184 DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D spyM18_2177 ruvA; putative Holliday junction DNA helicase K03550 ruvA; holliday junction DNA helicase RuvA D spyM18_0039 ruvB; putative Holliday junction DNA helicase, subunit B K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4] D spyM18_1857 recG; putative ATP-dependent DNA helicase K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4] D spyM18_1908 putative exodeoxyribonuclease V (alpha subunit) K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5] D spyM18_1232 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D spyM18_2028 dnaE; DNA polymerase III alpha chain K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D spyM18_0002 dnaN; beta subunit of DNA polymerase III K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D spyM18_1376 dnaX; DNA polymerase III gamma/tau subunits K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D spyM18_1415 DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D spyM18_0450 putative DNA polymerase III delta subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D spyM18_1928 putative DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D spyM18_1639 priA; putative primosomal replication factor Y K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4] C 03450 Non-homologous end-joining C 03460 Fanconi anemia pathway B B 09126 Chromosome C 03082 ATP-dependent chromatin remodeling C 03083 Polycomb repressive complex B B 09125 Information processing in viruses C 03230 Viral genome structure C 03240 Viral replication C 03250 Viral life cycle - HIV-1 [PATH:spm03250] D spyM18_0499 cypB; putative cyclophilin-type protein K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8] C 03260 Virion - Human immunodeficiency virus C 03271 Virion - Rotavirus C 03262 Virion - Coronavirus C 03261 Virion - Influenza virus C 03263 Virion - Enterovirus C 03264 Virion - Flavivirus C 03265 Virion - Ebolavirus and Lyssavirus C 03266 Virion - Herpesvirus C 03268 Virion - Orthopoxvirus C 03267 Virion - Adenovirus C 03259 Virion - Bacteriophages T4 and T7 C 03258 Virion - Bacteriophage lambda # A09130 Environmental Information Processing B B 09131 Membrane transport C 02010 ABC transporters [PATH:spm02010] D spyM18_1040 putative periplasmic-iron-binding protein K02012 afuA; iron(III) transport system substrate-binding protein D spyM18_1067 potD; putative spermidine / putrescine ABC transporter (periplasmic transport protein) K11069 potD; spermidine/putrescine transport system substrate-binding protein D spyM18_1066 potC; putative spermidine/putrescine ABC transporter (permease protein) K11070 potC; spermidine/putrescine transport system permease protein D spyM18_1065 potB; putative spermidine / putrescine ABC transporter (permease protein) K11071 potB; spermidine/putrescine transport system permease protein D spyM18_1064 potA; putative spermidine / putrescine ABC transporter K11072 potA; spermidine/putrescine transport system ATP-binding protein [EC:7.6.2.11] D spyM18_0182 putative glycine-betaine binding permease protein K02001 proW; glycine betaine/proline transport system permease protein D spyM18_0181 putative glycine betaine/proline ABC transporter K02000 proV; glycine betaine/proline transport system ATP-binding protein [EC:7.6.2.9] D spyM18_1094 putative ABC transporter (binding protein) K05845 opuC; osmoprotectant transport system substrate-binding protein D spyM18_1093 putative ABC transporter (ATP-binding protein) K05847 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9] D spyM18_2040 multiple sugar-binding ABC transport system (ATP-binding protein) K10112 msmX; multiple sugar transport system ATP-binding protein [EC:7.5.2.-] D spyM18_1314 malE; putative maltose/maltodextrin-binding protein K15770 cycB; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein D spyM18_1315 malF; putative maltose/maltodextrin ABC transport system (permease) K15771 ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D spyM18_1316 malG; putative maltose/maltodextrin ABC transport system (permease) K15772 ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D spyM18_1598 conserved hypothetical protein K17318 lplA; putative aldouronate transport system substrate-binding protein D spyM18_1601 putative sugar-binding transport protein K17319 lplB; putative aldouronate transport system permease protein D spyM18_1599 putative sugar-binding transport protein K17320 lplC; putative aldouronate transport system permease protein D spyM18_1180 putative lipoprotein K07335 bmpA; basic membrane protein A and related proteins D spyM18_0158 putative ABC transporter K07335 bmpA; basic membrane protein A and related proteins D spyM18_1178 putative sugar ABC transporter (permease protein) K23535 nupB; general nucleoside transport system permease protein D spyM18_1177 putative sugar ABC transporter (permease protein) K23536 nupC; general nucleoside transport system permease protein D spyM18_1179 putative sugar ABC transporter (ATP-binding protein) K23537 nupA; general nucleoside transport system ATP-binding protein D spyM18_1194 pstS; putative phosphate ABC transporter, periplasmic phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein D spyM18_1193 pstC; putative phosphate ABC transporter K02037 pstC; phosphate transport system permease protein D spyM18_1192 pstA; putative phosphate ABC transporter (permease protein) K02038 pstA; phosphate transport system permease protein D spyM18_1190 pstB1; phosphate ABC transporter (ATP-binding protein) K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D spyM18_1191 pstB2; putative phosphate ABC transporter (ATP-binding protein) K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D spyM18_1327 glnH; hypothetical protein K10036 glnH; glutamine transport system substrate-binding protein D spyM18_1328 glnQ; putative ABC transporter (ATP-binding protein) K10038 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1] D spyM18_0962 putative ABC transporter (binding protein) K02424 tcyA; L-cystine transport system substrate-binding protein D spyM18_0312 conserved hypothetical protein K02424 tcyA; L-cystine transport system substrate-binding protein D spyM18_0963 putative ABC transporter (permease) K10009 tcyB; L-cystine transport system permease protein D spyM18_1669 putative amino acid ABC transproter (permease protein) K10009 tcyB; L-cystine transport system permease protein D spyM18_1668 putative amino acid ABC transport system (ATP-binding protein) K10010 tcyC; L-cystine transport system ATP-binding protein [EC:7.4.2.1] D spyM18_0837 putative ABC transporter (substrate-binding protein) K23059 artP; arginine/lysine/histidine transporter system substrate-binding protein D spyM18_1525 putative amino acid ABC transporter (permease protein) K17077 artQ; arginine/lysine/histidine transport system permease protein D spyM18_1524 putative amino acid ABC transporter (ATP-binding protein) K23060 artR; arginine/lysine/histidine transport system ATP-binding protein [EC:7.4.2.1] D spyM18_0264 putative glutamine-binding periplasmic protein K17073 lysX1; putative lysine transport system substrate-binding protein D spyM18_0263 putative amino acid ABC transporter (ATP-binding protein) K17076 lysY; putative lysine transport system ATP-binding protein D spyM18_0314 conserved hypothetical protein K02073 metQ; D-methionine transport system substrate-binding protein D spyM18_0316 putative ABC transporter (permease protein) K02072 metI; D-methionine transport system permease protein D spyM18_0315 putative ABC transporter (ATP-binding protein) K02071 metN; D-methionine transport system ATP-binding protein D spyM18_0281 oppA; oligopeptide permease K15580 oppA; oligopeptide transport system substrate-binding protein D spyM18_0282 oppB; oligopeptide permease K15581 oppB; oligopeptide transport system permease protein D spyM18_0283 oppC; oligopeptide permease K15582 oppC; oligopeptide transport system permease protein D spyM18_0284 oppD; oligopeptide permease K15583 oppD; oligopeptide transport system ATP-binding protein D spyM18_0285 oppF; oligopeptide permease K10823 oppF; oligopeptide transport system ATP-binding protein D spyM18_0781 putative adhesion protein K09815 znuA; zinc transport system substrate-binding protein D spyM18_2073 putative laminin adhesion K09815 znuA; zinc transport system substrate-binding protein D spyM18_0094 adrB; putative ABC transporter (permease) K09816 znuB; zinc transport system permease protein D spyM18_0093 adrC; ABC transporter (ATP-binding protein) K09817 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20] D spyM18_0494 mtsA; putative metal binding protein of ABC transporter (lipoprotein) K11704 mtsA; iron/zinc/manganese/copper transport system substrate-binding protein D spyM18_0498 mtsC; integral membrane protein MtsC K11705 mtsC; iron/zinc/manganese/copper transport system permease protein D spyM18_0496 mtsB; ATP-binding protein MtsB K11706 mtsB; iron/zinc/manganese/copper transport system ATP-binding protein D spyM18_0193 putative biotin synthase K03523 bioY; biotin transport system substrate-specific component D spyM18_2228 conserved hypothetical protein K16785 ecfT; energy-coupling factor transport system permease protein D spyM18_1860 conserved hypothetical protein K16785 ecfT; energy-coupling factor transport system permease protein D spyM18_2230 ABC transporter (ATP-binding protein) K16786 ecfA1; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D spyM18_2229 putative ABC transporter (ATP-binding protein) K16787 ecfA2; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D spyM18_0707 fts; putative cell-division protein K09811 ftsX; cell division transport system permease protein D spyM18_0706 ftsE; putative cell-division ATP-binding protein K09812 ftsE; cell division transport system ATP-binding protein D spyM18_0214 putative ABC transporter, ATP-binding protein K18891 patA; ATP-binding cassette, subfamily B, multidrug efflux pump D spyM18_0215 putative ABC transporter (ATP-binding protein) K18892 patB; ATP-binding cassette, subfamily B, multidrug efflux pump D spyM18_1108 putative ABC transporter (ATP-binding protein) K18887 efrA; ATP-binding cassette, subfamily B, multidrug efflux pump D spyM18_1109 putative ABC transporter (ATP-binding protein) K18888 efrB; ATP-binding cassette, subfamily B, multidrug efflux pump D spyM18_0543 putative transport ATP-binding protein K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter C 02060 Phosphotransferase system (PTS) [PATH:spm02060] D spyM18_1384 pts1; putative phosphoenolpyruvate:sugar PTS enzyme I K08483 ptsI; phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9] D spyM18_1385 His containing phosphocarrier protein K02784 ptsH; phosphocarrier protein HPr D spyM18_2050 ptsG; putative PTS system, enzyme II, A component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208] D spyM18_1881 putative sucrose-specific PTS permease, enzyme II K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211] D spyM18_0641 beta-glucoside permease IIABC component K02757 bglF; beta-glucoside PTS system EIICBA component [EC:2.7.1.-] D spyM18_2155 putative PTS system enzyme II K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201] D spyM18_1986 putative PTS system, lactose-specific component IIA K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207] D spyM18_1985 putative PTS system, lactose-specific component IIBC K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207] D spyM18_1333 ptcA; putative PTS enzyme III K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D spyM18_2114 putative PTS system, enzyme III K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D spyM18_1334 ptcB; putative PTS system enzyme II K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D spyM18_2113 putative PTS system, enzyme IIB K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D spyM18_1331 putative PTS system IIC component K02761 celB; cellobiose PTS system EIIC component D spyM18_2111 putative PTS system, enzyme IIC component K02761 celB; cellobiose PTS system EIIC component D spyM18_1034 hypothetical protein K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191] D spyM18_1810 mannose-specific phosphotransferase system component IIAB K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191] D spyM18_1036 putative phosphotransferase system (PTS), enzyme II, component C K02795 manY; mannose PTS system EIIC component D spyM18_1811 putative mannose-specific phosphotransferase system component II K02795 manY; mannose PTS system EIIC component D spyM18_1812 putative mannose-specific phosphotransferase system component IID K02796 manZ; mannose PTS system EIID component D spyM18_1037 putative phospotransferase system (PTS), enzyme II component D K02796 manZ; mannose PTS system EIID component D spyM18_1035 putative phosphotransferase system (PTS), enzyme II component B K19507 gfrB; fructoselysine/glucoselysine PTS system EIIB component [EC:2.7.1.-] D spyM18_0698 putative PTS dependent N-acetyl-galactosamine- and galactosamine IIA component K02744 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-] D spyM18_0696 putative PTS dependent N-acetyl-galactosamine-IIB component K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-] D spyM18_0695 putative PTS dependent N-acetyl-galactosamine-IIC component K02746 agaW; N-acetylgalactosamine PTS system EIIC component D spyM18_0694 putative PTS dependent galactosamine IID component K02747 agaE; N-acetylgalactosamine PTS system EIID component D spyM18_1721 putative PTS system, enzyme IIA component K20112 gatA; galactose PTS system EIIA component [EC:2.7.1.204] D spyM18_1720 putative PTS system, enzyme IIB component K20113 gatB; galactose PTS system EIIB component [EC:2.7.1.204] D spyM18_1719 putative PTS system, enzyme IIC component K20114 gatC; galactose PTS system EIIC component D spyM18_0175 conserved hypothetical protein K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D spyM18_2018 conserved hypothetical protein K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D spyM18_0174 conserved hypothetical protein K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D spyM18_2017 conserved hypothetical protein K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D spyM18_0173 conserved hypothetical protein K03475 ulaA; ascorbate PTS system EIIC component D spyM18_2016 conserved hypothetical protein K03475 ulaA; ascorbate PTS system EIIC component D spyM18_0914 fruA; putative fructose-specific enzyme II, PTS system BC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202] D spyM18_0913 fruK; putative fructose-1-phosphate kinase K00882 fruK; 1-phosphofructokinase [EC:2.7.1.56] C 03070 Bacterial secretion system [PATH:spm03070] D spyM18_2119 secE; hypothetical protein K03073 secE; preprotein translocase subunit SecE D spyM18_0561 hypothetical protein K03075 secG; preprotein translocase subunit SecG D spyM18_0073 secY; putative preprotein translocase K03076 secY; preprotein translocase subunit SecY D spyM18_2035 hypothetical protein K03210 yajC; preprotein translocase subunit YajC D spyM18_0229 conserved hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D spyM18_0404 hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D spyM18_1873 secA; putative preprotein translocase binding subunit K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D spyM18_0638 putative signal recognition particle (docking protein) K03110 ftsY; fused signal recognition particle receptor D spyM18_1151 ffh; putative signal recognition particle -inhibited division protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] B B 09132 Signal transduction C 02020 Two-component system [PATH:spm02020] D spyM18_1194 pstS; putative phosphate ABC transporter, periplasmic phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein D spyM18_2256 putative serine protease K04771 degP; serine protease Do [EC:3.4.21.107] D spyM18_0595 vicK; two-component sensor histidine kinase K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] D spyM18_0594 vicR; two-component response regulator K07668 vicR; two-component system, OmpR family, response regulator VicR D spyM18_0001 dnaA; chromosomal replication initiator protein K02313 dnaA; chromosomal replication initiator protein D spyM18_1324 dltA; putative D-alanine-D-alanyl carrier protein ligase K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D spyM18_1323 putative integral membrane protein K03739 dltB; membrane protein involved in D-alanine export D spyM18_1322 putative D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D spyM18_1321 putative extramembranal protein K03740 dltD; D-alanine transfer protein D spyM18_1186 putative histidine kinase protein K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] D spyM18_1187 putative response regulator K14983 ciaR; two-component system, OmpR family, response regulator CiaR D spyM18_1835 putative D,D-carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D spyM18_0329 covS; CovS K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3] D spyM18_0328 covR; CovR K18941 arlR; two-component system, OmpR family, response regulator ArlR D spyM18_2083 putative histidine kinase K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3] D spyM18_2084 putative two-component response regulator K18987 irr; two-component system, OmpR family, response regulator Irr D spyM18_1143 citC; putative citrate lyase synthetase K01910 citC; [citrate (pro-3S)-lyase] ligase [EC:6.2.1.22] D spyM18_1137 citD; putative citrate lyase, gamma subunit K01646 citD; citrate lyase subunit gamma (acyl carrier protein) D spyM18_1139 citE; putative citrate lyase, beta subunit K01644 citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34] D spyM18_1140 citF; putative citrate lyase, alpha subunit K01643 citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10] D spyM18_1141 citX; putative apo-citrate lyase K05964 citX; holo-ACP synthase [EC:2.7.7.61] D spyM18_1130 putative CitG K05966 citG; triphosphoribosyl-dephospho-CoA synthase [EC:2.4.2.52] D spyM18_1072 putative malic enzyme ((S)-malate:NAD+ oxidoreductase (decarboxylating)) K00027 ME2; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38] D spyM18_1071 malP; putative L-malate permease K11616 maeN; malate:Na+ symporter D spyM18_0539 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D spyM18_0224 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D spyM18_0226 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D spyM18_0538 putative response regulator K07707 agrA; two-component system, LytTR family, response regulator AgrA D spyM18_0227 putative response regulator K07707 agrA; two-component system, LytTR family, response regulator AgrA D spyM18_0300 putative competence protein K12296 comX1_2; competence protein ComX D spyM18_1967 putative competence protein K12296 comX1_2; competence protein ComX D spyM18_0011 hypothetical protein K01467 ampC; beta-lactamase class C [EC:3.5.2.6] D spyM18_1631 putative two-component sensor histidine kinase K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3] D spyM18_1630 putative two-component response regulator K11618 liaR; two-component system, NarL family, response regulator LiaR D spyM18_1979 putative SalK homologue K14988 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK D spyM18_1978 putative response regulator of salavaricin regulon K14989 salR; two-component system, NarL family, secretion system response regulator SalR D spyM18_1942 glnA; putative glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D spyM18_1646 atoD; putative Acetyl-CoA:acetoacetyl-CoA transferase A subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D spyM18_0137 putative acetyl-CoA:acetoacetyl-CoA transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D spyM18_0138 butyrate-acetoacetate CoA-transferase, beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D spyM18_1647 atoA; putative Acetyl-CoA:acetoacetyl-CoA transferase b subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D spyM18_0134 putative short-chain fatty acids transporter K02106 atoE; short-chain fatty acids transporter D spyM18_0136 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1645 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0590 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1569 putative histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] D spyM18_1596 putative two-component sensor histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] D spyM18_1595 putative two-component sensor response regulator K07720 yesN; two-component system, response regulator YesN D spyM18_1039 putative two-component response regulator K07720 yesN; two-component system, response regulator YesN D spyM18_0040 putative protein-tyrosine phosphatase K25307 wzb; low molecular weight protein-tyrosine phosphatase [EC:3.1.3.48] C 04010 MAPK signaling pathway C 04013 MAPK signaling pathway - fly C 04016 MAPK signaling pathway - plant C 04011 MAPK signaling pathway - yeast C 04012 ErbB signaling pathway C 04014 Ras signaling pathway C 04015 Rap1 signaling pathway C 04310 Wnt signaling pathway C 04330 Notch signaling pathway C 04340 Hedgehog signaling pathway C 04341 Hedgehog signaling pathway - fly C 04350 TGF-beta signaling pathway C 04390 Hippo signaling pathway C 04391 Hippo signaling pathway - fly C 04392 Hippo signaling pathway - multiple species C 04370 VEGF signaling pathway C 04371 Apelin signaling pathway C 04630 JAK-STAT signaling pathway C 04064 NF-kappa B signaling pathway C 04668 TNF signaling pathway C 04066 HIF-1 signaling pathway C 04068 FoxO signaling pathway C 04020 Calcium signaling pathway C 04070 Phosphatidylinositol signaling system C 04072 Phospholipase D signaling pathway C 04071 Sphingolipid signaling pathway C 04024 cAMP signaling pathway C 04022 cGMP-PKG signaling pathway C 04151 PI3K-Akt signaling pathway C 04152 AMPK signaling pathway C 04150 mTOR signaling pathway C 04075 Plant hormone signal transduction B B 09133 Signaling molecules and interaction C 04080 Neuroactive ligand-receptor interaction C 04060 Cytokine-cytokine receptor interaction C 04061 Viral protein interaction with cytokine and cytokine receptor C 04512 ECM-receptor interaction C 04514 Cell adhesion molecules # A09140 Cellular Processes B B 09141 Transport and catabolism C 04144 Endocytosis C 04145 Phagosome C 04142 Lysosome C 04146 Peroxisome C 04140 Autophagy - animal C 04138 Autophagy - yeast C 04136 Autophagy - other C 04137 Mitophagy - animal C 04139 Mitophagy - yeast C 04148 Efferocytosis B B 09143 Cell growth and death C 04110 Cell cycle C 04111 Cell cycle - yeast C 04112 Cell cycle - Caulobacter C 04113 Meiosis - yeast C 04114 Oocyte meiosis C 04210 Apoptosis C 04214 Apoptosis - fly C 04215 Apoptosis - multiple species C 04216 Ferroptosis C 04217 Necroptosis C 04115 p53 signaling pathway C 04218 Cellular senescence B B 09144 Cellular community - eukaryotes C 04510 Focal adhesion C 04520 Adherens junction C 04530 Tight junction C 04540 Gap junction C 04550 Signaling pathways regulating pluripotency of stem cells B B 09145 Cellular community - prokaryotes C 02024 Quorum sensing [PATH:spm02024] D spyM18_1653 luxS; LuxS K07173 luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21] D spyM18_2057 anthranilate synthase component II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27] D spyM18_0592 hypothetical protein K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D spyM18_0539 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D spyM18_0224 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D spyM18_0226 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D spyM18_0538 putative response regulator K07707 agrA; two-component system, LytTR family, response regulator AgrA D spyM18_0227 putative response regulator K07707 agrA; two-component system, LytTR family, response regulator AgrA D spyM18_0165 slo; streptolysin O K11031 slo; thiol-activated cytolysin D spyM18_1186 putative histidine kinase protein K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] D spyM18_1187 putative response regulator K14983 ciaR; two-component system, OmpR family, response regulator CiaR D spyM18_0281 oppA; oligopeptide permease K15580 oppA; oligopeptide transport system substrate-binding protein D spyM18_0282 oppB; oligopeptide permease K15581 oppB; oligopeptide transport system permease protein D spyM18_0283 oppC; oligopeptide permease K15582 oppC; oligopeptide transport system permease protein D spyM18_0284 oppD; oligopeptide permease K15583 oppD; oligopeptide transport system ATP-binding protein D spyM18_0285 oppF; oligopeptide permease K10823 oppF; oligopeptide transport system ATP-binding protein D spyM18_0038 hypothetical protein K20342 comR; HTH-type transcriptional regulator, regulator for ComX D spyM18_0300 putative competence protein K12296 comX1_2; competence protein ComX D spyM18_1967 putative competence protein K12296 comX1_2; competence protein ComX D spyM18_0543 putative transport ATP-binding protein K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter D spyM18_0542 N-terminal fragment of BlpB K20345 blpB; membrane fusion protein, peptide pheromone/bacteriocin exporter D spyM18_0554 putative positive transcriptional regulator K20373 rgg2; HTH-type transcriptional regulator, SHP2-responsive activator D spyM18_0599 putative positive regulator K20374 rgg3; HTH-type transcriptional regulator, SHP3-responsive repressor D spyM18_2066 dppA; surface lipoprotein K02035 ABC.PE.S; peptide/nickel transport system substrate-binding protein D spyM18_2067 dppB; transmembrane transport protein K02033 ABC.PE.P; peptide/nickel transport system permease protein D spyM18_2068 dppC; transmembrane transport protein K02034 ABC.PE.P1; peptide/nickel transport system permease protein D spyM18_2069 dppD; ATPase protein K02031 ddpD; peptide/nickel transport system ATP-binding protein D spyM18_2070 dppE; ATPase protein K02032 ddpF; peptide/nickel transport system ATP-binding protein D spyM18_2103 Rgg K20375 ropB; HTH-type transcriptional regulator, pheromone-responsive regulator D spyM18_2099 speB; pyrogenic exotoxin B precursor K01364 speB; streptopain [EC:3.4.22.10] D spyM18_1714 putative tagatose 1,6-diphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40] D spyM18_1987 putative tagatose 1,6-diphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40] D spyM18_0229 conserved hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D spyM18_0404 hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D spyM18_2119 secE; hypothetical protein K03073 secE; preprotein translocase subunit SecE D spyM18_0561 hypothetical protein K03075 secG; preprotein translocase subunit SecG D spyM18_0073 secY; putative preprotein translocase K03076 secY; preprotein translocase subunit SecY D spyM18_2035 hypothetical protein K03210 yajC; preprotein translocase subunit YajC D spyM18_1873 secA; putative preprotein translocase binding subunit K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D spyM18_0638 putative signal recognition particle (docking protein) K03110 ftsY; fused signal recognition particle receptor D spyM18_1151 ffh; putative signal recognition particle -inhibited division protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] C 05111 Biofilm formation - Vibrio cholerae C 02025 Biofilm formation - Pseudomonas aeruginosa C 02026 Biofilm formation - Escherichia coli B B 09142 Cell motility C 02030 Bacterial chemotaxis C 02040 Flagellar assembly [PATH:spm02040] D spyM18_0962 putative ABC transporter (binding protein) K02424 tcyA; L-cystine transport system substrate-binding protein D spyM18_0312 conserved hypothetical protein K02424 tcyA; L-cystine transport system substrate-binding protein D spyM18_0841 rpoD; putative RNA polymerase sigma 42 protein K03086 rpoD; RNA polymerase primary sigma factor C 04814 Motor proteins C 04820 Cytoskeleton in muscle cells D spyM18_0798 eno; putative enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] C 04810 Regulation of actin cytoskeleton # A09150 Organismal Systems B B 09151 Immune system C 04640 Hematopoietic cell lineage C 04610 Complement and coagulation cascades C 04611 Platelet activation C 04613 Neutrophil extracellular trap formation C 04620 Toll-like receptor signaling pathway C 04624 Toll and Imd signaling pathway C 04621 NOD-like receptor signaling pathway C 04622 RIG-I-like receptor signaling pathway C 04623 Cytosolic DNA-sensing pathway C 04625 C-type lectin receptor signaling pathway C 04650 Natural killer cell mediated cytotoxicity C 04612 Antigen processing and presentation C 04660 T cell receptor signaling pathway C 04658 Th1 and Th2 cell differentiation C 04659 Th17 cell differentiation C 04657 IL-17 signaling pathway C 04662 B cell receptor signaling pathway C 04664 Fc epsilon RI signaling pathway C 04666 Fc gamma R-mediated phagocytosis C 04670 Leukocyte transendothelial migration C 04672 Intestinal immune network for IgA production C 04062 Chemokine signaling pathway B B 09152 Endocrine system C 04911 Insulin secretion C 04910 Insulin signaling pathway C 04922 Glucagon signaling pathway C 04923 Regulation of lipolysis in adipocytes C 04920 Adipocytokine signaling pathway C 03320 PPAR signaling pathway C 04929 GnRH secretion C 04912 GnRH signaling pathway C 04913 Ovarian steroidogenesis C 04915 Estrogen signaling pathway C 04914 Progesterone-mediated oocyte maturation C 04917 Prolactin signaling pathway C 04921 Oxytocin signaling pathway C 04926 Relaxin signaling pathway C 04935 Growth hormone synthesis, secretion and action C 04918 Thyroid hormone synthesis C 04919 Thyroid hormone signaling pathway C 04928 Parathyroid hormone synthesis, secretion and action C 04916 Melanogenesis C 04924 Renin secretion C 04614 Renin-angiotensin system C 04925 Aldosterone synthesis and secretion C 04927 Cortisol synthesis and secretion B B 09153 Circulatory system C 04260 Cardiac muscle contraction C 04261 Adrenergic signaling in cardiomyocytes C 04270 Vascular smooth muscle contraction B B 09154 Digestive system C 04970 Salivary secretion C 04971 Gastric acid secretion C 04972 Pancreatic secretion C 04976 Bile secretion C 04973 Carbohydrate digestion and absorption C 04974 Protein digestion and absorption C 04975 Fat digestion and absorption C 04979 Cholesterol metabolism C 04977 Vitamin digestion and absorption C 04980 Cobalamin transport and metabolism C 04978 Mineral absorption B B 09155 Excretory system C 04962 Vasopressin-regulated water reabsorption C 04960 Aldosterone-regulated sodium reabsorption C 04961 Endocrine and other factor-regulated calcium reabsorption C 04964 Proximal tubule bicarbonate reclamation C 04966 Collecting duct acid secretion B B 09156 Nervous system C 04724 Glutamatergic synapse C 04727 GABAergic synapse C 04725 Cholinergic synapse C 04728 Dopaminergic synapse C 04726 Serotonergic synapse C 04720 Long-term potentiation C 04730 Long-term depression C 04723 Retrograde endocannabinoid signaling C 04721 Synaptic vesicle cycle C 04722 Neurotrophin signaling pathway B B 09157 Sensory system C 04744 Phototransduction C 04745 Phototransduction - fly C 04740 Olfactory transduction C 04742 Taste transduction C 04750 Inflammatory mediator regulation of TRP channels B B 09158 Development and regeneration C 04320 Dorso-ventral axis formation C 04360 Axon guidance C 04361 Axon regeneration C 04380 Osteoclast differentiation B B 09149 Aging C 04211 Longevity regulating pathway C 04212 Longevity regulating pathway - worm C 04213 Longevity regulating pathway - multiple species B B 09159 Environmental adaptation C 04710 Circadian rhythm C 04713 Circadian entrainment C 04711 Circadian rhythm - fly C 04712 Circadian rhythm - plant C 04714 Thermogenesis C 04626 Plant-pathogen interaction # A09160 Human Diseases B B 09161 Cancer: overview C 05200 Pathways in cancer C 05202 Transcriptional misregulation in cancer C 05206 MicroRNAs in cancer C 05205 Proteoglycans in cancer C 05204 Chemical carcinogenesis - DNA adducts C 05207 Chemical carcinogenesis - receptor activation C 05208 Chemical carcinogenesis - reactive oxygen species C 05203 Viral carcinogenesis C 05230 Central carbon metabolism in cancer C 05231 Choline metabolism in cancer C 05235 PD-L1 expression and PD-1 checkpoint pathway in cancer B B 09162 Cancer: specific types C 05210 Colorectal cancer C 05212 Pancreatic cancer C 05225 Hepatocellular carcinoma C 05226 Gastric cancer C 05214 Glioma C 05216 Thyroid cancer C 05221 Acute myeloid leukemia C 05220 Chronic myeloid leukemia C 05217 Basal cell carcinoma C 05218 Melanoma C 05211 Renal cell carcinoma C 05219 Bladder cancer C 05215 Prostate cancer C 05213 Endometrial cancer C 05224 Breast cancer C 05222 Small cell lung cancer C 05223 Non-small cell lung cancer B B 09172 Infectious disease: viral C 05166 Human T-cell leukemia virus 1 infection C 05170 Human immunodeficiency virus 1 infection C 05161 Hepatitis B C 05160 Hepatitis C C 05171 Coronavirus disease - COVID-19 C 05164 Influenza A C 05162 Measles C 05168 Herpes simplex virus 1 infection C 05163 Human cytomegalovirus infection C 05167 Kaposi sarcoma-associated herpesvirus infection C 05169 Epstein-Barr virus infection C 05165 Human papillomavirus infection B B 09171 Infectious disease: bacterial C 05110 Vibrio cholerae infection C 05120 Epithelial cell signaling in Helicobacter pylori infection C 05130 Pathogenic Escherichia coli infection C 05132 Salmonella infection C 05131 Shigellosis C 05135 Yersinia infection C 05133 Pertussis C 05134 Legionellosis C 05150 Staphylococcus aureus infection C 05152 Tuberculosis C 05100 Bacterial invasion of epithelial cells D spyM18_0126 cbp; putative collagen binding protein K13734 sfb1; fibronectin-binding protein 1 D spyM18_0132 prtF2l; protein F2-like protein K13734 sfb1; fibronectin-binding protein 1 B B 09174 Infectious disease: parasitic C 05146 Amoebiasis C 05144 Malaria C 05145 Toxoplasmosis C 05140 Leishmaniasis C 05142 Chagas disease C 05143 African trypanosomiasis B B 09163 Immune disease C 05310 Asthma C 05322 Systemic lupus erythematosus C 05323 Rheumatoid arthritis C 05320 Autoimmune thyroid disease C 05321 Inflammatory bowel disease C 05330 Allograft rejection C 05332 Graft-versus-host disease C 05340 Primary immunodeficiency B B 09164 Neurodegenerative disease C 05010 Alzheimer disease C 05012 Parkinson disease C 05014 Amyotrophic lateral sclerosis C 05016 Huntington disease C 05017 Spinocerebellar ataxia C 05020 Prion disease C 05022 Pathways of neurodegeneration - multiple diseases B B 09165 Substance dependence C 05030 Cocaine addiction C 05031 Amphetamine addiction C 05032 Morphine addiction C 05033 Nicotine addiction C 05034 Alcoholism B B 09166 Cardiovascular disease C 05417 Lipid and atherosclerosis C 05418 Fluid shear stress and atherosclerosis C 05410 Hypertrophic cardiomyopathy C 05412 Arrhythmogenic right ventricular cardiomyopathy C 05414 Dilated cardiomyopathy C 05415 Diabetic cardiomyopathy C 05416 Viral myocarditis B B 09167 Endocrine and metabolic disease C 04930 Type II diabetes mellitus C 04940 Type I diabetes mellitus C 04950 Maturity onset diabetes of the young C 04936 Alcoholic liver disease C 04932 Non-alcoholic fatty liver disease C 04931 Insulin resistance C 04933 AGE-RAGE signaling pathway in diabetic complications C 04934 Cushing syndrome B B 09175 Drug resistance: antimicrobial C 01501 beta-Lactam resistance [PATH:spm01501] D spyM18_0011 hypothetical protein K01467 ampC; beta-lactamase class C [EC:3.5.2.6] D spyM18_0281 oppA; oligopeptide permease K15580 oppA; oligopeptide transport system substrate-binding protein D spyM18_0282 oppB; oligopeptide permease K15581 oppB; oligopeptide transport system permease protein D spyM18_0283 oppC; oligopeptide permease K15582 oppC; oligopeptide transport system permease protein D spyM18_0284 oppD; oligopeptide permease K15583 oppD; oligopeptide transport system ATP-binding protein D spyM18_0285 oppF; oligopeptide permease K10823 oppF; oligopeptide transport system ATP-binding protein D spyM18_1661 putative penicillin-binding protein 1a K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D spyM18_0098 pbp; putative penicillin-binding protein 1b K03693 pbp1b; penicillin-binding protein 1B D spyM18_2120 penicillin-binding protein 2a K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4] D spyM18_1674 putative penicillin binding protein K12556 pbp2X; penicillin-binding protein 2X C 01502 Vancomycin resistance [PATH:spm01502] D spyM18_1431 putative D-ala,D-ala ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D spyM18_1871 putative alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1] D spyM18_1429 putative D-Ala-D-Ala adding enzyme K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10] D spyM18_1673 putative undecaprenyl-phosphate-UDP-MurNAc-pentapeptide phospho-MurNAc-pentapeptide transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] D spyM18_1541 murG; putative undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] D spyM18_1835 putative D,D-carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] C 01503 Cationic antimicrobial peptide (CAMP) resistance [PATH:spm01503] D spyM18_2256 putative serine protease K04771 degP; serine protease Do [EC:3.4.21.107] D spyM18_0499 cypB; putative cyclophilin-type protein K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8] D spyM18_1324 dltA; putative D-alanine-D-alanyl carrier protein ligase K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D spyM18_1323 putative integral membrane protein K03739 dltB; membrane protein involved in D-alanine export D spyM18_1322 putative D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D spyM18_1321 putative extramembranal protein K03740 dltD; D-alanine transfer protein D spyM18_2099 speB; pyrogenic exotoxin B precursor K01364 speB; streptopain [EC:3.4.22.10] B B 09176 Drug resistance: antineoplastic C 01521 EGFR tyrosine kinase inhibitor resistance C 01524 Platinum drug resistance C 01523 Antifolate resistance C 01522 Endocrine resistance # A09180 Brite Hierarchies B B 09181 Protein families: metabolism C 01000 Enzymes [BR:spm01000] C 01001 Protein kinases [BR:spm01001] D spyM18_1634 pnk; putative protein kinase K12132 prkC; eukaryotic-like serine/threonine-protein kinase [EC:2.7.11.1] D spyM18_0595 vicK; two-component sensor histidine kinase K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] D spyM18_1186 putative histidine kinase protein K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] D spyM18_0329 covS; CovS K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3] D spyM18_2083 putative histidine kinase K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3] D spyM18_1631 putative two-component sensor histidine kinase K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3] D spyM18_1979 putative SalK homologue K14988 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK D spyM18_1069 putative two-component sensor histidine kinase K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3] D spyM18_0539 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D spyM18_0224 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D spyM18_0226 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D spyM18_1569 putative histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] D spyM18_1596 putative two-component sensor histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] C 01009 Protein phosphatases and associated proteins [BR:spm01009] D spyM18_1231 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D spyM18_1635 putative phosphoprotein phosphatase K20074 prpC; PPM family protein phosphatase [EC:3.1.3.16] C 01002 Peptidases and inhibitors [BR:spm01002] D spyM18_0888 lspA; putative prolipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36] D spyM18_1662 pepC; putative cysteine aminopeptidase C K01372 BLMH; bleomycin hydrolase [EC:3.4.22.40] D spyM18_2099 speB; pyrogenic exotoxin B precursor K01364 speB; streptopain [EC:3.4.22.10] D spyM18_0565 pcp; putative pyrrolidone carboxyl peptidase K01304 pcp; pyroglutamyl-peptidase [EC:3.4.19.3] D spyM18_1155 guaA; putative GMP synthase K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] D spyM18_1080 conserved hypothetical protein K07010 K07010; putative glutamine amidotransferase D spyM18_0543 putative transport ATP-binding protein K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter D spyM18_0020 putative secreted protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] D spyM18_2076 emm18; M18 protein precursor K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] D spyM18_0027 purF; putative phosphoribosylpyrophosphate amidotransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14] D spyM18_1228 glmS; putative L-glutamine-D-fructose-6-phosphate amidotransferase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] D spyM18_1113 hypothetical protein K07284 srtA; sortase A [EC:3.4.22.70] D spyM18_0129 hypothetical protein K08600 srtB; sortase B [EC:3.4.22.71] D spyM18_0780 putative dipeptidase K08659 pepDA; dipeptidase [EC:3.4.-.-] D spyM18_1394 hypothetical protein K07052 K07052; CAAX protease family protein D spyM18_0803 hypothetical protein K07052 K07052; CAAX protease family protein D spyM18_1188 pepN; putative lysyl-aminopeptidase K01256 pepN; aminopeptidase N [EC:3.4.11.2] D spyM18_1403 pepB; putative oligopeptidase K08602 pepF; oligoendopeptidase F [EC:3.4.24.-] D spyM18_2153 pepO; putative endopeptidase O K07386 pepO; putative endopeptidase [EC:3.4.24.-] D spyM18_1835 putative D,D-carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D spyM18_1044 putative dipeptidase K01274 pepV; beta-Ala-Xaa dipeptidase [EC:3.4.13.-] D spyM18_0861 pepT; putative tripeptidase K01258 pepT; tripeptide aminopeptidase [EC:3.4.11.4] D spyM18_1366 map; putative methionine aminopeptidase K01265 map; methionyl aminopeptidase [EC:3.4.11.18] D spyM18_0571 pepQ; putative XAA-PRO dipeptidase K01271 pepQ; Xaa-Pro dipeptidase [EC:3.4.13.9] D spyM18_1889 pepP; putative aminopeptidase K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9] D spyM18_0014 ftsH; putative cell division protein K03798 ftsH; cell division protease FtsH [EC:3.4.24.-] D spyM18_0115 putative glutamyl-aminopeptidase K01261 pepA; glutamyl aminopeptidase [EC:3.4.11.7] D spyM18_0325 htpX; putative heat shock protein K03799 htpX; heat shock protein HtpX [EC:3.4.24.-] D spyM18_2031 hypothetical protein K11749 rseP; regulator of sigma E protease [EC:3.4.24.-] D spyM18_2256 putative serine protease K04771 degP; serine protease Do [EC:3.4.21.107] D spyM18_0464 putative cell envelope proteinase K01361 E3.4.21.96; lactocepin [EC:3.4.21.96] D spyM18_2074 scpA; C5A peptidase precursor K08652 C5AP; C5a peptidase [EC:3.4.21.110] D spyM18_1051 putative D,D-carboxypeptidase, penicillin-binding protein K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D spyM18_0280 dacA; putative penicillin-binding protein K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D spyM18_0446 clpP; putative ATP-dependent protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] D spyM18_1922 putative X-Pro dipeptidyl-peptidase IV K01281 pepX; X-Pro dipeptidyl-peptidase [EC:3.4.14.11] D spyM18_1553 conserved hypothetical protein K07177 K07177; Lon-like protease D spyM18_1150 putative repressor protein K01356 lexA; repressor LexA [EC:3.4.21.88] D spyM18_1229 putative signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D spyM18_1907 lepB; putative signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D spyM18_0127 lepA; LepA K03100 lepB; signal peptidase I [EC:3.4.21.89] D spyM18_0630 putative immunity protein K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13] D spyM18_0660 putative protease K08303 prtC; U32 family peptidase [EC:3.4.-.-] C 01003 Glycosyltransferases [BR:spm01003] D spyM18_0575 putative glucosyl transferase K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337] D spyM18_2236 hasA; hyaluronate synthase A K00752 hasA; hyaluronan synthase [EC:2.4.1.212] D spyM18_0574 putative sugar transferase K13677 dgs; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-glucosyltransferase [EC:2.4.1.208] D spyM18_1661 putative penicillin-binding protein 1a K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D spyM18_0098 pbp; putative penicillin-binding protein 1b K03693 pbp1b; penicillin-binding protein 1B D spyM18_2120 penicillin-binding protein 2a K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4] D spyM18_0270 rgpG; putative regulator of genetic competence K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] C 01005 Lipopolysaccharide biosynthesis proteins [BR:spm01005] D spyM18_0845 conserved hypothetical protein K12996 rgpA; rhamnosyltransferase [EC:2.4.1.-] D spyM18_0846 putative rhamnosyltransferase K12997 rgpB; rhamnosyltransferase [EC:2.4.1.-] D spyM18_0852 putative glycosyltransferase K12998 rgpE; glucosyltransferase [EC:2.4.1.-] D spyM18_0853 conserved hypothetical protein K07272 rgpF; rhamnosyltransferase [EC:2.4.1.-] D spyM18_0270 rgpG; putative regulator of genetic competence K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D spyM18_0568 putative sugar transferase K12999 rgpI; glucosyltransferase [EC:2.4.1.-] C 01011 Peptidoglycan biosynthesis and degradation proteins [BR:spm01011] D spyM18_1371 murA; putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D spyM18_0821 murA; putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D spyM18_1063 murB; putative UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] D spyM18_0398 putative UDP-N-acetyl muramate-alanine ligase K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8] D spyM18_1542 murD; putative UDP-N-acetylmuramoylalanine-D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] D spyM18_0440 murE; putative UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate ligase K05362 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7] D spyM18_1431 putative D-ala,D-ala ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D spyM18_1156 putative antimicrobial resistance factor K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10] D spyM18_0683 femB; putative peptidoglycan branched peptide synthesis protein, serine/alanine adding enzyme K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10] D spyM18_0682 femA; putative peptidoglycan branched peptide synthesis protein alanine adding enzyme K12554 murN; alanine adding enzyme [EC:2.3.2.-] D spyM18_1871 putative alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1] D spyM18_0411 putative glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3] D spyM18_0630 putative immunity protein K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13] D spyM18_1673 putative undecaprenyl-phosphate-UDP-MurNAc-pentapeptide phospho-MurNAc-pentapeptide transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] D spyM18_1541 murG; putative undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] D spyM18_0268 putative undecaprenol kinase K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] D spyM18_0428 conserved hypothetical protein K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] D spyM18_1661 putative penicillin-binding protein 1a K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D spyM18_0098 pbp; putative penicillin-binding protein 1b K03693 pbp1b; penicillin-binding protein 1B D spyM18_2120 penicillin-binding protein 2a K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4] D spyM18_1674 putative penicillin binding protein K12556 pbp2X; penicillin-binding protein 2X D spyM18_1051 putative D,D-carboxypeptidase, penicillin-binding protein K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D spyM18_0280 dacA; putative penicillin-binding protein K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D spyM18_1835 putative D,D-carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D spyM18_0020 putative secreted protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] D spyM18_2076 emm18; M18 protein precursor K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] D spyM18_1113 hypothetical protein K07284 srtA; sortase A [EC:3.4.22.70] D spyM18_0129 hypothetical protein K08600 srtB; sortase B [EC:3.4.22.71] D spyM18_0401 putative aminodeoxychorismate lyase K07082 mltG; peptidoglycan lytic transglycosylase G [EC:4.2.2.29] C 01004 Lipid biosynthesis proteins [BR:spm01004] D spyM18_1822 putative malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] D spyM18_1826 putative beta-ketoacyl-[ACP] synthase III K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] D spyM18_1820 putative beta-ketoacyl-ACP synthase II K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D spyM18_1821 putative beta-ketoacyl-ACP reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D spyM18_0483 putative dehydrogenease / oxidoreductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D spyM18_1818 putative beta-hydroxyacyl-ACP dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] D spyM18_1823 putative trans-2-enoyl-ACP reductase II K02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9] D spyM18_1829 putative enoyl CoA hydratase K18474 fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14] D spyM18_0592 hypothetical protein K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D spyM18_0023 putative fatty acid/phospholipid synthesis protein K03621 plsX; phosphate acyltransferase [EC:2.3.1.274] D spyM18_0966 conserved hypothetical protein K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] D spyM18_1418 putative 1-acylglycerol-3-phosphate O-acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] C 01008 Polyketide biosynthesis proteins C 01006 Prenyltransferases [BR:spm01006] D spyM18_1516 ispA; putative geranyltranstransferase K13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29] D spyM18_2033 uppS; putative undecaprenyl pyrophosphate synthetase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] D spyM18_0978 miaA; putative tRNA isopentenylpyrophosphate transferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75] C 01007 Amino acid related enzymes [BR:spm01007] D spyM18_0223 gluS; putative glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24] D spyM18_0096 tyrS; putative tyrosine-tRNA ligase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D spyM18_2245 trpS; putative tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] D spyM18_2008 putative cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16] D spyM18_2183 argS; putative arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D spyM18_0468 metS; putative methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] D spyM18_1531 ileS; putative isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5] D spyM18_1579 valS; putative valine-tRNA ligase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9] D spyM18_0171 leuS; putative leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D spyM18_0663 lysS; putative lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] D spyM18_2188 aspS; putative aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D spyM18_0712 asnS; putative asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D spyM18_0624 hypothetical protein K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D spyM18_2189 hisS; putative histidine-tRNA ligase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21] D spyM18_1701 glyQ; putative glycyl-tRNA synthetase (alpha subunit) K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14] D spyM18_1700 glyS; putative glycyl-tRNA synthetase (beta subunit) K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14] D spyM18_1814 serS; putative seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11] D spyM18_2030 proS; putative prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15] D spyM18_0576 putative threonyl-tRNA synthetase 1 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3] D spyM18_1399 alaS; putative alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7] D spyM18_0827 pheS; putative phenylalanyl-tRNA synthetase (alpha subunit) K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] D spyM18_0828 pheT; phenylalanyl-tRNA synthetase (beta subunit) K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] D spyM18_1849 putative aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] D spyM18_0969 ilvE; putative branched-chain-amino-acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D spyM18_2056 putative para-aminobenzoate synthetase K03342 pabBC; para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38] C 00199 Cytochrome P450 C 00194 Photosynthesis proteins [BR:spm00194] D spyM18_0819 atpE; putative proton-translocating ATPase, epsiron subunit K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon D spyM18_0818 atpD; putative proton-translocating ATPase, beta subunit K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1] D spyM18_0817 atpG; putative proton-translocating ATPase, gamma subunit K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma D spyM18_0816 atpA; putative proton-translocating ATPase, alpha subunit K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1] D spyM18_0815 atpH; putative proton-translocating ATPase, delta subunit K02113 ATPF1D; F-type H+-transporting ATPase subunit delta D spyM18_0814 atpF; putative proton-translocating ATPase, subunit b K02109 ATPF0B; F-type H+-transporting ATPase subunit b D spyM18_0812 atpL7; H+-transporting ATP synthase chain C K02110 ATPF0C; F-type H+-transporting ATPase subunit c D spyM18_0813 atpB; putative proton-translocating ATPase a subunit K02108 ATPF0A; F-type H+-transporting ATPase subunit a B B 09182 Protein families: genetic information processing C 03000 Transcription factors [BR:spm03000] D spyM18_1722 putative lactose phosphotransferase system repressor protein K02530 lacR; DeoR family transcriptional regulator, lactose phosphotransferase system repressor D spyM18_1993 putative lactose phosphotransferase system repressor protein K02530 lacR; DeoR family transcriptional regulator, lactose phosphotransferase system repressor D spyM18_0912 fruR; putative transcriptional repressor K03436 fruR2; DeoR family transcriptional regulator, fructose operon transcriptional repressor D spyM18_1552 putative ribose transport operon repressor K02529 galR; LacI family transcriptional regulator, galactose operon repressor D spyM18_0573 ccpA; catabolite control protein A K02529 galR; LacI family transcriptional regulator, galactose operon repressor D spyM18_1313 malR; putative maltose operon transcriptional repressor K02529 galR; LacI family transcriptional regulator, galactose operon repressor D spyM18_0692 putative transcriptional regulator K02525 kdgR; LacI family transcriptional regulator, kdg operon repressor D spyM18_1883 putative sucrose operon repressor K03484 scrR; LacI family transcriptional regulator, sucrose operon repressor D spyM18_1609 putative transcription regulator K02103 araR; GntR family transcriptional regulator, arabinose operon transcriptional repressor D spyM18_2157 putative transcriptional regulator K03486 treR2; GntR family transcriptional regulator, trehalose operon transcriptional repressor D spyM18_1153 putative transcription regulator K24967 nagR; GntR family transcriptional regulator, N-acetylglucosamine utilization regulator D spyM18_0783 putative transcriptional regulator K24967 nagR; GntR family transcriptional regulator, N-acetylglucosamine utilization regulator D spyM18_1943 glnR; putative transcriptional regulator K03713 glnR; MerR family transcriptional regulator, glutamine synthetase repressor D spyM18_0186 ferric transport regulator protein K09825 perR; Fur family transcriptional regulator, peroxide stress response regulator D spyM18_1565 hypothetical protein K21828 arcR; CRP/FNR family transcriptional regulator, arginine deiminase pathway regulator D spyM18_2199 putative cadmium efflux system accessory K21903 cadC; ArsR family transcriptional regulator, lead/cadmium/zinc/bismuth-responsive transcriptional repressor D spyM18_2210 conserved hypothetical protein K10947 K10947; PadR family transcriptional regulator D spyM18_0492 putative metal-dependent transcriptional regulator K03709 troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator D spyM18_1374 birA; putative biotin operon repressor K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] D spyM18_0038 hypothetical protein K20342 comR; HTH-type transcriptional regulator, regulator for ComX D spyM18_0554 putative positive transcriptional regulator K20373 rgg2; HTH-type transcriptional regulator, SHP2-responsive activator D spyM18_0599 putative positive regulator K20374 rgg3; HTH-type transcriptional regulator, SHP3-responsive repressor D spyM18_2103 Rgg K20375 ropB; HTH-type transcriptional regulator, pheromone-responsive regulator D spyM18_0255 purR; putative purine operon repressor K09685 purR; HTH-type transcriptional regulator, purine operon repressor D spyM18_1081 conserved hypothetical protein K01926 rex; redox-sensing transcriptional repressor D spyM18_1846 putative transcriptional pleiotropic repressor K03706 codY; transcriptional pleiotropic repressor D spyM18_1396 putative transcriptional regulator K07729 K07729; putative transcriptional regulator D spyM18_2001 putative transcription regulator K07729 K07729; putative transcriptional regulator D spyM18_0722 putative cro protein K07729 K07729; putative transcriptional regulator D spyM18_0640 putative transcription antiterminator K03488 licT; beta-glucoside operon transcriptional antiterminator D spyM18_0179 putative transcriptional regulator K03493 bglG1; transcriptional antiterminator D spyM18_1335 putative transcriptional antiterminator K03491 licR; probable licABCH operon transcriptional regulator D spyM18_2257 spo0J; putative chromosome segregation protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein D spyM18_1784 conserved hypothetical phage protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein D spyM18_1566 argR; putative arginine repressor K03402 argR; transcriptional regulator of arginine metabolism D spyM18_1514 argR; putative repressor protein K03402 argR; transcriptional regulator of arginine metabolism D spyM18_2182 argR; putative arginine repressor K03402 argR; transcriptional regulator of arginine metabolism D spyM18_1833 hrcA; putative heat shock transcription repressor protein K03705 hrcA; heat-inducible transcriptional repressor D spyM18_2135 putative transcriptional regulator K03708 ctsR; transcriptional regulator of stress and heat shock response D spyM18_0890 pyrR; putative pyrimidine regulatory protein K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9] D spyM18_0330 conserved hypothetical protein K07738 nrdR; transcriptional repressor NrdR D spyM18_0300 putative competence protein K12296 comX1_2; competence protein ComX D spyM18_1967 putative competence protein K12296 comX1_2; competence protein ComX C 03021 Transcription machinery [BR:spm03021] D spyM18_0079 rpoA; DNA-directed RNA polymerase alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] D spyM18_0099 ropB; putative DNA-dependent RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] D spyM18_0100 ropC; RNA polymerase beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] D spyM18_1960 rpoE; probable DNA-directed RNA polymerase delta subunit K03048 rpoE; DNA-directed RNA polymerase subunit delta D spyM18_1640 putative DNA-directed RNA polymerase omega chain K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6] D spyM18_0841 rpoD; putative RNA polymerase sigma 42 protein K03086 rpoD; RNA polymerase primary sigma factor D spyM18_1732 nusA; transcription termination-antitermination factor K02600 nusA; transcription termination/antitermination protein NusA D spyM18_1884 putative transcriptional terminator K03625 nusB; transcription antitermination protein NusB D spyM18_0159 putative transcription antitermination factor K02601 nusG; transcription termination/antitermination protein NusG D spyM18_0402 putative transcription elongation factor K03624 greA; transcription elongation factor GreA C 03019 Messenger RNA biogenesis [BR:spm03019] D spyM18_0597 rnc; putative ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3] D spyM18_1941 conserved hypothetical protein K12574 rnj; ribonuclease J [EC:3.1.-.-] D spyM18_1003 conserved hypothetical protein K12574 rnj; ribonuclease J [EC:3.1.-.-] D spyM18_1643 conserved hypothetical protein K18682 rny; ribonucrease Y [EC:3.1.-.-] D spyM18_0562 vacB; putative exoribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1] D spyM18_0251 putative CMP-binding factor K03698 cbf; 3'-5' exoribonuclease [EC:3.1.-.-] D spyM18_1424 deaD; putative ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7] D spyM18_1670 putative ATP-dependent RNA helicase K18692 cshB; ATP-dependent RNA helicase CshB [EC:5.6.2.7] D spyM18_0798 eno; putative enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D spyM18_2014 pnp; putative polynucleotide phosphorylase, alpha chain K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] D spyM18_1231 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D spyM18_1831 dnaK; heat shock protein 70 K04043 dnaK; molecular chaperone DnaK D spyM18_2129 groL; heat shock protein (chaperonin) K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D spyM18_0713 conserved hypothetical protein K06958 rapZ; RNase adapter protein RapZ C 03041 Spliceosome C 03011 Ribosome [BR:spm03011] D spyM18_0971 putative ribosomal protein S1-like DNA-binding protein K02945 RP-S1; small subunit ribosomal protein S1 D spyM18_2151 rpsB; 30S ribosomal protein S2 K02967 RP-S2; small subunit ribosomal protein S2 D spyM18_0057 rpsC; 30S ribosomal protein S3 K02982 RP-S3; small subunit ribosomal protein S3 D spyM18_2215 rpsD; 30S ribosomal protein S4 K02986 RP-S4; small subunit ribosomal protein S4 D spyM18_0069 rpsE; 30S ribosomal protein S5 K02988 RP-S5; small subunit ribosomal protein S5 D spyM18_1897 rpS6; 30S ribosomal protein S6 K02990 RP-S6; small subunit ribosomal protein S6 D spyM18_0259 rpsG; 30S ribosomal protein S7 K02992 RP-S7; small subunit ribosomal protein S7 D spyM18_0066 rpsH; 30S ribosomal protein S8 K02994 RP-S8; small subunit ribosomal protein S8 D spyM18_1999 rpS9; ribosomal protein S9 K02996 RP-S9; small subunit ribosomal protein S9 D spyM18_0049 rpsJ; 30S ribosomal protein S10 K02946 RP-S10; small subunit ribosomal protein S10 D spyM18_0078 rpsK; 30S ribosomal protein S11 K02948 RP-S11; small subunit ribosomal protein S11 D spyM18_0258 rpsL; 30S ribosomal protein S12 K02950 RP-S12; small subunit ribosomal protein S12 D spyM18_0077 rpsM; 30S ribosomal protein S13 K02952 RP-S13; small subunit ribosomal protein S13 D spyM18_1936 rs14; 30S ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14 D spyM18_0065 rpsN; 30S ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14 D spyM18_2021 rpS15; 30S ribosomal protein S15 K02956 RP-S15; small subunit ribosomal protein S15 D spyM18_0900 rpsP; 30S ribosomal protein S1 K02959 RP-S16; small subunit ribosomal protein S16 D spyM18_0061 rpsQ; 30S ribosomal protein S17 K02961 RP-S17; small subunit ribosomal protein S17 D spyM18_1895 rpsR; 30S ribosomal protein S18 K02963 RP-S18; small subunit ribosomal protein S18 D spyM18_0054 rpsS; 30S ribosomal protein S19 K02965 RP-S19; small subunit ribosomal protein S19 D spyM18_1184 rpS20; 30S ribosomal protein S20 K02968 RP-S20; small subunit ribosomal protein S20 D spyM18_0838 rpsU; 30S ribosomal protein S21 K02970 RP-S21; small subunit ribosomal protein S21 D spyM18_0504 rl1; 50S ribosomal protein L1 K02863 RP-L1; large subunit ribosomal protein L1 D spyM18_0053 rplB; 50S ribosomal protein L2 K02886 RP-L2; large subunit ribosomal protein L2 D spyM18_0050 rplC; 50S ribosomal protein L3 K02906 RP-L3; large subunit ribosomal protein L3 D spyM18_0051 rplD; 50S ribosomal protein L4 K02926 RP-L4; large subunit ribosomal protein L4 D spyM18_0064 rplE; 50S ribosomal protein L5 K02931 RP-L5; large subunit ribosomal protein L5 D spyM18_0067 rplF; 50S ribosomal protein L6 K02933 RP-L6; large subunit ribosomal protein L6 D spyM18_2218 rpL9; 50S ribosomal protein L9 K02939 RP-L9; large subunit ribosomal protein L9 D spyM18_1048 rpl10; 50S ribosomal protein L10 K02864 RP-L10; large subunit ribosomal protein L10 D spyM18_0503 rl11; 50S ribosomal protein L11 K02867 RP-L11; large subunit ribosomal protein L11 D spyM18_2000 rpL13; 50S ribosomal protein L13 K02871 RP-L13; large subunit ribosomal protein L13 D spyM18_0062 rplN; 50S ribosomal protein L14 K02874 RP-L14; large subunit ribosomal protein L14 D spyM18_0072 rplO; 50S ribosomal protein L15 K02876 RP-L15; large subunit ribosomal protein L15 D spyM18_0058 rplP; 50S ribosomal protein L16 K02878 RP-L16; large subunit ribosomal protein L16 D spyM18_0080 rplQ; 50S ribosomal protein L17 K02879 RP-L17; large subunit ribosomal protein L17 D spyM18_0068 rplR; 50S ribosomal protein L18 K02881 RP-L18; large subunit ribosomal protein L18 D spyM18_0791 rpl19; 50S ribosomal protein L19 K02884 RP-L19; large subunit ribosomal protein L19 D spyM18_0868 rl20; 50S ribosomal protein L20 K02887 RP-L20; large subunit ribosomal protein L20 D spyM18_0883 rpL21; 50S ribosomal protein L21 K02888 RP-L21; large subunit ribosomal protein L21 D spyM18_0056 rplV; 50S ribosomal protein L22 K02890 RP-L22; large subunit ribosomal protein L22 D spyM18_0052 rplW; 50S ribosomal protein L23 K02892 RP-L23; large subunit ribosomal protein L23 D spyM18_0063 rplX; 50S ribosomal protein L24 K02895 RP-L24; large subunit ribosomal protein L24 D spyM18_0885 rpl27; 50S ribosomal protein L27 K02899 RP-L27; large subunit ribosomal protein L27 D spyM18_1953 rl28; 50S ribosomal protein L28 K02902 RP-L28; large subunit ribosomal protein L28 D spyM18_0060 rpmC; 50S ribosomal protein L29 K02904 RP-L29; large subunit ribosomal protein L29 D spyM18_0071 rpmD; 50S ribosomal protein L30 K02907 RP-L30; large subunit ribosomal protein L30 D spyM18_0785 rl31; 50S ribosomal protein L31 K02909 RP-L31; large subunit ribosomal protein L31 D spyM18_2196 rpmF; 50S ribosomal protein L32 K02911 RP-L32; large subunit ribosomal protein L32 D spyM18_2197 rpmG; 50S ribosomal protein L33 K02913 RP-L33; large subunit ribosomal protein L33 D spyM18_0232 rpmH; 50S ribosomal protein L34 K02914 RP-L34; large subunit ribosomal protein L34 D spyM18_0867 rpl35; 50S ribosomal protein L35 K02916 RP-L35; large subunit ribosomal protein L35 D spyM18_0076 rpmJ; 50S ribosomal protein B K02919 RP-L36; large subunit ribosomal protein L36 D spyM18_r05 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r03 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r12 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r01 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r10 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r07 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r02 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r09 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r11 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r04 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r08 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r06 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA C 03009 Ribosome biogenesis [BR:spm03009] D spyM18_0597 rnc; putative ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3] D spyM18_0517 era; putative GTP-binding protein K03595 era; GTPase D spyM18_1342 obg; putative GTP-binding protein K03979 obgE; GTPase [EC:3.6.5.-] D spyM18_1732 nusA; transcription termination-antitermination factor K02600 nusA; transcription termination/antitermination protein NusA D spyM18_1884 putative transcriptional terminator K03625 nusB; transcription antitermination protein NusB D spyM18_0159 putative transcription antitermination factor K02601 nusG; transcription termination/antitermination protein NusG D spyM18_1406 putative 16S pseudouridylate synthetase K06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19] D spyM18_1351 putative 16S pseudouridylate synthase K06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19] D spyM18_0246 ksgA; putative dimethyladenosine transferase K02528 ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182] D spyM18_1637 putative RNA-binding Sun protein K03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176] D spyM18_1182 conserved hypothetical protein K00564 rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172] D spyM18_1555 conserved hypothetical protein K08316 rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171] D spyM18_2051 conserved hypothetical protein K09761 rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193] D spyM18_0323 gidB; putative glucose-inhibited division protein K03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170] D spyM18_1676 conserved hypothetical protein K03438 mraW; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199] D spyM18_0456 conserved hypothetical protein K07056 rsmI; 16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198] D spyM18_1515 putative hemolysin K06442 tlyA; 23S rRNA (cytidine1920-2'-O)/16S rRNA (cytidine1409-2'-O)-methyltransferase [EC:2.1.1.226 2.1.1.227] D spyM18_2005 putative tRNA/rRNA methyltransferase K03218 rlmB; 23S rRNA (guanosine2251-2'-O)-methyltransferase [EC:2.1.1.185] D spyM18_2255 conserved hypothetical protein K00783 rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177] D spyM18_0870 conserved hypothetical protein K06969 rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191] D spyM18_1550 conserved hypothetical protein K06941 rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192] D spyM18_1360 putative RNA methyltransferase K03215 rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190] D spyM18_0418 putative hypothetical protein K06178 rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22] D spyM18_0889 sfhB; conserved hypothetical protein K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] D spyM18_2124 conserved hypothetical protein K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] D spyM18_1088 conserved hypothetical protein K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] D spyM18_1938 rimI; putative ribosomal-protein-alanine acetyltransferase K03789 rimI; [ribosomal protein S18]-alanine N-acetyltransferase [EC:2.3.1.266] D spyM18_0907 rimM; putative 16S rRNA processing protein RIMM K02860 rimM; 16S rRNA processing protein RimM D spyM18_2052 prmA; putative methyltransferase K02687 prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-] D spyM18_2171 conserved hypothetical protein K07447 ruvX; putative pre-16S rRNA nuclease [EC:3.1.-.-] D spyM18_2007 conserved hypothetical protein K11145 mrnC; mini-ribonuclease III [EC:3.1.26.-] D spyM18_1424 deaD; putative ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7] D spyM18_1670 putative ATP-dependent RNA helicase K18692 cshB; ATP-dependent RNA helicase CshB [EC:5.6.2.7] D spyM18_0247 conserved hypothetical protein K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] D spyM18_0334 putative phosphoglycerate dehydrogenase K03977 engA; GTPase D spyM18_1121 conserved hypothetical protein K14540 rbgA; ribosome biogenesis GTPase A D spyM18_0979 hflX; putative GTP-binding protein K03665 hflX; GTPase D spyM18_0302 conserved hypothetical protein K06948 yqeH; 30S ribosome assembly GTPase D spyM18_1103 hypothetical protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87] D spyM18_2045 (p)ppGpp synthetase K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2] D spyM18_1728 putative ribosome binding factor A K02834 rbfA; ribosome-binding factor A D spyM18_1733 conserved hypothetical protein K09748 rimP; ribosome maturation factor RimP D spyM18_2241 conserved hypothetical protein K14761 rlbA; ribosome-associated protein D spyM18_0306 conserved hypothetical protein K09710 ybeB; ribosome-associated protein D spyM18_0515 conserved hypothetical protein K07042 ybeY; probable rRNA maturation factor D spyM18_0303 conserved hypothetical protein K07574 yhbY; RNA-binding protein D spyM18_1623 conserved hypothetical protein K05808 hpf; ribosome hibernation promoting factor D spyM18_0004 putative GTP-binding protein K06942 ychF; ribosome-binding ATPase D spyM18_0326 conserved hypothetical protein K07040 yceD; DUF177 domain-containing protein C 03016 Transfer RNA biogenesis [BR:spm03016] D spyM18_0981 conserved hypothetical protein K00784 rnz; ribonuclease Z [EC:3.1.26.11] D spyM18_0927 papS; putative poly(A) polymerase K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-] D spyM18_2030 proS; putative prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15] D spyM18_1531 ileS; putative isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5] D spyM18_0171 leuS; putative leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D spyM18_0468 metS; putative methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] D spyM18_2183 argS; putative arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D spyM18_0663 lysS; putative lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] D spyM18_2188 aspS; putative aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D spyM18_1399 alaS; putative alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7] D spyM18_0712 asnS; putative asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D spyM18_0624 hypothetical protein K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D spyM18_0576 putative threonyl-tRNA synthetase 1 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3] D spyM18_1814 serS; putative seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11] D spyM18_2008 putative cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16] D spyM18_1579 valS; putative valine-tRNA ligase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9] D spyM18_2189 hisS; putative histidine-tRNA ligase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21] D spyM18_0827 pheS; putative phenylalanyl-tRNA synthetase (alpha subunit) K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] D spyM18_0828 pheT; phenylalanyl-tRNA synthetase (beta subunit) K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] D spyM18_0096 tyrS; putative tyrosine-tRNA ligase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D spyM18_2245 trpS; putative tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] D spyM18_2044 conserved hypothetical protein K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96] D spyM18_1738 putative cell-cycle regulation histidine triad (HIT) protein K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-] D spyM18_1734 putative methyltransferase K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33] D spyM18_1966 truA; putative tRNA pseudouridine synthase A K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12] D spyM18_1200 truB; putative tRNA pseudouridine 55 synthase K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25] D spyM18_0878 nifS; putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D spyM18_1083 nifS; putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D spyM18_1103 hypothetical protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87] D spyM18_0978 miaA; putative tRNA isopentenylpyrophosphate transferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75] D spyM18_1045 putative thiophene degradation protein F K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-] D spyM18_2220 gidA; glucose inhibited division protein K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme D spyM18_0228 rnpA; putative ribonuclease P protein component K03536 rnpA; ribonuclease P protein component [EC:3.1.26.5] D spyM18_1701 glyQ; putative glycyl-tRNA synthetase (alpha subunit) K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14] D spyM18_1700 glyS; putative glycyl-tRNA synthetase (beta subunit) K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14] D spyM18_0223 gluS; putative glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24] D spyM18_0666 putative transcription regulator K03976 ybaK; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-] D spyM18_0196 conserved hypothetical protein K11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33] D spyM18_0122 hypothetical protein K05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-] D spyM18_1125 putative glucose-inhibited division protein K04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74] D spyM18_0908 trmD; putative tRNA (guanine-N1)-methyltransferase K00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228] D spyM18_0987 conserved hypothetical protein K06967 trmK; tRNA (adenine22-N1)-methyltransferase [EC:2.1.1.217] D spyM18_0424 putative rRNA methylase K03216 trmL; tRNA (cytidine/uridine-2'-O-)-methyltransferase [EC:2.1.1.207] D spyM18_0406 putative rRNA methylase K03437 spoU; RNA methyltransferase, TrmH family D spyM18_2222 trmU; tRNA-methyltransferase K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13] D spyM18_1408 queA; putative S-adenosylmethionine-tRNA ribosyltransferase-isomerase K07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17] D spyM18_0704 conserved hypothetical protein K18979 queG; epoxyqueuosine reductase [EC:1.17.99.6] D spyM18_0218 conserved hypothetical protein K09765 queH; epoxyqueuosine reductase [EC:1.17.99.6] D spyM18_0189 tgt; putative tRNA-guanine transglycosylase K00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29] D spyM18_0879 thiI; putative thiamine biosynthesis protein K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4] D spyM18_0012 mesJ; putative cell-cycle protein K04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19] D spyM18_1939 putative glycoprotein endopeptidase K14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB D spyM18_1937 putative glycoprotein endopeptidase K25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234] D spyM18_1743 conserved hypothetical protein K06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE D spyM18_0309 conserved hypothetical protein K27343 tmcAL; tRNA(Met) cytidine acetate ligase [EC:6.3.4.-] D spyM18_0562 vacB; putative exoribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1] D spyM18_2014 pnp; putative polynucleotide phosphorylase, alpha chain K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] C 03012 Translation factors [BR:spm03012] D spyM18_1729 putative initiation factor 2 K02519 infB; translation initiation factor IF-2 D spyM18_0866 infC; translation initiation factor IF-3 K02520 infC; translation initiation factor IF-3 D spyM18_1008 putative ABC transporter (ATP-binding protein) K06158 ABCF3; ATP-binding cassette, subfamily F, member 3 D spyM18_2152 putative elongation factor TS K02357 tsf; elongation factor Ts D spyM18_0678 tufA; putative translation elongation factor EF-Tu K02358 tuf; elongation factor Tu D spyM18_0260 fusA; elongation factor G K02355 fusA; elongation factor G D spyM18_1101 prfA; putative peptide chain release factor 1 K02835 prfA; peptide chain release factor 1 D spyM18_0506 rrf; putative ribosome recycling factor K02838 frr; ribosome recycling factor D spyM18_1102 hemK; putative protoporphyrinogen oxidase K02493 hemK; release factor glutamine methyltransferase [EC:2.1.1.297] D spyM18_0005 pth; putative peptidyl-tRNA hydrolase K01056 PTH1; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29] D spyM18_0075 infA; putative translation initiation factor IF-1 K02518 infA; translation initiation factor IF-1 D spyM18_1887 efp; translation elongation factor EF-P K02356 efp; elongation factor P D spyM18_0705 prfB; putative peptide chain release factor 2 K02836 prfB; peptide chain release factor 2 D spyM18_1425 putative peptide-chain-release factor 3 K02837 prfC; peptide chain release factor 3 C 03110 Chaperones and folding catalysts [BR:spm03110] D spyM18_2134 clp; putative endopeptidase Clp ATP-binding chain C K03696 clpC; ATP-dependent Clp protease ATP-binding subunit ClpC D spyM18_1527 clp; putative ATP-dependent protease K03697 clpE; ATP-dependent Clp protease ATP-binding subunit ClpE D spyM18_0949 clpC; putative ATP-dependent Clp proteinase (ATP-binding subunit) K04086 clpL; ATP-dependent Clp protease ATP-binding subunit ClpL D spyM18_0946 clpX; putative ATP-dependent Clp protease subunit X K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX D spyM18_1831 dnaK; heat shock protein 70 K04043 dnaK; molecular chaperone DnaK D spyM18_2129 groL; heat shock protein (chaperonin) K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D spyM18_1830 dnaJ; heat-shock (chaperone) protein K03686 dnaJ; molecular chaperone DnaJ D spyM18_0123 putative HSP33 K04083 hslO; molecular chaperone Hsp33 D spyM18_1832 grpE; putative Hsp-70 cofactor K03687 GRPE; molecular chaperone GrpE D spyM18_2131 groS; heat shock protein - cochaperonin K04078 groES; chaperonin GroES D spyM18_2256 putative serine protease K04771 degP; serine protease Do [EC:3.4.21.107] D spyM18_0014 ftsH; putative cell division protein K03798 ftsH; cell division protease FtsH [EC:3.4.24.-] D spyM18_0813 atpB; putative proton-translocating ATPase a subunit K02108 ATPF0A; F-type H+-transporting ATPase subunit a D spyM18_0464 putative cell envelope proteinase K01361 E3.4.21.96; lactocepin [EC:3.4.21.96] D spyM18_2074 scpA; C5A peptidase precursor K08652 C5AP; C5a peptidase [EC:3.4.21.110] D spyM18_0499 cypB; putative cyclophilin-type protein K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8] D spyM18_1629 hypothetical protein K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8] D spyM18_1400 putative protease maturation protein K07533 prsA; foldase protein PrsA [EC:5.2.1.8] D spyM18_2097 conserved hypothetical K07533 prsA; foldase protein PrsA [EC:5.2.1.8] D spyM18_1901 trxA; putative thioredoxin K03671 TXN; thioredoxin C 04131 Membrane trafficking [BR:spm04131] D spyM18_0924 hypothetical protein K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6] D spyM18_1611 conserved hypothetical protein K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24] D spyM18_0261 gapA; glyceraldehyde-3-phosphate dehydrogenase, plasmin receptor K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D spyM18_1439 putative phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] D spyM18_1230 pyk; putative pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] C 04121 Ubiquitin system C 03051 Proteasome C 03032 DNA replication proteins [BR:spm03032] D spyM18_0001 dnaA; chromosomal replication initiator protein K02313 dnaA; chromosomal replication initiator protein D spyM18_2217 dnaC; DNA polymerase III delta prime subunit K02314 dnaB; replicative DNA helicase [EC:5.6.2.3] D spyM18_0348 putative DNA polymerase III delta prime subunit K02314 dnaB; replicative DNA helicase [EC:5.6.2.3] D spyM18_1801 putative phage DNA replication protein K02315 dnaC; DNA replication protein DnaC D spyM18_0350 putative phage DNA replication protein K02315 dnaC; DNA replication protein DnaC D spyM18_0840 dnaE; putative DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101] D spyM18_0331 hypothetical protein K03346 dnaB; replication initiation and membrane attachment protein D spyM18_0332 putative primosome component (helicase loader) K11144 dnaI; primosomal protein DnaI D spyM18_1795 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_0359 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_1896 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_0120 ssb; putative single-strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_1232 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D spyM18_2028 dnaE; DNA polymerase III alpha chain K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D spyM18_0002 dnaN; beta subunit of DNA polymerase III K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D spyM18_1415 DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D spyM18_0450 putative DNA polymerase III delta subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D spyM18_1928 putative DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D spyM18_1376 dnaX; DNA polymerase III gamma/tau subunits K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D spyM18_1122 rnhB; putative ribonuclease HII K03470 rnhB; ribonuclease HII [EC:3.1.26.4] D spyM18_1906 putative ribonuclease HIII K03471 rnhC; ribonuclease HIII [EC:3.1.26.4] D spyM18_0184 DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D spyM18_0810 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] D spyM18_1112 gyrA; DNA gyrase A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] D spyM18_0795 gryB; putative DNA gyrase, subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] D spyM18_0968 parC; DNA topoisomerase IV subunit C K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] D spyM18_0967 parE; putative DNA topoisomerase IV (subunit B) K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] D spyM18_1124 topA; putative DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1] C 03036 Chromosome and associated proteins [BR:spm03036] D spyM18_0597 rnc; putative ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3] D spyM18_0001 dnaA; chromosomal replication initiator protein K02313 dnaA; chromosomal replication initiator protein D spyM18_1548 putative peroxide resistance protein K04047 dps; starvation-inducible DNA-binding protein D spyM18_0598 smc; putative chromosome segregation SMC K03529 smc; chromosome segregation protein D spyM18_0416 conserved hypothetical protein K05896 scpA; segregation and condensation protein A D spyM18_0417 conserved hypothetical protein K06024 scpB; segregation and condensation protein B D spyM18_1538 ftsA; cell division protein K03590 ftsA; cell division protein FtsA D spyM18_0009 divIC; putative cell division protein K13052 divIC; cell division protein DivIC D spyM18_0706 ftsE; putative cell-division ATP-binding protein K09812 ftsE; cell division transport system ATP-binding protein D spyM18_0500 ftsK; conserved hypothetical protein K03466 ftsK; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family D spyM18_1675 putative cell division protein K03586 ftsL; cell division protein FtsL D spyM18_1540 ftsQ; cell division protein K03589 ftsQ; cell division protein FtsQ D spyM18_0676 ftsW; putative cell division protein K03588 ftsW; cell division protein FtsW D spyM18_0707 fts; putative cell-division protein K09811 ftsX; cell division transport system permease protein D spyM18_1537 ftsZ; putative cell division protein K03531 ftsZ; cell division protein FtsZ D spyM18_0796 conserved hypothetical protein K06286 ezrA; septation ring formation regulator D spyM18_1532 cell-division initiation protein K04074 divIVA; cell division initiation protein D spyM18_1535 conserved hypothetical protein K09772 sepF; cell division inhibitor SepF D spyM18_2257 spo0J; putative chromosome segregation protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein D spyM18_1784 conserved hypothetical phage protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein D spyM18_0968 parC; DNA topoisomerase IV subunit C K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] D spyM18_0967 parE; putative DNA topoisomerase IV (subunit B) K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] D spyM18_2220 gidA; glucose inhibited division protein K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme D spyM18_0323 gidB; putative glucose-inhibited division protein K03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170] D spyM18_1125 putative glucose-inhibited division protein K04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74] D spyM18_0947 conserved hypothetical GTP-binding protein K03978 engB; GTP-binding protein D spyM18_0715 conserved hypothetical protein K09762 whiA; cell division protein WhiA C 03400 DNA repair and recombination proteins [BR:spm03400] D spyM18_1523 putative deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] D spyM18_0964 ung; putative uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] D spyM18_1899 mutY; putative A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] D spyM18_0986 putative endonuclease III (DNA repair) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] D spyM18_0994 mutT; putative 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] D spyM18_1528 putative mutator protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] D spyM18_0219 dut; putative dUTPase, phage associated K01520 dut; dUTP diphosphatase [EC:3.6.1.23] D spyM18_2176 tag; putative 3-methyl-adenine DNA glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] D spyM18_0555 putative formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18] D spyM18_0461 putative 3'-exo-deoxyribonuclease K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2] D spyM18_0983 recJ; putative single-strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D spyM18_0810 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] D spyM18_0184 DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D spyM18_1890 uvrA; putative excinuclease ABC (subunit A) K03701 uvrA; excinuclease ABC subunit A D spyM18_1326 uvrB; putative excinuclease ABC (subunit B) K03702 uvrB; excinuclease ABC subunit B D spyM18_1042 excinuclease ABC (subunit C) K03703 uvrC; excinuclease ABC subunit C D spyM18_1217 pcrA; putative ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D spyM18_0099 ropB; putative DNA-dependent RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] D spyM18_0100 ropC; RNA polymerase beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] D spyM18_0079 rpoA; DNA-directed RNA polymerase alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] D spyM18_1960 rpoE; probable DNA-directed RNA polymerase delta subunit K03048 rpoE; DNA-directed RNA polymerase subunit delta D spyM18_1640 putative DNA-directed RNA polymerase omega chain K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6] D spyM18_0007 trcF; putative transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4] D spyM18_2180 putative DNA mismatch repair protein K03555 mutS; DNA mismatch repair protein MutS D spyM18_1903 putative DNA mismatch repair protein K07456 mutS2; DNA mismatch repair protein MutS2 D spyM18_2179 putative DNA mismatch repair protein K03572 mutL; DNA mismatch repair protein MutL D spyM18_1518 putative exodeoxyribonuclease VII (large subunit) K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6] D spyM18_1517 exodeoxyribonuclease VII (small subunit) K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6] D spyM18_1232 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D spyM18_2028 dnaE; DNA polymerase III alpha chain K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D spyM18_0002 dnaN; beta subunit of DNA polymerase III K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D spyM18_1415 DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D spyM18_0450 putative DNA polymerase III delta subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D spyM18_1928 putative DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D spyM18_1376 dnaX; DNA polymerase III gamma/tau subunits K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D spyM18_1795 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_0359 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_1896 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_0120 ssb; putative single-strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_1908 putative exodeoxyribonuclease V (alpha subunit) K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5] D spyM18_2174 recA; recombination protein K03553 recA; recombination protein RecA D spyM18_2177 ruvA; putative Holliday junction DNA helicase K03550 ruvA; holliday junction DNA helicase RuvA D spyM18_0039 ruvB; putative Holliday junction DNA helicase, subunit B K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4] D spyM18_1794 hypothetical phage protein K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10] D spyM18_1639 priA; putative primosomal replication factor Y K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4] D spyM18_0220 radA; putative DNA repair protein K04485 radA; DNA repair protein RadA/Sms D spyM18_2242 recF; recF protein K03629 recF; DNA replication and repair protein RecF D spyM18_1857 recG; putative ATP-dependent DNA helicase K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4] D spyM18_0022 conserved hypothetical protein K03584 recO; DNA repair protein RecO (recombination protein O) D spyM18_1432 recR; putative recombination protein K06187 recR; recombination protein RecR D spyM18_1513 recN; putative DNA repair and genetic recombination protein K03631 recN; DNA repair protein RecN (Recombination protein N) D spyM18_1660 putative recombination protein U K03700 recU; recombination protein U D spyM18_0836 rexA; putative ATP-dependent exonuclease, subunit A K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-] D spyM18_0835 rexB; putative ATP-dependent exonuclease, subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-] D spyM18_0558 conserved hypothetical protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase D spyM18_1112 gyrA; DNA gyrase A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] D spyM18_0795 gryB; putative DNA gyrase, subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] D spyM18_1124 topA; putative DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1] D spyM18_1495 putative recombinase K07455 recT; recombination protein RecT D spyM18_0731 putative recombinase K07455 recT; recombination protein RecT D spyM18_1910 dinP; putative DNA-damage-inducible protein P K02346 dinB; DNA polymerase IV [EC:2.7.7.7] D spyM18_1150 putative repressor protein K01356 lexA; repressor LexA [EC:3.4.21.88] D spyM18_1616 conserved hypothetical protein K03565 recX; regulatory protein D spyM18_0710 dinG; putative ATP-dependent DNA helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3] D spyM18_1387 nrdE; putative ribonucleotide reductase alpha-chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D spyM18_0472 ribonucleoside-diphosphate reductase, large chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D spyM18_1389 nrdF; ribonucleotide diphosphate reductase small subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D spyM18_0470 nrdF; putative ribonucleotide reductase 2 K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D spyM18_0787 conserved hypothetical protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3] C 03029 Mitochondrial biogenesis [BR:spm03029] D spyM18_1729 putative initiation factor 2 K02519 infB; translation initiation factor IF-2 D spyM18_0866 infC; translation initiation factor IF-3 K02520 infC; translation initiation factor IF-3 D spyM18_2152 putative elongation factor TS K02357 tsf; elongation factor Ts D spyM18_0678 tufA; putative translation elongation factor EF-Tu K02358 tuf; elongation factor Tu D spyM18_0260 fusA; elongation factor G K02355 fusA; elongation factor G D spyM18_0517 era; putative GTP-binding protein K03595 era; GTPase D spyM18_0096 tyrS; putative tyrosine-tRNA ligase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D spyM18_0171 leuS; putative leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D spyM18_2188 aspS; putative aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D spyM18_2183 argS; putative arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D spyM18_1840 gatA; putative Glutamyl-tRNA Gln amidotransferase subunit A K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7] D spyM18_1839 gatB; putative Glu-tRNAGln amidotransferase subunit B K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7] D spyM18_1841 gatC; putative Glu-tRNA Gln amidotransferase subunit C K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7] D spyM18_1795 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_0359 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_1896 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_0120 ssb; putative single-strand binding protein K03111 ssb; single-strand DNA-binding protein D spyM18_1831 dnaK; heat shock protein 70 K04043 dnaK; molecular chaperone DnaK D spyM18_1832 grpE; putative Hsp-70 cofactor K03687 GRPE; molecular chaperone GrpE D spyM18_2129 groL; heat shock protein (chaperonin) K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D spyM18_2131 groS; heat shock protein - cochaperonin K04078 groES; chaperonin GroES D spyM18_1830 dnaJ; heat-shock (chaperone) protein K03686 dnaJ; molecular chaperone DnaJ D spyM18_0878 nifS; putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D spyM18_1083 nifS; putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D spyM18_0229 conserved hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D spyM18_0404 hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D spyM18_0361 hypothetical phage protein K17080 PHB1; prohibitin 1 B B 09183 Protein families: signaling and cellular processes C 02000 Transporters [BR:spm02000] D spyM18_0214 putative ABC transporter, ATP-binding protein K18891 patA; ATP-binding cassette, subfamily B, multidrug efflux pump D spyM18_0215 putative ABC transporter (ATP-binding protein) K18892 patB; ATP-binding cassette, subfamily B, multidrug efflux pump D spyM18_1108 putative ABC transporter (ATP-binding protein) K18887 efrA; ATP-binding cassette, subfamily B, multidrug efflux pump D spyM18_1109 putative ABC transporter (ATP-binding protein) K18888 efrB; ATP-binding cassette, subfamily B, multidrug efflux pump D spyM18_0543 putative transport ATP-binding protein K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter D spyM18_1862 putative ABC transporter (ATP-binding protein) K06148 ABCC-BAC; ATP-binding cassette, subfamily C, bacterial D spyM18_1863 putative ABC transporter (ATP-binding protein) K06148 ABCC-BAC; ATP-binding cassette, subfamily C, bacterial D spyM18_0928 putative ABC transporter (ATP-binding protein) K15738 uup; ABC transport system ATP-binding/permease protein D spyM18_1040 putative periplasmic-iron-binding protein K02012 afuA; iron(III) transport system substrate-binding protein D spyM18_1067 potD; putative spermidine / putrescine ABC transporter (periplasmic transport protein) K11069 potD; spermidine/putrescine transport system substrate-binding protein D spyM18_1066 potC; putative spermidine/putrescine ABC transporter (permease protein) K11070 potC; spermidine/putrescine transport system permease protein D spyM18_1065 potB; putative spermidine / putrescine ABC transporter (permease protein) K11071 potB; spermidine/putrescine transport system permease protein D spyM18_1064 potA; putative spermidine / putrescine ABC transporter K11072 potA; spermidine/putrescine transport system ATP-binding protein [EC:7.6.2.11] D spyM18_0182 putative glycine-betaine binding permease protein K02001 proW; glycine betaine/proline transport system permease protein D spyM18_0181 putative glycine betaine/proline ABC transporter K02000 proV; glycine betaine/proline transport system ATP-binding protein [EC:7.6.2.9] D spyM18_1094 putative ABC transporter (binding protein) K05845 opuC; osmoprotectant transport system substrate-binding protein D spyM18_1093 putative ABC transporter (ATP-binding protein) K05847 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9] D spyM18_2040 multiple sugar-binding ABC transport system (ATP-binding protein) K10112 msmX; multiple sugar transport system ATP-binding protein [EC:7.5.2.-] D spyM18_1314 malE; putative maltose/maltodextrin-binding protein K15770 cycB; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein D spyM18_1315 malF; putative maltose/maltodextrin ABC transport system (permease) K15771 ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D spyM18_1316 malG; putative maltose/maltodextrin ABC transport system (permease) K15772 ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D spyM18_1598 conserved hypothetical protein K17318 lplA; putative aldouronate transport system substrate-binding protein D spyM18_1601 putative sugar-binding transport protein K17319 lplB; putative aldouronate transport system permease protein D spyM18_1599 putative sugar-binding transport protein K17320 lplC; putative aldouronate transport system permease protein D spyM18_1180 putative lipoprotein K07335 bmpA; basic membrane protein A and related proteins D spyM18_0158 putative ABC transporter K07335 bmpA; basic membrane protein A and related proteins D spyM18_1178 putative sugar ABC transporter (permease protein) K23535 nupB; general nucleoside transport system permease protein D spyM18_1177 putative sugar ABC transporter (permease protein) K23536 nupC; general nucleoside transport system permease protein D spyM18_1179 putative sugar ABC transporter (ATP-binding protein) K23537 nupA; general nucleoside transport system ATP-binding protein D spyM18_0234 putative sugar transporter sugar binding lipoprotein K02027 ABC.MS.S; multiple sugar transport system substrate-binding protein D spyM18_0236 putative sugar transport system (permease) K02025 ABC.MS.P; multiple sugar transport system permease protein D spyM18_0237 putative sugar transport protein (permease) K02026 ABC.MS.P1; multiple sugar transport system permease protein D spyM18_1194 pstS; putative phosphate ABC transporter, periplasmic phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein D spyM18_1193 pstC; putative phosphate ABC transporter K02037 pstC; phosphate transport system permease protein D spyM18_1192 pstA; putative phosphate ABC transporter (permease protein) K02038 pstA; phosphate transport system permease protein D spyM18_1190 pstB1; phosphate ABC transporter (ATP-binding protein) K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D spyM18_1191 pstB2; putative phosphate ABC transporter (ATP-binding protein) K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D spyM18_1327 glnH; hypothetical protein K10036 glnH; glutamine transport system substrate-binding protein D spyM18_1328 glnQ; putative ABC transporter (ATP-binding protein) K10038 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1] D spyM18_0962 putative ABC transporter (binding protein) K02424 tcyA; L-cystine transport system substrate-binding protein D spyM18_0312 conserved hypothetical protein K02424 tcyA; L-cystine transport system substrate-binding protein D spyM18_0963 putative ABC transporter (permease) K10009 tcyB; L-cystine transport system permease protein D spyM18_1669 putative amino acid ABC transproter (permease protein) K10009 tcyB; L-cystine transport system permease protein D spyM18_1668 putative amino acid ABC transport system (ATP-binding protein) K10010 tcyC; L-cystine transport system ATP-binding protein [EC:7.4.2.1] D spyM18_0837 putative ABC transporter (substrate-binding protein) K23059 artP; arginine/lysine/histidine transporter system substrate-binding protein D spyM18_1525 putative amino acid ABC transporter (permease protein) K17077 artQ; arginine/lysine/histidine transport system permease protein D spyM18_1524 putative amino acid ABC transporter (ATP-binding protein) K23060 artR; arginine/lysine/histidine transport system ATP-binding protein [EC:7.4.2.1] D spyM18_0314 conserved hypothetical protein K02073 metQ; D-methionine transport system substrate-binding protein D spyM18_0316 putative ABC transporter (permease protein) K02072 metI; D-methionine transport system permease protein D spyM18_0315 putative ABC transporter (ATP-binding protein) K02071 metN; D-methionine transport system ATP-binding protein D spyM18_0999 conserved hypothetical protein K01989 K01989; putative tryptophan/tyrosine transport system substrate-binding protein D spyM18_1001 putative ABC transport protein (permease) K05832 K05832; putative tryptophan/tyrosine transport system permease protein D spyM18_1002 putative ABC transporter (ATP-binding protein) K05833 K05833; putative tryptophan/tyrosine transport system ATP-binding protein D spyM18_0264 putative glutamine-binding periplasmic protein K17073 lysX1; putative lysine transport system substrate-binding protein D spyM18_0263 putative amino acid ABC transporter (ATP-binding protein) K17076 lysY; putative lysine transport system ATP-binding protein D spyM18_1223 putative amino acid ABC transporter, periplasmic amino acid-binding protein K02030 ABC.PA.S; polar amino acid transport system substrate-binding protein D spyM18_1225 putative amino acid ABC transporter (permease protein) K02029 ABC.PA.P; polar amino acid transport system permease protein D spyM18_1224 putative amino acid ABC transporter (ATP-binding protein) K02028 ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:7.4.2.1] D spyM18_0281 oppA; oligopeptide permease K15580 oppA; oligopeptide transport system substrate-binding protein D spyM18_0282 oppB; oligopeptide permease K15581 oppB; oligopeptide transport system permease protein D spyM18_0283 oppC; oligopeptide permease K15582 oppC; oligopeptide transport system permease protein D spyM18_0284 oppD; oligopeptide permease K15583 oppD; oligopeptide transport system ATP-binding protein D spyM18_0285 oppF; oligopeptide permease K10823 oppF; oligopeptide transport system ATP-binding protein D spyM18_2066 dppA; surface lipoprotein K02035 ABC.PE.S; peptide/nickel transport system substrate-binding protein D spyM18_2067 dppB; transmembrane transport protein K02033 ABC.PE.P; peptide/nickel transport system permease protein D spyM18_2068 dppC; transmembrane transport protein K02034 ABC.PE.P1; peptide/nickel transport system permease protein D spyM18_2069 dppD; ATPase protein K02031 ddpD; peptide/nickel transport system ATP-binding protein D spyM18_2070 dppE; ATPase protein K02032 ddpF; peptide/nickel transport system ATP-binding protein D spyM18_0438 fhuD; ferrichrome ABC transporter (ferrichrome-binding protein) K25308 fhuD; ferric hydroxamate/heme transport system substrate-binding protein D spyM18_0437 fhuB; putative ferrichrome ABC transporter (permease) K25288 fhuB; ferric hydroxamate/heme transport system permease protein D spyM18_0436 fhuG; putative ferrichrome ABC transporter (permease) K25289 fhuG; ferric hydroxamate/heme transport system permease protein D spyM18_0439 fhuC; putative ferrichrome ABC transporter (ATP-binding protein) K25290 fhuA; ferric hydroxamate/heme transport system ATP-binding protein [EC:7.2.2.16] D spyM18_1867 putative ABC transporter K25113 htsA; heme transport system substrate-binding protein D spyM18_1866 putative ABC transporter (permease) K25114 htsB; heme transport system permease protein D spyM18_1865 putative ABC transporter (ATP-binding protein) K25115 htsC; heme transport system ATP-binding protein [EC:7.6.2.5] D spyM18_1868 hypothetical protein K25120 shr; heme sequestration protein D spyM18_0781 putative adhesion protein K09815 znuA; zinc transport system substrate-binding protein D spyM18_2073 putative laminin adhesion K09815 znuA; zinc transport system substrate-binding protein D spyM18_0094 adrB; putative ABC transporter (permease) K09816 znuB; zinc transport system permease protein D spyM18_0093 adrC; ABC transporter (ATP-binding protein) K09817 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20] D spyM18_0494 mtsA; putative metal binding protein of ABC transporter (lipoprotein) K11704 mtsA; iron/zinc/manganese/copper transport system substrate-binding protein D spyM18_0498 mtsC; integral membrane protein MtsC K11705 mtsC; iron/zinc/manganese/copper transport system permease protein D spyM18_0496 mtsB; ATP-binding protein MtsB K11706 mtsB; iron/zinc/manganese/copper transport system ATP-binding protein D spyM18_0193 putative biotin synthase K03523 bioY; biotin transport system substrate-specific component D spyM18_1861 hypothetical protein K16926 htsT; energy-coupling factor transport system substrate-specific component D spyM18_0669 hypothetical protein K16927 cbrT; energy-coupling factor transport system substrate-specific component D spyM18_2228 conserved hypothetical protein K16785 ecfT; energy-coupling factor transport system permease protein D spyM18_1860 conserved hypothetical protein K16785 ecfT; energy-coupling factor transport system permease protein D spyM18_2230 ABC transporter (ATP-binding protein) K16786 ecfA1; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D spyM18_2229 putative ABC transporter (ATP-binding protein) K16787 ecfA2; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D spyM18_1859 putative ABC transporter (ATP-binding protein) K01552 ecfA; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D spyM18_0807 putative ABC transporter (ATP-binding protein) K25142 lnrN; linearmycin/streptolysin S transport system permease protein D spyM18_0806 sagH; SagH K25143 lnrM; linearmycin/streptolysin S transport system permease protein D spyM18_0805 putative ABC transporter (ATP-binding protein) K25144 lnrL; linearmycin/streptolysin S transport system ATP-binding protein D spyM18_0898 conserved hypothetical protein K24948 yknZ; antimicrobial peptide resistance transport system permease protein D spyM18_2087 putative ABC transporter (ATP-binding protein) K24948 yknZ; antimicrobial peptide resistance transport system permease protein D spyM18_0897 putative ABC transporter (ATP-binding protein) K24949 yknY; antimicrobial peptide resistance transport system ATP-binding protein [EC:7.6.2.-] D spyM18_2089 putative ABC transporter (ATP-binding protein) K24949 yknY; antimicrobial peptide resistance transport system ATP-binding protein [EC:7.6.2.-] D spyM18_0707 fts; putative cell-division protein K09811 ftsX; cell division transport system permease protein D spyM18_0706 ftsE; putative cell-division ATP-binding protein K09812 ftsE; cell division transport system ATP-binding protein D spyM18_0582 conserved hypothetical protein K25154 evrC; viologen exporter family transport system permease protein D spyM18_0580 conserved hypothetical protein K25155 evrB; viologen exporter family transport system permease protein D spyM18_0579 putative ABC transporter (ATP-binding protein) K25156 evrA; viologen exporter family transport system ATP-binding protein D spyM18_1736 putative ABC transporter (permease) K25157 ecsB; ABC-2 type transport system permease protein D spyM18_1737 putative ABC transporter (ATP-binding protein) K25158 ecsA; ABC-2 type transport system ATP-binding protein D spyM18_1684 hypothetical protein K01992 ABC-2.P; ABC-2 type transport system permease protein D spyM18_0848 putative ABC-transporter (permease protein) K01992 ABC-2.P; ABC-2 type transport system permease protein D spyM18_1855 hypothetical protein K01992 ABC-2.P; ABC-2 type transport system permease protein D spyM18_1685 putative ABC transporter (ATP-binding protein) K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D spyM18_1234 putative ABC transporter K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D spyM18_0849 ABC transporter (ATP-binding protein) K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D spyM18_1856 putative ABC transporter (ATP-binding protein) K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D spyM18_1205 hypothetical protein K02004 ABC.CD.P; putative ABC transport system permease protein D spyM18_1980 putative ABC transporter (permease) K02004 ABC.CD.P; putative ABC transport system permease protein D spyM18_0832 conserved hypothetical protein K02004 ABC.CD.P; putative ABC transport system permease protein D spyM18_1207 putative ABC transporter (ATP-binding protein) K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D spyM18_1981 putative salivaricin A ABC transporter K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D spyM18_0833 putative ABC transporter (ATP-binding protein) K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D spyM18_0273 putative ABC transporter (ATP-binding protein) K09013 sufC; Fe-S cluster assembly ATP-binding protein D spyM18_0048 conserved hypothetical protein K26937 dinF; MATE family, multidrug efflux pump D spyM18_1402 putative oxalateformate antiporter K08177 oxlT; MFS transporter, OFA family, oxalate/formate antiporter D spyM18_0485 glpT; putative glycerol-3-phosphate transporter K02445 glpT; MFS transporter, OPA family, glycerol-3-phosphate transporter D spyM18_0559 proP; putative multi-drug resistance efflux pump K08161 mdtG; MFS transporter, DHA1 family, multidrug resistance protein D spyM18_2178 putative integral membrane protein K08152 lmrP; MFS transporter, DHA1 family, multidrug resistance protein B D spyM18_0639 putative drug resistance protein K18926 lmrB; MFS transporter, DHA2 family, lincomycin resistance protein D spyM18_1384 pts1; putative phosphoenolpyruvate:sugar PTS enzyme I K08483 ptsI; phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9] D spyM18_1385 His containing phosphocarrier protein K02784 ptsH; phosphocarrier protein HPr D spyM18_2050 ptsG; putative PTS system, enzyme II, A component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208] D spyM18_1881 putative sucrose-specific PTS permease, enzyme II K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211] D spyM18_0641 beta-glucoside permease IIABC component K02757 bglF; beta-glucoside PTS system EIICBA component [EC:2.7.1.-] D spyM18_2155 putative PTS system enzyme II K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201] D spyM18_0914 fruA; putative fructose-specific enzyme II, PTS system BC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202] D spyM18_1986 putative PTS system, lactose-specific component IIA K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207] D spyM18_1985 putative PTS system, lactose-specific component IIBC K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207] D spyM18_1333 ptcA; putative PTS enzyme III K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D spyM18_2114 putative PTS system, enzyme III K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D spyM18_1334 ptcB; putative PTS system enzyme II K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D spyM18_2113 putative PTS system, enzyme IIB K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D spyM18_1331 putative PTS system IIC component K02761 celB; cellobiose PTS system EIIC component D spyM18_2111 putative PTS system, enzyme IIC component K02761 celB; cellobiose PTS system EIIC component D spyM18_1721 putative PTS system, enzyme IIA component K20112 gatA; galactose PTS system EIIA component [EC:2.7.1.204] D spyM18_1720 putative PTS system, enzyme IIB component K20113 gatB; galactose PTS system EIIB component [EC:2.7.1.204] D spyM18_1719 putative PTS system, enzyme IIC component K20114 gatC; galactose PTS system EIIC component D spyM18_1810 mannose-specific phosphotransferase system component IIAB K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191] D spyM18_1034 hypothetical protein K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191] D spyM18_1036 putative phosphotransferase system (PTS), enzyme II, component C K02795 manY; mannose PTS system EIIC component D spyM18_1811 putative mannose-specific phosphotransferase system component II K02795 manY; mannose PTS system EIIC component D spyM18_1812 putative mannose-specific phosphotransferase system component IID K02796 manZ; mannose PTS system EIID component D spyM18_1037 putative phospotransferase system (PTS), enzyme II component D K02796 manZ; mannose PTS system EIID component D spyM18_1035 putative phosphotransferase system (PTS), enzyme II component B K19507 gfrB; fructoselysine/glucoselysine PTS system EIIB component [EC:2.7.1.-] D spyM18_0698 putative PTS dependent N-acetyl-galactosamine- and galactosamine IIA component K02744 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-] D spyM18_0696 putative PTS dependent N-acetyl-galactosamine-IIB component K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-] D spyM18_0695 putative PTS dependent N-acetyl-galactosamine-IIC component K02746 agaW; N-acetylgalactosamine PTS system EIIC component D spyM18_0694 putative PTS dependent galactosamine IID component K02747 agaE; N-acetylgalactosamine PTS system EIID component D spyM18_0175 conserved hypothetical protein K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D spyM18_2018 conserved hypothetical protein K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D spyM18_0174 conserved hypothetical protein K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D spyM18_2017 conserved hypothetical protein K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D spyM18_0173 conserved hypothetical protein K03475 ulaA; ascorbate PTS system EIIC component D spyM18_2016 conserved hypothetical protein K03475 ulaA; ascorbate PTS system EIIC component D spyM18_0587 conserved hypothetical protein K05881 dhaM; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaM [EC:2.7.1.121] D spyM18_1694 glpF; putative glycerol uptake facilitator K02440 glpF; glycerol uptake facilitator D spyM18_1917 putative glycerol uptake facilitator K02440 glpF; glycerol uptake facilitator D spyM18_0588 putative glycerol uptake facilitator K02440 glpF; glycerol uptake facilitator D spyM18_0974 hypothetical protein K00799 GST; glutathione S-transferase [EC:2.5.1.18] D spyM18_0839 mscL; putative large conductance mechanosensitive channel K03282 mscL; large conductance mechanosensitive channel D spyM18_1962 conserved hypothetical protein K22044 ybiO; moderate conductance mechanosensitive channel D spyM18_1893 putative divalent cation transport K03284 corA; magnesium transporter D spyM18_0432 hylX; putative hemolysin K03699 tlyC; magnesium and cobalt exporter, CNNM family D spyM18_0905 putative cation-efflux system membrane protein K16264 czcD; cobalt-zinc-cadmium efflux system protein D spyM18_2243 conserved hypothetical protein K05340 glcU; glucose uptake protein D spyM18_0318 putative sodium/dicarboxylate symporter K07862 sstT; serine/threonine transporter D spyM18_0321 putative V-type Na+ -ATPase subunit J K03498 trkH; trk/ktr system potassium uptake protein D spyM18_0320 conserved hypothetical protein K03499 trkA; trk/ktr system potassium uptake protein D spyM18_0891 pyrP; putative uracil permease K02824 uraA; uracil permease D spyM18_1097 putative purine permease K16169 pbuX; xanthine permease D spyM18_1744 conserved hypothetical protein K06901 pbuG; adenine/guanine/hypoxanthine permease D spyM18_1075 conserved hypothetical protein K03281 clcA; chloride channel protein, CIC family D spyM18_1390 putative chloride channel protein K03281 clcA; chloride channel protein, CIC family D spyM18_0790 putative transmembrane protein K03281 clcA; chloride channel protein, CIC family D spyM18_1706 conserved hypothetical protein K03324 yjbB; phosphate:Na+ symporter D spyM18_1423 putative cation (K+) transport protein K03549 kup; KUP system potassium uptake protein D spyM18_0427 conserved hypothetical protein K23675 fmnP; riboflavin transporter D spyM18_0667 conserved hypothetical protein K16789 thiT; thiamine transporter D spyM18_1435 hypothetical protein K16788 niaX; niacin transporter D spyM18_0676 ftsW; putative cell division protein K03588 ftsW; cell division protein FtsW D spyM18_1129 putative methylmalonyl-CoA decarboxylase, beta-subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D spyM18_1135 putative decarboxylase, beta subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D spyM18_1126 putative transcarboxylase subunit K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2] D spyM18_1142 oadA; putative oxaloacetate decarboxylase alpha chain K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2] D spyM18_1127 hypothetical protein K01573 oadG; oxaloacetate decarboxylase (Na+ extruding) subunit gamma D spyM18_1128 putative methylmalonyl-CoA decarboxylase, gamma-subunit K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D spyM18_1134 putative decarboxylase, gamma chain K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D spyM18_1573 putative cytochrome C-type biogenesis protein K06196 ccdA; cytochrome c-type biogenesis protein D spyM18_0542 N-terminal fragment of BlpB K20345 blpB; membrane fusion protein, peptide pheromone/bacteriocin exporter D spyM18_2090 putative ATP-binding cassette transporter-like protein K24950 yknX; membrane fusion protein, antimicrobial resistance system D spyM18_0896 conserved hypothetical protein K24950 yknX; membrane fusion protein, antimicrobial resistance system D spyM18_1339 hypothetical protein K03811 pnuC; nicotinamide mononucleotide transporter C 02044 Secretion system [BR:spm02044] D spyM18_1534 conserved hypothetical protein K02221 yggT; YggT family protein D spyM18_1417 putative competence protein K02237 comEA; competence protein ComEA D spyM18_1888 putative late competence protein K01493 comEB; dCMP deaminase [EC:3.5.4.12] D spyM18_1416 putative competence protein K02238 comEC; competence protein ComEC D spyM18_1625 putative late competence protein K02240 comFA; competence protein ComFA D spyM18_1624 putative late competence protein K02242 comFC; competence protein ComFC D spyM18_0102 putative ABC transporter subunit ComYA K02243 comGA; competence protein ComGA D spyM18_0103 putative competence protein, ABC transporter subunit K02244 comGB; competence protein ComGB D spyM18_0105 putative competence protein K02245 comGC; competence protein ComGC D spyM18_0106 putative competence protein K02246 comGD; competence protein ComGD D spyM18_0108 putative competence protein K02248 comGF; competence protein ComGF D spyM18_1549 hypothetical protein K02236 comC; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-] D spyM18_1873 secA; putative preprotein translocase binding subunit K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D spyM18_2119 secE; hypothetical protein K03073 secE; preprotein translocase subunit SecE D spyM18_0561 hypothetical protein K03075 secG; preprotein translocase subunit SecG D spyM18_0073 secY; putative preprotein translocase K03076 secY; preprotein translocase subunit SecY D spyM18_1151 ffh; putative signal recognition particle -inhibited division protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] D spyM18_0638 putative signal recognition particle (docking protein) K03110 ftsY; fused signal recognition particle receptor D spyM18_2035 hypothetical protein K03210 yajC; preprotein translocase subunit YajC D spyM18_0229 conserved hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D spyM18_0404 hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase C 02042 Bacterial toxins [BR:spm02042] D spyM18_0476 conserved hypothetical protein K11044 spyA; C3 family ADP-ribosyltransferase [EC:2.4.2.-] D spyM18_0975 putative exfoliative toxin K11041 eta; exfoliative toxin A/B D spyM18_0165 slo; streptolysin O K11031 slo; thiol-activated cytolysin D spyM18_0432 hylX; putative hemolysin K03699 tlyC; magnesium and cobalt exporter, CNNM family D spyM18_1221 cfa; CAMP factor K11045 cfa; cAMP factor D spyM18_0799 sagA; streptolysin S associated protein K11046 sagA; streptolysin S associated protein D spyM18_1119 hylIII; putative hemolysin III K11068 hlyIII; hemolysin III D spyM18_0393 speA; exotoxin type A precursor K11040 se; staphylococcal enterotoxin D spyM18_1238 putative exotoxin precursor (SpeL) K11040 se; staphylococcal enterotoxin D spyM18_1239 putative exotoxin precursor (SpeM) K11040 se; staphylococcal enterotoxin D spyM18_2064 SMEZ; mitogenic exotoxin Z precursor K11040 se; staphylococcal enterotoxin D spyM18_0201 speG; exotoxin G precursor K11040 se; staphylococcal enterotoxin D spyM18_0778 speC; exotoxin C precursor K11040 se; staphylococcal enterotoxin D spyM18_0770 hylP; hyaluronidase - phage associated K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] D spyM18_1606 hyl; putative hyaluronidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] C 02022 Two-component system [BR:spm02022] D spyM18_0595 vicK; two-component sensor histidine kinase K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] D spyM18_0594 vicR; two-component response regulator K07668 vicR; two-component system, OmpR family, response regulator VicR D spyM18_1186 putative histidine kinase protein K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] D spyM18_1187 putative response regulator K14983 ciaR; two-component system, OmpR family, response regulator CiaR D spyM18_0329 covS; CovS K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3] D spyM18_0328 covR; CovR K18941 arlR; two-component system, OmpR family, response regulator ArlR D spyM18_2083 putative histidine kinase K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3] D spyM18_2084 putative two-component response regulator K18987 irr; two-component system, OmpR family, response regulator Irr D spyM18_1631 putative two-component sensor histidine kinase K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3] D spyM18_1630 putative two-component response regulator K11618 liaR; two-component system, NarL family, response regulator LiaR D spyM18_1979 putative SalK homologue K14988 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK D spyM18_1978 putative response regulator of salavaricin regulon K14989 salR; two-component system, NarL family, secretion system response regulator SalR D spyM18_1069 putative two-component sensor histidine kinase K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3] D spyM18_1068 putative two-component response regulator K02475 K02475; two-component system, CitB family, response regulator D spyM18_0539 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D spyM18_0224 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D spyM18_0226 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D spyM18_0538 putative response regulator K07707 agrA; two-component system, LytTR family, response regulator AgrA D spyM18_0227 putative response regulator K07707 agrA; two-component system, LytTR family, response regulator AgrA D spyM18_1569 putative histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] D spyM18_1596 putative two-component sensor histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] D spyM18_1595 putative two-component sensor response regulator K07720 yesN; two-component system, response regulator YesN D spyM18_1039 putative two-component response regulator K07720 yesN; two-component system, response regulator YesN C 02035 Bacterial motility proteins [BR:spm02035] D spyM18_0962 putative ABC transporter (binding protein) K02424 tcyA; L-cystine transport system substrate-binding protein D spyM18_0312 conserved hypothetical protein K02424 tcyA; L-cystine transport system substrate-binding protein C 03037 Cilium and associated proteins C 04812 Cytoskeleton proteins [BR:spm04812] D spyM18_1537 ftsZ; putative cell division protein K03531 ftsZ; cell division protein FtsZ D spyM18_1538 ftsA; cell division protein K03590 ftsA; cell division protein FtsA D spyM18_2257 spo0J; putative chromosome segregation protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein D spyM18_1784 conserved hypothetical phage protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein C 04147 Exosome [BR:spm04147] D spyM18_0798 eno; putative enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D spyM18_0261 gapA; glyceraldehyde-3-phosphate dehydrogenase, plasmin receptor K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D spyM18_1946 pgk; putative phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3] D spyM18_1230 pyk; putative pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] D spyM18_0499 cypB; putative cyclophilin-type protein K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8] D spyM18_0361 hypothetical phage protein K17080 PHB1; prohibitin 1 D spyM18_2129 groL; heat shock protein (chaperonin) K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D spyM18_1831 dnaK; heat shock protein 70 K04043 dnaK; molecular chaperone DnaK D spyM18_0204 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D spyM18_2244 impd; inosine monophosphate dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205] D spyM18_0678 tufA; putative translation elongation factor EF-Tu K02358 tuf; elongation factor Tu D spyM18_1738 putative cell-cycle regulation histidine triad (HIT) protein K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-] D spyM18_1111 ldh; putative L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D spyM18_0592 hypothetical protein K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D spyM18_0136 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_1645 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0590 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D spyM18_0074 adk; adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3] D spyM18_0984 apt; putative adenine phosphoribosyltransferase K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7] D spyM18_1696 glpK; putative glycerol kinase K00864 glpK; glycerol kinase [EC:2.7.1.30] D spyM18_1942 glnA; putative glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D spyM18_0030 purH; putative phosphoribosyl carboxyamide aminoimidazole transformylase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] D spyM18_1013 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D spyM18_0680 tpiA; putative triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] D spyM18_1439 putative phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] C 02048 Prokaryotic defense system [BR:spm02048] D spyM18_1974 hsdR; putative type I site-specific deoxyribonuclease K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3] D spyM18_1975 hsdS; putative specificity determinant HsdS K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3] D spyM18_1976 hsdM; putative type I site-specific deoxyribonuclease K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72] D spyM18_0110 conserved hypothetical protein K00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72] D spyM18_0742 hypothetical phage protein K00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72] D spyM18_1488 hypothetical phage protein K00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72] D spyM18_0367 hypothetical phage protein K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] D spyM18_0748 hypothetical phage protein K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] D spyM18_0616 hypothetical protein K07473 dinJ; DNA-damage-inducible protein J D spyM18_0617 hypothetical protein K19092 parE1_3_4; toxin ParE1/3/4 D spyM18_1537 ftsZ; putative cell division protein K03531 ftsZ; cell division protein FtsZ D spyM18_0968 parC; DNA topoisomerase IV subunit C K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] D spyM18_0967 parE; putative DNA topoisomerase IV (subunit B) K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] D spyM18_0878 nifS; putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D spyM18_1083 nifS; putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] C 04030 G protein-coupled receptors C 04050 Cytokine receptors C 04054 Pattern recognition receptors C 03310 Nuclear receptors C 04040 Ion channels [BR:spm04040] C 04031 GTP-binding proteins C 04052 Cytokines and neuropeptides C 04515 Cell adhesion molecules C 04090 CD molecules [BR:spm04090] C 01504 Antimicrobial resistance genes [BR:spm01504] D spyM18_1835 putative D,D-carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D spyM18_1324 dltA; putative D-alanine-D-alanyl carrier protein ligase K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D spyM18_1323 putative integral membrane protein K03739 dltB; membrane protein involved in D-alanine export D spyM18_1322 putative D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D spyM18_1321 putative extramembranal protein K03740 dltD; D-alanine transfer protein C 00535 Proteoglycans C 00536 Glycosaminoglycan binding proteins [BR:spm00536] D spyM18_0770 hylP; hyaluronidase - phage associated K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] D spyM18_1606 hyl; putative hyaluronidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] C 00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:spm00537] D spyM18_0770 hylP; hyaluronidase - phage associated K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] D spyM18_1606 hyl; putative hyaluronidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] D spyM18_0163 nga; nicotine adenine dinucleotide glycohydrolase precursor K18153 nga; NAD+ glycohydrolase [EC:3.2.2.5] C 04091 Lectins C 04990 Domain-containing proteins not elsewhere classified B B 09185 Viral protein families C 03200 Viral proteins C 03210 Viral fusion proteins B B 09184 RNA family C 03100 Non-coding RNAs [BR:spm03100] D spyM18_r05 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r03 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r12 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r01 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r10 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r07 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D spyM18_r02 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r09 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r11 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r04 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r08 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D spyM18_r06 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA # A09190 Not Included in Pathway or Brite B B 09191 Unclassified: metabolism C 99980 Enzymes with EC numbers D spyM18_0699 putative 5-keto-D-gluconate 5-reductase K00046 idnO; gluconate 5-dehydrogenase [EC:1.1.1.69] D spyM18_0462 putative lactate oxidase K10530 lctO; L-lactate oxidase [EC:1.1.3.2] D spyM18_2138 putative NADH oxidase/alkyl hydroperoxidase reductase K03387 ahpF; NADH-dependent peroxiredoxin subunit F [EC:1.8.1.-] D spyM18_0509 msrA; putative peptide methionine sulfoxide reductase K07304 msrA; peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11] D spyM18_1571 putative peptide methionine sulfoxide K12267 msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12] D spyM18_1032 putative heavy metal stress response protein K07305 msrB; peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12] D spyM18_2137 ahpC; putative alkyl hydroperoxidase K24119 ahpC; NADH-dependent peroxiredoxin subunit C [EC:1.11.1.26] D spyM18_0909 trxB; putative thioredoxin reductase K21567 fnr; ferredoxin/flavodoxin---NADP+ reductase [EC:1.18.1.2 1.19.1.1] D spyM18_0952 arsC; putative arsenate reductase K00537 arsC; arsenate reductase (glutaredoxin) [EC:1.20.4.1] D spyM18_2164 nrdG; putative anaerobic ribonucleotide reductase activator K04068 nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4] D spyM18_2117 putative pyruvate formate-lyase activating enzyme K04069 pflA; pyruvate formate lyase activating enzyme [EC:1.97.1.4] D spyM18_0433 putative pyruvate-formatelyase activating enzyme K04069 pflA; pyruvate formate lyase activating enzyme [EC:1.97.1.4] D spyM18_1656 conserved hypothetical protein K07444 ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-] D spyM18_0564 putative glutamine cyclotransferase K22757 QCT; glutaminyl-peptide cyclotransferase [EC:2.3.2.5] D spyM18_0606 conserved hypothetical protein K21349 ggs; glucosylglycerate synthase [EC:2.4.1.268] D spyM18_0654 putative prolipoprotein diacylglycerol transferase K13292 lgt; phosphatidylglycerol---prolipoprotein diacylglyceryl transferase [EC:2.5.1.145] D spyM18_1098 putative thiamine biosynthesis lipoprotein precursor K03734 apbE; FAD:protein FMN transferase [EC:2.7.1.180] D spyM18_1950 conserved hypothetical protein K07030 fakA; fatty acid kinase [EC:2.7.2.18] D spyM18_1018 conserved hypothetical protein K18672 dacA; diadenylate cyclase [EC:2.7.7.85] D spyM18_0653 ptsK; Hpr kinase/phosphatase K06023 hprK; HPr kinase/phosphorylase [EC:2.7.11.- 2.7.4.-] D spyM18_1005 estA; putative tributyrin esterase K03930 estA; putative tributyrin esterase [EC:3.1.1.-] D spyM18_0301 conserved hypothetical protein K07015 yqeG; putative phosphatase [EC:3.1.3.-] D spyM18_2219 conserved hypothetical protein K22927 gdpP; cyclic-di-AMP phosphodiesterase [EC:3.1.4.59] D spyM18_0243 conserved hypothetical protein K03424 tatD; TatD DNase family protein [EC:3.1.21.-] D spyM18_0244 conserved hypothetical protein K05985 rnmV; ribonuclease M5 [EC:3.1.26.8] D spyM18_2039 putative dextran glucosidase K01215 dexB; glucan 1,6-alpha-glucosidase [EC:3.2.1.70] D spyM18_0697 putative unsaturated glucuronyl hydrolase K18581 ugl; unsaturated chondroitin disaccharide hydrolase [EC:3.2.1.180] D spyM18_0279 putative DD-carboxypeptidase K01286 E3.4.16.4; D-alanyl-D-alanine carboxypeptidase [EC:3.4.16.4] D spyM18_2042 streptokinase precursor K14745 ska; streptokinase A [EC:3.4.-.-] D spyM18_2025 def; putative polypeptide deformylase K01462 PDF; peptide deformylase [EC:3.5.1.88] D spyM18_0932 def; putative polypeptide deformylase K01462 PDF; peptide deformylase [EC:3.5.1.88] D spyM18_1382 deadD2; putative deacetylase K22278 pgdA; peptidoglycan-N-acetylglucosamine deacetylase [EC:3.5.1.104] D spyM18_0141 conserved hypothetical protein K09022 ridA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10] D spyM18_0512 67 kDa Myosin-crossreactive streptococcal antigen K10254 ohyA; oleate hydratase [EC:4.2.1.53] D spyM18_1014 hylA; extracellular hyaluronate lyase K01727 hysA; hyaluronate lyase [EC:4.2.2.1] D spyM18_0689 pacL; putative calcium-transporting ATPase K01537 ATP2C; P-type Ca2+ transporter type 2C [EC:7.2.2.10] D spyM18_1443 putative heavy metal-transporting ATPase K01534 zntA; Zn2+/Cd2+-exporting ATPase [EC:7.2.2.12 7.2.2.21] C 99981 Carbohydrate metabolism C 99982 Energy metabolism D spyM18_0863 putative ferredoxin K05337 fer; ferredoxin D spyM18_0277 putative NifU protein K04488 iscU; nitrogen fixation protein NifU and related proteins C 99983 Lipid metabolism D spyM18_0926 conserved hypothetical protein K25232 fakB; fatty acid kinase fatty acid binding subunit D spyM18_1511 conserved hypothetical protein K25232 fakB; fatty acid kinase fatty acid binding subunit C 99984 Nucleotide metabolism D spyM18_0471 nrdI; putative ribonucleotide reductase K03647 nrdI; protein involved in ribonucleotide reduction D spyM18_2048 nrdI; ribonucleotide reductase-like protein K03647 nrdI; protein involved in ribonucleotide reduction D spyM18_0779 MF2; MF2 K15051 endA; DNA-entry nuclease D spyM18_1746 streptodornase K15051 endA; DNA-entry nuclease D spyM18_2104 mitogenic factor, 25K, precursor K15051 endA; DNA-entry nuclease D spyM18_1446 MF3 K15051 endA; DNA-entry nuclease C 99985 Amino acid metabolism D spyM18_1114 conserved hypothetical protein K08234 yaeR; glyoxylase I family protein D spyM18_1536 conserved hypothetical protein K06997 yggS; PLP dependent protein C 99986 Glycan metabolism C 99987 Cofactor metabolism C 99988 Secondary metabolism C 99999 Others B B 09192 Unclassified: genetic information processing C 99973 Transcription D spyM18_2136 cspC; putative cold shock protein K03704 cspA; cold shock protein D spyM18_1802 hypothetical phage protein K07741 antB; anti-repressor protein D spyM18_0723 putative antirepressor K07741 antB; anti-repressor protein D spyM18_1198 conserved hypothetical protein K16509 spxA; regulatory protein spx D spyM18_2173 conserved hypothetical protein K16509 spxA; regulatory protein spx D spyM18_0648 conserved hypothetical protein K06959 tex; protein Tex C 99974 Translation D spyM18_1628 putative polyribonucleotide nucleotidyltransferase K07570 GSP13; general stress protein 13 C 99975 Protein processing D spyM18_1961 ropA; RopA K03545 tig; trigger factor D spyM18_0563 smpB; conserved hypothetical protein K03664 smpB; SsrA-binding protein D spyM18_1386 nrdH; putative glutaredoxin K06191 nrdH; glutaredoxin-like protein NrdH D spyM18_0269 putative negative regulator of genetic competence K16511 mecA1_2; adapter protein MecA 1/2 C 99976 Replication and repair D spyM18_1079 radC; putative DNA repair protein K03630 radC; DNA repair protein RadC D spyM18_0250 conserved hypothetical protein K09760 rmuC; DNA recombination protein RmuC D spyM18_1420 conserved hypothetical protein K07461 K07461; putative endonuclease D spyM18_1123 smf; putative DNA processing protein K04096 smf; DNA processing protein D spyM18_0985 conserved hypothetical protein K02086 dnaD; DNA replication protein D spyM18_1500 conserved hypothetical phage protein K02086 dnaD; DNA replication protein D spyM18_0726 conserved hypothetical phage protein K02086 dnaD; DNA replication protein D spyM18_1278 putative terminase, small subunit K07474 xtmA; phage terminase small subunit D spyM18_1277 putative terminase, large subunit K06909 xtmB; phage terminase large subunit D spyM18_2058 conserved hypothetical protein K07478 ycaJ; putative ATPase D spyM18_1046 tra; putative transposase K07482 K07482; transposase, IS30 family D spyM18_1057 tra; putative transposase K07482 K07482; transposase, IS30 family D spyM18_0882 tra; putative transposase K07482 K07482; transposase, IS30 family D spyM18_0116 tra; putative transposase K07482 K07482; transposase, IS30 family D spyM18_0199 putative transposase K07482 K07482; transposase, IS30 family D spyM18_0421 putative transposase K07482 K07482; transposase, IS30 family D spyM18_0426 putative transposase K07482 K07482; transposase, IS30 family D spyM18_0577 tra; putative transposase-IS1239 K07482 K07482; transposase, IS30 family D spyM18_0572 tra; putative transposase-IS1239 K07482 K07482; transposase, IS30 family D spyM18_1875 putative transposase K07482 K07482; transposase, IS30 family D spyM18_2190 putative transposase K07482 K07482; transposase, IS30 family D spyM18_2133 tra; putative transposase K07482 K07482; transposase, IS30 family D spyM18_1918 tra; putative transposase K07482 K07482; transposase, IS30 family D spyM18_1344 tra; conserved hypothetical protein K07483 K07483; transposase D spyM18_0635 transposase fragment K07483 K07483; transposase D spyM18_1345 putative transposase, IS861 K07497 K07497; putative transposase D spyM18_0634 tnpA; transposase TnpA fragment K07497 K07497; putative transposase C 99979 Viral proteins C 99998 Others D spyM18_1926 conserved hypothetical protein K09747 ebfC; nucleoid-associated protein EbfC B B 09193 Unclassified: signaling and cellular processes C 99977 Transport D spyM18_1665 putative amino acid permease K03293 TC.AAT; amino acid transporter, AAT family D spyM18_0015 putative amino acid permease K03294 TC.APA; basic amino acid/polyamine antiporter, APA family D spyM18_1132 putative Mg2+/citrate complex transporter K03300 TC.CITMHS; citrate-Mg2+:H+ or citrate-Ca2+:H+ symporter, CitMHS family D spyM18_1219 putative amino acid symporter K03310 TC.AGCS; alanine or glycine:cation symporter, AGCS family D spyM18_0317 putative branched-chain amino acid transport protein K03311 TC.LIVCS; branched-chain amino acid:cation transporter, LIVCS family D spyM18_1932 putative nucleoside transporter K03317 TC.CNT; concentrative nucleoside transporter, CNT family C 99978 Cell growth D spyM18_1655 hypothetical protein K20073 mapZ; mid-cell-anchored protein Z D spyM18_0230 hypothetical protein K06346 jag; spoIIIJ-associated protein D spyM18_0716 int; putative integrase; bacteriophage 370.1 K06400 spoIVCA; site-specific DNA recombinase C 99993 Cell motility C 99995 Signaling proteins D spyM18_1544 typA; putative GTP-binding protein K06207 typA; GTP-binding protein D spyM18_0513 phoH; phosphate starvation-induced protein K06217 phoH; phosphate starvation-inducible protein PhoH and related proteins C 99992 Structural proteins D spyM18_0668 putative endolysin, phage associated K07273 acm; lysozyme C 99994 Others D spyM18_1189 phoU; putative phosphate uptake regulatory protein K02039 phoU; phosphate transport system protein D spyM18_0458 hypothetical protein K06201 cutC; copper homeostasis protein B B 09194 Poorly characterized C 99996 General function prediction only D spyM18_2166 putative oxidoreductase K03810 mviM; virulence factor D spyM18_1405 putative transcription factor K06198 coiA; competence protein CoiA D spyM18_0119 pheT1; hypothetical protein K06878 K06878; tRNA-binding protein D spyM18_0664 conserved hypothetical protein K07025 K07025; putative hydrolase of the HAD superfamily D spyM18_0278 conserved hypothetical protein K09014 sufB; Fe-S cluster assembly protein SufB D spyM18_0275 conserved hypothetical protein K09015 sufD; Fe-S cluster assembly protein SufD D spyM18_1365 conserved hypothetical protein K07058 K07058; membrane protein D spyM18_0973 conserved hypothetical protein K07146 K07146; UPF0176 protein D spyM18_0324 lemA; putative cytoplasmic membrane protein K03744 lemA; LemA protein D spyM18_0649 conserved hypothetical protein K03095 sprL; SprT-like protein D spyM18_2213 conserved hypothetical protein K01421 yhgE; putative membrane protein D spyM18_2207 conserved hypothetical protein K08974 K08974; putative membrane protein D spyM18_0643 conserved hypothetical protein K08986 ycgQ; putative membrane protein D spyM18_1226 conserved hypothetical protein K06193 phnA; protein PhnA C 99997 Function unknown D spyM18_0687 conserved hypothetical protein K06885 K06885; uncharacterized protein D spyM18_1957 conserved hypothetical protein K06889 K06889; uncharacterized protein D spyM18_0408 conserved hypothetical protein K06890 K06890; uncharacterized protein D spyM18_0185 conserved hypothetical protein K06929 K06929; uncharacterized protein D spyM18_0407 conserved hypothetical protein K06950 K06950; uncharacterized protein D spyM18_0901 conserved hypothetical protein K06960 K06960; uncharacterized protein D spyM18_2004 conserved hypothetical protein K06962 K06962; uncharacterized protein D spyM18_0808 conserved hypothetical protein K07004 K07004; uncharacterized protein D spyM18_0904 conserved hypothetical protein K07006 K07006; uncharacterized protein D spyM18_0910 putative regulatory protein K07035 K07035; uncharacterized protein D spyM18_0834 conserved hypothetical protein K07054 K07054; uncharacterized protein D spyM18_0644 conserved hypothetical protein K07089 K07089; uncharacterized protein D spyM18_0413 conserved hypothetical protein K07095 K07095; uncharacterized protein D spyM18_1437 putative transcriptional regulator K07105 K07105; uncharacterized protein D spyM18_0982 putative oxidoreductase K07124 K07124; uncharacterized protein D spyM18_0430 conserved hypothetical protein K07139 K07139; uncharacterized protein D spyM18_0419 conserved hypothetical protein K08998 K08998; uncharacterized protein D spyM18_1610 conserved hypothetical protein K09704 K09704; uncharacterized protein D spyM18_1152 ylmX; putative DNA-binding protein K09787 K09787; uncharacterized protein D spyM18_0507 conserved hypothetical protein K00243 K00243; uncharacterized protein D spyM18_2163 conserved hypothetical protein K09861 K09861; uncharacterized protein D spyM18_1336 conserved hypothetical protein K09963 K09963; uncharacterized protein D spyM18_0409 hypothetical protein K09976 K09976; uncharacterized protein D spyM18_1456 hypothetical protein K01163 K01163; uncharacterized protein D spyM18_0884 conserved hypothetical protein K07584 ysxB; uncharacterized protein D spyM18_1617 conserved hypothetical protein K07586 ygaC; uncharacterized protein D spyM18_1731 conserved hypothetical protein K07742 ylxR; uncharacterized protein ! #
#[ KO | BRITE | KEGG2 | KEGG ]
#Last updated: May 19, 2024