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#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Mitochondrial Biogenesis - Streptococcus pyogenes MGAS8232 (serotype M18)</h2>
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A<b>Mitochondrial DNA transcription, translation, and replication factors</b>
B  Mitochondrial DNA-encoded proteins
C    Mitochondrial respiratory chain complex I
C    Mitochondrial respiratory chain complex III
C    Cytochrome c oxidase
C    F-type ATPase
B  Mitochondrial transcription and translation factors
C    Mitochondrial RNA polymerase
C    Mitochondrial transcription factors
C    Mitochondrial translation factors
D      spyM18_1729 putative initiation factor 2	K02519 infB; translation initiation factor IF-2 
D      spyM18_0866 infC; translation initiation factor IF-3	K02520 infC; translation initiation factor IF-3 
D      spyM18_2152 putative elongation factor TS	K02357 tsf; elongation factor Ts 
D      spyM18_0678 tufA; putative translation elongation factor EF-Tu	K02358 tuf; elongation factor Tu 
D      spyM18_0260 fusA; elongation factor G	K02355 fusA; elongation factor G 
C    RNase MRP
C    Mitochondrial ribonuclease P
C    Other mitochondrial DNA transcription and translation factors
D      spyM18_0517 era; putative GTP-binding protein	K03595 era; GTPase 
D      spyM18_0096 tyrS; putative tyrosine-tRNA ligase	K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] 
D      spyM18_0171 leuS; putative leucyl-tRNA synthetase	K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] 
D      spyM18_2188 aspS; putative aspartyl-tRNA synthetase	K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] 
D      spyM18_2183 argS; putative arginyl-tRNA synthetase	K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] 
D      spyM18_1840 gatA; putative Glutamyl-tRNA Gln amidotransferase subunit A	K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7] 
D      spyM18_1839 gatB; putative Glu-tRNAGln amidotransferase subunit B	K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7] 
D      spyM18_1841 gatC; putative Glu-tRNA Gln amidotransferase subunit C	K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7] 
B  Mitochondrial DNA replication factors
C    Mitochondrial DNA polymerase
C    Mitochondrial DNA maintenance factors
C    Other Mitochondrial DNA replication factors
D      spyM18_1795 ssb; putative single strand binding protein	K03111 ssb; single-strand DNA-binding protein 
D      spyM18_0359 ssb; putative single strand binding protein	K03111 ssb; single-strand DNA-binding protein 
D      spyM18_1896 ssb; putative single strand binding protein	K03111 ssb; single-strand DNA-binding protein 
D      spyM18_0120 ssb; putative single-strand binding protein	K03111 ssb; single-strand DNA-binding protein 
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A<b>Mitochondrial protein import machinery</b>
B  Endoplasmic reticulum membrane and cytosol
C    ER-mitochondria encounter structure (ERMES) complex
C    Other ER-memrane and cytosol factors
B  Outer membrane
C    Transporter outer membrane (TOM) complex
C    TOB/SAM complex
C    Porin
C    ERMES complex
C    Other outer membrane factor
B  Inter membrane space
C    Transporter inner membrane (TIM) 9/10 complex
C    TIM8/13 complex
C    Mitochondrial intermembrane space assembly (MIA) complex
B  Inner mambrane
C    MICOS complex
C    MICOS complex (yeast)
C    TIM22 complex
C    TIM23 complex
C    Mitochondrial calcium uniporter complex
C    Other inner membrane factors
B  Matrix
C    MMC/PAM proteins
D      spyM18_1831 dnaK; heat shock protein 70	K04043 dnaK; molecular chaperone DnaK 
D      spyM18_1832 grpE; putative Hsp-70 cofactor	K03687 GRPE; molecular chaperone GrpE 
C    Other matrix factors
D      spyM18_2129 groL; heat shock protein (chaperonin)	K04077 groEL; chaperonin GroEL [EC:5.6.1.7] 
D      spyM18_2131 groS; heat shock protein - cochaperonin	K04078 groES; chaperonin GroES 
D      spyM18_1830 dnaJ; heat-shock (chaperone) protein	K03686 dnaJ; molecular chaperone DnaJ 
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A<b>Mitochondrial quality control factors</b>
B  Regulator of mitochondrial biogenesis
C    Ubiquitas transcription factors
D      spyM18_0260 fusA; elongation factor G	K02355 fusA; elongation factor G 
C    Nuclear respiratory factors
C    Coactivators
C    Proteins involved in Fe-S cluster biogenesis
D      spyM18_0878 nifS; putative iron-sulfur cofactor synthesis protein	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
D      spyM18_1083 nifS; putative iron-sulfur cofactor synthesis protein	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
D      spyM18_1831 dnaK; heat shock protein 70	K04043 dnaK; molecular chaperone DnaK 
C    Other regulator of mitochondrial biogenesis
B  Mitochondrial respiratory chain complex assembly factors
C    Complex-I assembly factors
C    Complex-II assembly factors
C    Complex-III assembly factors
C    Complex-IV assembly factors
D      spyM18_0229 conserved hypothetical protein	K03217 yidC; YidC/Oxa1 family membrane protein insertase 
D      spyM18_0404 hypothetical protein	K03217 yidC; YidC/Oxa1 family membrane protein insertase 
C    Complex-V assembly factors
B  Mitochondrial dynamics
C    Fission and Fusion factors
C    Actin cytoskeleton organization
C    Mitochondrial movement
D      spyM18_0361 hypothetical phage protein	K17080 PHB1; prohibitin 1 
C    Retention of mitochondria
C    Morphogenesis factors
B  Mitophagy factors
C    Autophagy-related proteins
C    Parkin-dependent mechanism factors
C    Parkin-independent mechanism factors
C    Other mitophagy factors
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#Last updated: March 14, 2024