+F Repair protein KO
#
DNA Repair and Recombination Proteins - Streptococcus pyogenes MGAS8232 (serotype M18)
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D spyM18_1523 putative deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E spyM18_0964 ung; putative uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E spyM18_1899 mutY; putative A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E spyM18_0986 putative endonuclease III (DNA repair) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D spyM18_0994 mutT; putative 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D spyM18_1528 putative mutator protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D spyM18_0219 dut; putative dUTPase, phage associated K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D spyM18_1523 putative deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E spyM18_0964 ung; putative uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E spyM18_1899 mutY; putative A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E spyM18_2176 tag; putative 3-methyl-adenine DNA glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E spyM18_0555 putative formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E spyM18_0986 putative endonuclease III (DNA repair) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E spyM18_0461 putative 3'-exo-deoxyribonuclease K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E spyM18_0983 recJ; putative single-strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E spyM18_0810 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E spyM18_0184 DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E spyM18_1890 uvrA; putative excinuclease ABC (subunit A) K03701 uvrA; excinuclease ABC subunit A
E spyM18_1326 uvrB; putative excinuclease ABC (subunit B) K03702 uvrB; excinuclease ABC subunit B
E spyM18_1042 excinuclease ABC (subunit C) K03703 uvrC; excinuclease ABC subunit C
E spyM18_1217 pcrA; putative ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E spyM18_0184 DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E spyM18_0810 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F spyM18_0099 ropB; putative DNA-dependent RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F spyM18_0100 ropC; RNA polymerase beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F spyM18_0079 rpoA; DNA-directed RNA polymerase alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F spyM18_1960 rpoE; probable DNA-directed RNA polymerase delta subunit K03048 rpoE; DNA-directed RNA polymerase subunit delta
F spyM18_1640 putative DNA-directed RNA polymerase omega chain K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F spyM18_0007 trcF; putative transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E spyM18_2180 putative DNA mismatch repair protein K03555 mutS; DNA mismatch repair protein MutS
E spyM18_1903 putative DNA mismatch repair protein K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E spyM18_2179 putative DNA mismatch repair protein K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E spyM18_1518 putative exodeoxyribonuclease VII (large subunit) K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E spyM18_1517 exodeoxyribonuclease VII (small subunit) K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E spyM18_1232 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E spyM18_2028 dnaE; DNA polymerase III alpha chain K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E spyM18_0002 dnaN; beta subunit of DNA polymerase III K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E spyM18_1415 DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E spyM18_0450 putative DNA polymerase III delta subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E spyM18_1928 putative DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E spyM18_1376 dnaX; DNA polymerase III gamma/tau subunits K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E spyM18_0810 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E spyM18_1217 pcrA; putative ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E spyM18_1795 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein
E spyM18_0359 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein
E spyM18_1896 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein
E spyM18_0120 ssb; putative single-strand binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E spyM18_1908 putative exodeoxyribonuclease V (alpha subunit) K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E spyM18_2174 recA; recombination protein K03553 recA; recombination protein RecA
E spyM18_2177 ruvA; putative Holliday junction DNA helicase K03550 ruvA; holliday junction DNA helicase RuvA
E spyM18_0039 ruvB; putative Holliday junction DNA helicase, subunit B K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E spyM18_1794 hypothetical phage protein K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E spyM18_1639 priA; putative primosomal replication factor Y K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D RecFOR pathway proteins
E spyM18_2174 recA; recombination protein K03553 recA; recombination protein RecA
E spyM18_0220 radA; putative DNA repair protein K04485 radA; DNA repair protein RadA/Sms
E spyM18_2242 recF; recF protein K03629 recF; DNA replication and repair protein RecF
E spyM18_1857 recG; putative ATP-dependent DNA helicase K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E spyM18_0983 recJ; putative single-strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E spyM18_0022 conserved hypothetical protein K03584 recO; DNA repair protein RecO (recombination protein O)
E spyM18_1432 recR; putative recombination protein K06187 recR; recombination protein RecR
E spyM18_1513 recN; putative DNA repair and genetic recombination protein K03631 recN; DNA repair protein RecN (Recombination protein N)
E spyM18_1660 putative recombination protein U K03700 recU; recombination protein U
E spyM18_2177 ruvA; putative Holliday junction DNA helicase K03550 ruvA; holliday junction DNA helicase RuvA
E spyM18_0039 ruvB; putative Holliday junction DNA helicase, subunit B K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
D AddAB pathway proteins
E spyM18_0836 rexA; putative ATP-dependent exonuclease, subunit A K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E spyM18_0835 rexB; putative ATP-dependent exonuclease, subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
D Archaeal homologous recombinant proteins
E spyM18_0558 conserved hypothetical protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F spyM18_1112 gyrA; DNA gyrase A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F spyM18_0795 gryB; putative DNA gyrase, subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F spyM18_1124 topA; putative DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F spyM18_1495 putative recombinase K07455 recT; recombination protein RecT
F spyM18_0731 putative recombinase K07455 recT; recombination protein RecT
F spyM18_0983 recJ; putative single-strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F spyM18_0022 conserved hypothetical protein K03584 recO; DNA repair protein RecO (recombination protein O)
F spyM18_1432 recR; putative recombination protein K06187 recR; recombination protein RecR
F spyM18_0810 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F spyM18_1890 uvrA; putative excinuclease ABC (subunit A) K03701 uvrA; excinuclease ABC subunit A
F spyM18_1326 uvrB; putative excinuclease ABC (subunit B) K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D spyM18_1910 dinP; putative DNA-damage-inducible protein P K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D spyM18_2174 recA; recombination protein K03553 recA; recombination protein RecA
D spyM18_1150 putative repressor protein K01356 lexA; repressor LexA [EC:3.4.21.88]
D spyM18_1513 recN; putative DNA repair and genetic recombination protein K03631 recN; DNA repair protein RecN (Recombination protein N)
D spyM18_1795 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein
D spyM18_0359 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein
D spyM18_1896 ssb; putative single strand binding protein K03111 ssb; single-strand DNA-binding protein
D spyM18_0120 ssb; putative single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D spyM18_1616 conserved hypothetical protein K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D spyM18_0710 dinG; putative ATP-dependent DNA helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D spyM18_0994 mutT; putative 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D spyM18_1528 putative mutator protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D spyM18_0219 dut; putative dUTPase, phage associated K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D spyM18_1387 nrdE; putative ribonucleotide reductase alpha-chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D spyM18_0472 ribonucleoside-diphosphate reductase, large chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D spyM18_1389 nrdF; ribonucleotide diphosphate reductase small subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D spyM18_0470 nrdF; putative ribonucleotide reductase 2 K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D spyM18_0787 conserved hypothetical protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024