+E Messenger RNA Biogenesis KO
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Messenger RNA Biogenesis - Schizosaccharomyces pombe (fission yeast)
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AEukaryotic type
B mRNA processing factors
C 5' end processing
D Capping factors
E SPCC330.10 pcm1; P-TEFb-cap methyltransferase Pcm1 K00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]
E SPBC11B10.09 cdc2; cyclin-dependent protein kinase Cdk1/Cdc2 K04563 CDC28; cyclin-dependent kinase [EC:2.7.11.22]
E SPBC19F8.07 mcs6; cyclin-dependent protein kinase/CDK-activating kinase Mcs6 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E SPBC2F12.08c ceg1; mRNA guanylyltransferase Ceg1 K00987 CEG1; mRNA guanylyltransferase [EC:2.7.7.50]
E SPAC644.04 pct1; RNA 5'-triphosphatase K01098 CET1; polynucleotide 5'-triphosphatase [EC:3.6.1.74]
D Cap binding complex
E SPAC6G10.07 putative nuclear cap-binding complex large subunit K12882 NCBP1; nuclear cap-binding protein subunit 1
E SPBC13A2.01c putative nuclear cap-binding complex large subunit K12883 NCBP2; nuclear cap-binding protein subunit 2
C 3' end processing
D Pre-mRNA cleavage factor Im (CFIm)
D Pre-mRNA cleavage factor IIm (CFIIm)
E SPAC22H10.05c putative cleavage and polyadenylation specificity factor complex subunit K14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]
E SPAC4G9.04c putative cleavage and polyadenylation specificity factor K14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11
D Cleavage and polyadenylation specificity factor (CPSF) complex
E SPBC1709.08 cft1; putative protein Cft1 K14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1
E SPBC1709.15c cft2; putative cleavage/polyadenylation factor Cft2/CPSF-73 K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2
E SPAC17G6.16c ysh1; cleavage and polyadenylation specificity factor complex endoribonuclease subunit Ysh1 K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E SPAC227.08c yth1; cleavage and polyadenylation specificity factor complex subunit Yth1 K14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4
E SPAC22G7.10 fip1-like pre-mRNA polyadenylation factor K14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1
E SPBP8B7.15c putative RBBP6 family ubiquitin-protein ligase E3 K15541 MPE1; protein MPE1
E SPAC12G12.14c pfs2; WD repeat protein Pfs2 K15542 PFS2; polyadenylation factor subunit 2
E SPBC18H10.06c swd2; Set1C complex subunit Swd2.1 K14962 WDR82; COMPASS component SWD2
E SPBC776.02c dis2; serine/threonine protein phosphatase PP1 K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
E SPCC31H12.05c sds21; serine/threonine protein phosphatase Sds21 K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
E SPAC57A7.08 pzh1; serine/threonine protein phosphatase Pzh1 K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
E SPAC3G9.04 ssu72; putative phosphoric ester hydrolase Ssu72 K15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]
D Cleavage stimulation factor (CSTF) complex
E SPAC644.16 putative RNA-binding protein K14407 CSTF2; cleavage stimulation factor subunit 2
E SPAC6F12.17 rna14; putative cleavage and polyadenylation specificity factor complex subunit Rna14 K14408 CSTF3; cleavage stimulation factor subunit 3
E SPAC1071.01c pta1; cleavage and polyadenylation specificity factor complex subunit Pta1 K06100 SYMPK; symplekin
D U7-dependent histone pre-mRNA processing factors
E SPAC26A3.08 smb1; Sm snRNP core protein Smb1 K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E SPBC19C2.14 smd3; Sm snRNP core protein Smd3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E SPBC11G11.06c sme1; Sm snRNP core protein Sme1 K11097 SNRPE; small nuclear ribonucleoprotein E
E SPBC3E7.14 smf1; Sm snRNP core protein Smf1 K11098 SNRPF; small nuclear ribonucleoprotein F
E SPBC4B4.05 smg1; U4/U6 x U5 tri-snRNP complex Sm snRNP core protein Smg1 K11099 SNRPG; small nuclear ribonucleoprotein G
E SPBC1709.15c cft2; putative cleavage/polyadenylation factor Cft2/CPSF-73 K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2
E SPAC17G6.16c ysh1; cleavage and polyadenylation specificity factor complex endoribonuclease subunit Ysh1 K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E SPAC644.16 putative RNA-binding protein K14407 CSTF2; cleavage stimulation factor subunit 2
E SPAC1071.01c pta1; cleavage and polyadenylation specificity factor complex subunit Pta1 K06100 SYMPK; symplekin
D DRB sensitivity inducing factor (DSIF) complex
E SPBC21C3.16c spt4; transcription elongation factor complex subunit Spt4 K15171 SUPT4H1; transcription elongation factor SPT4
E SPAC23C4.19 spt5; transcription elongation factor Spt5 K15172 SUPT5H; transcription elongation factor SPT5
D N6-methyltransferase complex
E SPAC27D7.08c uncharacterized protein K11393 METTL16; U6 snRNA m6A methyltransferase [EC:2.1.1.346]
D Poly(A) addition factors
E SPBC646.04 pla1; poly(A) polymerase Pla1 K14376 PAP; poly(A) polymerase [EC:2.7.7.19]
D Negative regulators of mRNA 3' end processing
C Other processing factors
D SPBC365.09c KIN17-like protein K13102 KIN; DNA/RNA-binding protein KIN17
B mRNA surveillance and transport factors
C Transport factors
D EJC complex
E SPAC23A1.09 putative RNA-binding protein K12876 RBM8A; RNA-binding protein 8A
E SPBC3B9.08c mnh1; protein mago nashi K12877 MAGOH; protein mago nashi
E SPBC1D7.04 mlo3; RNA-binding protein Mlo3 K12881 THOC4; THO complex subunit 4
E SPBC106.12c putative THO complex subunit K12881 THOC4; THO complex subunit 4
E SPAC17G6.14c uap56; ATP-dependent RNA helicase Uap56 K12812 DDX39B; ATP-dependent RNA helicase UAP56/SUB2 [EC:5.6.2.7]
E SPAC1F5.10 putative ATP-dependent RNA helicase K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]
E SPCC126.13c putative SAP128 family histone deacetylase complex subunit K14324 SAP18; histone deacetylase complex subunit SAP18
E SPBC13G1.14c putative RNA-binding protein K14325 RNPS1; RNA-binding protein with serine-rich domain 1
E SPCC825.05c putative splicing coactivator SRRM1 K13171 SRRM1; serine/arginine repetitive matrix protein 1
D TREX complex
E SPCP25A2.03 putative THO complex subunit K12878 THOC1; THO complex subunit 1
E SPAC1D4.14 tho2; putative THO complex subunit Tho2 K12879 THOC2; THO complex subunit 2
E SPCC18B5.10c putative TREX complex subunit Tex1 K12880 THOC3; THO complex subunit 3
E SPBC1D7.04 mlo3; RNA-binding protein Mlo3 K12881 THOC4; THO complex subunit 4
E SPBC106.12c putative THO complex subunit K12881 THOC4; THO complex subunit 4
D TREX-2 complex
E SPBC1105.07c putative nuclear pore-associated protein Thp1-Sac3 complex subunit K23801 PCID2; nuclear mRNA export protein PCID2/THP1
E SPAC3G6.02 dss1; mRNA export protein Dss1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E SPBC6B1.12c sus1; SAGA complex subunit Sus1 K11368 ENY2; enhancer of yellow 2 transcription factor
E SPCC1682.04 cdc31; centrin K16466 CETN3; centrin-3
E SPCC576.05 nuclear export factor sac3 K23719 SAC3; nuclear mRNA export protein SAC3
E SPCC70.06 putative nuclear export factor K23719 SAC3; nuclear mRNA export protein SAC3
D Nuclear pore complex
E SPAC1486.04c alm1; medial ring protein Alm1 K09291 TPR; nucleoprotein TPR
E SPCC162.08c nup211; nucleoporin nup211 K09291 TPR; nucleoprotein TPR
E SPBC16A3.05c rae1; nucleoporin Rae1 K14298 RAE1; mRNA export factor
E SPBC215.15 sec13; COPII-coated vesicle component Sec13 K14004 SEC13; protein transport protein SEC13
E SPBC17G9.04c nup85; nucleoporin Nup85 K14304 NUP85; nuclear pore complex protein Nup85
E SPAC26A3.15c nsp1; nucleoporin Nsp1 K14306 NUP62; nuclear pore complex protein Nup62
E SPCC1620.11 nup97; nuclear pore complex component nup97 K14309 NUP93; nuclear pore complex protein Nup93
E SPAC1486.05 nup189; nucleoporin Nup98 and Nup96 K14297 NUP98; nuclear pore complex protein Nup98-Nup96
E SPBC428.01c nup107; nucleoporin Nup107 K14301 NUP107; nuclear pore complex protein Nup107
E SPAC1805.04 nup132; nucleoporin Nup132 K14300 NUP133; nuclear pore complex protein Nup133
E SPAP27G11.10c nup184; nucleoporin Nup184 K14311 NUP188; nuclear pore complex protein Nup188
E SPAC890.06 nup155; nucleoporin Nup155 K14312 NUP155; nuclear pore complex protein Nup155
E SPCC290.03c nup186; nucleoporin Nup186 K14310 NUP205; nuclear pore complex protein Nup205
E SPAC22G7.09c nup45; nucleoporin Nup45 K14307 NUPL1; nucleoporin p58/p45
E SPBC15D4.10c amo1; nuclear rim protein Amo1 K14321 NUPL2; nucleoporin-like protein 2
E SPAC1786.03 cut11; spindle pole body docking protein Cut11 K14315 NDC1; nucleoporin NDC1
E SPAC15F9.02 seh1; nucleoporin Seh1 K14299 SEH1; nucleoporin SEH1
E SPAC23D3.06c nup146; nucleoporin Nup146 K18715 NUP159; nucleoporin NUP159
E SPBC13A2.02 nup82; nucleoporin Nup82 K18719 NUP82; nucleoporin NUP82
E SPCC18B5.07c nup61; nucleoporin Nup61 K18722 NUP2; nucleoporin NUP2
E SPCC1682.04 cdc31; centrin K16466 CETN3; centrin-3
E SPBC31E1.05 gle1; nucleoporin Gle1 K18723 GLE1; nucleoporin GLE1
E SPBC1921.03c mex67; nucleoporin Mex67 K14284 NXF; nuclear RNA export factor
E SPAPB1A10.03 nxt1; mRNA export receptor Nxt1 K14285 NXT1_2; NTF2-related export protein 1/2
E SPAC1002.02 pom34; nucleoporin Pom34 K18724 POM34; nucleoporin POM34
E SPBC29A10.07 pom152; nucleoporin Pom152 K18725 POM152; nucleoporin POM152
D Ran-mediated transport factors
E SPBC1289.03c spi1; Ran GTPase Spi1 K07936 RAN; GTP-binding nuclear protein Ran
E SPCC285.11 ucp10; putative UBA/UAS domain-containing protein Ucp10 K18726 FAF2; FAS-associated factor 2
E SPAC1565.08 cdc48; AAA family ATPase Cdc48 K13525 VCP; transitional endoplasmic reticulum ATPase
E SPAC1805.17 crm1; importin family nuclear export receptor Crm1 K14290 XPO1; exportin-1
E SPAC22E12.07 rna1; Ran GAP Rna1 K14319 RANGAP1; Ran GTPase-activating protein 1
D eIF4F and regulatory proteins
E SPAC16E8.15 tif45; translation initiation factor eIF4E tif45 K03259 EIF4E; translation initiation factor 4E
E SPBC1709.18 tif452; translation initiation factor eIF4E 4F complex subunit K03259 EIF4E; translation initiation factor 4E
E SPAC1006.07 putative translation initiation factor eIF4A K03257 EIF4A; translation initiation factor 4A
E SPAC17C9.03 tif471; translation initiation factor eIF4G K03260 EIF4G; translation initiation factor 4G
E SPBC18H10.04c sce3; putative translation initiation factor K03258 EIF4B; translation initiation factor 4B
E SPCC1795.11 sum3; ATP-dependent RNA helicase Sum3 K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E SPAC4F10.13c mpd2; GYF domain protein K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein
E SPAC57A7.04c pabp; mRNA export shuttling protein K13126 PABPC; polyadenylate-binding protein
E SPCC550.03c putative Ski complex RNA helicase Ski2 K12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]
E SPBC13G1.10c mug81; putative ATP-dependent RNA helicase Slh1 K18664 SLH1; antiviral helicase SLH1 [EC:5.6.2.6]
E SPBC31F10.12 putative RNA-binding protein Tma20 K07575 MCTS; malignant T-cell-amplified sequence
E SPBC16C6.05 putative mitochondrial translation initiation factor K24272 DENR; density-regulated protein
D APOBEC1-ACF complex
D Other transport factors
E SPBC19C7.01 mni1; protein mni1 K14294 WIBG; partner of Y14 and mago
E SPBC660.15 putative cleavage factor complex subunit K14411 MSI; RNA-binding protein Musashi
E SPCC18B5.06 putative translation release factor eRF1 family protein K06965 PELO; protein pelota
E SPBC16E9.12c pab2; poly(A)-binding protein Pab2 K14396 PABPN1; polyadenylate-binding protein 2
E SPBC12C2.06 putative ATP-dependent RNA helicase Dbp5 K18655 DDX19; ATP-dependent RNA helicase DDX19/DBP5 [EC:5.6.2.7]
E SPBC211.02c cwf3; protein Cwf3 K12867 SYF1; pre-mRNA-splicing factor SYF1
E SPCC31H12.03c putative RNA-binding protein K18732 SARNP; SAP domain-containing ribonucleoprotein
E SPBC557.03c pim1; Ran GDP/GTP exchange factor K11493 RCC1; regulator of chromosome condensation
E SPBC2A9.11c putative nuclear export factor K23802 LENG8; SAC3 family protein LENG8/THP3
C Surveillance factors
D Surveillance complex
E SPAC1834.01 sup45; translation release factor eRF1 K03265 ETF1; peptide chain release factor subunit 1
E SPCC584.04 sup35; eRF3-like class 2 translation release factor sup35 K03267 ERF3; peptide chain release factor subunit 3
E SPAC16C9.06c upf1; ATP-dependent RNA helicase Upf1 K14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]
E SPAC19A8.08 upf2; nonsense-mediated decay protein Upf2 K14327 UPF2; regulator of nonsense transcripts 2
E SPAC13G7.03 upf3; protein upf3 K14328 UPF3; regulator of nonsense transcripts 3
D Protein phosphatase 2A
E SPAC823.15 ppa1; minor serine/threonine protein phosphatase Ppa1 K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
E SPBC16H5.07c ppa2; serine/threonine protein phosphatase Ppa2 K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
E SPAP8A3.09c paa1; protein phosphatase regulatory subunit Paa1 K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
E SPAC227.07c pab1; protein phosphatase regulatory subunit Pab1 K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
E SPCC188.02 par1; protein phosphatase regulatory subunit Par1 K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
E SPAC6F12.12 par2; protein phosphatase regulatory subunit Par2 K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
D Other surveillance factors
E SPAC4F10.13c mpd2; GYF domain protein K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein
C Factors involved in mRNA localization
D Cargo complex
E SPCP1E11.11 puf6; putative Puf family RNA-binding protein Puf6 K14844 PUF6; pumilio homology domain family member 6
E SPCC757.09c rnc1; RNA-binding protein K18738 HEK; heterogeneous nuclear rnp K-like protein
E SPCC1919.10c myo52; myosin type V K10357 MYO5; myosin V
E SPBC2D10.14c myo51; myosin type V K10357 MYO5; myosin V
D Factors that have mRNA localization signals
D Trans-acting binding proteins
E SPCC794.09c ef1a-a; translation elongation factor EF-1 alpha Ef1a-a K03231 EEF1A; elongation factor 1-alpha
E SPAC23A1.10 tef102; translation elongation factor EF-1 alpha Ef1a-b K03231 EEF1A; elongation factor 1-alpha
E SPBC839.15c ef1a-c; translation elongation factor EF-1 alpha Ef1a-c K03231 EEF1A; elongation factor 1-alpha
E SPAC29A4.02c translation elongation factor EF-1 gamma subunit K03233 EEF1G; elongation factor 1-gamma
E SPCC1183.02 putative glutathione S-transferase K03233 EEF1G; elongation factor 1-gamma
D Other mRNA localization factors
E SPCC16C4.09 sts5; RNB-like protein K18748 SSD1; protein SSD1
E SPBC609.01 ribonuclease II family protein K18748 SSD1; protein SSD1
C mRNA cycle factors
D Common to processing body (P body) and stress granule
E SPAC17A5.14 exo2; exonuclease II Exo2 K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
E SPCC736.11 ago1; argonaute K11593 ELF2C; eukaryotic translation initiation factor 2C
E SPAC16E8.15 tif45; translation initiation factor eIF4E tif45 K03259 EIF4E; translation initiation factor 4E
E SPBC1709.18 tif452; translation initiation factor eIF4E 4F complex subunit K03259 EIF4E; translation initiation factor 4E
E SPAC16C9.06c upf1; ATP-dependent RNA helicase Upf1 K14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]
E SPCC1795.11 sum3; ATP-dependent RNA helicase Sum3 K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E SPBC776.09 ste13; ATP-dependent RNA helicase Ste13 K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
E SPBC800.09 sum2; G2/M transition checkpoint protein Sum2 K18749 LSM14; protein LSM14
E SPAC2F3.06c kap104; karyopherin Kap104 K18752 TNPO1; transportin-1
E SPBC106.10 pka1; cAMP-dependent protein kinase catalytic subunit Pka1 K04345 PKA; protein kinase A [EC:2.7.11.11]
E SPAC1527.03 putative RNA-binding protein K18757 LARP1; la-related protein 1
D P-body specific factors
E SPAC19A8.12 dcp2; mRNA-decapping complex catalytic subunit Dcp2 K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E SPBC3D6.08c lsm1; putative mRNA-decapping complex subunit lsm1 K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E SPCC1620.01c lsm2; putative U6 snRNP-associated core protein K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E SPBC9B6.05c lsm3; putative U6 snRNP-associated protein Lsm3 K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
E SPBC30D10.06 lsm4; putative U6 snRNP-associated protein Lsm4 K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E SPBC20F10.09 lsm5; putative U6 snRNP-associated protein Lsm5 K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E SPAC2F3.17c lsm6; putative U6 snRNP-associated protein Lsm6 K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E SPCC285.12 lsm7; putative U6 snRNP-associated protein Lsm7 K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E SPCC1840.10 lsm8; putative U6 snRNP-associated protein Lsm8 K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
E SPCC1919.10c myo52; myosin type V K10357 MYO5; myosin V
E SPBC2D10.14c myo51; myosin type V K10357 MYO5; myosin V
E SPBC16A3.15c nda2; tubulin alpha 1 K07374 TUBA; tubulin alpha
E SPBC800.05c atb2; tubulin alpha 2 K07374 TUBA; tubulin alpha
E SPAC20G8.06 not1; putative CCR4-Not complex subunit Not1 K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E SPCC4G3.15c not2; putative CCR4-Not complex subunit Not2 K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E SPAC1B3.05 not3; putative CCR4-Not complex subunit Not3/5 K12580 CNOT3; CCR4-NOT transcription complex subunit 3
E SPAC16C9.04c mot2; putative CCR4-Not complex subunit Mot2 K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
E SPCC31H12.08c ccr4; putative CCR4-Not complex subunit Ccr4 K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E SPCC18.06c caf1; CCR4-Not complex CAF1 family ribonuclease subunit Caf1 K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E SPAC2C4.07c putative ribonuclease II family protein K18758 DIS3L2; DIS3-like exonuclease 2 [EC:3.1.13.-]
E SPAC22G7.04 ubp13; putative poly(A)-specific ribonuclease complex subunit Pan2 K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]
E SPBC336.14c ppk26; PAN complex subunit Ppk26 K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3
E SPBC19G7.10c putative topoisomerase II-associated deadenylation-dependent mRNA-decapping factor K12617 PATL1; DNA topoisomerase 2-associated protein PAT1
E SPBC18E5.11c edc3; putative mRNA-decapping enhancer Edc3 K12615 EDC3; enhancer of mRNA-decapping protein 3
E SPAC19A8.08 upf2; nonsense-mediated decay protein Upf2 K14327 UPF2; regulator of nonsense transcripts 2
E SPAC13G7.03 upf3; protein upf3 K14328 UPF3; regulator of nonsense transcripts 3
E SPACUNK4.06c rpb7; DNA-directed RNA polymerase complex II subunit Rpb7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
D Stress granule specific factors
E SPAC57A7.04c pabp; mRNA export shuttling protein K13126 PABPC; polyadenylate-binding protein
E SPBP8B7.11 nxt3; putative ubiquitin protease cofactor Glp1 K24983 G3BP2; Ras GTPase-activating protein-binding protein 2
E SPBC4B4.04 putative translation initiation factor eIF2A K15026 EIF2A; translation initiation factor 2A
E SPAC25G10.08 translation initiation factor eIF3b (p84) K03253 EIF3B; translation initiation factor 3 subunit B
E SPAC1006.07 putative translation initiation factor eIF4A K03257 EIF4A; translation initiation factor 4A
E SPAC1F5.10 putative ATP-dependent RNA helicase K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]
E SPBC18H10.04c sce3; putative translation initiation factor K03258 EIF4B; translation initiation factor 4B
E SPAC17C9.03 tif471; translation initiation factor eIF4G K03260 EIF4G; translation initiation factor 4G
E SPAC6B12.15 cpc2; 40S ribosomal protein cpc2/RACK1 K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein
E SPBC1921.03c mex67; nucleoporin Mex67 K14284 NXF; nuclear RNA export factor
E SPBC800.03 clr3; class 2 histone deacetylase Clr3 K11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]
B mRNA degradation factors
C 5'-3' decay
D Decapping complex
E SPAC19A8.12 dcp2; mRNA-decapping complex catalytic subunit Dcp2 K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E SPBC776.09 ste13; ATP-dependent RNA helicase Ste13 K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
E SPBC18E5.11c edc3; putative mRNA-decapping enhancer Edc3 K12615 EDC3; enhancer of mRNA-decapping protein 3
E SPBC19G7.10c putative topoisomerase II-associated deadenylation-dependent mRNA-decapping factor K12617 PATL1; DNA topoisomerase 2-associated protein PAT1
D Lsm complex
E SPBC3D6.08c lsm1; putative mRNA-decapping complex subunit lsm1 K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E SPCC1620.01c lsm2; putative U6 snRNP-associated core protein K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E SPBC9B6.05c lsm3; putative U6 snRNP-associated protein Lsm3 K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
E SPBC30D10.06 lsm4; putative U6 snRNP-associated protein Lsm4 K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E SPBC20F10.09 lsm5; putative U6 snRNP-associated protein Lsm5 K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E SPAC2F3.17c lsm6; putative U6 snRNP-associated protein Lsm6 K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E SPCC285.12 lsm7; putative U6 snRNP-associated protein Lsm7 K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E SPCC1840.10 lsm8; putative U6 snRNP-associated protein Lsm8 K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
D 5' exonucleases
E SPAC17A5.14 exo2; exonuclease II Exo2 K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
E SPAC26A3.12c dhp1; 5'-3' exoribonuclease Dhp1 K12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
D Other 5'-3' decay factors
E SPBP4H10.20 nhm1; putative m7G(5')pppN diphosphatase K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]
C 3'-5' decay
D Core exosome factors
E SPCC1840.11 csl4; putative exosome subunit Csl4 K07573 CSL4; exosome complex component CSL4
E SPAC2F7.14c putative exosome subunit Rrp4 K03679 RRP4; exosome complex component RRP4
E SPAC22A12.12c putative exosome subunit Rrp40 K03681 RRP40; exosome complex component RRP40
E SPAC3G9.10c rrp41; putative exosome 3'-5' phosphorolytic exoribonuclease Rrp41 K11600 RRP41; exosome complex component RRP41
E SPBC115.01c rrp46; putative exosome subunit Rrp46 K12590 RRP46; exosome complex component RRP46
E SPBC211.08c exosome complex component mtr3 K12587 MTR3; exosome complex component MTR3
E SPBC16G5.10 putative exosome subunit Rrp42 K12589 RRP42; exosome complex component RRP42
E SPBC17D1.03c putative exosome subunit Rrp43 K12586 RRP43; exosome complex component RRP43
E SPCC757.08 putative exosome subunit Rrp45 K03678 RRP45; exosome complex component RRP45
D Exosome cofactors
E SPBC26H8.10 dis3; putative 3'-5' exoribonuclease subunit Dis3 K12585 DIS3; exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-]
E SPAC1F3.01 rrp6; putative exosome 3'-5' exoribonuclease subunit Rrp6 K12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-]
E SPCC1739.07 cti1; Cut3-interacting putative exosome subunit Cti1 K12592 C1D; exosome complex protein LRP1
E SPACUNK4.11c M-phase phosphoprotein 6 family protein K12593 MPHOSPH6; M-phase phosphoprotein 6, animal type
E SPAC694.02 DEAD/DEAH box helicase K20103 DDX60; ATP-dependent RNA helicase DDX60 [EC:5.6.2.7]
D TRAMP complex
E SPAC12G12.13c cid14; poly(A) polymerase Cid14 K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
E SPBP35G2.08c air1; zinc knuckle TRAMP complex subunit Air1 K12597 AIR1_2; protein AIR1/2
E SPAC6F12.16c mtr4; TRAMP complex ATP-dependent RNA helicase subunit Mtr4 K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
E SPAC17H9.02 putative TRAMP complex ATP-dependent RNA helicase K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
D Ski complex
E SPCC550.03c putative Ski complex RNA helicase Ski2 K12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]
E SPCC1919.05 putative Ski complex TPR repeat subunit Ski3 K12600 SKI3; superkiller protein 3
E SPBC32F12.02 rec14; Ski complex subunit Rec14 K12601 SKI8; superkiller protein 8
D Ccr4-NOT complex
E SPCC31H12.08c ccr4; putative CCR4-Not complex subunit Ccr4 K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E SPAC20G8.06 not1; putative CCR4-Not complex subunit Not1 K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E SPCC4G3.15c not2; putative CCR4-Not complex subunit Not2 K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E SPAC1B3.05 not3; putative CCR4-Not complex subunit Not3/5 K12580 CNOT3; CCR4-NOT transcription complex subunit 3
E SPAC16C9.04c mot2; putative CCR4-Not complex subunit Mot2 K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
E SPCC18.06c caf1; CCR4-Not complex CAF1 family ribonuclease subunit Caf1 K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E SPAC29B12.06c rcd1; CCR4-NOT complex subunit Rcd1 K12606 RCD1; CCR4-NOT transcription complex subunit 9
E SPAC20G4.01 caf16; putative CCR4-Not complex subunit Caf16 K12608 CAF16; CCR4-NOT complex subunit CAF16
D Pan complex
E SPAC22G7.04 ubp13; putative poly(A)-specific ribonuclease complex subunit Pan2 K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]
E SPBC336.14c ppk26; PAN complex subunit Ppk26 K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3
D Other 3'-5' decay factors
E SPBC30B4.08 eri1; double-strand siRNA ribonuclease Eri1 K18416 THEX1; 3'-5' exoribonuclease 1 [EC:3.1.-.-]
E SPBP4H10.20 nhm1; putative m7G(5')pppN diphosphatase K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]
E SPBC20F10.05 nrl1; putative NRDE-2 family protein K26109 NRDE2; nuclear exosome regulator NRDE2
E SPBC13E7.03c putative RNA hairpin-binding protein K27407 VTS1; RNA-binding protein VTS1
C Other degradation factors
D RNases
#
AProkaryotic type
B Bacterial mRNA degradation factors
C RNA degradosome components
D Ribonucreases
E SPBC119.11c pac1; double-strand-specific ribonuclease Pac1 K03685 rnc; ribonuclease III [EC:3.1.26.3]
E SPBC1347.07 rex2; putative RNA exonuclease K13288 orn; oligoribonuclease [EC:3.1.-.-]
D Helicases
D Other RNA degradosome components
E SPBC1815.01 eno101; putative enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
E SPBPB21E7.01c eno102; putative enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
E SPBC16H5.02 pfk1; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
C Other RNA degradation factors
D Chaperones
E SPAC664.11 ssc1; protein Hsp70 K04043 dnaK; molecular chaperone DnaK
E SPAC12G12.04 mcp60; protein Mcp60 K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D Others
D Bacterial Small RNA Regulators
B Archeal mRNA degradation factors
C Exosome components
D Core exosome
E SPAC2F7.14c putative exosome subunit Rrp4 K03679 RRP4; exosome complex component RRP4
E SPCC1840.11 csl4; putative exosome subunit Csl4 K07573 CSL4; exosome complex component CSL4
D Cofactors
E SPAC3G9.10c rrp41; putative exosome 3'-5' phosphorolytic exoribonuclease Rrp41 K11600 RRP41; exosome complex component RRP41
E SPBC16G5.10 putative exosome subunit Rrp42 K12589 RRP42; exosome complex component RRP42
D Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 25, 2024