+D Protein KO
#
Membrane Trafficking - Schizosaccharomyces pombe (fission yeast)
%
!
AExocytosis
B Calcium ion-dependent exocytosis
C Synaptotagmins
C Septins
D SPAC4F10.11 spn1; septin Spn1 K16944 SEPT7; septin 7
C DOC-2 proteins
C Acrosomal exocytosis proteins
D SPCC576.15c ksg1; serine/threonine protein kinase Ksg1 K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
C Phospholipases
D SPAC22F8.11 plc1; phosphoinositide phospholipase C Plc1 K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D SPAC2F7.16c pld1; phospholipase D Pld1 K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
C Kinases and associated proteins
D SPAC19G12.14 its3; 1-phosphatidylinositol-4-phosphate 5-kinase Its3 K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D SPBC1604.14c shk1; PAK-like kinase Shk1 K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
D SPAC2C4.14c ppk11; PAK-like kinase Ppk11 K08838 STK24_25_MST4; serine/threonine-protein kinase 24/25/MST4 [EC:2.7.11.1]
D SPAC9G1.09 sid1; PAK-like GC kinase Sid1 K08838 STK24_25_MST4; serine/threonine-protein kinase 24/25/MST4 [EC:2.7.11.1]
D SPAC806.07 ndk1; nucleoside diphosphate kinase Ndk1 K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D SPBC4F6.06 kin1; microtubule affinity-regulating kinase Kin1 K19852 KIN1_2; serine/threonine protein kinase KIN1/2 [EC:2.7.11.1]
C Others
D SPAC18B11.04 ncs1; calcium-binding protein K19932 NCS1; neuronal calcium sensor
B Small GTPases and associated proteins
C Rab GTPases
D SPAC9E9.07c ypt2; GTPase Ypt2 K07901 RAB8A; Ras-related protein Rab-8A
C Rab associated proteins
D SPAC29A4.05 cam2; myosin I light chain Cam2 K02183 CALM; calmodulin
D SPAC3A12.14 cam1; calmodulin Cam1 K02183 CALM; calmodulin
D SPAC23C4.10 sec2; putative guanyl-nucleotide exchange factor Sec2 K19940 SEC2; Rab guanine nucleotide exchange factor SEC2
D SPCC584.05 sec1; putative SNARE-binding protein Sec1 K15292 STXBP1; syntaxin-binding protein 1
D SPAC1F3.03 putative Lgl family protein K08518 STXBP5; syntaxin-binding protein 5
D SPBC4C3.04c putative guanyl-nucleotide exchange factor K19952 RABIF; guanine nucleotide exchange factor
D SPCC4G3.09c gyp3; putative GTPase-activating protein Gyp3 K19953 GRTP1; TBC1 domain family member 6
D SPBC215.01 putative GTPase-activating protein K19951 TBC1D8_9; TBC1 domain family member 8/9
D SPBC725.07 pex5; peroxisomal targeting signal receptor Pex5 K13342 PEX5; peroxin-5
D SPBC15C4.03 putative Rab geranylgeranyltransferase escort protein K23460 CHM; Rab proteins geranylgeranyltransferase component A
D SPCC1620.05 putative Rab geranylgeranyltransferase alpha subunit K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D SPAC167.02 ptb1; geranylgeranyltransferase type 2 beta subunit Ptb1 K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D SPBC1105.10 rav1; RAVE complex subunit Rav1 K24155 DMXL; rabconnectin-3a
C Rho GTPases
D SPAC110.03 cdc42; Rho family GTPase Cdc42 K04393 CDC42; cell division control protein 42
C Other small GTPases and associated proteins
B Tethering complex
C Exocyst complex
D SPCC1235.10c sec6; exocyst complex subunit Sec6 K06110 EXOC3; exocyst complex component 3
D SPCC970.09 sec8; exocyst complex subunit Sec8 K06111 EXOC4; exocyst complex component 4
D SPAC13F5.06c sec10; putative exocyst complex subunit Sec10 K19984 EXOC5; exocyst complex component 5
D SPCC1183.01 sec15; putative exocyst complex subunit Sec15 K19985 EXOC6; exocyst complex component 6
D SPBC106.20 exo70; putative exocyst complex subunit Exo70 K07195 EXOC7; exocyst complex component 7
C Exocyst complex assembly proteins
D SPAC3G6.02 dss1; mRNA export protein Dss1 K10881 SHFM1; 26 proteasome complex subunit DSS1
D SPAC27F1.02c cdc8; tropomyosin K17945 TPM1_2; tropomyosin, fungi type
B Others
C Exomer complex
D SPAC6G9.12 cfr1; CHS5-like protein Cfr1 K19877 CHS5; chitin biosynthesis protein CHS5
D SPBC31F10.16 putative ChAPs family protein K19881 BUD7; Chs5-Arf1p-binding protein BUD7/BCH1
C Others
D SPAC17G6.08 pep7; putative FYVE tethering component Pep7 K12481 RBSN; rabenosyn-5
#
ASNARE
B Syntaxin (Qa)
C Stx-PM
D SPCC825.03c psy1; SNARE Psy1 K08486 STX1B_2_3; syntaxin 1B/2/3
C Stx-Endo
C Stx-TGN / EE
D SPAC823.05c tlg2; putative SNARE protein Tlg2 K08489 STX16; syntaxin 16
C Stx-cisGolgi
D SPBC8D2.14c sed5; putative SNARE protein Sed5 K08490 STX5; syntaxin 5
C Stx-sER
C Stx-rER
D SPCC895.04c ufe1; putative SNARE protein Ufe1 K08492 STX18; syntaxin 18
B SNAP-25[N] (Qb)
C Vti1
D SPBC3B9.10 vti1; putative SNARE protein Vti1 K08493 VTI1; vesicle transport through interaction with t-SNAREs 1
C NPSN
C Gos1 (Gos28)
D SPAC4G8.10 gos1; putative SNARE protein Gos1 K08495 GOSR1; golgi SNAP receptor complex member 1
C Bos1 / Membrin
D SPAP14E8.03 bos1; putative SNARE protein Bos1 K08496 GOSR2; golgi SNAP receptor complex member 2
C Sec20
D SPAC23A1.15c sec20; putative SNARE protein Sec20 K08497 SEC20; protein transport protein SEC20
B SNAP-25[C] (Qc)
C STX6
D SPBC36B7.07 tlg1; putative SNARE protein Tgl1 K08499 TLG1; member of the syntaxin family of t-SNAREs
C STX8
D SPAC6F12.03c fsv1; SNARE Fsv1 K08501 STX8; syntaxin 8
D SPCC594.06c putative SNARE protein Vam7 K08502 VAM7; regulator of vacuolar morphogenesis
C STX10
C Bet1
D SPAC23C4.13 bet1; putative SNARE protein Bet1 K08504 BET1; blocked early in transport 1
C Sft1
D SPAC31A2.13c sft1; putative SNARE protein Sft1 K08505 SFT1; protein transport protein SFT1
C Syp7
C Use1
B SNAP-25 (Qb,c)
C SNAP-23
C SNAP-25
D SPBC26H8.02c sec9; protein transport protein K19950 SEC9; protein transport protein SEC9
C SNAP-29
C SNAP-47
B VAMP, Ykt6, Sec22 (R)
C VAMP
D SPAC6G9.11 syb1; synaptobrevin family receptor K08513 VAMP4; vesicle-associated membrane protein 4
C Ykt6
D SPBC13G1.11 ykt6; putative SNARE protein Ykt6 K08516 YKT6; synaptobrevin homolog YKT6
C Sec22
D SPBC2A9.08c sec22; putative SNARE protein Sec22 K08517 SEC22; vesicle transport protein SEC22
C Tomosyn
D SPAC1F3.03 putative Lgl family protein K08518 STXBP5; syntaxin-binding protein 5
C Putative SNAREs
B SNARE associated proteins
C Syntaxin-binding proteins
D SPCC584.05 sec1; putative SNARE-binding protein Sec1 K15292 STXBP1; syntaxin-binding protein 1
D SPCC74.01 sly1; putative SNARE-binding protein Sly1 K19998 SCFD1; sec1 family domain-containing protein 1
C Palmitoyltransferases
D SPBC13G1.07 swf1; putative palmitoyltransferase Swf1 K20003 ZDHHC4; palmitoyltransferase ZDHHC4 [EC:2.3.1.225]
D SPAC2F7.10 akr1; putative palmitoyltransferase Akr1 K20032 ZDHHC13_17; palmitoyltransferase ZDHHC13/17 [EC:2.3.1.225]
C Others
D SPAC1834.11c sec18; putative secretory pathway protein Sec18 K06027 NSF; vesicle-fusing ATPase [EC:3.6.4.6]
D SPAC959.02 sec17; putative alpha SNAP K15296 NAPA; alpha-soluble NSF attachment protein
D SPAC6F6.12 putative autophagy associated protein Atg24 K17919 SNX4; sorting nexin-4
D SPBC14F5.11c mug186; putative sorting nexin Snx41 K21996 SNX41_42; sorting nexin-41/42
D SPAC5D6.13 putative golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
D SPAC1565.08 cdc48; AAA family ATPase Cdc48 K13525 VCP; transitional endoplasmic reticulum ATPase
D SPAC343.09 ubx3; UBX domain-containing protein Ubx3 K14012 NSFL1C; UBX domain-containing protein 1
D SPBC13E7.03c putative RNA hairpin-binding protein K27407 VTS1; RNA-binding protein VTS1
#
AEndocytosis
B Clathrin-mediated endocytosis
C Clathrin
D SPAC26A3.05 chc1; putative clathrin heavy chain Chc1 K04646 CLTC; clathrin heavy chain
C Dynamin
D SPBC12C2.08 dnm1; dynamin Dnm1 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
C AP-2 complex
D SPBC691.03c apl3; putative AP-2 adaptor complex subunit Alp3 K11824 AP2A; AP-2 complex subunit alpha
D SPAC31A2.09c apm4; putative AP-2 adaptor complex subunit Apm4 K11826 AP2M1; AP-2 complex subunit mu-1
D SPBC685.04c aps2; putative AP-2 adaptor complex subunit Aps2 K11827 AP2S1; AP-2 complex subunit sigma-1
C Other core components
D SPBC4C3.06 syp1; putative cytoskeletal protein Syp1 K20042 FCHO; F-BAR domain only protein
D SPCC162.07 ent1; epsin K12471 EPN; epsin
D SPCC794.11c putative ENTH/VHS domain-containing protein Ent3 K12471 EPN; epsin
D SPBC800.10c putative EPS15 repeat-containing family actin cortical patch component protein K12472 EPS15; epidermal growth factor receptor substrate 15
D SPBC19F8.03c putative ENTH/VHS domain protein K20044 PICALM; phosphatidylinositol-binding clathrin assembly protein
D SPBC21D10.12 hob1; BAR adaptor protein Hob1 K12562 AMPH; amphiphysin
D SPAC16E8.01 shd1; putative Sla1 family protein Shd1 K20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1
D SPAC25G10.09c pan1; putative actin cortical patch component protein PanI K20047 PAN1; actin cytoskeleton-regulatory complex protein PAN1
D SPBC11G11.02c end3; putative actin cortical patch component End3 K20048 END3; actin cytoskeleton-regulatory complex protein END3
D SPAC13G7.02c ssa1; putative heat shock protein Ssa1 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D SPCC1739.13 ssa2; putative heat shock protein Ssa2 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D SPBC1709.05 sks2; ribosome-associated molecular chaperone Sks2 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C Low-density lipoprotein receptor (LDLR) family proteins
C LDLR adaptor proteins
D SPAC19G12.14 its3; 1-phosphatidylinositol-4-phosphate 5-kinase Its3 K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
C GPCR adaptor proteins
D SPAC1F12.05 putative endocytosis regulator K20059 LDB19; arrestin-related trafficking adapter 1
D SPBC18H10.20c putative endocytosis regulator K20059 LDB19; arrestin-related trafficking adapter 1
D SPBC2D10.04 arrestin Aly1-like protein K20061 ALY1_2; arrestin-related trafficking adapter 3/6
D SPBC839.02 arrestin-related trafficking adapter K20061 ALY1_2; arrestin-related trafficking adapter 3/6
D SPAC31A2.12 putative arrestin/PY protein 1 K20062 ART4_5_7; arrestin-related trafficking adapter 4/5/7
D SPCC584.15c arrestin/PY protein 2 K20062 ART4_5_7; arrestin-related trafficking adapter 4/5/7
C Receptor tyrosine kinase (RTK) adaptor proteins
C Inositol 5-phosphatases
D SPBC2G2.02 syj1; inositol-1,4,5-trisphosphate 5-phosphatase 1 K20279 SYNJ; synaptojanin [EC:3.1.3.36]
D SPBC577.13 syj2; inositol-1,4,5-trisphosphate 5-phosphatase 2 K20279 SYNJ; synaptojanin [EC:3.1.3.36]
C Kinases
D SPBC6B1.02 ppk30; Ark1/Prk1 family protein kinase Ppk30 K08853 AAK; AP2-associated kinase [EC:2.7.11.1]
D SPCP1E11.02 ppk38; Ark1/Prk1 family protein kinase Ppk38 K08853 AAK; AP2-associated kinase [EC:2.7.11.1]
D SPBP23A10.10 ppk32; putative serine/threonine protein kinase Ppk32 K17541 SCYL2; SCY1-like protein 2
C Ubiquitin E3 ligases
D SPAC11G7.02 pub1; HECT-type ubiquitin-protein ligase E3 Pub1 K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
D SPAC1805.15c pub2; HECT-type ubiquitin-protein ligase Pub2 K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
D SPBC16E9.11c pub3; putative HECT-type ubiquitin-protein ligase Pub3 K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
C Others
D SPAC688.11 end4; endocytosis protein K20040 HIP1R; huntingtin-interacting protein 1-related protein
D SPAC3C7.11c cnx1; calnexin Cnx1 K08054 CANX; calnexin
B Lipid raft mediated endocytosis
C Caveolin-mediated endocytosis
D SPBC12C2.08 dnm1; dynamin Dnm1 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
D SPAC17G8.14c pck1; protein kinase C (PKC)-like Pck1 K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
D SPBC12D12.04c pck2; protein kinase C (PKC)-like Pck2 K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
C Flotillin-dependent endocytosis
C GRAF1-dependent endocytosis
D SPAC110.03 cdc42; Rho family GTPase Cdc42 K04393 CDC42; cell division control protein 42
D SPBC4F6.18c arf1; ADP-ribosylation factor-like protein Arf1 K07937 ARF1_2; ADP-ribosylation factor 1/2
C Arf6-dependent endocytosis
D SPBC1539.08 arf6; ADP-ribosylation factor-like protein Arf6 K07941 ARF6; ADP-ribosylation factor 6
C RhoA-dependent endocytosis
D SPAC1F7.04 rho1; Rho family GTPase Rho1 K04513 RHOA; Ras homolog gene family, member A
D SPAC20H4.11c rho5; Rho family GTPase Rho5 K04513 RHOA; Ras homolog gene family, member A
D SPBC12C2.08 dnm1; dynamin Dnm1 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
B Phagocytosis
C Fc receptors
C Integrins (complement receptors)
C Opsonins
C Toll-like receptors
C C-lectin receptors
C Scavenger receptors
C Coronins
C Others
D SPBC146.13c myo1; myosin I myo1 K10356 MYO1; myosin I
B Macropinocytosis
C Ras GTPases
D SPAC17H9.09c ras1; GTPase Ras1 K07827 KRAS; GTPase KRas
D SPAC110.03 cdc42; Rho family GTPase Cdc42 K04393 CDC42; cell division control protein 42
C Kinases
D SPAC458.05 pik3; phosphatidylinositol 3-kinase Pik3 K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D SPBC3E7.01 fab1; 1-phosphatidylinositol-3-phosphate 5-kinase Fab1 K00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
D SPBC1604.14c shk1; PAK-like kinase Shk1 K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
C Phospholipase C
D SPAC22F8.11 plc1; phosphoinositide phospholipase C Plc1 K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
C Sorting nexins
D SPCPJ732.01 vps5; retromer complex subunit Vps5 K17917 SNX1_2; sorting nexin-1/2
C Others
B Bin/Amphiphysin/Rvs (BAR) family proteins
C N-BAR proteins
D SPBC21D10.12 hob1; BAR adaptor protein Hob1 K12562 AMPH; amphiphysin
D SPBC725.09c hob3; BAR adaptor protein Hob3 K20120 BIN3; bridging integrator 3
C F-BAR proteins
D SPBC12C2.05c bzz1; putative diacylglycerol-binding protein Bzz1 K20121 FNBP1; formin-binding protein 1
D SPBC4C3.06 syp1; putative cytoskeletal protein Syp1 K20042 FCHO; F-BAR domain only protein
D SPBC23G7.08c rga7; Rho-type GTPase-activating protein Rga7 K20643 RGD1; Rho GTPase-activating protein RGD1
C I-BAR proteins
B Rab GTPases and associated proteins
C Rab GTPases
D SPAC6F6.15 ypt5; GTPase Ypt5 K07889 RAB5C; Ras-related protein Rab-5C
C Rab associated proteins
D SPBC4F6.10 vps901; putative guanyl-nucleotide exchange factor Vps901 K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D SPAC17G6.08 pep7; putative FYVE tethering component Pep7 K12481 RBSN; rabenosyn-5
D SPAC458.05 pik3; phosphatidylinositol 3-kinase Pik3 K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D SPBC119.07 ppk19; serine/threonine protein kinase Ppk19 K08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
D SPAC2G11.03c vps45; vacuolar sorting protein Vps45 K12479 VPS45; vacuolar protein sorting-associated protein 45
B Arf GTPases and associated proteins
C Arf GTPases
D SPBC4F6.18c arf1; ADP-ribosylation factor-like protein Arf1 K07937 ARF1_2; ADP-ribosylation factor 1/2
D SPBC1539.08 arf6; ADP-ribosylation factor-like protein Arf6 K07941 ARF6; ADP-ribosylation factor 6
C Arf associated proteins
D SPAC824.09c putative GTPase-activating protein K12486 SMAP; stromal membrane-associated protein
B Others
C Fucosyltransferase
C EFR3-PI4KIII alpha complex and associated proteins
D SPBC577.06c stt4; putative 1-phosphatidylinositol 4-kinase Stt4 K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D SPCC794.08 protein efr3 K21842 EFR3; protein EFR3
D SPAC637.04 putative cargo transport protein Ypp1 K21845 YPP1; cargo-transport protein YPP1
C Insulin-like growth factor-binding proteins
C Others
#
AEndosome - Lysosome transport
B Rab GTPases and associated proteins
C Rab GTPases
D SPAC6F6.15 ypt5; GTPase Ypt5 K07889 RAB5C; Ras-related protein Rab-5C
D SPBC405.04c ypt7; GTPase Ypt7 K07897 RAB7A; Ras-related protein Rab-7A
D SPAPB1A10.10c ypt71; GTPase Ypt71 K07897 RAB7A; Ras-related protein Rab-7A
C Retromer subcomplex
D SPCC777.13 vps35; retromer complex subunit Vps35 K18468 VPS35; vacuolar protein sorting-associated protein 35
D SPAC15E1.06 vps29; retromer complex subunit Vps29 K18467 VPS29; vacuolar protein sorting-associated protein 29
D SPAC4G9.13c vps26; retromer complex subunit Vps26 K18466 VPS26A_B; vacuolar protein sorting-associated protein 26A/B
C FTS/Hook/FHIP (FHF) complex
C Rab associated proteins
D SPAP32A8.03c putative ubiquitin-protein ligase E3 K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
D SPAC458.05 pik3; phosphatidylinositol 3-kinase Pik3 K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D SPBC106.16 pre6; 20S proteasome component alpha 4 Pre6 K02731 PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
D SPAC630.05 gyp7; putative GTPase-activating protein Gyp7 K20168 TBC1D15; TBC1 domain family member 15
D SPBC15C4.03 putative Rab geranylgeranyltransferase escort protein K23460 CHM; Rab proteins geranylgeranyltransferase component A
D SPCC1620.05 putative Rab geranylgeranyltransferase alpha subunit K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D SPAC167.02 ptb1; geranylgeranyltransferase type 2 beta subunit Ptb1 K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D SPAC4G8.04 putative GTPase-activating protein K20176 SGSM3; small G protein signaling modulator 3
D SPAC5D6.13 putative golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
B Arf GTPases and associated proteins
C Arf GTPases
C BLOC-one-related complex (BORC)
C N-acetyl transferase complex C (NatC)
D SPBC15D4.06 naa30; putative NatC N-acetyltransferase complex catalytic subunit Naa30 K00670 NAA30; N-alpha-acetyltransferase 30 [EC:2.3.1.256]
D SPBC1861.03 mak10; putative NatC N-acetyltransferase complex subunit Mak10 K20823 NAA35; N-alpha-acetyltransferase 35, NatC auxiliary subunit
D SPBC947.03c naa38; putative NatC N-acetyltransferase non-catalytic subunit Naa38 K20824 NAA38; N-alpha-acetyltransferase 38, NatC auxiliary subunit
C Other Arf associated proteins
B Endosomal sorting complexes required for transport (ESCRT)
C ESCRT-0 complex
D SPAC19A8.05c sst4; ESCRT 0 complex subunit sst4 K12182 HGS; hepatocyte growth factor-regulated tyrosine kinase substrate
D SPBC1734.08 hse1; STAM-like protein Hse1 K04705 STAM; signal transducing adaptor molecule
C ESCRT-I complex
D SPAC1B3.07c vps28; ESCRT I complex subunit Vps28 K12184 VPS28; ESCRT-I complex subunit VPS28
C ESCRT-II complex
D SPBC651.05c dot2; ESCRT II complex subunit Dot2 K12188 SNF8; ESCRT-II complex subunit VPS22
D SPBC4B4.06 vps25; ESCRT II complex subunit Vps25 K12189 VPS25; ESCRT-II complex subunit VPS25
D SPBC3B9.09 vps36; ESCRT II complex subunit Vps36 K12190 VPS36; ESCRT-II complex subunit VPS36
C ESCRT-III complex
D SPBC13G1.12 did2; putative ESCRT III complex subunit Did2 K12197 CHMP1; charged multivesicular body protein 1
D SPAC4F8.01 did4; ESCRT III complex subunit Did4 K12191 CHMP2A; charged multivesicular body protein 2A
D SPAC9E9.14 vps24; ESCRT III complex subunit Vps24 K12193 VPS24; charged multivesicular body protein 3
D SPAC1142.07c vps32; ESCRT III complex subunit Vps32 K12194 CHMP4A_B; charged multivesicular body protein 4A/B
D SPCC162.06c putative sorting protein Vps60 K12198 CHMP5; charged multivesicular body protein 5
D SPBC215.14c vps20; ESCRT III complex subunit Vps20 K12195 CHMP6; charged multivesicular body protein 6
D SPBC1604.18c putative ESCRT III complex subunit K15053 CHMP7; charged multivesicular body protein 7
D SPAC2G11.06 vps4; putative AAA family ATPase Vps4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
C ESCRT associated proteins
D SPAC2G11.05c putative BRO1 domain-containing protein K12200 PDCD6IP; programmed cell death 6-interacting protein
B Tethering complex
C CORVET complex
D SPCC364.05 vps3; putative GTPase regulator Vps3 K20177 VPS3; vacuolar protein sorting-associated protein 3
D SPAC17A2.06c vps8; putative WD repeat-containing protein Vps8 K20178 VPS8; vacuolar protein sorting-associated protein 8
D SPAC823.12 vps11; putative HOPs complex subunit Pep5/Vps11 K20179 VPS11; vacuolar protein sorting-associated protein 11
D SPAC824.05 vps16; putative HOPS complex subunit Vps16 K20180 VPS16; vacuolar protein sorting-associated protein 16
D SPCC790.02 pep3; putative ubiquitin-protein ligase E3 K20181 VPS18; vacuolar protein sorting-associated protein 18
D SPBC1703.15c vps33; vacuolar sorting protein Vps33 K20182 VPS33A; vacuolar protein sorting-associated protein 33A
C Hops complex
D SPAC823.12 vps11; putative HOPs complex subunit Pep5/Vps11 K20179 VPS11; vacuolar protein sorting-associated protein 11
D SPAC824.05 vps16; putative HOPS complex subunit Vps16 K20180 VPS16; vacuolar protein sorting-associated protein 16
D SPCC790.02 pep3; putative ubiquitin-protein ligase E3 K20181 VPS18; vacuolar protein sorting-associated protein 18
D SPBC1703.15c vps33; vacuolar sorting protein Vps33 K20182 VPS33A; vacuolar protein sorting-associated protein 33A
D SPAC23H4.14 vam6; putative guanyl-nucleotide exchange factor Vam6 K20183 VPS39; Vam6/Vps39-like protein vacuolar protein sorting-associated protein 39
D SPAP27G11.05c vps41; putative HOPS complex subunit Vps41 K20184 VPS41; vacuolar protein sorting-associated protein 41
B Acidification regulators
C Rabconnectin-3 complex
D SPBC1105.10 rav1; RAVE complex subunit Rav1 K24155 DMXL; rabconnectin-3a
C RAVE complex
D SPBC1105.10 rav1; RAVE complex subunit Rav1 K24155 DMXL; rabconnectin-3a
D SPBC409.05 skp1; SCF ubiquitin ligase complex subunit Skp1 K03094 SKP1; S-phase kinase-associated protein 1
B Others
C AP-3 complex
D SPAC144.06 apl5; putative AP-3 adaptor complex subunit Apl5 K12396 AP3D; AP-3 complex subunit delta
D SPAC23H3.06 apl6; putative AP-3 adaptor complex subunit Apl6 K12397 AP3B; AP-3 complex subunit beta
D SPBC651.11c apm3; putative AP-3 adaptor complex subunit Apm3 K12398 AP3M; AP-3 complex subunit mu
D SPAC30D11.05 aps3; putative AP-3 adaptor complex subunit Aps3 K12399 AP3S; AP-3 complex subunit sigma
C BLOC-1 complex
C BLOC-1 complex (yeast)
C BLOC-2 complex
C BLOC-3 complex
C Ferlins
C Others
D SPAC1D4.03c aut12; putative autophagy associated protein Aut12 K20195 MON1; vacuolar fusion protein MON1
D SPBC18H10.08c ubp4; ubiquitin hydrolase Ubp4 K11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
D SPAC19B12.10 sst2; AMSH-like ubiquitin-specific protease K11866 STAMBP; STAM-binding protein [EC:3.4.19.12]
D SPAC767.01c vps1; dynamin family protein Vps1 K23481 VPS1; vacuolar protein sorting-associated protein 1
D SPBC28E12.06c lvs1; beige protein 1 K24781 BPH1; beige protein homolog 1
#
AProtein recycling
B Rab GTPases and associated proteins
C Rab GTPases
D SPAC1B3.11c ypt4; GTPase Ypt4 K07880 RAB4B; Ras-related protein Rab-4B
D SPAC18G6.03 ypt3; GTPase Ypt3 K07904 RAB11A; Ras-related protein Rab-11A
C Rab4 associated proteins
D SPAC17G6.08 pep7; putative FYVE tethering component Pep7 K12481 RBSN; rabenosyn-5
D SPAC6F6.12 putative autophagy associated protein Atg24 K17919 SNX4; sorting nexin-4
C Rab11 associated proteins
D SPAC3H5.08c WD repeat-containing protein K20241 WDR44; WD repeat-containing protein 44
D SPBC215.15 sec13; COPII-coated vesicle component Sec13 K14004 SEC13; protein transport protein SEC13
D SPCC1183.01 sec15; putative exocyst complex subunit Sec15 K19985 EXOC6; exocyst complex component 6
D SPAC5D6.13 putative golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
C Other Rab GTPase associated proteins
D SPBC4F6.10 vps901; putative guanyl-nucleotide exchange factor Vps901 K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D SPAC644.14c rhp51; RecA family recombinase Rhp51 K04482 RAD51; DNA repair protein RAD51
B Others
C Glutamate receptor-interacting proteins (GRIPs)
C GRIP associated proteins
C EARP complex
D SPBC336.11 vps52; putative GARP complex subunit Vps52 K20298 VPS52; vacuolar protein sorting-associated protein 52
D SPAC3A12.15 vps53; putative GARP complex subunit Vps53 K20299 VPS53; vacuolar protein sorting-associated protein 53
C WASH complex
D SPAC12B10.07 acp1; F-actin-capping protein alpha subunit K10364 CAPZA; F-actin-capping protein subunit alpha
D SPAC631.01c acp2; putative F-actin-capping protein beta subunit acp2 K10365 CAPZB; F-actin-capping protein subunit beta
C Retriever complex
D SPAC15E1.06 vps29; retromer complex subunit Vps29 K18467 VPS29; vacuolar protein sorting-associated protein 29
C Others
#
AEndosome - Golgi transport
B Rab GTPases and associated proteins
C Rab GTPases
D SPAC4C5.02c ryh1; GTPase Ryh1 K07893 RAB6A; Ras-related protein Rab-6A
C Rab associated proteins
D SPAC5D6.13 putative golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
D SPBC215.01 putative GTPase-activating protein K19951 TBC1D8_9; TBC1 domain family member 8/9
D SPBC21C3.01c vps13a; vacuolar protein sorting-associated protein K19525 VPS13A_C; vacuolar protein sorting-associated protein 13A/C
B Arf GTPases and associated proteins
C Arf GTPases
D SPBC4F6.18c arf1; ADP-ribosylation factor-like protein Arf1 K07937 ARF1_2; ADP-ribosylation factor 1/2
C Arf GTPase associated proteins
D SPCC622.14 putative GTPase-activating protein K12492 ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1
D SPAC22E12.17c glo3; putative ARF GTPase-activating protein K12493 ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2/3
D SPAC824.09c putative GTPase-activating protein K12486 SMAP; stromal membrane-associated protein
D SPBC17G9.08c cnt5; Centaurin 5 K12488 ASAP; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein
D SPAC30.01c sec72; Sec7 domain-containing protein sec72 K18442 ARFGEF; brefeldin A-inhibited guanine nucleotide-exchange protein
D SPAC4D7.01c sec71; putative Sec7 domain-containing protein sec71 K18442 ARFGEF; brefeldin A-inhibited guanine nucleotide-exchange protein
D SPBC211.03c putative guanyl-nucleotide exchange factor K18443 GBF1; golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
B Tethering complex
C Conserved oligomeric Golgi (COG) complex
D SPBC1539.05 cog3; putative COG complex subunit Cog3 K20290 COG3; conserved oligomeric Golgi complex subunit 3
D SPCC338.13 cog4; putative COG complex subunit Cog4 K20291 COG4; conserved oligomeric Golgi complex subunit 4
D SPBC776.10c cog6; putative COG complex subunit Cog6 K20293 COG6; conserved oligomeric Golgi complex subunit 6
D SPBC11B10.03 cog8; putative COG complex subunit Cog8 K20295 COG8; conserved oligomeric Golgi complex subunit 8
C GARP complex
D SPBC336.11 vps52; putative GARP complex subunit Vps52 K20298 VPS52; vacuolar protein sorting-associated protein 52
D SPAC3A12.15 vps53; putative GARP complex subunit Vps53 K20299 VPS53; vacuolar protein sorting-associated protein 53
D SPAC2F3.10 vps54; putative GARP complex subunit Vps54 K17600 VPS54; vacuolar protein sorting-associated protein 54
C TRAPP complex II
D SPAC3G9.16c bet5; putative TRAPP complex subunit Bet5 K20300 TRAPPC1; trafficking protein particle complex subunit 1
D SPBC11G11.04 trs20; putative TRAPP complex subunit Trs20 K20301 TRAPPC2; trafficking protein particle complex subunit 2
D SPAC15A10.12c putative TRAPP complex subunit 2-like protein K20301 TRAPPC2; trafficking protein particle complex subunit 2
D SPAC644.18c bet3; putative TRAPP complex subunit Bet3 K20302 TRAPPC3; trafficking protein particle complex subunit 3
D SPBC3B9.12 trs23; putative TRAPP complex subunit Trs23 K20303 TRAPPC4; trafficking protein particle complex subunit 4
D SPBC1718.05 trs31; putative TRAPP complex subunit Trs31 K20280 TRAPPC5; trafficking protein particle complex subunit 5
D SPAC13G6.05c trs33; putative TRAPP complex subunit Trs33 K20304 TRAPPC6; trafficking protein particle complex subunit 6
D SPBC1604.19c putative TRAPP complex subunit Trs85 K20305 TRAPPC8; trafficking protein particle complex subunit 8
D SPBC1734.07c putative TRAPP complex subunit Trs85 K20305 TRAPPC8; trafficking protein particle complex subunit 8
D SPAC6G10.05c trs120; putative TRAPP complex subunit Trs120 K20306 TRAPPC9; trafficking protein particle complex subunit 9
D SPCC285.14 trs130; putative TRAPP complex subunit Trs130 K20307 TRAPPC10; trafficking protein particle complex subunit 10
B Others
C AP-1 complex
D SPCP1E11.06 apl4; AP-1 adaptor complex gamma subunit Apl4 K12391 AP1G1; AP-1 complex subunit gamma-1
D SPBP16F5.07 apm1; AP-1 adaptor complex mu subunit Apm1 K12393 AP1M; AP-1 complex subunit mu
C AP-3 complex
D SPAC144.06 apl5; putative AP-3 adaptor complex subunit Apl5 K12396 AP3D; AP-3 complex subunit delta
D SPAC23H3.06 apl6; putative AP-3 adaptor complex subunit Apl6 K12397 AP3B; AP-3 complex subunit beta
D SPBC651.11c apm3; putative AP-3 adaptor complex subunit Apm3 K12398 AP3M; AP-3 complex subunit mu
D SPAC30D11.05 aps3; putative AP-3 adaptor complex subunit Aps3 K12399 AP3S; AP-3 complex subunit sigma
C AP-4 complex
C GGA
D SPBC25H2.16c putative adaptin K12404 GGA; ADP-ribosylation factor-binding protein GGA
C Aftiphilin/p200/gamma-synergin complex
C Others
D SPAC2F7.16c pld1; phospholipase D Pld1 K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D SPBC577.06c stt4; putative 1-phosphatidylinositol 4-kinase Stt4 K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D SPAC19G12.14 its3; 1-phosphatidylinositol-4-phosphate 5-kinase Its3 K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D SPBC3E7.01 fab1; 1-phosphatidylinositol-3-phosphate 5-kinase Fab1 K00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
D SPAC17G8.08c GDT1-like protein K23541 TMEM165; Ca2+/H+ antiporter, TMEM165/GDT1 family
D SPAPB1A10.07c putative sphingolipid biosynthesis protein K23544 SERINC1; serine incorporator 1
D SPBC887.06c snx3; putative sorting nexin Snx3 K17918 SNX3_12; sorting nexin-3/12
D SPAC3A11.06 mvp1; putative sorting nexin Mvp1 K17922 SNX8; sorting nexin-8
D SPAC23D3.13c putative guanyl-nucleotide exchange factor K26678 MON2; protein MON2
D SPAPB21F2.02 putative family protein DOPEY K26680 DOP1; protein dopey
D SPAC6F12.04 putative COPI-coated vesicle-associated protein K26750 TVP15; golgi apparatus membrane protein TVP15
D SPBC32F12.12c golgi membrane protein involved in vesicle-mediated transport K26751 TVP18; golgi apparatus membrane protein TVP18
D SPBC2A9.05c tvp23; putative transport protein Tvp23 K26752 TVP23; golgi apparatus membrane protein TVP23
D SPBC1711.09c putative SNARE-associated protein K26753 TVP38; golgi apparatus membrane protein TVP38
D SPAC767.01c vps1; dynamin family protein Vps1 K23481 VPS1; vacuolar protein sorting-associated protein 1
#
AEndoplasmic reticulum (ER) - Golgi transport
B Forward pathways
C Coat protein complex II (COP-II)
D SPBC31F10.06c sar1; ADP-ribosylation factor Sar1 K07953 SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]
D SPBC215.15 sec13; COPII-coated vesicle component Sec13 K14004 SEC13; protein transport protein SEC13
D SPBC8D2.20c sec31; putative COPII-coated vesicle-associated protein Sec31 K14005 SEC31; protein transport protein SEC31
D SPCC31H12.07 sec231; putative COPII cargo receptor subunit Sec23a K14006 SEC23; protein transport protein SEC23
D SPBC776.04 sec2302; putative COPII cargo receptor subunit Sec23b K14006 SEC23; protein transport protein SEC23
D SPAC22F8.08 sec24; COPII cargo receptor Sec24/Sfb2 subunit K14007 SEC24; protein transport protein SEC24
D SPBC4.03c putative COPII-coated vesicle-associated protein Sfb3 K14007 SEC24; protein transport protein SEC24
D SPBC3H7.01 spo14; GDP/GTP exchange factor Spo14 K14003 PREB; prolactin regulatory element-binding protein
D SPAC29B12.07 sec16; putative multidomain vesicle coat component Sec16 K20353 SEC16; COPII coat assembly protein SEC16
C TRAPP complex I
D SPAC3G9.16c bet5; putative TRAPP complex subunit Bet5 K20300 TRAPPC1; trafficking protein particle complex subunit 1
D SPBC11G11.04 trs20; putative TRAPP complex subunit Trs20 K20301 TRAPPC2; trafficking protein particle complex subunit 2
D SPAC15A10.12c putative TRAPP complex subunit 2-like protein K20301 TRAPPC2; trafficking protein particle complex subunit 2
D SPAC644.18c bet3; putative TRAPP complex subunit Bet3 K20302 TRAPPC3; trafficking protein particle complex subunit 3
D SPBC3B9.12 trs23; putative TRAPP complex subunit Trs23 K20303 TRAPPC4; trafficking protein particle complex subunit 4
D SPBC1718.05 trs31; putative TRAPP complex subunit Trs31 K20280 TRAPPC5; trafficking protein particle complex subunit 5
D SPAC13G6.05c trs33; putative TRAPP complex subunit Trs33 K20304 TRAPPC6; trafficking protein particle complex subunit 6
C p24 family proteins
D SPBC16E9.09c putative COPII-coated vesicle-associated protein Erp5/Erp6 K20346 TMED4_9_11; p24 family protein alpha
D SPCC24B10.17 emp24; putative COPII-coated vesicle-associated protein Emp24 K20347 TMED2; p24 family protein beta-1
D SPAC23H4.03c erv25; putative COPII-coated vesicle-associated protein Erv25 K20352 TMED10; p24 family protein delta-1
C PDI family proteins
D SPAC1F5.02 putative protein disulfide isomerase K09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]
D SPAC17H9.14c protein disulfide isomerase K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
D SPAC13F5.05 putative thioredoxin family protein K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C Rab GTPases
D SPBC1703.10 ypt1; GTPase Ypt1 K07874 RAB1A; Ras-related protein Rab-1A
C Rab associated proteins
D SPCC306.02c putative Rab GTPase-binding protein K20359 RABAC1; PRA1 family protein 1
D SPBC651.03c gyp10; GTPase-activating protein Gyp10 K20372 TBC1D20; TBC1 domain family member 20
D SPBC530.01 gyp1; putative GTPase-activating protein Gyp1 K20360 TBC1D22; TBC1 domain family member 2
D SPBC25H2.06c hrf1; putative COPII-coated vesicle-associated protein Hrf1 K20362 YIF1; protein transport protein YIF1
D SPAC19A8.09 putative ransport protein Yos1 K22939 IER3IP1; immediate early response 3-interacting protein 1
D SPAC29E6.03c uso1; putative tethering factor Uso1 K20361 USO1; intracellular protein transport protein USO1
C ER-Golgi intermediate compartment (ERGIC) proteins
D SPCC126.08c putative lectin family glycoprotein receptor K10082 LMAN2; lectin, mannose-binding 2
D SPAC2E1P5.01c mns1; mannosyl-oligosaccharide 1,2-alpha-mannosidase K23741 MAN1B; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]
D SPBC2G5.04c putative COPII-coated vesicle-associated protein Erv41 K20366 ERGIC2; endoplasmic reticulum-Golgi intermediate compartment protein 2
D SPAC24B11.08c putative COPII-coated vesicle-associated protein Erv46 K20367 ERGIC3; endoplasmic reticulum-Golgi intermediate compartment protein 3
D SPAC2C4.05 putative cornichon family protein K20368 CNIH; protein cornichon
D SPAC30C2.05 erv14; putative cornichon family protein Erv14 K20368 CNIH; protein cornichon
D SPCC970.06 putative cargo receptor protein K20369 ERV29; ER-derived vesicles protein
D SPAC22A12.15c bip1; ER heat shock protein BiP K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
B Retrieval pathways
C Coat protein complex I (COP-I)
D SPBPJ4664.04 putative coatomer alpha subunit protein K05236 COPA; coatomer subunit alpha
D SPBC146.14c sec26; putative coatomer beta subunit protein K17301 COPB1; coatomer subunit beta
D SPBC16C6.13c sec27; putative coatomer beta' subunit protein K17302 COPB2; coatomer subunit beta'
D SPAC57A7.10c sec21; putative coatomer gamma subunit Sec21 K17267 COPG; coatomer subunit gamma
D SPCC285.08 ret2; putative coatomer delta subunit Ret2 K20471 COPD; coatomer subunit delta
D SPBC24C6.05 sec28; putative coatomer epsilon subunit protein K17268 COPE; coatomer subunit epsilon
D SPCC576.07 ret3; putative coatomer zeta subunit protein K20472 COPZ; coatomer subunit zeta
C NRZ (DSL1) complex
D SPBC691.02c putative RINT1 family protein K20474 RINT1; RAD50-interacting protein 1
D SPAC7D4.11c sec39; putative secretory pathway protein Sec39 K20475 SEC39; protein transport protein SEC39
C Golgi to ER traffic proteins (GET)
D SPBC543.10 get1; putative GET complex subunit Get1 K22384 GET1; tail-anchored protein insertion receptor
D SPAC1142.06 get3; putative GET complex ATPase subunit Get3 K01551 arsA; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
D SPCC1672.12c get4; putative protein Get4 K23387 GET4; golgi to ER traffic protein 4
C Rab GTPases
D SPAC4C5.02c ryh1; GTPase Ryh1 K07893 RAB6A; Ras-related protein Rab-6A
C Rab associated proteins
D SPAC1851.04c ric1; Ypt/Rab-specific guanyl-nucleotide exchange factor (GEF) subunit Ric1 K20476 RIC1; RAB6A-GEF complex partner protein 1
D SPBP8B7.22 erd2; putative HDEL receptor K10949 KDELR; ER lumen protein retaining receptor
D SPAC17G6.08 pep7; putative FYVE tethering component Pep7 K12481 RBSN; rabenosyn-5
D SPBC530.01 gyp1; putative GTPase-activating protein Gyp1 K20360 TBC1D22; TBC1 domain family member 2
B Others
C Oxysterol-binding proteins
D SPBC2F12.05c putative sterol binding ankyrin repeat protein K20456 OSBP; oxysterol-binding protein 1
D SPAC23H4.01c putative sterol binding ankyrin repeat protein K20463 OSBPL3_6_7; oxysterol-binding protein-related protein 3/6/7
D SPCC23B6.01c putative oxysterol binding protein K22285 OSBPL8; oxysterol-binding protein-related protein 8
D SPBC646.08c putative oxysterol binding protein K20465 OSBPL9_10_11; oxysterol-binding protein-related protein 9/10/11
D SPBC1271.12 kes1; putative oxysterol binding protein K20465 OSBPL9_10_11; oxysterol-binding protein-related protein 9/10/11
D SPBC354.07c putative oxysterol binding protein K20465 OSBPL9_10_11; oxysterol-binding protein-related protein 9/10/11
C FXYD proteins
C YIPF proteins
D SPAC227.06 putative Rab GTPase-binding protein K22940 YIPF1_2; protein YIPF1/2
D SPCC61.04c putative Rab GTPase-binding protein K20363 YIPF5_7; protein YIPF5/7
D SPAC644.13c putative Rab GTPase-binding protein K22943 YIPF6; protein YIPF6
C ER membrane protein complex
D SPAC25H1.07 emc1; putative protein Emc1 K23562 EMC1; ER membrane protein complex subunit 1
D SPBC15C4.01c oca3; putative TPR repeat-containing protein Oca3 K23563 EMC2; ER membrane protein complex subunit 2
D SPBC1711.03 aim27; putative protein Aim27 K23564 EMC3; ER membrane protein complex subunit 3
D SPCC1281.03c emc4; chaperone EMC4 K23565 EMC4; ER membrane protein complex subunit 4
D SPCC1020.11c uncharacterized protein K23567 EMC6; ER membrane protein complex subunit 6
C SEC61 complex
D SPBC354.02c sec61; translocon alpha subunit Sec61 K10956 SEC61A; protein transport protein SEC61 subunit alpha
D SPBC19G7.17 putative translocon subunit Sec61-like protein K10956 SEC61A; protein transport protein SEC61 subunit alpha
D SPBC2G2.03c sbh1; putative translocon beta subunit Sbh1 K09481 SEC61B; protein transport protein SEC61 subunit beta
D SPAC4G8.02c sss1; putative translocon gamma subunit Sss1 K07342 SEC61G; protein transport protein SEC61 subunit gamma and related proteins
C TRAP complex
C Multi-pass translocon (MPT) complex
D SPBC2G5.01 uncharacterized protein K24962 CCDC47; PAT complex subunit CCDC47
C Post-GPI attachment to proteins factors (PGAP)
D SPAC824.02 putative GPI inositol deacylase K05294 PGAP1; GPI inositol-deacylase [EC:3.-.-.-]
D SPAC823.07 putative GPI-phospholipase A2 activity regulator K23553 PGAP3; post-GPI attachment to proteins factor 3
D SPAC630.12 putative lipid phosphatase K23362 MPPE1; ethanolamine phosphate phosphodiesterase [EC:3.1.-.-]
C Others
D SPCC74.01 sly1; putative SNARE-binding protein Sly1 K19998 SCFD1; sec1 family domain-containing protein 1
D SPBC1539.04 tts1; tetra-spanning protein 1 K20724 TMEM33; transmembrane protein 33
D SPAPB1A10.15 arv1; putative Arv1-like family protein Arv1 K21848 ARV1; lipid intermediate transporter
D SPAC23H3.11c putative glucosidase K21850 KRE6; beta-glucan synthesis-associated protein KRE6
D SPAC5D6.13 putative golgi phosphoprotein 3 K15620 GOLPH3; golgi phosphoprotein 3
D SPCC306.05c ins1; INSIG domain protein K26681 INSIG; insulin-induced protein
D SPAC222.14c putative GTP-binding protein Sey1 K22698 SEY1; protein SEY1 [EC:3.6.5.-]
#
AAutophagy
B Autophagosome formation proteins
C ULK complex
D SPAC4F10.07c atg13; autophagy-associated protein kinase regulatory subunit Atg13 K08331 ATG13; autophagy-related protein 13
D SPAC25H1.03 mug66; protein mug66 K19730 ATG101; autophagy-related protein 101
C Atg1 complex
D SPCC63.08c atg1; autophagy and CVT pathway serine/threonine protein kinase Atg1 K08269 ULK2; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
D SPAC4F10.07c atg13; autophagy-associated protein kinase regulatory subunit Atg13 K08331 ATG13; autophagy-related protein 13
D SPAC10F6.11c atg17; autophagy-associated protein kinase activator Atg17 K08329 ATG17; autophagy-related protein 17
C PI3K complex
D SPAC458.05 pik3; phosphatidylinositol 3-kinase Pik3 K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D SPBC119.07 ppk19; serine/threonine protein kinase Ppk19 K08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
D SPAC20G8.10c atg6; beclin family protein K08334 BECN; beclin
C ATG9 transmembrane protein
D SPBC15D4.07c atg9; autophagy-associated protein Atg9 K17907 ATG9; autophagy-related protein 9
C Atg18-Atg2 complex
D SPAC589.07c atg18; WD repeat-containing protein Atg18 K17908 WIPI1_2; autophagy-related protein 18
D SPBC31E1.01c atg2; autophagy-associated protein Atg2 K17906 ATG2; autophagy-related protein 2
C Atg12 conjugation proteins
D SPAC1783.06c atg12; autophagy-associated ubiquitin-like modifier Atg12 K08336 ATG12; ubiquitin-like protein ATG12
D SPBC6B1.05c atg7; ubiquitin-like conjugating enzyme Atg7 K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D SPAC227.04 putative autophagy C terminal domain family protein K17888 ATG10L; ubiquitin-like-conjugating enzyme ATG10
D SPBC4B4.10c atg5; autophagy-associated protein Atg5 K08339 ATG5; autophagy-related protein 5
C Atg8 conjugation proteins
D SPBP8B7.24c atg8; autophagy-associated protein Atg8 K08341 GABARAP; GABA(A) receptor-associated protein
D SPAC19B12.08 atg4; putative Atg8 deconjugator Atg4 K08342 ATG4; cysteine protease ATG4 [EC:3.4.22.-]
D SPBC6B1.05c atg7; ubiquitin-like conjugating enzyme Atg7 K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D SPBC3B9.06c atg3; autophagy-associated protein Atg3 K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
B Cytoplasm to vacuolar targeting (CVT) pathway
C Selective cargos
D SPAC513.05 ams1; putative alpha-mannosidase K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24]
D SPAC4F10.02 aap1; aspartyl aminopeptidase Aap1 K01267 DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]
C Cargo receptors
C Scaffold protein
C Other Cvt associated proteins
D SPBC14F5.11c mug186; putative sorting nexin Snx41 K21996 SNX41_42; sorting nexin-41/42
D SPAC6F6.12 putative autophagy associated protein Atg24 K17919 SNX4; sorting nexin-4
D SPAC23C4.16c atg15; autophagy-associated lipase Atg15 K17900 ATG15; lipase ATG15 [EC:3.1.1.3]
D SPBC354.14c vac8; putative protein Vac8 K08332 VAC8; vacuolar protein 8
B Mitophagy
C Cargo receptors
C Scaffold proteins
C PINK1-Parkin associated proteins
D SPBC1706.03 fzo1; putative dynamin-like GTPase fzo1 K06030 MFN2; mitofusin 2 [EC:3.6.5.-]
C Other mitophagy associated proteins
D SPAC24H6.04 hxk1; hexokinase 1 K00844 HK; hexokinase [EC:2.7.1.1]
D SPAC4F8.07c hxk2; hexokinase 2 K00844 HK; hexokinase [EC:2.7.1.1]
D SPCC70.02c putative ATPase inhibitor K22255 ATPIF1; ATPase inhibitor, mitochondrial
D SPBC27B12.10c tom7; putative TOM complex subunit Tom7 K17771 TOM7; mitochondrial import receptor subunit TOM7
B Pexophagy
C Selective cargos
D SPAC29A4.14c putative peroxin-3 peroxisome import protein K13336 PEX3; peroxin-3
C Cargo receptors
C Other pexophagy associated proteins
D SPAC17A5.01 pex6; putative peroxin-6 K13339 PEX6; peroxin-6
B Aggrephagy
C Cargo receptors
C Scaffold proteins
C Other aggrephagy associated proteins
D SPAC1565.08 cdc48; AAA family ATPase Cdc48 K13525 VCP; transitional endoplasmic reticulum ATPase
D SPBC800.03 clr3; class 2 histone deacetylase Clr3 K11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]
B Xenophagy
C Cargo receptors
C Other xenophagy associated proteins
B Chaperone mediated autophagy (CMA)
C Selective cargos
D SPAC10F6.13c putative aspartate aminotransferase K14454 GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
D SPBC354.12 gpd3; glyceraldehyde 3-phosphate dehydrogenase Gpd3 K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D SPBC32F12.11 tdh1; glyceraldehyde-3-phosphate dehydrogenase Tdh1 K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D SPAC26F1.06 gpm1; monomeric 2,3-bisphosphoglycerate (BPG)-dependent phosphoglycerate mutase (PGAM), Gpm1 K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D SPAC4H3.10c pyk1; putative pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D SPAC26A3.16 dph1; UBA domain protein Dph1 K04523 UBQLN; ubiquilin
C Cargo receptors
C Chaperones
D SPAC13G7.02c ssa1; putative heat shock protein Ssa1 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D SPCC1739.13 ssa2; putative heat shock protein Ssa2 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D SPBC1709.05 sks2; ribosome-associated molecular chaperone Sks2 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D SPAC926.04c hsp90; Hsp90 chaperone K04079 HSP90A; molecular chaperone HtpG
C Co-chaperones
C Other CMA associated proteins
D SPCC794.09c ef1a-a; translation elongation factor EF-1 alpha Ef1a-a K03231 EEF1A; elongation factor 1-alpha
D SPAC23A1.10 tef102; translation elongation factor EF-1 alpha Ef1a-b K03231 EEF1A; elongation factor 1-alpha
D SPBC839.15c ef1a-c; translation elongation factor EF-1 alpha Ef1a-c K03231 EEF1A; elongation factor 1-alpha
D SPAC19G12.10c cpy1; vacuolar carboxypeptidase Y K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
B Other autophagy associated proteins
C RNautophagy/DNautophagy
C Micronucleophagy
D SPBC354.14c vac8; putative protein Vac8 K08332 VAC8; vacuolar protein 8
C Midbophagy
C Glycophagy
C TRIM-directed selective autophagy
C ER-mitochondria tethering complex
D SPBC1706.03 fzo1; putative dynamin-like GTPase fzo1 K06030 MFN2; mitofusin 2 [EC:3.6.5.-]
C mTORC1 complex
D SPBC216.07c tor2; phosphatidylinositol kinase Tor2 K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D SPBC30D10.10c tor1; phosphatidylinositol kinase Tor1 K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D SPBC21B10.05c pop3; WD repeat protein Pop3 K08266 MLST8; target of rapamycin complex subunit LST8
D SPAC57A7.11 mip1; WD repeat-containing protein K07204 RAPTOR; regulatory associated protein of mTOR
C mTORC2 complex
D SPBC216.07c tor2; phosphatidylinositol kinase Tor2 K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D SPBC30D10.10c tor1; phosphatidylinositol kinase Tor1 K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D SPBC21B10.05c pop3; WD repeat protein Pop3 K08266 MLST8; target of rapamycin complex subunit LST8
D SPAPYUG7.02c sin1; MAP kinase-interacting protein Sin1 K20410 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1/AVO1
D SPBC12C2.02c ste20; target of rapamycin complex 2 subunit ste20 K08267 RICTOR; rapamycin-insensitive companion of mTOR
D SPCC777.08c bit61; TORC2 subunit Bit61 K25577 BIT61_2; target of rapamycin complex 2 subunit BIT61/BIT2
C SEACIT/GATOR1 complex
D SPBC26H8.04c DEP domain protein K20404 DEPDC5; SEA/GATOR complex protein SEA1/DEPDC5
D SPAC23H3.03c npr2; putative Npr2/3 complex subunit Npr2 K20405 NPRL2; nitrogen permease regulator 2
D SPBC543.04 putative Npr2/3 complex subunit Npr3 K20406 NPRL3; nitrogen permease regulator 3
C SEACAT/GATOR2 complex
D SPAC4F8.11 WD repeat-containing protein K20408 WDR24; SEA/GATOR complex protein SEA2/WDR24
D SPAC11E3.05 ubiquitin-protein ligase E3 K20409 WDR59; SEA/GATOR complex protein SEA3/WDR59
D SPAC12G12.01c ubiquitin-protein ligase E3 K20407 MIOS; SEA/GATOR complex protein SEA4/MIOS
D SPAC15F9.02 seh1; nucleoporin Seh1 K14299 SEH1; nucleoporin SEH1
D SPBC215.15 sec13; COPII-coated vesicle component Sec13 K14004 SEC13; protein transport protein SEC13
C KICSTOR complex
C Rab GTPases
D SPBC1703.10 ypt1; GTPase Ypt1 K07874 RAB1A; Ras-related protein Rab-1A
D SPAC9E9.07c ypt2; GTPase Ypt2 K07901 RAB8A; Ras-related protein Rab-8A
C Rab associated proteins
C Others
D SPAC823.15 ppa1; minor serine/threonine protein phosphatase Ppa1 K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
D SPBC16H5.07c ppa2; serine/threonine protein phosphatase Ppa2 K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
D SPCC63.05 TAP42-like family protein K17606 IGBP1; immunoglobulin-binding protein 1
D SPBC18H10.19 atg14; putative phophatidylinositol 3-kinase complex subunit atg14 K21249 UVRAG; UV radiation resistance-associated gene protein
D SPAC2G11.13 atg22; vacuolar amino acid efflux transporter Atg22 K06902 UMF1; MFS transporter, UMF1 family
D SPAC3H1.09c avt3; vacuolar amino acid efflux transporter Avt3 K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D SPCC1235.16 vma21; putative vacuolar H+-ATPase assembly protein Vma21 K23952 VMA21; vacuolar ATPase assembly integral membrane protein VMA21
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AOthers
B NADPH oxidases (Nox) and associated proteins
C NADPH oxidases
C Nox associated proteins
B Actin-binding proteins
C Myosins
D SPBC146.13c myo1; myosin I myo1 K10356 MYO1; myosin I
D SPCC1919.10c myo52; myosin type V K10357 MYO5; myosin V
D SPBC2D10.14c myo51; myosin type V K10357 MYO5; myosin V
C Arp2/3 complex
D SPBC14C8.06 arc1; ARP2/3 actin-organizing complex subunit Sop2 K05757 ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
D SPAC6F6.10c arc2; ARP2/3 actin-organizing complex subunit Arc34 K05758 ARPC2; actin related protein 2/3 complex, subunit 2
D SPBC1778.08c arc3; ARP2/3 actin-organizing complex subunit Arc21 K05756 ARPC3; actin related protein 2/3 complex, subunit 3
D SPAC6G9.07c arc4; ARP2/3 actin-organizing complex subunit Arc4 K05755 ARPC4; actin related protein 2/3 complex, subunit 4
D SPAC17G8.04c arc5; ARP2/3 actin-organizing complex subunit Arc5 K05754 ARPC5; actin related protein 2/3 complex, subunit 5
D SPAC11H11.06 arp2; ARP2/3 actin-organizing complex subunit Arp2 K17260 ACTR2; actin-related protein 2
D SPAC630.03 arp3; actin-like protein Arp3 K18584 ACTR3; actin-related protein 3
C Nucleation-promoting factors (NPFs)
D SPAC4F10.15c wsp1; actin assembly factor K23612 WASL; neural Wiskott-Aldrich syndrome protein
D SPAPJ760.02c abp1; cofilin/tropomyosin family protein abp1 K20520 DBNL; drebrin-like protein
D SPAC25G10.09c pan1; putative actin cortical patch component protein PanI K20047 PAN1; actin cytoskeleton-regulatory complex protein PAN1
D SPBC21D10.12 hob1; BAR adaptor protein Hob1 K12562 AMPH; amphiphysin
D SPAC16E8.01 shd1; putative Sla1 family protein Shd1 K20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1
D SPAC23A1.17 SH3 domain-containing protein K20521 BBC1; myosin tail region-interacting protein MTI1
D SPBC119.05c SH3 domain-containing protein K20522 LSB1_2; LAS seventeen-binding protein 1/2
D SPAPJ696.02 putative actin cortical patch component Lsb4 K20523 SH3YL1; SH3 domain-containing YSC84-like protein 1
D SPBC31F10.07 lsb5; putative protein lsb5 K20524 LSB5; LAS seventeen-binding protein 5
D SPAC343.19 lsb6; putative 1-phosphatidylinositol 4-kinase Lsb6 K13711 PI4K2; phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]
C Others
D SPAC4A8.15c cdc3; profilin K05759 PFN; profilin
D SPAC20G4.06c adf1; cofilin K05765 CFL; cofilin
D SPCC306.09c cap1; adenylyl cyclase-associated protein Cap1 K17261 CAP1_2; adenylyl cyclase-associated protein
D SPAC4F8.10c stg1; SM22/transgelin-like actin-modulating protein Stg1 K20526 TAGLN; transgelin
B Mucins
C Membrane bound mucins
C Secretory mucins
B Rab GTPases of specific organelles
C Melanosome
C Auto phagosome
C Lipid droplets
C Mitochondrion
B Rho GTPase associated proteins
C Rho GTPase-activating proteins
D SPBC23G7.08c rga7; Rho-type GTPase-activating protein Rga7 K20643 RGD1; Rho GTPase-activating protein RGD1
D SPAC26A3.09c rga2; putative Rho-type GTPase-activating protein Rga2 K08773 RALBP1; RalA-binding protein 1
C Rho guanine nucleotide exchange factors (GEFs)
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 10, 2024