+E Replication protein KO
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DNA Replication Proteins - Strongylocentrotus purpuratus (purple sea urchin)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 594443 LOW QUALITY PROTEIN: origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 115923055 origin recognition complex subunit 1-like K02603 ORC1; origin recognition complex subunit 1
D 585053 origin recognition complex subunit 2 isoform X1 K02604 ORC2; origin recognition complex subunit 2
D 592407 origin recognition complex subunit 3 isoform X1 K02605 ORC3; origin recognition complex subunit 3
D 100890683 origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 105445204 origin recognition complex subunit 4-like isoform X1 K02606 ORC4; origin recognition complex subunit 4
D 589513 origin recognition complex subunit 5 isoform X1 K02607 ORC5; origin recognition complex subunit 5
D 115929140 origin recognition complex subunit 5-like K02607 ORC5; origin recognition complex subunit 5
D 588540 origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 575779 DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 373248 Cdc6; cell division control protein 6 K02213 CDC6; cell division control protein 6
D 115928963 cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 579797 LOW QUALITY PROTEIN: DNA replication licensing factor mcm2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 589928 zygotic DNA replication licensing factor mcm3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 582341 DNA replication licensing factor mcm4-A K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 578688 DNA replication licensing factor mcm5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 577868 LOW QUALITY PROTEIN: zygotic DNA replication licensing factor mcm6-B K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 115918006 zygotic DNA replication licensing factor mcm6-B-like K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 574771 DNA replication licensing factor mcm7-A K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 373210 CycA; cyclin A K06627 CCNA; cyclin-A
D 579860 G1/S-specific cyclin-E K06626 CCNE; G1/S-specific cyclin-E1
D 585950 cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 580385 cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 105436566 cell division cycle 7-related protein kinase-like K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 575293 DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 115919091 DNA replication complex GINS protein PSF1-like K10732 GINS1; GINS complex subunit 1
D 585278 DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 576325 DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 574880 DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
D 115918856 DNA replication complex GINS protein SLD5-like K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 574701 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 753011 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 593200 DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 580624 DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 577033 protein MCM10 homolog isoform X1 K10736 MCM10; minichromosome maintenance protein 10
D 594069 DNA helicase B K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 105439490 DNA helicase B-like K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 577352 cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 100893406 mdm2-binding protein K26116 MTBP; Mdm2-binding protein
D 587816 uncharacterized protein LOC587816 K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 756629 DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 584095 DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 574732 DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 586401 DNA primase small subunit-like K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 590516 DNA primase large subunit K02685 PRI2; DNA primase large subunit
D 590450 DNA primase large subunit K02685 PRI2; DNA primase large subunit
D 100889028 probable DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 589064 DNA polymerase epsilon catalytic subunit A isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 115921308 LOW QUALITY PROTEIN: DNA polymerase epsilon catalytic subunit A-like K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 592195 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 580013 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 763808 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 100893055 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 577017 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 586784 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D 100889220 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D 115926799 DNA polymerase delta subunit 4-like K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 100891679 DNA polymerase subunit gamma-1-like K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 115920735 DNA polymerase subunit gamma-1-like K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 105444352 DNA polymerase subunit gamma-2, mitochondrial-like K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 757112 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
D 580037 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
D 752535 replication protein A 32 kDa subunit-B-like isoform X1 K10739 RFA2; replication factor A2
D 105446431 replication protein A 32 kDa subunit-B-like isoform X1 K10739 RFA2; replication factor A2
D 576263 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 593379 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
D 582287 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 585743 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 115918535 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 576419 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 590824 LOW QUALITY PROTEIN: replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 764228 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 584833 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 115918531 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 763203 ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 105444017 ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 752797 ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 765052 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 115918456 LOW QUALITY PROTEIN: proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 592140 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 757166 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 762697 exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 752989 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 100892842 ATPase family AAA domain-containing protein 5 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 574665 DNA (cytosine-5)-methyltransferase PliMCI K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 582367 DNA (cytosine-5)-methyltransferase 3A isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
C Prevention of re-replication factors
D 584760 geminin K10749 GMNN; geminin
D 576779 cyclin B K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 591240 G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 100891747 cyclin-A3-1 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 575965 cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 100893753 protection of telomeres protein 1 K11109 POT1; protection of telomeres protein 1
E 576798 telomeric repeat-binding factor 2 K11111 TERF2; telomeric repeat-binding factor 2
E 763087 telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
D TERB1-TERB2-MAJIN complex
E 100892727 uncharacterized protein LOC100892727 isoform X1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 594347 telomere repeats-binding bouquet formation protein 2 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 589352 uncharacterized protein LOC589352 isoform X1 K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 105440617 CST complex subunit CTC1-like isoform X1 K23311 CTC1; CST complex subunit CTC1
E 587211 CST complex subunit STN1 isoform X2 K23312 STN1; CST complex subunit STN1
E 592355 uncharacterized protein LOC592355 K23313 TEN1; CST complex subunit TEN1
E 115918432 uncharacterized protein LOC115918432 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 589683 telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 594440 protein SMG5 K11125 SMG5; protein SMG5
D 105447117 telomerase reverse transcriptase-long isoform 2 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 584519 telomerase protein component 1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 592267 H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 577044 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 584530 H/ACA ribonucleoprotein complex subunit DKC1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 105447117 telomerase reverse transcriptase-long isoform 2 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 581143 small nuclear ribonucleoprotein-associated protein B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 115917952 small nuclear ribonucleoprotein-associated protein B'-like K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 580433 small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 754356 small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 105438529 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 580958 small nuclear ribonucleoprotein polypeptide E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 100892396 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 592177 LOW QUALITY PROTEIN: small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 583159 small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 582287 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 585743 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 115918535 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 576419 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 590824 LOW QUALITY PROTEIN: replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 764228 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 583059 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
D 593604 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 115921269 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
D 581691 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 578057 nibrin isoform X1 K10867 NBN; nibrin
C Other termination factors
D 105440179 serine-protein kinase ATM-like K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 100889659 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 754123 Werner syndrome ATP-dependent helicase homolog K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 575579 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 576405 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 586799 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 588601 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 752216 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 575677 formin-like protein 20 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 579954 protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 763210 poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 105437220 protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 590750 protein mono-ADP-ribosyltransferase PARP4-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 577455 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 579780 uncharacterized protein LOC579780 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 584303 poly [ADP-ribose] polymerase tankyrase-2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 591382 PIN2/TERF1-interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 756739 uncharacterized protein LOC756739 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 100888138 regulator of telomere elongation helicase 1 isoform X1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 588739 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 582696 telomere-associated protein RIF1 K11138 RIF1; telomere-associated protein RIF1
D 580276 ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 579034 transcriptional activator protein Pur-beta isoform X1 K21772 PURA; transcriptional activator protein Pur-alpha
D 594691 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 757154 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 754268 replication termination factor 2 isoform X1 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 588512 DNA topoisomerase I, mitochondrial isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 578275 DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 582001 DNA topoisomerase 2-alpha isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 591288 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 576753 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 100894038 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 584833 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 115918531 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 584833 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 115918531 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 592140 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 757166 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 752989 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022