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Transfer RNA Biogenesis - Sus scrofa (pig)
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AEukaryotic type
B 5'processing factors
C Ribonucrease P
D 100739449 POP1; ribonucleases P/MRP protein subunit POP1 K01164 POP1; ribonuclease P/MRP protein subunit POP1 [EC:3.1.26.5]
D 100523065 POP4; ribonuclease P protein subunit p29 K03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]
D 100151786 POP5; ribonuclease P/MRP protein subunit POP5 K03537 POP5; ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5]
D 100156540 RPP30; ribonuclease P protein subunit p30 K03539 RPP1; ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5]
D 100152493 RPP21; ribonuclease P protein subunit p21 K03540 RPR2; ribonuclease P protein subunit RPR2 [EC:3.1.26.5]
D 110255173 RPP14; ribonuclease P protein subunit p14 K14529 RPP14; ribonuclease P protein subunit RPP14 [EC:3.1.26.5]
D 100627239 POP7; ribonuclease P protein subunit p20 K14527 RPP20; ribonuclease P/MRP protein subunit RPP20 [EC:3.1.26.5]
D 100157338 RPP25; ribonuclease P protein subunit p25 K14525 RPP25; ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5]
D 100522095 RPP25L; ribonuclease P protein subunit p25-like protein K14525 RPP25; ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5]
D 100626611 RPP38; ribonuclease P protein subunit p38 K14523 RPP38; ribonucleases P/MRP protein subunit RPP38 [EC:3.1.26.5]
D 110255215 RPP40; ribonuclease P protein subunit p40 isoform X1 K14530 RPP40; ribonucleases P/MRP protein subunit RPP40 [EC:3.1.26.5]
B 3'processing and CCA adding factors
C 3'processing factors
D 100520804 ELAC2; zinc phosphodiesterase ELAC protein 2 K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D 100524839 ELAC1; zinc phosphodiesterase ELAC protein 1 K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D 100157985 RNASET2; ribonuclease T2 K01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]
D 102160620 PTCD1; LOW QUALITY PROTEIN: pentatricopeptide repeat-containing protein 1, mitochondrial K17710 PTCD1; pentatricopeptide repeat domain-containing protein 1
C CCA adding factors
D 100153838 TRNT1; CCA tRNA nucleotidyltransferase 1, mitochondrial K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
B tRNA spricing factors
C tRNA splicing endonuclease complex
D 100525362 TSEN2; tRNA-splicing endonuclease subunit Sen2 K15322 TSEN2; tRNA-splicing endonuclease subunit Sen2 [EC:4.6.1.16]
D 100518973 TSEN34; tRNA-splicing endonuclease subunit Sen34 isoform X1 K15323 TSEN34; tRNA-splicing endonuclease subunit Sen34 [EC:4.6.1.16]
D 100516387 TSEN15; tRNA-splicing endonuclease subunit Sen15 isoform X1 K15324 TSEN15; tRNA-splicing endonuclease subunit Sen15
D 110255969 TSEN54; tRNA-splicing endonuclease subunit Sen54 isoform X1 K15326 TSEN54; tRNA-splicing endonuclease subunit Sen54
C tRNA splicing ligase complex
D 733658 RTCB; tRNA-splicing ligase RtcB homolog K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
D 110259971 C3H2orf49; ashwin isoform X1 K15432 ASW; ashwin
D 100154555 C1H14orf166; UPF0568 protein C14orf166 homolog K15433 CGI99; RLL motif containing protein 1
D 100522915 FAM98B; protein FAM98B K15434 FAM98B; protein FAM98B
D 100627404 DDX1; LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX1 K13177 DDX1; ATP-dependent RNA helicase DDX1 [EC:5.6.2.7]
D 102160721 ZBTB8OS; protein archease isoform X1 K24956 ZBTB8OS; protein archease
C Other tRNA splicing factors
D 100521427 TRPT1; tRNA 2'-phosphotransferase 1 isoform X4 K10669 TRPT1; 2'-phosphotransferase [EC:2.7.1.160]
B tRNA transport factors
C tRNA export factors
D 397655 RAN; GTP-binding nuclear protein Ran K07936 RAN; GTP-binding nuclear protein Ran
D 100511016 XPOT; exportin-T isoform X1 K14288 XPOT; exportin-T
D 397330 XPO1; exportin-1 isoform X3 K14290 XPO1; exportin-1
D 100155084 XPO5; exportin-5 K14289 XPO5; exportin-5
D 574059 EEF1A1; elongation factor 1-alpha 1 K03231 EEF1A; elongation factor 1-alpha
D 100514912 elongation factor 1-alpha, oocyte form-like K03231 EEF1A; elongation factor 1-alpha
D 110257403 EEF1A2; elongation factor 1-alpha 2 K03231 EEF1A; elongation factor 1-alpha
D 100620900 LOW QUALITY PROTEIN: elongation factor 1-alpha, somatic form-like K03231 EEF1A; elongation factor 1-alpha
D 100517698 SCYL1; N-terminal kinase-like protein isoform X1 K08876 SCYL1; SCY1-like protein 1
D 100520611 GTPBP1; GTP-binding protein 1 isoform X1 K24887 GTPBP1; GTP-binding protein 1
C tRNA import factors
D 100515455 TNPO3; transportin-3 isoform X1 K15436 TRPO3; transportin-3
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D 449526 EPRS; bifunctional glutamate/proline--tRNA ligase isoform X1 K14163 EPRS; bifunctional glutamyl/prolyl-tRNA synthetase [EC:6.1.1.17 6.1.1.15]
D 100523812 EARS2; probable glutamate--tRNA ligase, mitochondrial isoform X1 K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D 100513158 PARS2; LOW QUALITY PROTEIN: probable proline--tRNA ligase, mitochondrial K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D 100624746 IARS; isoleucine--tRNA ligase, cytoplasmic isoform X1 K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D 100739845 IARS2; isoleucine--tRNA ligase, mitochondrial K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D 100525981 LARS; LOW QUALITY PROTEIN: leucine--tRNA ligase, cytoplasmic K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D 100513625 LARS2; probable leucine--tRNA ligase, mitochondrial K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D 100516610 MARS; methionine--tRNA ligase, cytoplasmic isoform X1 K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D 110257078 MARS2; methionine--tRNA ligase, mitochondrial isoform X1 K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D 110256443 QARS; glutamine--tRNA ligase K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D 414410 RARS; arginine--tRNA ligase, cytoplasmic K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D 100518457 RARS2; probable arginine--tRNA ligase, mitochondrial isoform X1 K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D 100521452 KARS; lysine--tRNA ligase isoform X2 K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D 100524908 DARS; aspartate--tRNA ligase, cytoplasmic isoform X1 K22503 DARS1; aspartyl-tRNA synthetase [EC:6.1.1.12]
D 100624574 DARS2; LOW QUALITY PROTEIN: aspartate--tRNA ligase, mitochondrial K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D 100135670 AIMP1; aminoacyl tRNA synthase complex-interacting multifunctional protein 1 K15437 AIMP1; aminoacyl tRNA synthase complex-interacting multifunctional protein 1
D 100514707 AIMP2; aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform 1 K15438 AIMP2; aminoacyl tRNA synthase complex-interacting multifunctional protein 2
D 100155141 EEF1E1; eukaryotic translation elongation factor 1 epsilon-1 K15439 EEF1E1; eukaryotic translation elongation factor 1 epsilon-1
C Other AARSs
D 100155115 AARS2; alanine--tRNA ligase, mitochondrial K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D 100525399 AARS; LOW QUALITY PROTEIN: alanine--tRNA ligase, cytoplasmic K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D 100513328 NARS; asparagine--tRNA ligase, cytoplasmic isoform X2 K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D 100514245 NARS2; probable asparagine--tRNA ligase, mitochondrial isoform X1 K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D 100512260 GARS; glycine--tRNA ligase K01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]
D 100523715 TARSL2; probable threonine--tRNA ligase 2, cytoplasmic K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 100526191 TARS; LOW QUALITY PROTEIN: threonine--tRNA ligase, cytoplasmic K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 100620180 TARS2; threonine--tRNA ligase, mitochondrial isoform X1 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 100155484 SARS; serine--tRNA ligase, cytoplasmic K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D 100620899 SARS2; LOW QUALITY PROTEIN: serine--tRNA ligase, mitochondrial K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D 100515851 CARS2; probable cysteine--tRNA ligase, mitochondrial isoform X1 K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D 100516312 CARS; cysteine--tRNA ligase, cytoplasmic isoform X1 K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D 100144457 VARS2; valine--tRNA ligase, mitochondrial precursor K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D 100270813 VARS; valine--tRNA ligase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D 100518652 HARS; histidine--tRNA ligase, cytoplasmic isoform X2 K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D 100521256 probable histidine--tRNA ligase, mitochondrial isoform X1 K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D 100524304 FARSA; phenylalanine--tRNA ligase alpha subunit isoform X2 K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D 100625424 FARS2; LOW QUALITY PROTEIN: phenylalanine--tRNA ligase, mitochondrial K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D 100524650 FARSB; phenylalanine--tRNA ligase beta subunit isoform X1 K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D 110261142 LOW QUALITY PROTEIN: phenylalanine--tRNA ligase beta subunit-like K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D 100621140 YARS; tyrosine--tRNA ligase, cytoplasmic isoform X1 K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D 100624597 YARS2; tyrosine--tRNA ligase, mitochondrial K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D 100515390 WARS; tryptophan--tRNA ligase, cytoplasmic K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D 100737714 WARS2; tryptophan--tRNA ligase, mitochondrial K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
C Trans-editing factors
D 100524407 DTD1; D-tyrosyl-tRNA(Tyr) deacylase 1 K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 100522380 DTD2; probable D-tyrosyl-tRNA(Tyr) deacylase 2 isoform X2 K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 110255998 AARSD1; alanyl-tRNA editing protein Aarsd1 K07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]
C AARS associated factors
D 100621644 TRNAU1AP; tRNA selenocysteine 1-associated protein 1 isoform X1 K25102 TRNAU1AP; tRNA selenocysteine 1-associated protein 1
D 100518898 HINT1; histidine triad nucleotide-binding protein 1 K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D 100512882 HINT2; histidine triad nucleotide-binding protein 2, mitochondrial isoform 1 precursor K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D 100158022 HINT3; histidine triad nucleotide-binding protein 3 K12150 HINT3; adenosine 5'-monophosphoramidase HINT3 [EC:3.9.1.-]
B tRNA modification factors
C Deaminases
D 100521793 ADAT1; tRNA-specific adenosine deaminase 1 isoform X2 K15440 TAD1; tRNA-specific adenosine deaminase 1 [EC:3.5.4.34]
D 100154785 ADAT2; tRNA-specific adenosine deaminase 2 K15441 TAD2; tRNA-specific adenosine deaminase 2 [EC:3.5.4.-]
D 102159223 ADAT3; probable inactive tRNA-specific adenosine deaminase-like protein 3 K15442 TAD3; tRNA-specific adenosine deaminase 3
C Dihydorouridine synthases
D 100623965 DUS1L; tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like K05542 DUS1; tRNA-dihydrouridine synthase 1 [EC:1.3.1.88]
D 100621573 DUS2; tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1 K05543 DUS2; tRNA-dihydrouridine synthase 2 [EC:1.3.1.91]
D 100513458 DUS3L; tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like K05544 DUS3; tRNA-dihydrouridine synthase 3 [EC:1.3.1.89]
D 100623288 DUS4L; tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform X2 K05545 DUS4; tRNA-dihydrouridine synthase 4 [EC:1.3.1.90]
C Methylthiotransferase
D 100512355 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase isoform X1 K15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1 [EC:2.8.4.5]
C Methyltransferases
D 100627711 TRMT1; tRNA (guanine(26)-N(2))-dimethyltransferase K00555 TRMT1; tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216]
D 100154701 TRMT2A; tRNA (uracil-5-)-methyltransferase homolog A isoform X2 K15332 TRMT2A; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.-]
D 100517798 TRMT2B; tRNA (uracil(54)-C(5))-methyltransferase homolog isoform X1 K15331 TRMT2B; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35]
D 100152410 TARBP1; probable methyltransferase TARBP1 isoform X1 K15333 TRM3; tRNA guanosine-2'-O-methyltransferase [EC:2.1.1.34]
D 100518405 NSUN2; tRNA (cytosine(34)-C(5))-methyltransferase isoform X2 K15335 NSUN2; tRNA (cytosine34-C5)-methyltransferase [EC:2.1.1.203]
D 100625260 NSUN3; tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial K21969 NSUN3; tRNA (cytosine34-C5)-methyltransferase [EC:2.1.1.-]
D 100524391 putative methyltransferase NSUN6 isoform X1 K21971 NSUN6; methyltransferase NSUN6 [EC:2.1.1.-]
D 100519406 TRMT5; tRNA (guanine(37)-N1)-methyltransferase isoform X1 K15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D 100623657 TRMT61A; tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A K07442 TRM61; tRNA (adenine57-N1/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]
D 100520017 TRMT61B; tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial K07442 TRM61; tRNA (adenine57-N1/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]
D 100155529 TRMT6; tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X2 K03256 TRM6; tRNA (adenine58-N1)-methyltransferase non-catalytic subunit
D 100431100 FTSJ1; putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase K14864 FTSJ1; tRNA (cytidine32/guanosine34-2'-O)-methyltransferase [EC:2.1.1.205]
D 100622469 METTL1; tRNA (guanine-N(7)-)-methyltransferase K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D 100515752 METTL2A; methyltransferase-like protein 2A K24974 METTL2; tRNA N(3)-methylcytidine methyltransferase METTL2 [EC:2.1.1.-]
D 100517369 METTL6; methyltransferase-like protein 6 isoform 1 K00599 METTL6; tRNA N(3)-methylcytidine methyltransferase METTL6 [EC:2.1.1.-]
D 100626321 ALKBH8; LOW QUALITY PROTEIN: alkylated DNA repair protein alkB homolog 8 K10770 ALKBH8; alkylated DNA repair protein alkB homolog 8 [EC:1.14.11.- 2.1.1.229]
D 100512243 TRMT10A; tRNA methyltransferase 10 homolog A K15445 TRMT10; tRNA (guanine9-N1)-methyltransferase [EC:2.1.1.221]
D 100153604 TRMT10B; tRNA methyltransferase 10 homolog B K15445 TRMT10; tRNA (guanine9-N1)-methyltransferase [EC:2.1.1.221]
D 100152782 TRMT11; tRNA (guanine(10)-N2)-methyltransferase homolog isoform X1 K15430 TRM11; tRNA (guanine10-N2)-methyltransferase [EC:2.1.1.214]
D 102167932 TRMT13; tRNA:m(4)X modification enzyme TRM13 homolog K15446 TRM13; tRNA:m4X modification enzyme [EC:2.1.1.225]
D 110262048 TRMT44; LOW QUALITY PROTEIN: probable tRNA (uracil-O(2)-)-methyltransferase K15447 TRM44; tRNASer (uridine44-2'-O)-methyltransferase [EC:2.1.1.211]
D 100620715 WDR4; tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X1 K15443 TRM82; tRNA (guanine-N(7)-)-methyltransferase subunit TRM82
D 100520885 TRMT112; multifunctional methyltransferase subunit TRM112-like protein K15448 TRM112; multifunctional methyltransferase subunit TRM112
D 100302362 TRDMT1; tRNA (cytosine(38)-C(5))-methyltransferase K15336 TRDMT1; tRNA (cytosine38-C5)-methyltransferase [EC:2.1.1.204]
D 100156700 TRMO; tRNA (adenine(37)-N6)-methyltransferase K22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
D 100516854 TYW1; S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase isoform X1 K15449 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44]
D 100155406 TRMT12; tRNA wybutosine-synthesizing protein 2 homolog K07055 TRM12; tRNA wybutosine-synthesizing protein 2 [EC:2.5.1.114]
D 733652 TYW3; tRNA wybutosine-synthesizing protein 3 homolog K15450 TYW3; tRNA wybutosine-synthesizing protein 3 [EC:2.1.1.282]
D 100156590 LCMT2; tRNA wybutosine-synthesizing protein 4 K15451 PPM2; tRNA wybutosine-synthesizing protein 4 [EC:2.1.1.290 2.3.1.231]
D 100522402 TYW5; tRNA wybutosine-synthesizing protein 5 isoform X2 K18066 TYW5; tRNA wybutosine-synthesizing protein 5 [EC:1.14.11.42]
D 100516732 BCDIN3D; pre-miRNA 5'-monophosphate methyltransferase K25191 BCDIN3D; RNA 5'-monophosphate methyltransferase [EC:2.1.1.-]
C Psudouridine synthases
D 100157224 PUS1; tRNA pseudouridine synthase A, mitochondrial isoform X2 K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D 100512802 PUS3; tRNA pseudouridine(38/39) synthase K01855 PUS3; tRNA pseudouridine38/39 synthase [EC:5.4.99.45]
D 100151860 TRUB1; probable tRNA pseudouridine synthase 1 isoform X3 K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D 100518209 PUS7; pseudouridylate synthase 7 homolog isoform X1 K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D 100155187 PUS7L; pseudouridylate synthase 7 homolog-like protein isoform X1 K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D 100523369 PUS10; LOW QUALITY PROTEIN: putative tRNA pseudouridine synthase Pus10 K07583 PUS10; tRNA pseudouridine synthase 10 [EC:5.4.99.25]
D 100514357 RPUSD4; RNA pseudouridylate synthase domain-containing protein 4 K22538 RPUSD4; mitochondrial RNA pseudouridine synthase RPUSD4 [EC:5.4.99.-]
C Thiolation factors
D 100521087 TRMU; mitochondrial tRNA-specific 2-thiouridylase 1 isoform X1 K21027 TRMU; tRNA-5-taurinomethyluridine 2-sulfurtransferase [EC:2.8.1.14]
D 100516084 cytoplasmic tRNA 2-thiolation protein 1 K14168 CTU1; cytoplasmic tRNA 2-thiolation protein 1 [EC:2.7.7.-]
D 110261035 CTU1; LOW QUALITY PROTEIN: cytoplasmic tRNA 2-thiolation protein 1 K14168 CTU1; cytoplasmic tRNA 2-thiolation protein 1 [EC:2.7.7.-]
D 110260881 CTU2; cytoplasmic tRNA 2-thiolation protein 2 isoform X1 K14169 CTU2; cytoplasmic tRNA 2-thiolation protein 2
D 100156145 NFS1; cysteine desulfurase, mitochondrial K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D 100154341 URM1; ubiquitin-related modifier 1 K12161 URM1; ubiquitin related modifier 1
D 100124378 MOCS3; adenylyltransferase and sulfurtransferase MOCS3 K11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C KEOPS/EKC complex
D 100519282 TP53RK; TP53-regulating kinase K08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]
D 100156698 OSGEPL1; probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X4 K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
D 100153498 OSGEP; probable tRNA N6-adenosine threonylcarbamoyltransferase isoform X1 K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
D 100240744 TPRKB; EKC/KEOPS complex subunit TPRKB K15901 TPRKB; EKC/KEOPS complex subunit TPRKB/CGI121
D 100622898 LAGE3; EKC/KEOPS complex subunit LAGE3 K15902 LAGE3; EKC/KEOPS complex subunit LAGE3/PCC1
D 100155082 GON7; EKC/KEOPS complex subunit GON7 K15903 GON7; EKC/KEOPS complex subunit GON7
C Elongator complex
D 100157586 ELP1; elongator complex protein 1 K11373 ELP1; elongator complex protein 1
D 100621519 ELP2; elongator complex protein 2 K11374 ELP2; elongator complex protein 2
D 102167101 ELP3; elongator complex protein 3 K07739 ELP3; elongator complex protein 3 (tRNA carboxymethyluridine synthase) [EC:2.3.1.311]
D 100514702 ELP4; elongator complex protein 4 isoform X1 K11375 ELP4; elongator complex protein 4
D 100739487 ELP5; elongator complex protein 5 K11376 ELP5; elongator complex protein 5
D 100154579 ELP6; elongator complex protein 6 K11377 ELP6; elongator complex protein 6
C Elongator related proteins
D 100156362 DPH3; DPH3 homolog K15455 DPH3; diphthamide biosynthesis protein 3
D 110257684 DPH3 homolog K15455 DPH3; diphthamide biosynthesis protein 3
D 102158636 KTI12; protein KTI12 homolog K15456 KTI12; protein KTI12
C Other tRNA modification factors
D 110261153 YRDC; yrdC domain-containing protein, mitochondrial isoform X1 K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D 100517163 TRIT1; tRNA dimethylallyltransferase, mitochondrial isoform X1 K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D 110259323 GTPBP3; tRNA modification GTPase GTPBP3, mitochondrial isoform X1 K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
D 100515594 MTO1; protein MTO1 homolog, mitochondrial isoform X1 K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D 100524546 QTRT1; queuine tRNA-ribosyltransferase catalytic subunit 1 K00777 QTRT1; queuine tRNA-ribosyltransferase catalytic subunit [EC:2.4.2.64]
D 100514190 QTRT2; queuine tRNA-ribosyltransferase accessory subunit 2 isoform X1 K15407 QTRT2; queuine tRNA-ribosyltransferase accessory subunit
D 100037302 SEPHS2; selenide, water dikinase 2 K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D 100626870 SEPHS1; selenide, water dikinase 1 K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D 100512402 THUMPD1; THUMP domain-containing protein 1 K06963 TAN1; tRNA acetyltransferase TAN1
D 100521164 THG1L; probable tRNA(His) guanylyltransferase K10761 THG1; tRNA(His) guanylyltransferase [EC:2.7.7.79]
D 100512816 ATE1; arginyl-tRNA--protein transferase 1 isoform X9 K00685 ATE1; arginyl-tRNA---protein transferase [EC:2.3.2.8]
D 100525127 DALRD3; DALR anticodon-binding domain-containing protein 3 isoform X1 K24973 DALRD3; DALR anticodon-binding domain-containing protein 3
B tRNA degradation factors
C TRAMP complex
D 100517864 PAPD7; non-canonical poly(A) RNA polymerase PAPD7 isoform X1 K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
D 100625961 PAPD5; non-canonical poly(A) RNA polymerase PAPD5 isoform X1 K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
D 100520354 ZCCHC7; zinc finger CCHC domain-containing protein 7 K12597 AIR1_2; protein AIR1/2
D 100518521 SKIV2L2; superkiller viralicidic activity 2-like 2 K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
C Rapid tRNA decay (RTD) pathway factors
D 100515927 XRN1; LOW QUALITY PROTEIN: 5'-3' exoribonuclease 1 K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
D 100517201 XRN2; LOW QUALITY PROTEIN: 5'-3' exoribonuclease 2 K12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
D 100515917 BPNT1; 3'(2'),5'-bisphosphate nucleotidase 1 isoform X4 K01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]
C Other tRNA degradation factors
D 733639 ANG; angiogenin precursor K16631 ANG; angiogenin [EC:3.1.27.-]
D 100151816 interferon-induced protein with tetratricopeptide repeats 5 K24850 IFIT5; interferon-induced protein with tetratricopeptide repeats 5
#
AProkaryotic type
B 5'processing factors
C Ribonucrease P
B 3'processing and CCA adding factors
C 3'processing factors
D 100520804 ELAC2; zinc phosphodiesterase ELAC protein 2 K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D 100524839 ELAC1; zinc phosphodiesterase ELAC protein 1 K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D 100157985 RNASET2; ribonuclease T2 K01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]
C CCA adding factors
D 100153838 TRNT1; CCA tRNA nucleotidyltransferase 1, mitochondrial K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
B tRNA spricing factors
C tRNA splicing endonucleases
C tRNA splicing ligases
D 733658 RTCB; tRNA-splicing ligase RtcB homolog K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
C Other tRNA splicing factors
B tRNA transport factors
C tRNA export factors
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D 100525981 LARS; LOW QUALITY PROTEIN: leucine--tRNA ligase, cytoplasmic K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D 100513625 LARS2; probable leucine--tRNA ligase, mitochondrial K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D 100513158 PARS2; LOW QUALITY PROTEIN: probable proline--tRNA ligase, mitochondrial K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
C Other AARSs
D 100621140 YARS; tyrosine--tRNA ligase, cytoplasmic isoform X1 K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D 100624597 YARS2; tyrosine--tRNA ligase, mitochondrial K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D 100515390 WARS; tryptophan--tRNA ligase, cytoplasmic K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D 100737714 WARS2; tryptophan--tRNA ligase, mitochondrial K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D 100523715 TARSL2; probable threonine--tRNA ligase 2, cytoplasmic K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 100526191 TARS; LOW QUALITY PROTEIN: threonine--tRNA ligase, cytoplasmic K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 100620180 TARS2; threonine--tRNA ligase, mitochondrial isoform X1 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 100624746 IARS; isoleucine--tRNA ligase, cytoplasmic isoform X1 K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D 100739845 IARS2; isoleucine--tRNA ligase, mitochondrial K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D 100521452 KARS; lysine--tRNA ligase isoform X2 K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D 100155115 AARS2; alanine--tRNA ligase, mitochondrial K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D 100525399 AARS; LOW QUALITY PROTEIN: alanine--tRNA ligase, cytoplasmic K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D 100144457 VARS2; valine--tRNA ligase, mitochondrial precursor K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D 100270813 VARS; valine--tRNA ligase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D 100516610 MARS; methionine--tRNA ligase, cytoplasmic isoform X1 K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D 110257078 MARS2; methionine--tRNA ligase, mitochondrial isoform X1 K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D 100155484 SARS; serine--tRNA ligase, cytoplasmic K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D 100620899 SARS2; LOW QUALITY PROTEIN: serine--tRNA ligase, mitochondrial K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D 100624574 DARS2; LOW QUALITY PROTEIN: aspartate--tRNA ligase, mitochondrial K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D 100515851 CARS2; probable cysteine--tRNA ligase, mitochondrial isoform X1 K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D 100516312 CARS; cysteine--tRNA ligase, cytoplasmic isoform X1 K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D 100523812 EARS2; probable glutamate--tRNA ligase, mitochondrial isoform X1 K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D 110256443 QARS; glutamine--tRNA ligase K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D 414410 RARS; arginine--tRNA ligase, cytoplasmic K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D 100518457 RARS2; probable arginine--tRNA ligase, mitochondrial isoform X1 K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D 100524304 FARSA; phenylalanine--tRNA ligase alpha subunit isoform X2 K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D 100625424 FARS2; LOW QUALITY PROTEIN: phenylalanine--tRNA ligase, mitochondrial K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D 100524650 FARSB; phenylalanine--tRNA ligase beta subunit isoform X1 K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D 110261142 LOW QUALITY PROTEIN: phenylalanine--tRNA ligase beta subunit-like K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D 100518652 HARS; histidine--tRNA ligase, cytoplasmic isoform X2 K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D 100521256 probable histidine--tRNA ligase, mitochondrial isoform X1 K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D 100513328 NARS; asparagine--tRNA ligase, cytoplasmic isoform X2 K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D 100514245 NARS2; probable asparagine--tRNA ligase, mitochondrial isoform X1 K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
C Trans-editing factors
D 100524407 DTD1; D-tyrosyl-tRNA(Tyr) deacylase 1 K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 100522380 DTD2; probable D-tyrosyl-tRNA(Tyr) deacylase 2 isoform X2 K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 110255998 AARSD1; alanyl-tRNA editing protein Aarsd1 K07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]
B tRNA modification factors
C Deaminases
C Dihydorouridine synthases
C Methylthiotransferases
C Methyltransferases
D 100622469 METTL1; tRNA (guanine-N(7)-)-methyltransferase K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D 110259323 GTPBP3; tRNA modification GTPase GTPBP3, mitochondrial isoform X1 K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
D 100156700 TRMO; tRNA (adenine(37)-N6)-methyltransferase K22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
C Psudouridine synthases
D 100157224 PUS1; tRNA pseudouridine synthase A, mitochondrial isoform X2 K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D 100151860 TRUB1; probable tRNA pseudouridine synthase 1 isoform X3 K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D 100518209 PUS7; pseudouridylate synthase 7 homolog isoform X1 K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D 100155187 PUS7L; pseudouridylate synthase 7 homolog-like protein isoform X1 K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
C Thiolation factors
D 100156145 NFS1; cysteine desulfurase, mitochondrial K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C KEOPS/EKC complex
D 100519282 TP53RK; TP53-regulating kinase K08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]
D 100156698 OSGEPL1; probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X4 K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
D 100153498 OSGEP; probable tRNA N6-adenosine threonylcarbamoyltransferase isoform X1 K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
C Other tRNA modification factors
D 100515594 MTO1; protein MTO1 homolog, mitochondrial isoform X1 K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D 100517163 TRIT1; tRNA dimethylallyltransferase, mitochondrial isoform X1 K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D 100737784 PTS; 6-pyruvoyl tetrahydrobiopterin synthase isoform X2 K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
D 100037302 SEPHS2; selenide, water dikinase 2 K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D 100626870 SEPHS1; selenide, water dikinase 1 K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D 110261153 YRDC; yrdC domain-containing protein, mitochondrial isoform X1 K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
B tRNA degradation factors
C 100642182 PNPT1; polyribonucleotide nucleotidyltransferase 1, mitochondrial K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
C 448855 ISG20; interferon-stimulated gene 20 kDa protein isoform X2 K12579 ISG20; interferon-stimulated gene 20 kDa protein [EC:3.1.13.1]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: February 29, 2024