+F Repair protein KO
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DNA Repair and Recombination Proteins - Xenopus laevis (African clawed frog)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 108697181 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 108716036 alkbh2.L; DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 496071 alkbh3.L; alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase L homeolog K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 108716857 ascc3.L; activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 733427 phr.L; CPD photolyase-like L homeolog K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 443838 ung.L; uracil DNA glycosylase L homeolog K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 734931 ccno.S; cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 108714968 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 108715405 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 734946 ccno.L; cyclin-O protein A K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 108705888 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 108704689 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 108704511 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 399413 tdg.S; thymine DNA glycosylase S homeolog K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 108701508 mpg.L; DNA-3-methyladenine glycosylase isoform X3 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 399139 smug1.L; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 108714269 mutyh.L; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 108714643 mbd4.L; methyl-CpG-binding domain protein 4 isoform X1 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 733253 ogg1.L; N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 443713 neil1.L; endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 108717236 neil2.L; endonuclease 8-like 2 isoform X1 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 100380996 neil3.L; endonuclease 8-like 3 isoform X1 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 432324 apex1.L; APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 108707047 apex1.S; DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 446614 apex2.L; apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 447518 pold1.L; DNA-directed DNA polymerase delta 1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 379793 pold2.L; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 398707 pold3.L; DNA-directed DNA polymerase delta 3 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 394427 pole.L; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 399116 pole2.L; DNA-directed DNA polymerase epsilon 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 407748 pole3.L; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 779084 pole4.L; DNA-directed DNA polymerase epsilon 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 398425 pcna.L; proliferating cell nuclear antigen L homeolog K04802 PCNA; proliferating cell nuclear antigen
E 394328 pcna.S; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 394303 fen1.L; flap endonuclease 1-A K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 394311 fen1.S; flap endonuclease 1-B K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 108696916 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 397978 lig1.L; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 397973 polb.S; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 380403 xrcc1.L; X-ray repair complementing defective repair in Chinese hamster cells 1 L homeolog K10803 XRCC1; DNA-repair protein XRCC1
E 446884 xndc1.l; Xrcc1 N-terminal domain containing 1 L homeolog K10803 XRCC1; DNA-repair protein XRCC1
E 108704966 xrcc1.S; DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 398275 lig3.L; ligase III, DNA, ATP-dependent L homeolog K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 446983 tdp1.L; tyrosyl-DNA phosphodiesterase 1 L homeolog K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 398657 aptx.L; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 108716577 aplf.L; aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 100137702 pnkp.S; polynucleotide kinase 3'-phosphatase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 380530 hmgb1.L; high mobility group box 1 L homeolog K10802 HMGB1; high mobility group protein B1
E 108709952 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 108696155 poll.L; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 397928 parp1.L; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 446370 parp2.S; poly(ADP-ribose) polymerase 2 S homeolog K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 496154 parp3.L; poly(ADP-ribose) polymerase family member 3 L homeolog K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 108715186 parp2.L; poly [ADP-ribose] polymerase 2 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 108708726 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 108708727 protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 108708728 parp4.1.L; protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 108709018 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 108714651 xpc.L; DNA repair protein complementing XP-C cells isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 398507 rad23b.S; RAD23 homolog B, nucleotide excision repair protein S homeolog K10839 RAD23; UV excision repair protein RAD23
F 734481 rad23b.L; uncharacterized protein LOC734481 K10839 RAD23; UV excision repair protein RAD23
F 379819 cetn1.S; centrin 1 S homeolog K10840 CETN2; centrin-2
F 397814 cetn1.L; centrin 1 L homeolog K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 108714482 rbx1.L; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 108715730 rbx1.S; RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 735163 cul4b.S; cullin 4B S homeolog K10609 CUL4; cullin 4
F 108698360 cul4b.L; cullin-4B isoform X1 K10609 CUL4; cullin 4
F 108708452 cul4a.L; cullin-4A K10609 CUL4; cullin 4
F 100158294 cul4a.S; cullin-4A K10609 CUL4; cullin 4
F 399026 ddb1.S; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 108713786 ddb2.L; DNA damage-binding protein 2 K10140 DDB2; DNA damage-binding protein 2
F 108715228 ddb2.S; LOW QUALITY PROTEIN: DNA damage-binding protein 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 108703583 polr2a.S; DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 108711840 polr2a.L; DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 398890 polr2b.S; polymerase (RNA) II (DNA directed) polypeptide B, 140kDa S homeolog K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 108712074 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 432060 polr2c.S; polymerase (RNA) II (DNA directed) polypeptide C, 33kDa S homeolog K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 447138 polr2d.L; polymerase (RNA) II (DNA directed) polypeptide D L homeolog K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 398968 polr2e.S; polymerase (RNA) II (DNA directed) polypeptide E, 25kDa S homeolog K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 108696070 polr2e.L; DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 495684 polr2f.S; DNA directed RNA polymerase II polypeptide F K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 108714542 polr2f.L; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 100037112 polr2g.L; polymerase (RNA) II (DNA directed) polypeptide G L homeolog K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 108715161 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 443896 polr2h.L; polymerase (RNA) II subunit H L homeolog K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 108718026 polr2h.S; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 734341 polr2i.S; polymerase (RNA) II subunit I S homeolog K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 108698537 polr2i.L; DNA-directed RNA polymerase II subunit RPB9 isoform X1 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 734578 polr2l.1.S; polymerase (RNA) II subunit L S homeolog K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 108713863 polr2l.1.L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 108696737 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 496260 polr2j.S; polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa S homeolog K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 108708305 polr2j.L; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 443871 polr2k.L; polymerase (RNA) II (DNA directed) polypeptide K K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
F 447189 polr2k.S; polymerase (RNA) II (DNA directed) polypeptide K K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 108714482 rbx1.L; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 108715730 rbx1.S; RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 735163 cul4b.S; cullin 4B S homeolog K10609 CUL4; cullin 4
F 108698360 cul4b.L; cullin-4B isoform X1 K10609 CUL4; cullin 4
F 108708452 cul4a.L; cullin-4A K10609 CUL4; cullin 4
F 100158294 cul4a.S; cullin-4A K10609 CUL4; cullin 4
F 399026 ddb1.S; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 496353 ercc8.S; excision repair cross-complementation group 8 S homeolog K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 108696345 ercc6.L; DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 108697653 uvssa.L; UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 108703482 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
F 443748 elof1.S; ELF1 homolog, elongation factor 1 S homeolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 100036984 ercc3.L; general transcription and DNA repair factor IIH helicase subunit XPB isoform X1 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 108698517 ercc2.L; general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 379969 gtf2h1.L; general transcription factor IIH subunit 1 L homeolog K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 108715324 general transcription factor IIH subunit 1 isoform X1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 443754 gtf2h2.S; general transcription factor IIH subunit 2 S homeolog K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 108716557 gtf2h3.L; general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 432181 gtf2h4.S; general transcription factor IIH subunit 4 S homeolog K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 108716713 gtf2h5.L; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 399461 cdk7.L; cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 394356 ccnh.L; cyclin-H K06634 CCNH; cyclin H
E 380053 mnat1.L; CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
E 108700473 mnat1.S; LOW QUALITY PROTEIN: CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 108708846 rpa1.S; replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 397937 rpa1.L; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 443819 rpa2.L; replication protein A 32 kDa subunit-A K10739 RFA2; replication factor A2
E 100036853 rpa2.S; replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 495401 rpa3.L; replication protein A3 L homeolog K10740 RPA3; replication factor A3
E 446650 rpa3.S; replication protein A3 S homeolog K10740 RPA3; replication factor A3
D Other NER factors
E 397790 xpa.L; DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 380190 ercc1.L; excision repair cross-complementing 1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 446411 ercc4.L; excision repair cross-complementation group 4 L homeolog K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 397963 ercc5.L; DNA repair protein complementing XP-G cells homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 397978 lig1.L; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 447045 mms19.L; MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 108705258 MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 446487 cul3.L; cullin-3-A K03869 CUL3; cullin 3
E 444103 cul3.S; cullin-3-B K03869 CUL3; cullin 3
E 100126611 cul5.L; cullin 5 L homeolog K10612 CUL5; cullin 5
E 108709992 cul5.S; cullin-5 isoform X1 K10612 CUL5; cullin 5
E 379820 eloc.L; elongin C L homeolog K03872 ELOC; elongin-C
E 108695349 elongin-C K03872 ELOC; elongin-C
E 108719192 elongin-C K03872 ELOC; elongin-C
E 108705708 elongin-C K03872 ELOC; elongin-C
E 380106 elob.L; elongin B L homeolog K03873 ELOB; elongin-B
E 108703269 elongin-B isoform X1 K03873 ELOB; elongin-B
E 108716910 elongin-A isoform X1 K15076 ELOA; elongin-A
E 495514 eloa.S; elongin-A isoform X1 K15076 ELOA; elongin-A
E 108708278 eloa.L; elongin-A K15076 ELOA; elongin-A
E 108700413 ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 108699165 ubap2l.L; ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 108707358 ubap2.S; ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 595045 msh2.L; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 108717641 msh3.L; DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 734294 msh6.L; mutS homolog 6 L homeolog K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 379232 pms1.S; postmeiotic segregation increased 1 K10864 PMS1; DNA mismatch repair protein PMS1
E 100036779 mlh1.S; mutL homolog 1 S homeolog K08734 MLH1; DNA mismatch repair protein MLH1
E 108701593 pms2.L; mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 444223 mlh3.L; mutL homolog 3 L homeolog K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 447518 pold1.L; DNA-directed DNA polymerase delta 1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 379793 pold2.L; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 398707 pold3.L; DNA-directed DNA polymerase delta 3 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 108708846 rpa1.S; replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 397937 rpa1.L; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 443819 rpa2.L; replication protein A 32 kDa subunit-A K10739 RFA2; replication factor A2
E 100036853 rpa2.S; replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 495401 rpa3.L; replication protein A3 L homeolog K10740 RPA3; replication factor A3
E 446650 rpa3.S; replication protein A3 S homeolog K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 100380972 rfc1.L; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 431883 rfc2.L; replication factor C subunit 2 L homeolog K10755 RFC2_4; replication factor C subunit 2/4
E 398706 rfc4.L; replication factor C subunit 4 L homeolog K10755 RFC2_4; replication factor C subunit 2/4
E 108709658 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
E 380369 rfc5.L; replication factor C subunit 5 L homeolog K10756 RFC3_5; replication factor C subunit 3/5
E 734626 rfc3.L; replication factor C subunit 3 L homeolog K10756 RFC3_5; replication factor C subunit 3/5
E 443952 rfc5.S; replication factor C subunit 5 S homeolog K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 398425 pcna.L; proliferating cell nuclear antigen L homeolog K04802 PCNA; proliferating cell nuclear antigen
E 394328 pcna.S; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 399140 exo1.S; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 380530 hmgb1.L; high mobility group box 1 L homeolog K10802 HMGB1; high mobility group protein B1
E 108709952 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 397978 lig1.L; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 735144 wdr76.S; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 394308 mre11.L; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 495064 rad50.L; RAD50 homolog, double strand break repair protein L homeolog K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 108713276 rad50.S; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 403373 nbn.L; nibrin L homeolog K10867 NBN; nibrin
D BRCA1-core complex
E 399391 brca1.L; breast cancer 1 L homeolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 398242 bard1.L; BRCA1 associated RING domain 1 L homeolog K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 399391 brca1.L; breast cancer 1 L homeolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 443765 abraxas1.S; BRCA1-A complex subunit Abraxas 1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 108710980 BRCA1-A complex subunit RAP80 isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 444814 babam1.L; BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 444077 babam2.L; BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 447688 brcc3.L; lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 399391 brca1.L; breast cancer 1 L homeolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 398837 brip1.L; BRCA1 interacting helicase 1 L homeolog K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 398573 topbp1.L; DNA topoisomerase II binding protein 1 L homeolog K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 399391 brca1.L; breast cancer 1 L homeolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 108695266 rbbp8.S; LOW QUALITY PROTEIN: DNA endonuclease RBBP8-like K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 444252 rbbp8.L; DNA endonuclease RBBP8 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 394308 mre11.L; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 495064 rad50.L; RAD50 homolog, double strand break repair protein L homeolog K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 108713276 rad50.S; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 403373 nbn.L; nibrin L homeolog K10867 NBN; nibrin
D BRCA complex
E 399391 brca1.L; breast cancer 1 L homeolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 108708691 brca2.L; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 108703181 partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
E 733293 palb2.L; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 380251 rad51.L; DNA repair protein RAD51 homolog B K04482 RAD51; DNA repair protein RAD51
E 397726 rad51.S; DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 380251 rad51.L; DNA repair protein RAD51 homolog B K04482 RAD51; DNA repair protein RAD51
E 397726 rad51.S; DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
E 108708318 rad51c.L; DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 444788 rad51d.L; RAD51 paralog D L homeolog K10871 RAD51L3; RAD51-like protein 3
E 443613 xrcc2.S; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 379577 xrcc3.L; X-ray repair complementing defective repair in Chinese hamster cells 3 L homeolog K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 734642 rad52.S; RAD52 homolog, DNA repair protein S homeolog K10873 RAD52; DNA repair and recombination protein RAD52
E 108713785 rdm1.L; RAD52 motif-containing protein 1 isoform X2 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 108715578 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 108715825 rad54l2.S; helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 398513 rad54l2.L; helicase ARIP4 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 432195 rad54b.L; RAD54 homolog B L homeolog K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 734924 recql.L; RecQ like helicase L homeolog K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 398079 wrn.L; Werner syndrome ATP-dependent helicase homolog K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 373628 blm.S; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 108711520 blm.L; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 733317 rts; RECQL4-helicase-like protein K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 108701115 recql5.L; ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 373628 blm.S; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 108711520 blm.L; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 398564 top3b.L; DNA topoisomerase III beta L homeolog K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 444125 top3a.L; DNA topoisomerase III alpha L homeolog K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 446710 rmi1.L; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 108701524 rmi2.L; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 108708846 rpa1.S; replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 397937 rpa1.L; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 443819 rpa2.L; replication protein A 32 kDa subunit-A K10739 RFA2; replication factor A2
E 100036853 rpa2.S; replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 495401 rpa3.L; replication protein A3 L homeolog K10740 RPA3; replication factor A3
E 446650 rpa3.S; replication protein A3 S homeolog K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 432334 ppp4c.S; serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 108703929 ppp4c.L; serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 446904 ppp4r1.S; protein phosphatase 4 regulatory subunit 1 S homeolog K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 108700941 ppp4r1l.L; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 108702645 ppp4r1l.S; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 108719195 ppp4r1.L; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 446890 ppp4r2.S; serine/threonine-protein phosphatase 4 regulatory subunit 2-B K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 496232 ppp4r2.L; serine/threonine-protein phosphatase 4 regulatory subunit 2-A K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 379307 ppp4r3b.L; serine/threonine-protein phosphatase 4 regulatory subunit 3-A K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 379384 ppp4r3b.S; serine/threonine-protein phosphatase 4 regulatory subunit 3-B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 432127 ppp4r3a.S; serine/threonine-protein phosphatase 4 regulatory subunit 3 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 108698717 ppp4r3a.L; serine/threonine-protein phosphatase 4 regulatory subunit 3-like isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 108698732 ppp4r4.L; serine/threonine-protein phosphatase 4 regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
E 108699812 ppp4r4.S; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 108696574 ap5b1.L; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 108700469 AP-5 complex subunit mu-1-like K19023 AP5M1; AP-5 complex subunit mu-1
E 495420 ap5m1.L; adaptor related protein complex 5 subunit mu 1 L homeolog K19023 AP5M1; AP-5 complex subunit mu-1
E 446282 ap5s1.L; adaptor related protein complex 5, sigma 1 subunit L homeolog K19024 AP5S1; AP-5 complex subunit sigma-1
E 444387 ap5z1.S; adaptor related protein complex 5 subunit zeta 1 S homeolog K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 398492 smc5.S; structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 108717191 structural maintenance of chromosomes protein 6 isoform X2 K22804 SMC6; structural maintenance of chromosomes protein 6
E 398986 smc6.1.L; structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 108717189 protein LRATD1 K22805 FAM84A; protein FAM84A
E 108718252 protein LRATD1 K22805 FAM84A; protein FAM84A
E 398764 nsmce1.L; non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 379272 nsmce2.L; E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 108718079 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 108699990 non-structural maintenance of chromosomes element 3 homolog isoform X2 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 100158435 nsmce4a.L; NSE4 homolog A, SMC5-SMC6 complex component L homeolog K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 108697371 nsmce4a.S; non-structural maintenance of chromosomes element 4 homolog A isoform X1 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 108717373 slf1.L; SMC5-SMC6 complex localization factor protein 1 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 108696148 slf2.L; SMC5-SMC6 complex localization factor protein 2-like K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 100137639 eme1.L; essential meiotic structure-specific endonuclease 1 L homeolog K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 108701630 eme2.L; probable crossover junction endonuclease EME2 K10883 EME2; crossover junction endonuclease EME2
E 100158397 exd2.S; exonuclease 3'-5' domain containing 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 398805 exd2.L; exonuclease 3'-5' domain containing 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 108713940 mus81.L; crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 447126 sem1.S; split hand/foot malformation (ectrodactyly) type 1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 108718846 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 121397101 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 447306 sfr1.L; swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 779287 slx1a.L; structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 432277 slx4.L; uncharacterized protein LOC432277 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 108717192 flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 108711516 spg11.L; spatacsin isoform X3 K19026 SPG11; spatacsin
E 108699296 zfyve26.L; zinc finger FYVE domain-containing protein 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 446940 rad51ap1.L; RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 447480 morf4l1.S; mortality factor 4 like 1 S homeolog K11339 MORF4L1; mortality factor 4-like protein 1
E 108711514 morf4l1.L; mortality factor 4-like protein 1 isoform X2 K11339 MORF4L1; mortality factor 4-like protein 1
E 108701075 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 108701076 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 432222 samhd1.L; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 446598 fignl1.L; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 108718581 spidr.L; DNA repair-scaffolding protein K22806 SPIDR; DNA repair-scaffolding protein
E 108719411 protein LRATD2 isoform X2 K22810 FAM84B; protein FAM84B
E 108695445 protein LRATD2 K22810 FAM84B; protein FAM84B
E 108701552 brat1.L; BRCA1-associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 447342 cfap410.S; cilia and flagella associated protein 410 S homeolog K23456 CFAP410; cilla- and flagella-associated protein
E 432209 hdgfl2.L; hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 108706807 hdgfl2.S; hepatoma-derived growth factor-related protein 2-like K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 100381033 zswim7.L; zinc finger, SWIM-type containing 7 L homeolog K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 108711707 swsap1.L; ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 108710040 emsy.S; BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 108707623 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 108707791 heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 100137659 mms22l.L; protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 108695481 tonsoku-like protein isoform X2 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 108719487 tonsoku-like protein isoform X3 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 108706544 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 734977 parpbp.L; PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 398357 xrcc6.L; X-ray repair complementing defective repair in Chinese hamster cells 6 L homeolog K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 394397 xrcc5.L; X-ray repair complementing defective repair in Chinese hamster cells 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 373602 prkdc.L; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 394308 mre11.L; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 495064 rad50.L; RAD50 homolog, double strand break repair protein L homeolog K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 108713276 rad50.S; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 394389 lig4.L; DNA ligase (ATP) 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 443786 xrcc4.L; X-ray repair complementing defective repair in Chinese hamster cells 4 L homeolog K10886 XRCC4; DNA-repair protein XRCC4
E 445871 nhej1.S; non-homologous end-joining factor 1 isoform X1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 108696155 poll.L; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 108712749 polm.S; DNA-directed DNA/RNA polymerase mu isoform X1 K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 378525 dntt.L; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 397973 polb.S; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 398657 aptx.L; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 108716577 aplf.L; aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 108713054 dclre1c.S; protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 100049743 tdp2.S; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 108719212 smchd1.L; structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 108712566 pwwp3a.L; PWWP domain-containing DNA repair factor 3A isoform X1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 108706083 protein PAXX-like isoform X1 K25772 PAXX; protein PAXX
E 108710738 cell cycle regulator of non-homologous end joining K26155 CYREN; cell cycle regulator of non-homologous end joining
E 108701692 jmjd8.L; jmjC domain-containing protein 8 K25792 JMJD8; jumonji domain-containing protein 8
E 121394167 uncharacterized protein LOC121394167 K26128 SHLD1; shieldin complex subunit 1
E 108714463 shld2.L; shieldin complex subunit 2 K26129 SHLD2; shieldin complex subunit 2
C FA (Fanconi anemia) pathway
D FA core complex
E 734195 fanca.L; FA complementation group A L homeolog K10888 FANCA; fanconi anemia group A protein
E 108707919 Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 100329211 fancc.L; FA complementation group C L homeolog K10890 FANCC; fanconi anemia group C protein
E 108708145 Fanconi anemia group E protein isoform X1 K10892 FANCE; fanconi anemia group E protein
E 446262 fancf.L; FA complementation group F L homeolog K10893 FANCF; fanconi anemia group F protein
E 100125673 fancg.S; FA complementation group G S homeolog K10894 FANCG; fanconi anemia group G protein
E 734197 fancl.L; FA complementation group L L homeolog K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 100286772 fancm.L; FA complementation group M L homeolog K10896 FANCM; fanconi anemia group M protein
E 496036 faap24.L; uncharacterized protein LOC496036 K10898 FAAP24; fanconi anemia-associated protein
E 414454 faap100.L; uncharacterized protein LOC414454 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 397813 hes1.L; transcription factor HES-1-A K06054 HES1; hairy and enhancer of split 1
E 379073 hes1.S; transcription factor HES-1-B K06054 HES1; hairy and enhancer of split 1
E 398579 hes4.S; transcription factor HES-4-A K06054 HES1; hairy and enhancer of split 1
E 398258 hes4.L; transcription factor HES-4-B K06054 HES1; hairy and enhancer of split 1
E 431958 cenps.L; centromere protein S K11511 APITD1; centromere protein S
E 108700977 centromere protein X isoform X1 K15360 STRA13; centromere protein X
E 379797 ube2t.S; ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 373628 blm.S; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 108711520 blm.L; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 398564 top3b.L; DNA topoisomerase III beta L homeolog K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 444125 top3a.L; DNA topoisomerase III alpha L homeolog K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 446710 rmi1.L; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 108701524 rmi2.L; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 734196 fancd2.L; FA complementation group D2 L homeolog K10891 FANCD2; fanconi anemia group D2 protein
E 100327240 fanci.L; FA complementation group I L homeolog K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 399391 brca1.L; breast cancer 1 L homeolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 108708691 brca2.L; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 398837 brip1.L; BRCA1 interacting helicase 1 L homeolog K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 108703181 partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
E 733293 palb2.L; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 108711349 fan1.L; fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 380251 rad51.L; DNA repair protein RAD51 homolog B K04482 RAD51; DNA repair protein RAD51
E 397726 rad51.S; DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
E 108708318 rad51c.L; DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 443621 telo2.L; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
E 447465 usp1.S; ubiquitin specific peptidase 1 S homeolog K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 398530 usp1.L; ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 414700 wdr48.S; WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
E 108718722 wdr48.L; WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 734439 ppp6c.S; protein phosphatase 6, catalytic subunit S homeolog K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 108700017 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 379706 ppp6r1.L; protein phosphatase 6 regulatory subunit 1 L homeolog K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 108697806 ppp6r1.S; serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X1 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 444243 ppp6r2.L; protein phosphatase 6 regulatory subunit 2 L homeolog K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 431944 ppp6r3.S; serine/threonine-protein phosphatase 6 regulatory subunit 3-B K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 431955 ppp6r3.L; serine/threonine-protein phosphatase 6 regulatory subunit 3-A K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 108719943 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X3 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 108718914 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 431863 ankrd52.L; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C isoform X1 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
E 108709829 ankrd52.S; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C isoform X1 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 431911 rnf8.L; E3 ubiquitin-protein ligase rnf8-B K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 380076 rnf8.S; E3 ubiquitin-protein ligase rnf8-A K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 108718197 rnf168.S; E3 ubiquitin-protein ligase rnf168 isoform X1 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 432198 rnf168.L; E3 ubiquitin-protein ligase rnf168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 108707636 rnf169.L; E3 ubiquitin-protein ligase RNF169 isoform X1 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 108710062 rnf169.S; E3 ubiquitin-protein ligase RNF169 isoform X1 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 108708436 herc2.L; E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
E 108709727 herc2.S; E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 108711780 wrap53.L; telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 108698112 taperin K24164 TPRN; taperin
E 108699858 taperin K24164 TPRN; taperin
E 108711823 zinc finger CW-type PWWP domain protein 1 isoform X1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 444069 wdr70.L; WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 735144 wdr76.S; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 446909 polh.S; DNA-directed DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 108707336 poli.S; DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 446387 polk.L; DNA-directed DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 431964 rev1.S; REV1, DNA directed polymerase S homeolog K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
D 108708422 rev1.L; DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 100316923 rev3l.L; REV3 like, DNA directed polymerase zeta catalytic subunit L homeolog K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
D 108717934 rev3l.S; DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 398788 ube2a.L; ubiquitin conjugating enzyme E2 A L homeolog K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 108700138 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 443745 ube2b.S; ubiquitin conjugating enzyme E2 B S homeolog K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 108710808 ube2b.L; ubiquitin-conjugating enzyme E2 B isoform X1 K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 108714633 rad18.L; E3 ubiquitin-protein ligase RAD18 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 735224 hltf.L; helicase-like transcription factor L homeolog K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 399425 ube2v1.L; ubiquitin conjugating enzyme E2 variant 1 L homeolog K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 380089 ube2v2.S; ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 108702591 ube2v1.S; ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 108719244 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 380524 ube2n.S; ubiquitin conjugating enzyme E2 N S homeolog K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 108711058 ube2n.L; ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 398425 pcna.L; proliferating cell nuclear antigen L homeolog K04802 PCNA; proliferating cell nuclear antigen
D 394328 pcna.S; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 734977 parpbp.L; PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
D 100036995 sprtn.S; DNA-dependent metalloprotease SPRTN K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 108698317 gcna.L; uncharacterized protein gcna.L isoform X1 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 398594 rad9a.L; RAD9 checkpoint clamp component A L homeolog K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 496251 rad9b.L; cell cycle checkpoint control protein RAD9B isoform X1 K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 398571 hus1.L; HUS1 checkpoint clamp component L homeolog K10903 HUS1; HUS1 checkpoint protein
D 398405 rad1.L; RAD1 checkpoint DNA exonuclease L homeolog K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 398572 rad17.L; RAD17 checkpoint clamp loader component L homeolog K06662 HRAD17; cell cycle checkpoint protein
D 431883 rfc2.L; replication factor C subunit 2 L homeolog K10755 RFC2_4; replication factor C subunit 2/4
D 398706 rfc4.L; replication factor C subunit 4 L homeolog K10755 RFC2_4; replication factor C subunit 2/4
D 108709658 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 380369 rfc5.L; replication factor C subunit 5 L homeolog K10756 RFC3_5; replication factor C subunit 3/5
D 734626 rfc3.L; replication factor C subunit 3 L homeolog K10756 RFC3_5; replication factor C subunit 3/5
D 443952 rfc5.S; replication factor C subunit 5 S homeolog K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 398405 rad1.L; RAD1 checkpoint DNA exonuclease L homeolog K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 108709842 timeless.S; protein timeless homolog isoform X1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 446242 timeless.L; protein timeless homolog isoform X1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 394376 tipin.L; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 444047 tipin.S; timeless interacting protein S homeolog K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 398192 clspn.S; claspin K25773 CLSPN; claspin
C Triple T complex
D 443621 telo2.L; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 108704602 tti1.L; TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
D 108711603 tti2.L; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 379698 bag6.L; large proline-rich protein bag6-A K23390 BAG6; large proline-rich protein BAG6
D 398926 bag6.S; large proline-rich protein bag6-B K23390 BAG6; large proline-rich protein BAG6
D 108699967 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 100381043 ubl4a.S; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 431835 get4.L; Golgi to ER traffic protein 4 homolog A K23387 GET4; golgi to ER traffic protein 4
D 444741 get4.S; Golgi to ER traffic protein 4 homolog B K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 398197 atr.L; serine/threonine-protein kinase atr K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 443563 atrip.L; ATR interacting protein L homeolog K10905 ATRIP; ATR interacting protein
D 496388 atrip.S; ATR interacting protein S homeolog K10905 ATRIP; ATR interacting protein
D 398148 atm.L; ATM serine/threonine kinase L homeolog K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 397926 tp53.L; cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 108703451 tp53.S; cellular tumor antigen p53-like K04451 TP53; tumor protein p53
D 398191 chek1.S; serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 108696394 chek1.L; serine/threonine-protein kinase Chk1-like isoform X1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 398179 chek2.L; checkpoint kinase 2 L homeolog K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 398141 cdc25a.L; cell division cycle 25A L homeolog K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 734734 cdc25a.S; cell division cycle 25A S homeolog K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 100158454 cdc25b.L; cell division cycle 25B L homeolog K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 100158455 cdc25b.S; cell division cycle 25B S homeolog K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 398119 cdc25c.L; M-phase inducer phosphatase 1-B K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 100337563 cdc25c.S; M-phase inducer phosphatase 3 K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 379809 ywhaz.S; 14-3-3 protein zeta a K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 380064 ywhaq.S; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta S homeolog K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 399276 ywhab.L; 14-3-3-like protein K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 379608 ywhaz.L; 14-3-3 protein zeta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 380457 ywhab.S; 14-3-3 protein beta/alpha-B K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 108717177 ywhaq.L; 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 444832 ywhah.L; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta L homeolog K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 432005 ywhag.S; 14-3-3 protein gamma-B K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 379724 ywhag.L; 14-3-3 protein gamma-A K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 108707111 ywhah.S; 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 380397 ywhae.S; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon S homeolog K06630 YWHAE; 14-3-3 protein epsilon
D 108708028 ywhae.L; 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 108713725 nav2.L; neuron navigator 2 isoform X10 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 108715296 nav2.S; neuron navigator 2 isoform X9 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 399355 wee1.S; wee1-like protein kinase 1-B K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 398049 wee2.L; wee1-like protein kinase 2-A K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 398017 wee2.S; wee1-like protein kinase 2-B K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 398396 wee1.L; wee1-like protein kinase 1-A K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 373754 per1.L; period circadian regulator 1 L homeolog K21944 PER1; period circadian protein 1
D 394381 per2.L; period circadian regulator 2 L homeolog K02633 PER2; period circadian protein 2
D 108697704 per3.S; period circadian protein homolog 3 isoform X1 K21945 PER3; period circadian protein 3
D 108696622 per3.L; period circadian protein homolog 3 K21945 PER3; period circadian protein 3
D 108698580 mdc1.L; mediator of DNA damage checkpoint protein 1 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 399002 pls3.L; plastin 3 L homeolog K17336 PLS3; plastin-3
D 108700168 pls3.S; plastin-3 isoform X2 K17336 PLS3; plastin-3
D 494737 aen.L; apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 108712465 aen.S; apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 100381164 plk3.S; serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 100505422 plk3.L; serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 108712438 serine/threonine-protein kinase PLK2 K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 108699026 nek1.L; serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 414527 nek4.S; NIMA-related kinase 4 S homeolog K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 108706631 nek1.S; serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 108708675 nek5.L; serine/threonine-protein kinase Nek5 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 108718926 nek10.L; serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 108704815 serine/threonine-protein kinase Nek11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 108718960 nek11.L; serine/threonine-protein kinase Nek11 isoform X1 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 495432 donson.L; protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 108703473 kank2.S; KN motif and ankyrin repeat domain-containing protein 2 isoform X4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 108706855 kank3.S; KN motif and ankyrin repeat domain-containing protein 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 108706961 kank1.S; KN motif and ankyrin repeat domain-containing protein 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 108712666 kank3.L; KN motif and ankyrin repeat domain-containing protein 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 108714234 kank4.L; KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 108715532 kank4.S; KN motif and ankyrin repeat domain-containing protein 4 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 380032 kank2.L; KN motif and ankyrin repeat domains 2 L homeolog K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 446299 kank1.L; KN motif and ankyrin repeat domains 1 L homeolog K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 444307 chmp4c.L; charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 108695363 chmp4c.S; charged multivesicular body protein 4c-like K24782 CHMP4C; charged multivesicular body protein 4C
D 444796 vps4b.L; vacuolar protein sorting 4 homolog B L homeolog K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 379801 vps4b.S; vacuolar protein sorting 4 homolog B S homeolog K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 447546 vps4a.L; vacuolar protein sorting 4 homolog A L homeolog K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 100381132 sntb2.S; vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 108699266 zfyve19.L; abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 431906 sde2.S; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 108716487 sde2.L; replication stress response regulator SDE2-like K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 108707807 polq.L; DNA polymerase theta isoform X2 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 108708354 mybbp1a.L; myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 108698767 primpol.L; DNA-directed primase/polymerase protein isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 108706216 three prime repair exonuclease 2 isoform X1 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 108699991 trex2.S; three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 733261 dclre1a.L; uncharacterized protein LOC733261 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 108708167 dclre1b.L; 5' exonuclease Apollo isoform X1 K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 108708047 exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 108700990 endonuclease V isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 108701282 zranb3.L; DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 108712891 uncharacterized protein LOC108712891 isoform X1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 108704113 helq.S; helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 108714706 ercc6l2.L; DNA excision repair protein ERCC-6-like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 380586 prpf19.L; pre-mRNA processing factor 19 L homeolog K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 108697536 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 443636 cdc5l.L; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 443641 cdc5l.S; cell division cycle 5 like S homeolog K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 496329 bcas2.L; breast carcinoma amplified sequence 2 L homeolog K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 495399 plrg1.L; pleiotropic regulator 1 L homeolog K12862 PLRG1; pleiotropic regulator 1
D 108706653 plrg1.S; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 398640 nudt15.L; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 108703127 nudt1.S; 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 108712701 nudt18.S; 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 100037200 dut.L; deoxyuridine triphosphatase L homeolog K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 108712910 dut.S; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 399431 rrm1.L; ribonucleotide reductase M1 L homeolog K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 108710085 rrm1.S; ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 443815 rrm2.1.L; ribonucleotide reductase M2, gene 1 L homeolog K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 380465 rrm2.2.L; ribonucleotide reductase M2 polypeptide K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 379056 rrm2b.S; ribonucleotide reductase M2 B (TP53 inducible) S homeolog K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 108695407 ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 108697181 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 733427 phr.L; CPD photolyase-like L homeolog K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 443838 ung.L; uracil DNA glycosylase L homeolog K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 399139 smug1.L; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 108701508 mpg.L; DNA-3-methyladenine glycosylase isoform X3 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 108714269 mutyh.L; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 100037159 ssbp1.S; single-stranded DNA-binding protein 1-B, mitochondrial K03111 ssb; single-strand DNA-binding protein
E 397915 ssbp1.L; single-stranded DNA-binding protein 1-A, mitochondrial precursor K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 100037159 ssbp1.S; single-stranded DNA-binding protein 1-B, mitochondrial K03111 ssb; single-strand DNA-binding protein
D 397915 ssbp1.L; single-stranded DNA-binding protein 1-A, mitochondrial precursor K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 398640 nudt15.L; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 100037200 dut.L; deoxyuridine triphosphatase L homeolog K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 108712910 dut.S; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024