KEGG Modules

Carbohydrate metabolism
Central carbohydrate metabolism
M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:pme00010 pme01200 pme01100]
M00002 Glycolysis, core module involving three-carbon compounds [PATH:pme00010 pme01200 pme01230 pme01100]
M00003 Gluconeogenesis, oxaloacetate => fructose-6P [PATH:pme00010 pme00020 pme01100]
M00307 Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:pme00010 pme00020 pme00620 pme00785 pme01200 pme01210 pme01100]
M00009 Citrate cycle (TCA cycle, Krebs cycle) [PATH:pme00020 pme01200 pme01100]
M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:pme00020 pme01200 pme01210 pme01230 pme01100]
M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:pme00020 pme01200 pme01210 pme01100]
M00004 Pentose phosphate pathway (Pentose phosphate cycle) [PATH:pme00030 pme01200 pme01100 pme01120]
M00006 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:pme00030 pme01200 pme01100 pme01120]
M00007 Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:pme00030 pme01200 pme01230 pme01100 pme01120]
M00005 PRPP biosynthesis, ribose 5P => PRPP [PATH:pme00030 pme00230 pme01200 pme01230 pme01100]
M00008 Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH:pme00030 pme01200 pme01100 pme01120]

Other carbohydrate metabolism
M00014 Glucuronate pathway (uronate pathway) [PATH:pme00040 pme01100]
M00631 D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P [PATH:pme00040 pme00030 pme01100]
M00061 D-Glucuronate degradation, D-glucuronate => pyruvate + D-glyceraldehyde 3P [PATH:pme00040 pme00030 pme01100]
M00632 Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P [PATH:pme00052 pme01100]
M00552 D-galactonate degradation, De Ley-Doudoroff pathway, D-galactonate => glycerate-3P [PATH:pme00052 pme01100]
M00854 Glycogen biosynthesis, glucose-1P => glycogen/starch [PATH:pme00500 pme01100]
M00855 Glycogen degradation, glycogen => glucose-6P [PATH:pme00500 pme01100]
M00565 Trehalose biosynthesis, D-glucose 1P => trehalose [PATH:pme00500 pme01100 pme01110]
M00549 Nucleotide sugar biosynthesis, glucose => UDP-glucose [PATH:pme00520 pme01250 pme01100]
M00554 Nucleotide sugar biosynthesis, galactose => UDP-galactose [PATH:pme00520 pme00052 pme01250 pme01100]
M00892 UDP-N-acetyl-D-glucosamine biosynthesis, eukaryotes, glucose => UDP-GlcNAc [PATH:pme00520 pme01250 pme01100]
M00909 UDP-N-acetyl-D-glucosamine biosynthesis, prokaryotes, glucose => UDP-GlcNAc [PATH:pme00520 pme01250 pme01100]
M00012 Glyoxylate cycle [PATH:pme00630 pme01200 pme01100 pme01110]
M00373 Ethylmalonyl pathway [PATH:pme00630 pme01200 pme01100 pme01120]
M00741 Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:pme00280 pme00630 pme00640 pme01200 pme01100]
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 [PATH:pme00562 pme01100]
M00131 Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol [PATH:pme00562 pme01100]
M00132 Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate [PATH:pme00562 pme01100]

Energy metabolism
Carbon fixation
M00165 Reductive pentose phosphate cycle (Calvin cycle) [PATH:pme00710 pme01200 pme01100 pme01120]
M00168 CAM (Crassulacean acid metabolism), dark [PATH:pme00620 pme00710 pme01200 pme01100 pme01120]
M00169 CAM (Crassulacean acid metabolism), light [PATH:pme00620 pme00710 pme01200 pme01100 pme01120]
M00579 Phosphate acetyltransferase-acetate kinase pathway, acetyl-CoA => acetate [PATH:pme00620 pme01200 pme01100 pme01120]

Methane metabolism
Nitrogen metabolism
M00531 Assimilatory nitrate reduction, nitrate => ammonia [PATH:pme00910 pme01100 pme01120]
M00530 Dissimilatory nitrate reduction, nitrate => ammonia [PATH:pme00910 pme01100 pme01120]
M00529 Denitrification, nitrate => nitrogen [PATH:pme00910 pme01100 pme01120]

Sulfur metabolism
M00176 Assimilatory sulfate reduction, sulfate => H2S [PATH:pme00920 pme01100 pme01120]

Photosynthesis
M00163 Photosystem I [PATH:pme00195 pme01100]
M00597 Anoxygenic photosystem II

ATP synthesis
M00144 NADH:quinone oxidoreductase, prokaryotes [PATH:pme00190 pme01100]
M00143 NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria [PATH:pme00190 pme01100]
M00146 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex [PATH:pme00190 pme01100]
M00149 Succinate dehydrogenase, prokaryotes [PATH:pme00190 pme01100]
M00148 Succinate dehydrogenase (ubiquinone) [PATH:pme00190 pme01100]
M00151 Cytochrome bc1 complex respiratory unit [PATH:pme00190 pme01100]
M00155 Cytochrome c oxidase, prokaryotes [PATH:pme00190 pme01100]
M00153 Cytochrome bd ubiquinol oxidase [PATH:pme00190]
M00417 Cytochrome o ubiquinol oxidase [PATH:pme00190 pme01100]
M00156 Cytochrome c oxidase, cbb3-type [PATH:pme00190 pme01100]
M00157 F-type ATPase, prokaryotes and chloroplasts [PATH:pme00190 pme00195 pme01100]
M00160 V-type ATPase, eukaryotes [PATH:pme00190 pme01100]

Lipid metabolism
Fatty acid metabolism
M00082 Fatty acid biosynthesis, initiation [PATH:pme00061 pme01212 pme01100]
M00083 Fatty acid biosynthesis, elongation [PATH:pme00061 pme01212 pme01100]
M00873 Fatty acid biosynthesis in mitochondria, animals [PATH:pme00061 pme01212 pme01100]
M00085 Fatty acid elongation in mitochondria [PATH:pme01212 pme01100]
M00415 Fatty acid elongation in endoplasmic reticulum [PATH:pme01212 pme01100]
M00086 beta-Oxidation, acyl-CoA synthesis [PATH:pme00061 pme00071 pme01212 pme01100]
M00087 beta-Oxidation [PATH:pme00071 pme01212 pme01100]
M00861 beta-Oxidation, peroxisome, VLCFA [PATH:pme01212 pme01100]

Sterol biosynthesis
M00101 Cholesterol biosynthesis, FPP => cholesterol [PATH:pme01100]
M00103 Cholecalciferol biosynthesis [PATH:pme01100]
M00107 Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone [PATH:pme01100]
M00109 C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone [PATH:pme01100]
M00110 C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone [PATH:pme01100]
M00976 C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone [PATH:pme01100]

Lipid metabolism
M00089 Triacylglycerol biosynthesis [PATH:pme00561 pme01100]
M00098 Acylglycerol degradation [PATH:pme00561 pme01100]
M00090 Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:pme00564 pme01100]
M00091 Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:pme00564 pme01100]
M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:pme00564 pme01100]
M00093 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:pme00564 pme01100]
M00094 Ceramide biosynthesis [PATH:pme01100]
M00066 Lactosylceramide biosynthesis [PATH:pme01100]
M00067 Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:pme01100]
M00099 Sphingosine biosynthesis [PATH:pme01100]
M00100 Sphingosine degradation [PATH:pme01100]

Nucleotide metabolism
Purine metabolism
M00048 De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:pme00230 pme01100]
M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:pme00230 pme01232 pme01240 pme01100]
M00050 Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:pme00230 pme01232 pme01100]
M00053 Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:pme00230 pme00240 pme01232 pme01100]
M00958 Adenine ribonucleotide degradation, AMP => Urate [PATH:pme00230 pme01232 pme01100]
M00959 Guanine ribonucleotide degradation, GMP => Urate [PATH:pme00230 pme01232 pme01100]
M00546 Purine degradation, xanthine => urea [PATH:pme00230 pme01100]

Pyrimidine metabolism
M00051 De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP [PATH:pme00240 pme01240 pme01100]
M00052 Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [PATH:pme00240 pme01232 pme01240 pme01100]
M00938 Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP [PATH:pme00240 pme01232 pme01100]
M00046 Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate [PATH:pme00240 pme00410 pme00770 pme01100]

Amino acid metabolism
Serine and threonine metabolism
M00020 Serine biosynthesis, glycerate-3P => serine [PATH:pme00260 pme00680 pme01200 pme01230 pme01100]
M00018 Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pme00260 pme01230 pme01100 pme01110]
M00621 Glycine cleavage system [PATH:pme00260 pme00630 pme00785 pme01200 pme01100]
M00555 Betaine biosynthesis, choline => betaine [PATH:pme00260 pme01100]
M00974 Betaine metabolism, animals, betaine => glycine [PATH:pme00260 pme01100]
M00975 Betaine degradation, bacteria, betaine => pyruvate [PATH:pme00260 pme01100]
M00919 Ectoine degradation, ectoine => aspartate [PATH:pme00260 pme01100 pme01120]

Cysteine and methionine metabolism
M00021 Cysteine biosynthesis, serine => cysteine [PATH:pme00270 pme00920 pme01200 pme01230 pme01100 pme01110]
M00338 Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pme00260 pme00270 pme01230 pme01100]
M00017 Methionine biosynthesis, aspartate => homoserine => methionine [PATH:pme00270 pme01230 pme01100]
M00034 Methionine salvage pathway [PATH:pme00270 pme01100]
M00035 Methionine degradation [PATH:pme00270 pme01100]

Branched-chain amino acid metabolism
M00019 Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:pme00290 pme00770 pme01210 pme01230 pme01100 pme01110]
M00535 Isoleucine biosynthesis, pyruvate => 2-oxobutanoate [PATH:pme00290 pme00660 pme01210 pme01230 pme01100]
M00570 Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:pme00290 pme01230 pme01100]
M00432 Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:pme00290 pme01210 pme01230 pme01100 pme01110]
M00036 Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:pme00280 pme01100]

Lysine metabolism
M00016 Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:pme00300 pme01230 pme01100]
M00526 Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine [PATH:pme00300 pme01230 pme01100]
M00527 Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine [PATH:pme00300 pme01230 pme01100 pme01110]
M00031 Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine [PATH:pme00300 pme01210 pme01230 pme01100]
M00032 Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:pme00310 pme01210 pme01100]

Arginine and proline metabolism
M00028 Ornithine biosynthesis, glutamate => ornithine [PATH:pme00220 pme01210 pme01230 pme01100]
M00844 Arginine biosynthesis, ornithine => arginine [PATH:pme00220 pme01230 pme01100]
M00845 Arginine biosynthesis, glutamate => acetylcitrulline => arginine [PATH:pme00220 pme01230 pme01100]
M00029 Urea cycle [PATH:pme00220 pme01230 pme01100]
M00015 Proline biosynthesis, glutamate => proline [PATH:pme00330 pme01230 pme01100]
M00970 Proline degradation, proline => glutamate [PATH:pme00330 pme01100]
M00972 Proline metabolism [PATH:pme00330 pme01100]
M00047 Creatine pathway [PATH:pme00330 pme00260 pme01100]
M00879 Arginine succinyltransferase pathway, arginine => glutamate [PATH:pme00330 pme01100]

Polyamine biosynthesis
M00133 Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine [PATH:pme00330 pme01100]
M00134 Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:pme00330 pme01100]
M00135 GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:pme00330 pme01100]

Histidine metabolism
M00026 Histidine biosynthesis, PRPP => histidine [PATH:pme00340 pme01230 pme01100 pme01110]
M00045 Histidine degradation, histidine => N-formiminoglutamate => glutamate [PATH:pme00340 pme01100]

Aromatic amino acid metabolism
M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate [PATH:pme00400 pme01230 pme01100 pme01110]
M00023 Tryptophan biosynthesis, chorismate => tryptophan [PATH:pme00400 pme01230 pme01100 pme01110]
M00024 Phenylalanine biosynthesis, chorismate => phenylpyruvate => phenylalanine [PATH:pme00400 pme01230 pme01100 pme01110]
M00025 Tyrosine biosynthesis, chorismate => HPP => tyrosine [PATH:pme00400 pme01230 pme01100]
M00040 Tyrosine biosynthesis, chorismate => arogenate => tyrosine [PATH:pme00400 pme01230 pme01100 pme01110]
M00042 Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:pme00350 pme01100]
M00043 Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:pme00350 pme01100]
M00044 Tyrosine degradation, tyrosine => homogentisate [PATH:pme00350 pme01100]
M00533 Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:pme00350 pme01100 pme01120]
M00037 Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin [PATH:pme00380 pme01100]
M00038 Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:pme00380 pme01100]

Other amino acid metabolism
M00027 GABA (gamma-Aminobutyrate) shunt [PATH:pme00250 pme01100]
M00118 Glutathione biosynthesis, glutamate => glutathione [PATH:pme00480 pme01240 pme01100]
M00947 D-Arginine racemization, D-arginine => L-arginine [PATH:pme00470 pme01100]
M00948 Hydroxyproline degradation, trans-4-hydroxy-L-proline => 2-oxoglutarate [PATH:pme00470 pme01100]

Glycan metabolism
Glycan biosynthesis
M00055 N-glycan precursor biosynthesis [PATH:pme01100]
M00073 N-glycan precursor trimming [PATH:pme01100]
M00075 N-glycan biosynthesis, complex type [PATH:pme01100]
M00872 O-glycan biosynthesis, mannose type (core M3) [PATH:pme01100]
M00065 GPI-anchor biosynthesis, core oligosaccharide [PATH:pme01100]
M00070 Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer [PATH:pme01100]
M00071 Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer [PATH:pme01100]
M00069 Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3 [PATH:pme01100]

Glycosaminoglycan metabolism
M00057 Glycosaminoglycan biosynthesis, linkage tetrasaccharide [PATH:pme01100]
M00058 Glycosaminoglycan biosynthesis, chondroitin sulfate backbone [PATH:pme01100]
M00059 Glycosaminoglycan biosynthesis, heparan sulfate backbone [PATH:pme01100]
M00076 Dermatan sulfate degradation [PATH:pme01100]
M00077 Chondroitin sulfate degradation [PATH:pme01100]
M00078 Heparan sulfate degradation [PATH:pme01100]
M00079 Keratan sulfate degradation [PATH:pme01100]

Lipopolysaccharide metabolism
M00063 CMP-KDO biosynthesis [PATH:pme00540 pme01250 pme01100]
M00064 ADP-L-glycero-D-manno-heptose biosynthesis [PATH:pme00540 pme01250 pme01100]

Metabolism of cofactors and vitamins
Cofactor and vitamin metabolism
M00896 Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP [PATH:pme00730 pme01240 pme01100]
M00125 Riboflavin biosynthesis, plants and bacteria, GTP => riboflavin/FMN/FAD [PATH:pme00740 pme01240 pme01100 pme01110]
M00124 Pyridoxal-P biosynthesis, erythrose-4P => pyridoxal-P [PATH:pme00750 pme01240 pme01100]
M00916 Pyridoxal-P biosynthesis, R5P + glyceraldehyde-3P + glutamine => pyridoxal-P [PATH:pme00750 pme01240 pme01100]
M00115 NAD biosynthesis, aspartate => quinolinate => NAD [PATH:pme00760 pme01240 pme01100]
M00912 NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:pme00380 pme00760 pme01240 pme01100]
M00811 Nicotine degradation, pyrrolidine pathway, nicotine => succinate semialdehyde [PATH:pme00760 pme01100 pme01120]
M00119 Pantothenate biosynthesis, valine/L-aspartate => pantothenate [PATH:pme00770 pme01240 pme01100 pme01110]
M00120 Coenzyme A biosynthesis, pantothenate => CoA [PATH:pme00770 pme01240 pme01100]
M00572 Pimeloyl-ACP biosynthesis, BioC-BioH pathway, malonyl-ACP => pimeloyl-ACP [PATH:pme00780 pme01240 pme01100]
M00123 Biotin biosynthesis, pimeloyl-ACP/CoA => biotin [PATH:pme00780 pme01240 pme01100]
M00881 Lipoic acid biosynthesis, plants and bacteria, octanoyl-ACP => dihydrolipoyl-E2/H [PATH:pme00785 pme01240 pme01100]
M00882 Lipoic acid biosynthesis, eukaryotes, octanoyl-ACP => dihydrolipoyl-H [PATH:pme00785 pme01240 pme01100]
M00883 Lipoic acid biosynthesis, animals and bacteria, octanoyl-ACP => dihydrolipoyl-H => dihydrolipoyl-E2 [PATH:pme00785 pme01240 pme01100]
M00126 Tetrahydrofolate biosynthesis, GTP => THF [PATH:pme00790 pme00670 pme01240 pme01100]
M00842 Tetrahydrobiopterin biosynthesis, GTP => BH4 [PATH:pme00790 pme01240 pme01100]
M00880 Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:pme00790 pme01240 pme01100]
M00140 C1-unit interconversion, prokaryotes [PATH:pme00670 pme01240 pme01100]
M00141 C1-unit interconversion, eukaryotes [PATH:pme00670 pme01240 pme01100]
M00846 Siroheme biosynthesis, glutamyl-tRNA => siroheme [PATH:pme00860 pme01240 pme01100 pme01110]
M00868 Heme biosynthesis, animals and fungi, glycine => heme [PATH:pme00860 pme01240 pme01100 pme01110]
M00121 Heme biosynthesis, plants and bacteria, glutamate => heme [PATH:pme00860 pme01240 pme01100 pme01110]
M00925 Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide [PATH:pme00860 pme01240 pme01100]
M00122 Cobalamin biosynthesis, cobyrinate a,c-diamide => cobalamin [PATH:pme00860 pme01240 pme01100]
M00117 Ubiquinone biosynthesis, prokaryotes, chorismate (+ polyprenyl-PP) => ubiquinol [PATH:pme00130 pme01240 pme01100 pme01110]
M00128 Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate + polyprenyl-PP => ubiquinol [PATH:pme00130 pme01240 pme01100]

Biosynthesis of terpenoids and polyketides
Terpenoid backbone biosynthesis
M00095 C5 isoprenoid biosynthesis, mevalonate pathway [PATH:pme00900 pme01100 pme01110]
M00364 C10-C20 isoprenoid biosynthesis, bacteria [PATH:pme00900 pme01100 pme01110]
M00367 C10-C20 isoprenoid biosynthesis, non-plant eukaryotes [PATH:pme00900 pme01100 pme01110]

Plant terpenoid biosynthesis
M00097 beta-Carotene biosynthesis, GGAP => beta-carotene [PATH:pme00906 pme01100 pme01110]

Macrolide biosynthesis
Enediyne biosynthesis
Type II polyketide biosynthesis
Polyketide sugar unit biosynthesis
M00793 dTDP-L-rhamnose biosynthesis [PATH:pme00521 pme00523 pme00541 pme01250 pme01100 pme01110]

Biosynthesis of other secondary metabolites
Biosynthesis of phytochemical compounds
Biosynthesis of beta-lactams
Biosynthesis of other antibiotics
Biosynthesis of other fungal compounds
Biosynthesis of other bacterial compounds
Xenobiotics biodegradation
Aromatics degradation

Gene set
Pathogenicity
Drug resistance
M00627 beta-Lactam resistance, Bla system [PATH:pme01501]
M00745 Imipenem resistance, repression of porin OprD
M00641 Multidrug resistance, efflux pump MexEF-OprN
M00642 Multidrug resistance, efflux pump MexJK-OprM
M00698 Multidrug resistance, efflux pump BpeEF-OprC

Plant pathogenicity
Symbiosis
Module set
Metabolic capacity
M00611 Oxygenic photosynthesis in plants and cyanobacteria
M00615 Nitrate assimilation
M00616 Sulfate-sulfur assimilation