Two-Component System

Group 1. OmpR family

Organism	Signal	Sensor kinase	Response regulator	Comment
eco [ P \| G \| T ]	Inorganic phosphate limitation	b0400(phoR)	b0399(phoB)	Alkaline phosphatase, Pst system, Ugp system, Autoamplification [UI:21359336]
eco [ P \| G \| T ]	Mg2+ starvation	b1129(phoQ)	b1130(phoP)	Mg2+ transport [UI:99395066]
eco [ P \| G \| T ]	Osmotic upshift (By an increase of K+ concentration)	b3404(envZ)	b3405(ompR)	Porins of outer membrane [UI:21538875] Initial adhesion and biofilm formation via csgD gene [UI:21574159]
eco [ P \| G \| T ]	Stress	b1609(rstB)	b1608(rstA)
eco [ P \| G \| T ]	Misfolded proteins in extracytoplasmic compartments	b3911(cpxA)	b3912(cpxR)	Cell envelope protein folding and degrading factors [UI:20429149]
eco [ P \| G \| T ]		b4399(creC)	b4398(creB)	Catabolite repression
eco [ P \| G \| T ]		b2078(baeS)	b2079(baeR)
eco [ P \| G \| T ]		b4112(basS)	b4113(basR)	Virulence
eco [ P \| G \| T ]	Increasing level of copper ions	b0570(cusS)	b0571(cusR)	Copper resistance [UI:20461235]
eco [ P \| G \| T ]		b1968	b1969
eco [ P \| G \| T ]		b3026	b3025
eco [ P \| G \| T ]	Lowering of the intracellular K+ content	b0695(kdpD)	b0694(kdpE)	K+ transport [UI:21264394] [PATH:tab03230]
eco [ P \| G \| T ]	Trimethylamine N-oxide	b0993(torS)	b0995(torR)	Trimethylamine N-oxide respiration [UI:21457294] [Hybrid]
eco [ P \| G \| T ]		b3210(arcB)	b4401(arcA)	Aerobic respiration [Hybrid] [UI:20582600]
sty [ P \| G \| T ]	Mg2+ and Ca2+	STY1270(phoQ)	STY1271(phoP)	Structural modifications of lipid A of the host [UI:97248636] Mg2+ regulation [UI:20390047 97153089 21125544]
sty [ P \| G \| T ]		STY4295(envZ)	STY4294(ompR)	Regulation of Vi polysaccharide synthesis [UI:94341908]
sty [ P \| G \| T ]	Iron	STY4490(pmrB)	STY4491(pmrA)	Iron homeostasis [UI:20503848 21125544]
sty [ P \| G \| T ]			STY2904(tctD)
stm [ P \| G \| T ]	Catabolite repression	STM2784(tctE)	STM2785(tctD)	Tricarboxylates transport [UI:89327162]
stm [ P \| G \| T ]	Mg2+ starvation Acid	STM1230(phoQ)	STM1231(phoP)	Virulence(Type III secretion system) [UI:90130314 21065122 21125544]
ype [ P \| G \| T ]	Oxidative stress Low pH Low Mg2+ concentration	YPO1633(phoQ)	YPO1634(phoP)	Virulence Intracellular survival in the flea and/or during transmission High affinity magnesium transport[UI:20278127]
hin [ P \| G \| T ]		HI1378(phoR)	HI1379(phoB)
hin [ P \| G \| T ]			HI0837(cpxR)
hin [ P \| G \| T ]		HI1707	HI1708
hin [ P \| G \| T ]	Oxygen limitation	HI0220(arcB)	HI0884(arcA)	Redox signal transduction[UI:21574158]
nme [ P \| G \| T ]		NMB0594	NMB0595
nme [ P \| G \| T ]		NMB1792	NMB1793
nma [ P \| G \| T ]	Mg2+ starvation	NMA0797(phoQ)	NMA0798(phoP)	May be involved in the regulation of virulence [UI:21150478]
nma [ P \| G \| T ]		NMA0670	NMA0669
hpy [ P \| G \| T ]		HP0165 HP0164	HP0166(ompR)	Essential for cell viability [UI:20200342]
hpy [ P \| G \| T ]		HP1364	HP1365
hpy [ P \| G \| T ]			HP1043	Essential for cell viability [UI:20200342]
hpj [ P \| G \| T ]		jhp0151	jhp0152
hpj [ P \| G \| T ]		jhp1282	jhp1443
hpj [ P \| G \| T ]			jhp0381
rpr [ P \| G \| T ]		RP465(phoR)
rpr [ P \| G \| T ]		RP426(envZ)	RP427(ompR)
rpr [ P \| G \| T ]			RP071(czcR)
bsu [ P \| G \| T ]	Phosphate starvation	BG10364(phoR)	BG10363(phoP)	Alkaline phosphatase [UI:20372631 20138145]
bsu [ P \| G \| T ]	Oxygen limitation	BG10535(resE)	BG10534(resD)	Essential : aerobic and Anaerobic respiration [UI:21125555 21225548 20429151]
bsu [ P \| G \| T ]		BG11461	BG10001	Regulation of cell division operon [UI:20340961]
bsu [ P \| G \| T ]		BG14146	BG12452
bsu [ P \| G \| T ]		BG12032	BG12031
bsu [ P \| G \| T ]		BG13253	BG13252
bsu [ P \| G \| T ]		BG14132(cssS)	BG14131(cssR)
bsu [ P \| G \| T ]		BG13919	BG12340
bsu [ P \| G \| T ]		BG12406	BG12405
bsu [ P \| G \| T ]		BG11127	BG11126	Inositol utilization(?) [UI:95039891]
bsu [ P \| G \| T ]		BG12724	BG12723
bsu [ P \| G \| T ]		BG11168	BG11167
bsu [ P \| G \| T ]		BG11783	BG11782
sau [ P \| G \| T ]	Temperature	SA0018(vicK)	SA0017(vicR)	Essential : regulation of bacterial cell wall or membrane composition [UI:99296574]
sau [ P \| G \| T ]		SA0067(kdpD)	SA0066(kdpE)	K+ transport
sau [ P \| G \| T ]		SA1882(kdpD)	SA1883(kdpE)	K+ transport
sau [ P \| G \| T ]		SA1515(phoR)	SA1516(phoP)	Alkaline phosphatase
sau [ P \| G \| T ]		SA1322(srrB)	SA1323(srrA)	TSST-1(an exotoxin) protein A(a surface associated virulence factor) [UI:21101792]
sau [ P \| G \| T ]		SA1246(arlS)	tr-arlR SA1247(arlR) SA1248(arlR)	Extrcellular serine protease Virulence(alpha, beta-haemolysin, lipase, coagulase, serine protease, Spa protein) downregulation [UI:21348486] Multidrug resistance protein NorA [UI:20100755]
sau [ P \| G \| T ]		SA0660(saeS)	SA0661(saeR)
sau [ P \| G \| T ]		SA0615	SA0614
sau [ P \| G \| T ]		SA2152	SA2151
sau [ P \| G \| T ]		SA2417	SA2418
lmo [ P \| G \| T ]	Acid	lmo1378(lisK)	lmo1377(lisR)	Virulence [UI:20011355]
lin [ P \| G \| T ]		lin1415(lisK)	lin1414(lisR)
mtu [ P \| G \| T ]		Rv0490(senX3)	Rv0491(regX3)	Autoamplification, Protein-protein interaction(?) [UI:20553172]
mtu [ P \| G \| T ]	Oxygen limitation(?) in Macrophage	Rv3245c(mtrB)	Rv3246c(mtrA)	Viability [UI:20309716 21246735]
mtu [ P \| G \| T ]		Rv0758(phoR)	Rv0757(phoP)	Multiplication, Virulence [UI:21348479]
mtu [ P \| G \| T ]	Mn2+ or Ca2+	Rv1032c(trcS)	Rv1033c(trcR)	Toxin [UI:99190746]
mtu [ P \| G \| T ]		Rv3764c	Rv3765c
mtu [ P \| G \| T ]	Oxygen limitation in Macrophage	Rv0982(mprB)	Rv0981(mprA)	Maintenance of persistent lung infection [UI:21532990]
mtu [ P \| G \| T ]		Rv1028c(kdpD)	Rv1027c(kdpE)
mtu [ P \| G \| T ]		Rv0902c	Rv0903c
mtu [ P \| G \| T ]		Rv0600c Rv0601c	Rv0602c(tcrA)
syn [ P \| G \| T ]	Phosphate	sll0337(phoR)	slr0081(phoB)	Alkaline phosphatase sll0654 [UI:21183140]
syn [ P \| G \| T ]			slr1584
syn [ P \| G \| T ]		sll0790(hik31)	sll0789(copR)
syn [ P \| G \| T ]	Changes in the PQ redox poise Ni2+	sll0798(rppB)	sll0797(rppA)	Photosystem I,II genes [UI:20353462] Ni2+ resistance proteins [UI:21839654]
syn [ P \| G \| T ]	High concentration of Mn ions	slr0640(manS)	slr1837(manR)	Repress mntCAB operon(ABC transporter of Mn ion) [PMID:12417709]
syn [ P \| G \| T ]			sll0649
syn [ P \| G \| T ]			slr0081
syn [ P \| G \| T ]			slr0115(rpaA)	Repression of energy transfer from phycobilisomes to photosystems II [UI:20054300]
syn [ P \| G \| T ]			slr0947(rpaB)	Activation of energy transfer from phycobilisomes to photosystems II [UI:20054300]
syn [ P \| G \| T ]			sll1330
syn [ P \| G \| T ]		slr0533
syn [ P \| G \| T ]		slr1731(kdpD)
aae [ P \| G \| T ]		aq_316(hksP2)	aq_319(phoB)
tma [ P \| G \| T ]		TM1654(hpkA)	TM1655(DrrA)
tma [ P \| G \| T ]		TM0853
tma [ P \| G \| T ]		TM1258	TM1259
tma [ P \| G \| T ]		TM0400	TM0399
tma [ P \| G \| T ]		TM0127	TM0126

Group 2. NarL family

Organism	Signal	Sensor kinase	Response regulator	Comment
eco [ P \| G \| T ]	Nitrate	b1222(narX)	b1221(narL)	Nitrate reduction
eco [ P \| G \| T ]		b2469(narQ)	b2193(narP)
eco [ P \| G \| T ]	Hexose phosphates	b3668(uhpB)	b3669(uhpA)	Hexsose phosphate transport
eco [ P \| G \| T ]		b2216(yojN)	b2217(rcsB)
eco [ P \| G \| T ]		b2218(rcsC)		Capsule synthesis [Hybrid]
eco [ P \| G \| T ]		b2370(evgS)	b2369(evgA)	[Hybrid]
eco [ P \| G \| T ]			b0535(fimZ)	Fimbrial synthesis
eco [ P \| G \| T ]			b1914(uvrY)
sty [ P \| G \| T ]		uhpB	uhpA
sty [ P \| G \| T ]			fimZ
hin [ P \| G \| T ]		HI0267(narQ)	HI0726(narP)
nme [ P \| G \| T ]		NMB1249	NMB1250
nma [ P \| G \| T ]		NMA1418	NMA1419
bsu [ P \| G \| T ]	Exogeneous DNA	BG10380(comP)	BG10381(comA)	Competence [UI:20576145]
bsu [ P \| G \| T ]		BG10392(degS)	BG10393(degU)	Degradative enzyme and competence regulation
bsu [ P \| G \| T ]		BG12155	BG12156
bsu [ P \| G \| T ]		BG12156	BG14133
bsu [ P \| G \| T ]		BG13005	BG13006
bsu [ P \| G \| T ]		BG12215	BG12216
bsu [ P \| G \| T ]	Cold shock	BG13519(desK)	BG13520(desR)	Regulation of fatty acid desaturase [UI:21181826]
bsu [ P \| G \| T ]		BG12445	BG12446
bsu [ P \| G \| T ]		BG11896	BG11895
sau [ P \| G \| T ]	Cell-wall stimulon	SA1701(vraS)	SA1700(vraR)	Peptide glycan synthesis(Vancomycin resistance)
sau [ P \| G \| T ]		SA1158	SA1159
sau [ P \| G \| T ]		SA1667	SA1666
sau [ P \| G \| T ]		SA2180	SA2179
mtu [ P \| G \| T ]		Rv3132c(devS)	Rv3133c(devR)
mtu [ P \| G \| T ]		Rv0845	Rv0844c(narL)
syn [ P \| G \| T ]		slr0311(hik29)	slr0312
syn [ P \| G \| T ]	Cold shock Drug	sll0698(dspA)	sll1905(hik19)	Fatty-acid-desaturase genes(des) [UI:21212131 96081505]
syn [ P \| G \| T ]		sll1590	sll1592
syn [ P \| G \| T ]		slr1805	sll1708
syn [ P \| G \| T ]			sll0921
syn [ P \| G \| T ]			slr1783
syn [ P \| G \| T ]			slr1909

Group 3. NtrC family

Organism	Sensor kinase	Response regulator	Comment
eco [ P \| G \| T ]	b3869(ntrB)	b3868(ntrC)	Nitrogen assimilation
eco [ P \| G \| T ]	b4003(hydH)	b4004(hydG)	Labile hydrogenase activity
eco [ P \| G \| T ]	b2219(atoS)	b2220(atoC)	Acetoacetate metabolism
eco [ P \| G \| T ]	b2556(yfhK)	b2554(yfhA)
sty [ P \| G \| T ]	glnL(ntrB)	glnG(ntrC)
sty [ P \| G \| T ]	pgtB	pgtA	exogenous induction of phosphoglycerate transport
sty [ P \| G \| T ]	hydH	hydG
hpy [ P \| G \| T ]	HP0244	HP0703
hpj [ P \| G \| T ]	jhp0229	jhp0643
rpr [ P \| G \| T ]		RP562
ctr [ P \| G \| T ]	CT467	CT468
cpn [ P \| G \| T ]	CPn0584	CPn0586
bbu [ P \| G \| T ]	BB0764	BB0763
tpa [ P \| G \| T ]		TP0519
aae [ P \| G \| T ]	aq_1115	aq_1117	(prediction)
aae [ P \| G \| T ]	aq_231	aq_230
aae [ P \| G \| T ]		aq_164

Group 4. Sporulation family

Organism	Sensor kinase	Response regulator	Comment
bsu [ P \| G \| T ]	BG10204(kinA)	BG10411(spo0F)	Sporulation [UI:98138452]
bsu [ P \| G \| T ]	BG10745(kinB)	BG10411(spo0F)	Sporulation [UI:98086114]
bsu [ P \| G \| T ]	BG10989(kinC)	BG10765(spo0A)
bsu [ P \| G \| T ]	BG10336(spo0B)	BG10765(spo0A)	repress abrB and express sporulation genes

Group 5. Chemotaxis family

Organism	Signal	Sensor kinase	Response regulator				Comment
		CheA	CheY	CheB	CheV	PilG
		CheA	chemotaxis; flagellar switch	chemotaxis; methylesterase	CheV	PilG
eco [ P \| G \| T ]		b1888(cheA)	b1882(cheY)	b1883(cheB)
hpy [ P \| G \| T ]		HP0392(cheA)	HP1067(cheY)		HP0393(cheV)		Chemotaxis [UI:20187473]
hpy [ P \| G \| T ]					HP0616(cheV)
hpy [ P \| G \| T ]					HP0019(cheV)
hpj [ P \| G \| T ]		jhp0989	jhp0358		jhp0988
hpj [ P \| G \| T ]					jhp0559
hpj [ P \| G \| T ]					jhp0017
bsu [ P \| G \| T ]		BG10256(cheA)	BG10258(cheY)	BG10255(cheB)
bsu [ P \| G \| T ]			BG11250
bsu [ P \| G \| T ]					BG10823(cheV)
bbu [ P \| G \| T ]		BB0567(cheA)	BB0570(cheY)	BB0568(cheB)
bbu [ P \| G \| T ]		BB0669(cheA)	BB0672(cheY)
tpa [ P \| G \| T ]		TP0363(cheA)	TP0366(cheY)	TP0631(cheB)
syn [ P \| G \| T ]		sll0043(cheA)	sll0039(cheY)			sll0038(pixG)
syn [ P \| G \| T ]		sll1296(cheA)	sll1292(cheY)			sll1291
syn [ P \| G \| T ]		slr0322(cheA)
syn [ P \| G \| T ]						slr1041
syn [ P \| G \| T ]						slr1214
syn [ P \| G \| T ]	Light	slr0473(cph1)	slr0474(rcp1)				Phytochrome [UI:20082840]
tma [ P \| G \| T ]		TM0702(cheA)	TM0700(cheY)	TM0408(cheB)
afu [ P \| G \| T ]		AF1040(cheA)	AF1042(cheY)	AF1041(cheB)
pho [ P \| G \| T ]		PH0484(cheA)	PH0482(cheY)	PH0483(cheB)
pab [ P \| G \| T ]		PAB1332(cheA)	PAB1330(cheY)	PAB1331(cheB)

Group 6. CitB family

Organism	Signal	Sensor kinase	Response regulator	Comment
eco [ P \| G \| T ]	Citrate	b0619(citA)	b0620(citB)	Induction of the citrate fermentation genes citCDEFXGT, and repression of the refulator gene appY [PMID:11889485] plasmid inheritance
eco [ P \| G \| T ]	C4-dicarboxylate	b4125(dcuS)	b4124(dcuR)	fumarate induction [UI:99138745]
bsu [ P \| G \| T ]	C4-dicarboxylate	BG12073(dctS)	BG12074(dctR)	Regulation of the transport system for C4-dicarboxylic acids [UI:20170658]
bsu [ P \| G \| T ]	Citrate	BG12576(citS)	BG12577(citT)	Regulates the expression of the Mg-citrate transporter [UI:20430113]
bsu [ P \| G \| T ]		BG12347	BG12348

Group 7. LytT family

Organism	Sensor kinase	Response regulator	Comment
eco [ P \| G \| T ]	b2126(yehU)	b2125(yehT)
eco [ P \| G \| T ]	b2380	b2381
bsu [ P \| G \| T ]	BG11952(lytS)	BG11953(lytT)	Control the rate of autolysis
bsu [ P \| G \| T ]	BG11997	BG11998
sau [ P \| G \| T ]	SA0250(lytS)	SA0251(lytR)	bacteriophage murein hydrolase transporter(holins) lrgAB [PMID:8824633]
sau [ P \| G \| T ]	SA0216	SA0215

Group 8. PleD related family

Organism	Sensor kinase	Response regulator	Comment
rpr [ P \| G \| T ]		RP237
bbu [ P \| G \| T ]	BB0420	BB0419	[Hybrid]
syn [ P \| G \| T ]	sll1672	sll1673	[Hybrid]
syn [ P \| G \| T ]		slr0687(pleD)
syn [ P \| G \| T ]	slr1759	slr1760	[Hybrid]
tma [ P \| G \| T ]		TM0143

Group 9. AgrA family

Organism	Signal	Autoinducing peptides		Sensor kinase	Response regulator	Comment
sau [ P \| G \| T ]	Staphylococcal autoinducing peptide(AIP) (Bacterial density; Quorum sensing)	SAS066(agrD)	SA1842(agrB)	SA1843(agrC)	SA1844(agrA)	Multipe enterotoxin and hemolysin [UI:21655147 21382775]
lmo [ P \| G \| T ]				lmo0051	lmo0050
lin [ P \| G \| T ]				lin0043	lin0044
spn [ P \| G \| T ]				SP_0527(blpH)	SP_0526(blpR)
spr [ P \| G \| T ]				spr0464(hk13)	spr0463(rr13)
cac [ P \| G \| T ]				CAC0080(agrC)	CAC0081(agrA)

Group 0. Other families

Organism	Signal	Sensor kinase	Response regulator	Comment
ath [ P \| G \| T ]	Light	F14J9.23(phyA) AT2G18790(phyB)	F9E10.26	Phytochrome
sce [ P \| G \| T ]		YIL147C(sln1)		High osmolarity
sce [ P \| G \| T ]		YDL235C(ypd1)	YLR006C(ssk1)
sce [ P \| G \| T ]			YHR206W(skn7)
eco [ P \| G \| T ]		b2786(barA)		(Supressor of envZ) [Hybrid]
eco [ P \| G \| T ]			b1235(hnr)	strongly similar to salmonella mouse virulence gene A(gb:STU53173)
rpr [ P \| G \| T ]		RP229(barA)
rpr [ P \| G \| T ]		RP614
bsu [ P \| G \| T ]		BG12498		[Hybrid]
bsu [ P \| G \| T ]		BG10871	BG10872
bsu [ P \| G \| T ]		BG12847	BG12848
syn [ P \| G \| T ]			slr1042
syn [ P \| G \| T ]			slr1037
syn [ P \| G \| T ]			slr2024
syn [ P \| G \| T ]		sll1871	slr1982
syn [ P \| G \| T ]		sll1871	slr1983
syn [ P \| G \| T ]		sll1228	sll1229
syn [ P \| G \| T ]		sll1555
syn [ P \| G \| T ]		slr2098
syn [ P \| G \| T ]		slr2099	slr2100
syn [ P \| G \| T ]		slr2104
tma [ P \| G \| T ]		TM1359	TM1360
tma [ P \| G \| T ]			TM0186
tma [ P \| G \| T ]			TM0468
tma [ P \| G \| T ]			TM0842
mth [ P \| G \| T ]		MTH444	MTH445
mth [ P \| G \| T ]		MTH446	MTH447	[Hybrid]
mth [ P \| G \| T ]		MTH459	MTH457
mth [ P \| G \| T ]			MTH548
mth [ P \| G \| T ]			MTH901	weak sensory kinase domain in C-terminal
mth [ P \| G \| T ]			MTH902	weak sensory kinase domain in C-terminal
afu [ P \| G \| T ]		AF0450	AF0449
afu [ P \| G \| T ]			AF1472
afu [ P \| G \| T ]			AF1473
afu [ P \| G \| T ]			AF2419

Last updated: August 9, 2004
Maintained by Junko Yabuzaki with the classification by Bono et al. (unpublished)