KEGG    Network variation - GPI-anchor biosynthesis
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ENTRYnt06018
NameGPI-anchor biosynthesis
CategoryPathway view; Glycan/glycoprotein metabolism
Pathwayhsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
Modulehsa_M00065 GPI-anchor biosynthesis, core oligosaccharide
DiseaseH01489 Inherited glycosylphosphatidylinositol deficiencies
Display drug-target relation   disease type
N00748    PI+UDP-GlcNAc−(PIGA+PIGC+PIGH+PI..⇉PIGL⇉PIGW⇉(PIGM+PIGX)⇉PIGV⇉PIGN⇉PIGB⇉(PIGO+PIGF)⇉(PIGG+PIGF)⇉(GPAA1+PIGK+PIGS+P..⇉PGAP1⇉PGAP5→G13046
    MCAHS2   PIGA*
    GPIBD16   PIGC*
    GPIBD17   PIGH*
    GPIBD14   PIGP*
    MCAHS4   PIGQ*
    HPMRS6   PIGY*
    CHIME     PIGL*
    HPMRS5       PIGW*
    PIGM-CDG         PIGM*
    HPMRS1           PIGV*
    MCAHS1             PIGN*
    GPIBD20               PIGB*
    HPMRS2                 PIGO*
    GPIBD13                   PIGG*
    GPIBD15                     GPAA1*
    GPIBD22                     PIGK*
    GPIBD18                     PIGS*
    MCAHS3                     PIGT*
    GPIBD21                     PIGU*
    MRT42                       PGAP1*

Disease nameDisease category
MCAHS2H01486Multiple congenital anomalies-hypotonia-seizures syndromeInherited metabolic disorder
GPIBD16H01489Inherited glycosylphosphatidylinositol deficienciesInherited metabolic disorder
GPIBD17H01489Inherited glycosylphosphatidylinositol deficienciesInherited metabolic disorder
GPIBD14H01489Inherited glycosylphosphatidylinositol deficienciesInherited metabolic disorder
MCAHS4H01486Multiple congenital anomalies-hypotonia-seizures syndromeInherited metabolic disorder
HPMRS6H01488Hyperphosphatasia with mental retardation syndromeInherited metabolic disorder
CHIMEH01487CHIME syndromeInherited metabolic disorder
HPMRS5H01488Hyperphosphatasia with mental retardation syndromeInherited metabolic disorder
PIGM-CDGH01127PIGM-congenital disorder of glycosylationInherited metabolic disorder
HPMRS1H01488Hyperphosphatasia with mental retardation syndromeInherited metabolic disorder
MCAHS1H01486Multiple congenital anomalies-hypotonia-seizures syndromeInherited metabolic disorder
GPIBD20H01489Inherited glycosylphosphatidylinositol deficienciesInherited metabolic disorder
HPMRS2H01488Hyperphosphatasia with mental retardation syndromeInherited metabolic disorder
GPIBD13H01489Inherited glycosylphosphatidylinositol deficienciesInherited metabolic disorder
GPIBD15H01489Inherited glycosylphosphatidylinositol deficienciesInherited metabolic disorder
GPIBD22H01489Inherited glycosylphosphatidylinositol deficienciesInherited metabolic disorder
GPIBD18H01489Inherited glycosylphosphatidylinositol deficienciesInherited metabolic disorder
MCAHS3H01486Multiple congenital anomalies-hypotonia-seizures syndromeInherited metabolic disorder
GPIBD21H01489Inherited glycosylphosphatidylinositol deficienciesInherited metabolic disorder
MRT42H01485Autosomal recessive mental retardation-42Inherited metabolic disorder