[ Network menu | Network entry | Help ]

ENTRY	nt06029
Name	Glycosaminoglycan biosynthesis
Category	Pathway view; Glycan/glycoprotein metabolism
Pathway	hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Module	hsa_M00057 Glycosaminoglycan biosynthesis, linkage tetrasaccharide hsa_M00058 Glycosaminoglycan biosynthesis, chondroitin sulfate backbone hsa_M00059 Glycosaminoglycan biosynthesis, heparan sulfate backbone
Display	drug-target relation   disease type

N01574    Protein-Ser − XYLT1/2 ⇉ B4GALT7 ⇉ B3GALT6 ⇉ B3GAT3 → G00157     DBQD2     XYLT1*     SOS     XYLT2*     EDSSPD1         B4GALT7*     EDSSPD2/SEMDJL1             B3GALT6*     JDSSDHD                 B3GAT3* N01580    G00157 − CSGALNACT1/2 ⇉ CHSY1/3,CHPF → Chondroitin − CHST3/7 → Chondroitin_6-sulf..     SDJLABA     CSGALNACT1*     TPBS         CHSY1*     SEDCJD                 CHST3* N01581    Chondroitin − DSE → Dermatan − CHST14 → Dermatan_4-sulfate     EDSMC2     DSE*     EDSMC1             CHST14* N01582    G00157 − EXTL2/3 ⇉ EXT1/2 ⇉ EXTL1/3 ⇉ NDST ⇉ GLCE ⇉ HS6ST1 → Heparan_sulfate     ISDNA     EXTL3*     Multiple exostoses         EXT1*     Multiple exostoses         EXT2*     MRT46                 NDST1*     HH15                         HS6ST1*

		Disease name	Disease category
DBQD2	H00494	Desbuquois syndrome	Congenital malformation
SOS	H01496	Spondyloocular syndrome	Congenital malformation
EDSSPD1	H02239	Ehlers-Danlos syndrome, spondylodysplastic type	Congenital malformation
EDSSPD2/SEMDJL1	H02239	Ehlers-Danlos syndrome, spondylodysplastic type	Congenital malformation
	H01494	SEMD with joint laxity type	Congenital malformation
JDSSDHD	H01498	Multiple joint dislocations, short stature, craniofacial dysmorphism, and congenital heart defects	Inherited metabolic disorder
SDJLABA	H02551	Skeletal dysplasia with joint laxity and advanced bone age	Congenital malformation
TPBS	H01497	Temtamy preaxial brachydactyly syndrome	Congenital malformation
SEDCJD	H00762	Spondyloepiphyseal dysplasia with congenital joint dislocations	Congenital malformation
EDSMC2	H02246	Ehlers-Danlos syndrome musculocontractural type	Congenital malformation
EDSMC1	H02246	Ehlers-Danlos syndrome musculocontractural type	Congenital malformation
ISDNA	H02491	Immunoskeletal dysplasia with neurodevelopmental abnormalities	Congenital malformation
Multiple exostoses	H00122	Multiple exostoses	Inherited metabolic disorder
MRT46	H00768	Autosomal recessive intellectual developmental disorder	Mental and behavioural disorder
HH15	H00255	Hypogonadotropic hypogonadism	Endocrine and metabolic disease