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ENTRY	nt06183
Name	Yersinia
Category	Disease view; Bacterial infection
Pathway	hsa05135 Yersinia infection
Disease	H00298 Yersiniosis
Display	drug-target relation   disease type

Calcium signaling N01106    (TCR+CD3+CD4) → (LCK,FYN,ZAP70) → (SLP76+GADS+LAT+VA.. → PLCG → IP3 → ITPR → Ca2+(cyto) N01107    YopH ⊣ LCK N01108        YopH ⊣ (SLP76,LAT,VAV) TLR signaling N00435    (TLR1,TLR2,TLR4) → (TIRAP+MYD88) → (IRAK4+IRAK1) → (TRAF6+TAK1+TAB2) → IKK → NFKBIA → NFKB ⇒ (TNF,IL6,IL12A,IL1.. N00859            YopP/J ⊣ (TRAF6+TRAF2+TAK1+.. N00438    (TLR2,TLR4) → (TIRAP+MYD88) → (IRAK4+IRAK1) → (TRAF6+TAK1+TAB2) → (MEK,MKK3/6,MKK4/7.. → (ERK,p38,JNK) → AP1 N00862                YopP/J ⊣ (MEK,MKK3/6,MKK4/7.. NLR signaling N00742        (NLRP3+PYCARD) → CASP1 → (IL1B,IL18,IL33) N00864    YopK ⊣ (NLRP3+PYCARD) N00863        YopM ⊣ CASP1 N00867        (NLRC4+PYCARD) → CASP1 → (IL1B,IL18) N00865    YopK ⊣ (NLRC4+PYCARD) N01570        PSTPIP1 → MEFV N00866    YopM → (PKN1,PKN2) ⊣ (MEFV+PYCARD) Cytoskeletal regulation N01072    FN1 → (ITGA+ITGB) → PTK2 → ARHGEF28 → RHOA N01098                YopT ⊣ RHOA N01099                YopE ⊣ RHOA N01104    LPA → LPAR → (GNAQ,GNA11) → ARHGEF12 → RHOA N01105        YpkA ⊣ GNAQ N01068    FN1 → (ITGA+ITGB) → (SRC,PTK2) → (PXN,CRK+BCAR1) → (DOCK1+ELMO1) → RAC N01111        YopH ⊣ PTK2 N01109            YopH ⊣ PXN N01110            YopH ⊣ BCAR1 N00951    FN1 → (ITGA+ITGB) → RHOG → (DOCK1+ELMO) → RAC N01100        YopE ⊣ RHOG N01101        YopT ⊣ RHOG N01102                YopE ⊣ RAC1 N01090    IGG → FCGR → CRK → DOCK1 → RAC N01103                YpkA ⊣ RAC