[ Network menu | Network entry | Help ]

ENTRY	nt06501
Name	HH signaling
Category	Pathway view; Signal transduction
Pathway	hsa04340 Hedgehog signaling pathway
Disease	H00039 Basal cell carcinoma H01835 Neuronal migration disorder
Display	drug-target relation   disease type

N00062    HH → PTCH ⌿ SMO → (SMO+EVC) → (SUFU+KIF7) ⌿ GLI ⇒ (GLI1,PTCH,HHIP)     HPE3/MCOPCB5 SHH*     BDA1/ACFD IHH*     BCC1     PTCH1*     HPE7/BCNS     PTCH1*     BCC1     PTCH2*     BCC1         SMO* ↗     EVC/WAD             EVC*     EVC/WAD             EVC2*     BCNS/JBTS32                 SUFU*     JBTS12/ACLS/HLS2                 KIF7*     PAPA8/PPD1                     GLI1*     HPE9                     GLI2*     GCPS/PAPA1/PAPB/PPD4/PHS                     GLI3* N01537    HHAT → HH − DISP1 ⇉ SCUBE2 → HH(extracellular)     NNMS HHAT* N01538    ((CDON,BOC),GAS1,L.. → (HH+PTCH)     HPE11 CDON*     DBS LRP2*

		Disease name	Disease category
HPE3/MCOPCB5	H00267	Holoprosencephaly	Congenital malformation
	H01027	Microphthalmia	Congenital malformation
BDA1/ACFD	H00482	Brachydactyly	Congenital malformation
	H00675	Acrocapitofemoral dysplasia	Congenital malformation
BCC1	H00039	Basal cell carcinoma	Cancer
HPE7/BCNS	H00267	Holoprosencephaly	Congenital malformation
	H00895	Basal cell nevus syndrome	Congenital malformation
EVC/WAD	H00503	Ellis-van Creveld syndrome	Congenital malformation
	H02158	Weyers acrofacial dysostosis	Congenital malformation
BCNS/JBTS32	H00895	Basal cell nevus syndrome	Congenital malformation
	H00530	Joubert syndrome and related disorders	Congenital malformation
JBTS12/ACLS/HLS2	H00530	Joubert syndrome and related disorders	Congenital malformation
	H00263	Acrocallosal syndrome	Congenital malformation
	H01265	Hydrolethalus syndrome	Congenital malformation
PAPA8/PPD1	H01852	Postaxial polydactyly	Congenital malformation
	H02332	Preaxial polydactyly	Congenital malformation
HPE9	H00267	Holoprosencephaly	Congenital malformation
GCPS/PAPA1/PAPB/PPD4/PHS	H02161	Greig cephalopolysyndactyly syndrome	Congenital malformation
	H01852	Postaxial polydactyly	Congenital malformation
	H02332	Preaxial polydactyly	Congenital malformation
	H00502	Pallister-Hall syndrome	Congenital malformation
NNMS	H02479	Nivelon-Nivelon-Mabille syndrome	Congenital malformation
HPE11	H00267	Holoprosencephaly	Congenital malformation
DBS	H00886	Donnai-Barrow syndrome	Congenital malformation