[ Network menu | Network entry | Help ]

ENTRY	nt06511
Name	NOTCH signaling
Category	Pathway view; Signal transduction
Pathway	hsa04330 Notch signaling pathway
Display	drug-target relation   disease type

N00086        (DLL,JAG) → NOTCH → (NICD+RBPJ) ⇒ (HES1,HEY1)     SCDO1     DLL3*     AOS6     DLL4*     TOF/ALGS1     JAG1*     AOVD1/AOS5         NOTCH1*     HJCYS/ALGS2         NOTCH2*     IFM2/CADASIL/LMS         NOTCH3*     AOS3             RBPJ* N00380    HPV E6 → JAG1 → NOTCH → (NICD+RBPJ+MAML) ⇒ (HES1,HEY1) N00381    HPV E6 ⊣ MFNG ⊣ NOTCH → (NICD+RBPJ+MAML) ⇒ (HES1,HEY1) N00382    HPV E6 → (NFX1+PSEN1) → NOTCH → (NICD+RBPJ+MAML) ⇒ (HES1,HEY1) N01478    NOTCH − ADAM17 ⇉ (PSEN+PSENEN+NCSTN.. → NICD     NISBD1     ADAM17*     ACNINV1         NCSTN*     ACNINV2         PSENEN*     ACNINV3         PSEN1* N01479    (MIB,NEUR) → (DLL,JAG)     LVNC7 MIB1* N01480    (NICD+RBPJ) ⇒ HES7 ⊣ LFNG     SCDO4     HES7*     SCDO3     LNFG* N01481    (NICD+RBPJ+TBX6) ⇒ MESP2 ⇒ (RIPPLY2,LFNG,EPHA..     SCDO5 TBX6*     SCDO2     MESP2*     SCDO6         RIPPLY2*

		Disease name	Disease category
SCDO1	H00517	Spondylocostal dysostosis	Congenital malformation
AOS6	H01413	Adams-Oliver syndrome	Congenital malformation
TOF/ALGS1	H00549	Tetralogy of Fallot	Congenital malformation
	H00551	Alagille syndrome	Congenital malformation
AOVD1/AOS5	H00554	Aortic valve disease	Congenital malformation
	H01413	Adams-Oliver syndrome	Congenital malformation
HJCYS/ALGS2	H00623	Hajdu-Cheney syndrome	Musculoskeletal disease
	H00551	Alagille syndrome	Congenital malformation
IFM2/CADASIL/LMS	H01910	Infantile myofibromatosis	Neoplasm
	H00536	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)	Congenital malformation
	H01893	Lateral meningocele syndrome	Congenital malformation
AOS3	H01413	Adams-Oliver syndrome	Congenital malformation
HPV	H00030	Cervical cancer	Cancer
NISBD1	H02467	Neonatal inflammatory skin and bowel disease	Immune system disease
ACNINV1	H00681	Acne inversa	Skin disease
ACNINV2	H00681	Acne inversa	Skin disease
ACNINV3	H00681	Acne inversa	Skin disease
LVNC7	H01216	Left ventricular noncompaction	Cardiovascular disease
SCDO4	H00517	Spondylocostal dysostosis	Congenital malformation
SCDO3	H00517	Spondylocostal dysostosis	Congenital malformation
SCDO5	H00517	Spondylocostal dysostosis	Congenital malformation
SCDO2	H00517	Spondylocostal dysostosis	Congenital malformation
SCDO6	H00517	Spondylocostal dysostosis	Congenital malformation