[ Network menu | Network entry | Help ]

ENTRY	nt06532
Name	Autophagy
Category	Pathway view; Cellular process
Pathway	hsa04140 Autophagy - animal
Display	drug-target relation   disease type

N00155        mTORC1 → ULK1_complex → PI3KC3-C1 N00177    KSHV         vBCL2 ⊣ (BECN1+PIK3C3+ATG1.. N01717            ATXN3 → BECN1     SCA3         ATXN3* N01715            PI − PI3KC3-C1 → PI3P → (WIPI,ZFYVE1)     NBIA5                     WDR45*     NEDSBAS                     WDR45B* N01142    RAB1A → (C9orf72+WDR41+SMC.. → ULK1_complex     FTDALS1     C9orf72* N00156    LC3 − ATG4 ⇉ ATG7 ⇉ ATG3 ⇉ (ATG12+ATG5+ATG16L.. → LC3-II     SCAR31         ATG7*     SCAR25                 ATG5*     IBD10                 ATG16L1* N00176    KSHV         vFLIP ⊣ ATG3 N01284    Shigella         IcsP ⊣ C3 = ATG16L N01716                Ubiquitinated_prot.. = (SQSTM1,NBR1,OPTN,.. = LC3-II     PDB3/DMRV/FTDALS3                 SQSTM1*     ALS12                 OPTN*     GLC1E                 OPTN* ↗ N01718    RUBCNL ⊣ RUBCN ⊣ PI3KC3-C2     SCAR15     RUBCN* N01719    (EPM2A+NHLRC1) → (BECN1,PIK3C3,PIK3..     EPM2A EPM2A*     EPM2B NHLRC1* N01720    (VAMP8,STX7) = SNAP29 = (STX17,YKT6)     CEDNIK     SNAP29* N01721    RAB7 = (EPG5,PLEKHM1,BIRC.. = LC3-II     CMT2B RAB7A*     HLD12/DYT32     VPS11*     HSAN9     TECPR2* N01722    LAMP2 = GORASP2 = LC3-II     DD LAMP2*

		Disease name	Disease category
KSHV	H00041	Kaposi sarcoma	Cancer
SCA3	H00063	Spinocerebellar ataxia (SCA)	Neurodegenerative disease
NBIA5	H00833	Neurodegeneration with brain iron accumulation	Nervous system disease
NEDSBAS	H02470	Neurodevelopmental disorder with structural brain abnormalities	Congenital malformation
FTDALS1	H02342	Frontotemporal dementia and amyotrophic lateral sclerosis	Nervous system disease
SCAR31	H01891	Autosomal recessive spinocerebellar ataxias	Neurodegenerative disease
SCAR25	H01891	Autosomal recessive spinocerebellar ataxias	Neurodegenerative disease
IBD10	H01227	Inflammatory bowel disease (IBD)	Immune system disease
Shigella	H00299	Shigellosis	Bacterial infectious disease
PDB3/DMRV/FTDALS3	H00437	Paget disease of bone	Musculoskeletal disease
	H00594	Distal myopathy	Nervous system disease
	H02342	Frontotemporal dementia and amyotrophic lateral sclerosis	Nervous system disease
ALS12	H00058	Amyotrophic lateral sclerosis (ALS)	Neurodegenerative disease
GLC1E	H00612	Primary open angle glaucoma	Nervous system disease
SCAR15	H01891	Autosomal recessive spinocerebellar ataxias	Neurodegenerative disease
EPM2A	H00810	Progressive myoclonic epilepsy	Nervous system disease
EPM2B	H00810	Progressive myoclonic epilepsy	Nervous system disease
CEDNIK	H00799	CEDNIK syndrome	Congenital malformation
CMT2B	H00264	Charcot-Marie-Tooth disease	Neurodegenerative disease
HLD12/DYT32	H00679	Hypomyelinating leukodystrophy	Inherited metabolic disorder
	H00831	Primary dystonia	Nervous system disease
HSAN9	H00265	Hereditary sensory and autonomic neuropathy	Nervous system disease
DD	H00150	Danon disease	Inherited metabolic disorder, Lysosomal disease