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ENTRY	nt06536
Name	Mitophagy
Category	Pathway view; Cellular process
Pathway	hsa04137 Mitophagy - animal
Disease	H00057 Parkinson disease H01600 Parkinsonian syndrome
Display	drug-target relation   disease type

N01756    AMBRA1 → PINK1 → (PRKN,ARIH1,SIAH1,.. → Outer_membrane_pro.. = (SQSTM1,OPTN,NDP52.. = LC3-II     MRXST         HUWE1* N01757        PINK1 → PRKN → Outer_membrane_pro..     PARK6     PINK1*     PARK2         PRKN* N01140                TBK1 → (SQSTM1,OPTN,NDP52.. = LC3-II     FTDALS4             TBK1*     FTDALS3/PDB3/DMRV                 SQSTM1*     ALS12                 OPTN*     GLC1E                 OPTN* ↗ N01759    VCP ⊣ MFN1/2 = OPA1     CMT2Y/FTDALS6 VCP*     CMT2A2/6     MFN2*     OPA1/MTDPS14         OPA1* N01760    RAB5(GDP) − RABGEF1 → RAB5(GTP) − (MON1+CCZ1) → RAB7(GTP) − (TBC1D15,TBC1D17) → RAB7(GDB)     CMT2B                 RAB7A*

		Disease name	Disease category
MRXST	H00658	X-linked syndromic intellectual developmental disorder	Mental and behavioural disorder
PARK6	H00057	Parkinson disease	Neurodegenerative disease
	H01600	Parkinsonian syndrome	Neurodegenerative disease
PARK2	H00057	Parkinson disease	Neurodegenerative disease
	H01600	Parkinsonian syndrome	Neurodegenerative disease
FTDALS4	H02342	Frontotemporal dementia and amyotrophic lateral sclerosis	Nervous system disease
FTDALS3/PDB3/DMRV	H02342	Frontotemporal dementia and amyotrophic lateral sclerosis	Nervous system disease
	H00437	Paget disease of bone	Musculoskeletal disease
	H00594	Distal myopathy	Nervous system disease
ALS12	H00058	Amyotrophic lateral sclerosis (ALS)	Neurodegenerative disease
GLC1E	H00612	Primary open angle glaucoma	Nervous system disease
CMT2Y/FTDALS6	H00264	Charcot-Marie-Tooth disease	Neurodegenerative disease
	H02342	Frontotemporal dementia and amyotrophic lateral sclerosis	Nervous system disease
CMT2A2/6	H00264	Charcot-Marie-Tooth disease	Neurodegenerative disease
OPA1/MTDPS14	H01020	Optic atrophy	Nervous system disease
	H00469	Mitochondrial DNA depletion syndrome	Inherited metabolic disorder, Mitochondrial disease
CMT2B	H00264	Charcot-Marie-Tooth disease	Neurodegenerative disease