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ENTRY	nt06530
Name	PI3K signaling
Category	Pathway view; Signal transduction
Pathway	hsa04151 PI3K-Akt signaling pathway
Display	drug-target relation   disease type

N01656    GF → RTK → PI3K → PIP3 → AKT     Many cancers GF* ↗     Many cancers     RTK* ↗     ALS19 NRG ⌿ ERBB4*     BC         PIK3CA* ↗     PROS         PIK3CA* ↗     MPPH1         PIK3R2* ↗     CWS6/PS                 AKT1* ↗     HIHGHH                 AKT2* ↗     MPPH2                 AKT3* ↗ N00220            PTEN ⊣ PIP3 → AKT     Many cancers         PTEN*     CWS1/MAS         PTEN* N00355                PP2A ⊣ AKT     NEDLBA             PPP2CA*     MRD36             PPP2R1A*     SCA12             PPP2R2B* ↗     SPGF36             PPP2R3C* ↗     MRD35             PPP2R5D* N01658    GF → RTK → GRB2 → SOS → RAS → PI3K → PIP3 → AKT     Many cancers                 RAS* ↗     AML     FLT3* ↗     EN     FGFR3* ↗     EN                 NRAS* ↗     EN                 HRAS* ↗     EN                     PIK3CA* ↗ N01657    (GPCR+GNB+GNG) → PI3Kgamma → PIP3 → AKT     MRD42 GNB1* ↗     IMD97     PIK3CG*     AOA3     PIK3R5* N01163    NRG → ERBB4 → PI3K → PIP3 → AKT

		Disease name	Disease category
ALS19	H00058	Amyotrophic lateral sclerosis (ALS)	Neurodegenerative disease
BC	H00031	Breast cancer	Cancer
PROS	H02647	Macrodactyly	Congenital malformation
	H02153	Megalencephaly-capillary malformation syndrome	Congenital malformation
	H01912	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Congenital malformation
	H02297	CLAPO syndrome	Congenital malformation
	H00534	Cerebral cavernous malformation	Congenital malformation
	H01222	Cowden syndrome	Congenital malformation
MPPH1	H01885	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome	Congenital malformation
CWS6/PS	H01222	Cowden syndrome	Congenital malformation
	H02119	Proteus syndrome	Congenital malformation
HIHGHH	H01909	Hypoinsulinemic hypoglycemia with hemihypertrophy	Inherited metabolic disorder
MPPH2	H01885	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome	Congenital malformation
CWS1/MAS	H01222	Cowden syndrome	Congenital malformation
	H02723	Macrocephaly/autism syndrome	Congenital malformation
NEDLBA	H02632	PP2A-related neurodevelopmental disorder	Congenital malformation
MRD36	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
SCA12	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
SPGF36	H01282	Spermatogenic failure	Reproductive system disease
MRD35	H02632	PP2A-related neurodevelopmental disorder	Congenital malformation
AML	H00003	Acute myeloid leukemia	Cancer
EN	H02627	Epidermal nevus	Congenital malformation
MRD42	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
IMD97	H00093	Combined immunodeficiency	Primary immunodeficiency
AOA3	H00848	Ataxia with ocular apraxia	Nervous system disease